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Conserved domains on  [gi|446161755|ref|WP_000239610|]
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MULTISPECIES: phospholipase [Staphylococcus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EEP super family cl00490
Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; This large superfamily includes ...
 43-61 2.03e-04

Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; This large superfamily includes the catalytic domain (exonuclease/endonuclease/phosphatase or EEP domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds; their substrates range from nucleic acids to phospholipids and perhaps proteins.


The actual alignment was detected with superfamily member TIGR03395:

Pssm-ID: 469791 [Multi-domain]  Cd Length: 283  Bit Score: 37.13  E-value: 2.03e-04
                          10
                  ....*....|....*....
gi 446161755   43 LKLVSHNVYMLSTVLYPNW 61
Cdd:TIGR03395   1 IKILSHNVYMLSTNLYPNW 19
 
Name Accession Description Interval E-value
sphingomy TIGR03395
sphingomyelin phosphodiesterase; Members of this family are bacterial proteins that act as ...
 43-61 2.03e-04

sphingomyelin phosphodiesterase; Members of this family are bacterial proteins that act as sphingomyelin phosphodiesterase (EC 3.1.4.12), also called sphingomyelinase. Some members of this family have been shown to act as hemolysins. [Cellular processes, Pathogenesis]


Pssm-ID: 132436 [Multi-domain]  Cd Length: 283  Bit Score: 37.13  E-value: 2.03e-04
                          10
                  ....*....|....*....
gi 446161755   43 LKLVSHNVYMLSTVLYPNW 61
Cdd:TIGR03395   1 IKILSHNVYMLSTNLYPNW 19
 
Name Accession Description Interval E-value
sphingomy TIGR03395
sphingomyelin phosphodiesterase; Members of this family are bacterial proteins that act as ...
 43-61 2.03e-04

sphingomyelin phosphodiesterase; Members of this family are bacterial proteins that act as sphingomyelin phosphodiesterase (EC 3.1.4.12), also called sphingomyelinase. Some members of this family have been shown to act as hemolysins. [Cellular processes, Pathogenesis]


Pssm-ID: 132436 [Multi-domain]  Cd Length: 283  Bit Score: 37.13  E-value: 2.03e-04
                          10
                  ....*....|....*....
gi 446161755   43 LKLVSHNVYMLSTVLYPNW 61
Cdd:TIGR03395   1 IKILSHNVYMLSTNLYPNW 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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