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Conserved domains on  [gi|431822385|ref|NP_001258878|]
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tubulin polyglutamylase complex subunit 2 isoform 2 [Homo sapiens]

Protein Classification

SMI1/KNR4 family protein( domain architecture ID 10657291)

SMI1/KNR4 family protein may be involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation

CATH:  3.40.1580.10
PubMed:  8289782
SCOP:  4002285

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SMI1_KNR4 smart00860
SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan ...
44-157 3.44e-14

SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.


:

Pssm-ID: 214864  Cd Length: 127  Bit Score: 67.67  E-value: 3.44e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431822385    44 PAERHMISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSV----------KLDDLEDDTHEASDDQPEKPHFDSRSVIFELD 113
Cdd:smart00860   1 PATEEEIAELEKKLGIKLPEDYKEFLLLYNGGELGGSAelplgglsllDLLELEAAIEDQEEIDSDIEEEEYALPGWLIF 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 431822385   114 SCNGSGKVCLVYKSGKPALAEDTE--IWFLDRALYWHFLTDTFTAY 157
Cdd:smart00860  81 IADGGGGGILIDLDDGPGGEGGEVgvILFGDDDDEKYVVADSFEEF 126
 
Name Accession Description Interval E-value
SMI1_KNR4 smart00860
SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan ...
44-157 3.44e-14

SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.


Pssm-ID: 214864  Cd Length: 127  Bit Score: 67.67  E-value: 3.44e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431822385    44 PAERHMISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSV----------KLDDLEDDTHEASDDQPEKPHFDSRSVIFELD 113
Cdd:smart00860   1 PATEEEIAELEKKLGIKLPEDYKEFLLLYNGGELGGSAelplgglsllDLLELEAAIEDQEEIDSDIEEEEYALPGWLIF 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 431822385   114 SCNGSGKVCLVYKSGKPALAEDTE--IWFLDRALYWHFLTDTFTAY 157
Cdd:smart00860  81 IADGGGGGILIDLDDGPGGEGGEVgvILFGDDDDEKYVVADSFEEF 126
SMI1_KNR4 pfam09346
SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1, ...
50-157 2.25e-03

SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.


Pssm-ID: 430545  Cd Length: 120  Bit Score: 37.03  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431822385   50 ISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVK----LDDLEDDTHEASDDQ----PEKPHFDSRSVIFEldSCNGSGKV 121
Cdd:pfam09346   7 IQEFEKELGVKLPEDYREFLLKTNGGGGLFEGLdllpLEEIEEEYEDLLAEDslyfIREWGLPEGLIPFA--DDGGGDYL 84
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 431822385  122 CLVYKSGKPalaEDTEIWFLDRALYWHFLTDTFTAY 157
Cdd:pfam09346  85 CLDLRDGGE---EGQVYFWDEDDDELKLVADSFEEF 117
 
Name Accession Description Interval E-value
SMI1_KNR4 smart00860
SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan ...
44-157 3.44e-14

SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.


Pssm-ID: 214864  Cd Length: 127  Bit Score: 67.67  E-value: 3.44e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431822385    44 PAERHMISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSV----------KLDDLEDDTHEASDDQPEKPHFDSRSVIFELD 113
Cdd:smart00860   1 PATEEEIAELEKKLGIKLPEDYKEFLLLYNGGELGGSAelplgglsllDLLELEAAIEDQEEIDSDIEEEEYALPGWLIF 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 431822385   114 SCNGSGKVCLVYKSGKPALAEDTE--IWFLDRALYWHFLTDTFTAY 157
Cdd:smart00860  81 IADGGGGGILIDLDDGPGGEGGEVgvILFGDDDDEKYVVADSFEEF 126
SMI1_KNR4 pfam09346
SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1, ...
50-157 2.25e-03

SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.


Pssm-ID: 430545  Cd Length: 120  Bit Score: 37.03  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431822385   50 ISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVK----LDDLEDDTHEASDDQ----PEKPHFDSRSVIFEldSCNGSGKV 121
Cdd:pfam09346   7 IQEFEKELGVKLPEDYREFLLKTNGGGGLFEGLdllpLEEIEEEYEDLLAEDslyfIREWGLPEGLIPFA--DDGGGDYL 84
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 431822385  122 CLVYKSGKPalaEDTEIWFLDRALYWHFLTDTFTAY 157
Cdd:pfam09346  85 CLDLRDGGE---EGQVYFWDEDDDELKLVADSFEEF 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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