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Conserved domains on  [gi|446003574|ref|WP_000081429|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Bacillus]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
12-93 2.41e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 87.64  E-value: 2.41e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446003574 12 EEDVQMLRALAHPLRLRLVMELMQRGtCNVTQLQEVLEIPQSTVSQHLTKLKQNKVVRFERRGLEVYYQIHNDKVSEVVK 91
Cdd:COG0640   8 EELAELFKALADPTRLRILRLLAEGE-LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86


                ..
gi 446003574 92 TL 93
Cdd:COG0640  87 WL 88
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
12-93 2.41e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 87.64  E-value: 2.41e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446003574 12 EEDVQMLRALAHPLRLRLVMELMQRGtCNVTQLQEVLEIPQSTVSQHLTKLKQNKVVRFERRGLEVYYQIHNDKVSEVVK 91
Cdd:COG0640   8 EELAELFKALADPTRLRILRLLAEGE-LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86


                ..
gi 446003574 92 TL 93
Cdd:COG0640  87 WL 88
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 15-90 2.03e-23

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 84.82  E-value: 2.03e-23
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446003574 15 VQMLRALAHPLRLRLVMELMQRGTCnVTQLQEVLEIPQSTVSQHLTKLKQNKVVRFERRGLEVYYQIHNDKVSEVV 90
Cdd:NF033788  2 AELFKALADPTRLRILELLAEGELC-VCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-93 3.66e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 63.86  E-value: 3.66e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446003574 18 LRALAHPLRLRLVMELMQRGTCnVTQLQEVLEIPQSTVSQHLTKLKQNKVVRFERRGLEVYYQI-HNDKVSEVVKTL 93
Cdd:cd00090   1 LKALSDPTRLRILRLLLEGPLT-VSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLtDAERLLALLESL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
30-93 1.43e-13

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 59.53  E-value: 1.43e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446003574   30 VMELMQRGTCNVTQLQEVLEIPQSTVSQHLTKLKQNKVVRFERRGLEVYYQIHNDKVSEVVKTL 93
Cdd:smart00418  2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 18-74 2.32e-11

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 53.70  E-value: 2.32e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446003574  18 LRALAHPLRLRLVMELMQRGTCNVTQLQEVLEIPQSTVSQHLTKLKQNKVVRFERRG 74
Cdd:pfam12840  4 AEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 20-95 1.46e-06

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 42.01  E-value: 1.46e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446003574 20 ALAHPLRlRLVMELMQRGTCNVTQLQEVLEIPQSTVSQHLTKLKQNKVVRFERRGLEVYYQIHNDKVSEVVKTLFS 95
Cdd:NF033789  4 ALSDPTR-REILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLD 78
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
12-93 2.41e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 87.64  E-value: 2.41e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446003574 12 EEDVQMLRALAHPLRLRLVMELMQRGtCNVTQLQEVLEIPQSTVSQHLTKLKQNKVVRFERRGLEVYYQIHNDKVSEVVK 91
Cdd:COG0640   8 EELAELFKALADPTRLRILRLLAEGE-LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86


                ..
gi 446003574 92 TL 93
Cdd:COG0640  87 WL 88
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 15-90 2.03e-23

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 84.82  E-value: 2.03e-23
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446003574 15 VQMLRALAHPLRLRLVMELMQRGTCnVTQLQEVLEIPQSTVSQHLTKLKQNKVVRFERRGLEVYYQIHNDKVSEVV 90
Cdd:NF033788  2 AELFKALADPTRLRILELLAEGELC-VCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-93 3.66e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 63.86  E-value: 3.66e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446003574 18 LRALAHPLRLRLVMELMQRGTCnVTQLQEVLEIPQSTVSQHLTKLKQNKVVRFERRGLEVYYQI-HNDKVSEVVKTL 93
Cdd:cd00090   1 LKALSDPTRLRILRLLLEGPLT-VSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLtDAERLLALLESL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
30-93 1.43e-13

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 59.53  E-value: 1.43e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446003574   30 VMELMQRGTCNVTQLQEVLEIPQSTVSQHLTKLKQNKVVRFERRGLEVYYQIHNDKVSEVVKTL 93
Cdd:smart00418  2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
9-73 6.22e-13

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 58.82  E-value: 6.22e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446003574  9 RISEEDVQMLRALAHPLRLRLVmELMQRGTCNVTQLQEVLEIPQSTVSQHLTKLKQNKVVRFERR 73
Cdd:COG4189   4 LDDEESLEVLKALASETRLRIL-RLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYK 67
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 18-74 2.32e-11

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 53.70  E-value: 2.32e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446003574  18 LRALAHPLRLRLVMELMQRGTCNVTQLQEVLEIPQSTVSQHLTKLKQNKVVRFERRG 74
Cdd:pfam12840  4 AEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
9-84 3.35e-09

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 50.65  E-value: 3.35e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446003574   9 RISEEDVQMLRALAHPLRLRLVMELMQRGTCNVTQLQEVLEIPQSTVSQHLTKLKQNKVVRFERRGLEVYYQIHND 84
Cdd:COG3398   82 TYSEEEKKILAYLRRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPP 157
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 23-68 3.29e-07

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 42.82  E-value: 3.29e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 446003574  23 HPLRLRLVMELMQRGTCnVTQLQEVLEIPQSTVSQHLTKLKQNKVV 68
Cdd:pfam01022  1 DPTRLKILKLLAEGELC-VCELAEELGLSQSTVSHHLKKLREAGLV 45
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 20-95 1.46e-06

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 42.01  E-value: 1.46e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446003574 20 ALAHPLRlRLVMELMQRGTCNVTQLQEVLEIPQSTVSQHLTKLKQNKVVRFERRGLEVYYQIHNDKVSEVVKTLFS 95
Cdd:NF033789  4 ALSDPTR-REILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLD 78
FliA COG1191
DNA-directed RNA polymerase specialized sigma subunit [Transcription]; DNA-directed RNA ...
 12-61 3.70e-04

DNA-directed RNA polymerase specialized sigma subunit [Transcription]; DNA-directed RNA polymerase specialized sigma subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 440804 [Multi-domain]  Cd Length: 236  Bit Score: 37.50  E-value: 3.70e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446003574  12 EEDVQMLRALAH--PLRLRLVMELMQRGTCNVTQLQEVLEIPQSTVSQHLTK 61
Cdd:COG1191  174 EELREALAEAIEqlPERERLVLSLYYFEELTLKEIAEVLGVSESRVSRLHKK 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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