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Conserved domains on  [gi|441494035|gb|AGC50726|]
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hypothetical protein LAW_30058 (plasmid) [Lawsonia intracellularis N343]

Protein Classification

autotransporter outer membrane beta-barrel domain-containing protein( domain architecture ID 10657847)

autotransporter outer membrane beta-barrel domain-containing protein similar to Neisseria Meningitidis autotransporter NalP, a virulence-related protein which is secreted via the C-terminal translocator domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Autotransporter smart00869
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 402-596 4.61e-08

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type IV pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different peptidase is used and in some cases no cleavage occurs.


:

Pssm-ID: 214872 [Multi-domain]  Cd Length: 268  Bit Score: 54.88  E-value: 4.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035   402 GSVKSKMETEGLSA-IVALNPANAGVTGHLVSSYNWGKVKNTRKIIHKGQEIiTKGSPKVNLLGGLVQLGYNFFLLNQVT 480
Cdd:smart00869  60 NKGSGKGDVDSYGLgLYAGYSLGNGLYLDAQLGYGRSDNDTKRKVTLGGAGR-AKGSYDGTGYGASLEAGYRFYLGGGLT 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035   481 LVPYVECMFSSVSWSSYKEQ-YSPGACKFGKNKEQILEKSIGLRSDIGVSMNSSMQLWVAGISGYSKTNSLISSSYLSSY 559
Cdd:smart00869 139 LTPFAGLAYSRVRQDGFTESgGGAFGLSVDSQSLDSLSLPLGLRLEYRLALGDGATLTPYLRLAYVHDFYDDNPVVTASL 218

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 441494035   560 YRHNLSTYAKKYQYIRT--ELGVSYDGTFSDNVSVSLSG 596
Cdd:smart00869 219 LGSGASFTTSGTDLDRNaaELGLGLSAKLSNGLSLSLNY 257
 
Name Accession Description Interval E-value
Autotransporter smart00869
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 402-596 4.61e-08

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type IV pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different peptidase is used and in some cases no cleavage occurs.


Pssm-ID: 214872 [Multi-domain]  Cd Length: 268  Bit Score: 54.88  E-value: 4.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035   402 GSVKSKMETEGLSA-IVALNPANAGVTGHLVSSYNWGKVKNTRKIIHKGQEIiTKGSPKVNLLGGLVQLGYNFFLLNQVT 480
Cdd:smart00869  60 NKGSGKGDVDSYGLgLYAGYSLGNGLYLDAQLGYGRSDNDTKRKVTLGGAGR-AKGSYDGTGYGASLEAGYRFYLGGGLT 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035   481 LVPYVECMFSSVSWSSYKEQ-YSPGACKFGKNKEQILEKSIGLRSDIGVSMNSSMQLWVAGISGYSKTNSLISSSYLSSY 559
Cdd:smart00869 139 LTPFAGLAYSRVRQDGFTESgGGAFGLSVDSQSLDSLSLPLGLRLEYRLALGDGATLTPYLRLAYVHDFYDDNPVVTASL 218

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 441494035   560 YRHNLSTYAKKYQYIRT--ELGVSYDGTFSDNVSVSLSG 596
Cdd:smart00869 219 LGSGASFTTSGTDLDRNaaELGLGLSAKLSNGLSLSLNY 257
Autotransporter pfam03797
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 364-595 2.70e-06

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.


Pssm-ID: 461054 [Multi-domain]  Cd Length: 255  Bit Score: 49.30  E-value: 2.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035  364 GQIGVLLDFSPGLTCG--FAYDSNKkeskeykgIQLGSTIGSVKSKmeTEGLSAIVALNPANaGVTGHLVSSYNWGKVKN 441
Cdd:pfam03797  28 LQVGADYRLGDNLRLGvaFGYSRSD--------ADVDGRGGSGDSD--SYSLGLYGTYYGDG-GWYLDGGLGYGWHDNDT 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035  442 TRKIIHKGQEIITKGSPKVNLLGGLVQLGYNFFLLNQVTLVPYVECMFSSVSWSSYKEQYSPGACKFGKNKEQILEKSIG 521
Cdd:pfam03797  97 RRSVDLGGFSETAKGDYDGNGFGASLEAGYRFALGGGWTLEPFAGLAYVRLRLDGFTESGGAAALSVDSQSYDSLTGRLG 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035  522 LRSDIGVSM-NSSMQLWV-AGI----SGYSKTNSLISSSYLSSYYRHNLSTYAKKYqyiRTELGVSYDGTFSDNVSVSLS 595
Cdd:pfam03797 177 LRLSYTFDLgGGTLTPYArLGWrhefGDDDPVTTAAFAGLSGAGSFTVAGADLARD---SLELGAGLSAQLSDNLSLYAN 253
COG4625 COG4625
Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function ...
 405-618 9.85e-03

Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function unknown];


Pssm-ID: 443664 [Multi-domain]  Cd Length: 900  Bit Score: 38.99  E-value: 9.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035 405 KSKMETEGLSAIVALNPANAGVTGHLvsSYNWGKVKNTRKIIHKGQEIITKGSPKVNLLGGLVQLGYNFfLLNQVTLVPY 484
Cdd:COG4625  688 SGDSDSYHLGLYGGYQFGALYLDGGL--GYGWNDYDTDRTIAFGGLSRTATADYDGDTASAFLEAGYRF-DLGGLTLTPF 764

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035 485 VECMFSSVSWSSYKEQYSPGACKFGKNKEQILEKSIGLRSDIGVSMNSSMQLWVAGISGYSKTnslisSSYLSSYYRHNL 564
Cdd:COG4625  765 AGLAYVRLRTDGFTETGGAAALSVDSQSTDSLRSTLGLRASRTFSLGGGVTLTPSGRLGWRHE-----FGDDDPSTTASF 839

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 441494035 565 STYAKKYQYIRT--------ELGVSYDGTFSDNVSVSLS--GLFRlnkwSKVDNQNIVAQVQYT 618
Cdd:COG4625  840 AGAPGAAFTVAGaplardalVLGAGLSARLSDGLSLGLGydGEFG----SGYTDHGGSAGLRYR 899
 
Name Accession Description Interval E-value
Autotransporter smart00869
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 402-596 4.61e-08

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type IV pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different peptidase is used and in some cases no cleavage occurs.


Pssm-ID: 214872 [Multi-domain]  Cd Length: 268  Bit Score: 54.88  E-value: 4.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035   402 GSVKSKMETEGLSA-IVALNPANAGVTGHLVSSYNWGKVKNTRKIIHKGQEIiTKGSPKVNLLGGLVQLGYNFFLLNQVT 480
Cdd:smart00869  60 NKGSGKGDVDSYGLgLYAGYSLGNGLYLDAQLGYGRSDNDTKRKVTLGGAGR-AKGSYDGTGYGASLEAGYRFYLGGGLT 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035   481 LVPYVECMFSSVSWSSYKEQ-YSPGACKFGKNKEQILEKSIGLRSDIGVSMNSSMQLWVAGISGYSKTNSLISSSYLSSY 559
Cdd:smart00869 139 LTPFAGLAYSRVRQDGFTESgGGAFGLSVDSQSLDSLSLPLGLRLEYRLALGDGATLTPYLRLAYVHDFYDDNPVVTASL 218

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 441494035   560 YRHNLSTYAKKYQYIRT--ELGVSYDGTFSDNVSVSLSG 596
Cdd:smart00869 219 LGSGASFTTSGTDLDRNaaELGLGLSAKLSNGLSLSLNY 257
Autotransporter pfam03797
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 364-595 2.70e-06

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.


Pssm-ID: 461054 [Multi-domain]  Cd Length: 255  Bit Score: 49.30  E-value: 2.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035  364 GQIGVLLDFSPGLTCG--FAYDSNKkeskeykgIQLGSTIGSVKSKmeTEGLSAIVALNPANaGVTGHLVSSYNWGKVKN 441
Cdd:pfam03797  28 LQVGADYRLGDNLRLGvaFGYSRSD--------ADVDGRGGSGDSD--SYSLGLYGTYYGDG-GWYLDGGLGYGWHDNDT 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035  442 TRKIIHKGQEIITKGSPKVNLLGGLVQLGYNFFLLNQVTLVPYVECMFSSVSWSSYKEQYSPGACKFGKNKEQILEKSIG 521
Cdd:pfam03797  97 RRSVDLGGFSETAKGDYDGNGFGASLEAGYRFALGGGWTLEPFAGLAYVRLRLDGFTESGGAAALSVDSQSYDSLTGRLG 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035  522 LRSDIGVSM-NSSMQLWV-AGI----SGYSKTNSLISSSYLSSYYRHNLSTYAKKYqyiRTELGVSYDGTFSDNVSVSLS 595
Cdd:pfam03797 177 LRLSYTFDLgGGTLTPYArLGWrhefGDDDPVTTAAFAGLSGAGSFTVAGADLARD---SLELGAGLSAQLSDNLSLYAN 253
COG4625 COG4625
Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function ...
 405-618 9.85e-03

Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function unknown];


Pssm-ID: 443664 [Multi-domain]  Cd Length: 900  Bit Score: 38.99  E-value: 9.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035 405 KSKMETEGLSAIVALNPANAGVTGHLvsSYNWGKVKNTRKIIHKGQEIITKGSPKVNLLGGLVQLGYNFfLLNQVTLVPY 484
Cdd:COG4625  688 SGDSDSYHLGLYGGYQFGALYLDGGL--GYGWNDYDTDRTIAFGGLSRTATADYDGDTASAFLEAGYRF-DLGGLTLTPF 764

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 441494035 485 VECMFSSVSWSSYKEQYSPGACKFGKNKEQILEKSIGLRSDIGVSMNSSMQLWVAGISGYSKTnslisSSYLSSYYRHNL 564
Cdd:COG4625  765 AGLAYVRLRTDGFTETGGAAALSVDSQSTDSLRSTLGLRASRTFSLGGGVTLTPSGRLGWRHE-----FGDDDPSTTASF 839

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 441494035 565 STYAKKYQYIRT--------ELGVSYDGTFSDNVSVSLS--GLFRlnkwSKVDNQNIVAQVQYT 618
Cdd:COG4625  840 AGAPGAAFTVAGaplardalVLGAGLSARLSDGLSLGLGydGEFG----SGYTDHGGSAGLRYR 899
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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