NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|440355926|gb|AGC00770|]
View 

desmin, partial [Homo sapiens]

Protein Classification

intermediate filament family protein( domain architecture ID 705869)

intermediate filament (IF) family protein is a primordial component of the cytoskeleton and the nuclear envelope; such as type I keratins

CATH:  1.20.5.170
Gene Ontology:  GO:0005882
PubMed:  2183847|12596228|28101862

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Filament super family cl25641
Intermediate filament protein;
1-86 5.02e-26

Intermediate filament protein;


The actual alignment was detected with superfamily member pfam00038:

Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 97.30  E-value: 5.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440355926    1 DVDAATLARIDLERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMS-KPDLTAALRDIRAQYETIAAKNISEA 79
Cdd:pfam00038 111 DLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSDTQVNVEMDAArKLDLTSALAEIRAQYEEIAAKNREEA 190


                  ....*..
gi 440355926   80 EEWYKSK 86
Cdd:pfam00038 191 EEWYQSK 197
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
1-86 5.02e-26

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 97.30  E-value: 5.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440355926    1 DVDAATLARIDLERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMS-KPDLTAALRDIRAQYETIAAKNISEA 79
Cdd:pfam00038 111 DLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSDTQVNVEMDAArKLDLTSALAEIRAQYEEIAAKNREEA 190


                  ....*..
gi 440355926   80 EEWYKSK 86
Cdd:pfam00038 191 EEWYQSK 197
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
1-86 5.02e-26

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 97.30  E-value: 5.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440355926    1 DVDAATLARIDLERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMS-KPDLTAALRDIRAQYETIAAKNISEA 79
Cdd:pfam00038 111 DLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSDTQVNVEMDAArKLDLTSALAEIRAQYEEIAAKNREEA 190


                  ....*..
gi 440355926   80 EEWYKSK 86
Cdd:pfam00038 191 EEWYQSK 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH