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Conserved domains on  [gi|42476068|ref|NP_054864|]
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transmembrane protein 230 isoform 2 [Homo sapiens]

Protein Classification

TMEM134/230 family protein( domain architecture ID 7010)

TMEM134/230 family protein is a DUF872 domain-containing protein similar to human transmembrane protein 230 that is involved in trafficking and recycling of synaptic vesicles

PubMed:  22855487
TCDB:  9.B.232.1.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM_230_134 super family cl05468
Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins ...
 2-118 1.25e-16

Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins 230 and 134 (TMEM230 and 134). TMEM134 function is unknown, but it has been shown to interact with E virus ORF2. TMEM 230 is involved in trafficking and recycling of synaptic vesicles.


The actual alignment was detected with superfamily member pfam05915:

Pssm-ID: 399128  Cd Length: 115  Bit Score: 69.77  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476068     2 MPSRTNLATGIPSSKVKYSRLSSTDDGYIDLQFKKTppKIPYKAIALATVLFLIGAFLIIIGSLLLSGYISkggADRAVP 81
Cdd:pfam05915   4 LENEDDDSLYGNSSQYSPSTLSSTPQRSYWTRHPLV--KKNWKVVLAAFLLLLLGLVLLFTGIFIFINPHE---GVSSAV 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 42476068    82 VLIIGILVFLPGFYHLRIAYYASKGYRGYSYDDIPDF 118
Cdd:pfam05915  79 FFVPGFLCFIPGFYHVRYIYCAVRGRRGYRFFYLPYF 115
 
Name Accession Description Interval E-value
TMEM_230_134 pfam05915
Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins ...
 2-118 1.25e-16

Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins 230 and 134 (TMEM230 and 134). TMEM134 function is unknown, but it has been shown to interact with E virus ORF2. TMEM 230 is involved in trafficking and recycling of synaptic vesicles.


Pssm-ID: 399128  Cd Length: 115  Bit Score: 69.77  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476068     2 MPSRTNLATGIPSSKVKYSRLSSTDDGYIDLQFKKTppKIPYKAIALATVLFLIGAFLIIIGSLLLSGYISkggADRAVP 81
Cdd:pfam05915   4 LENEDDDSLYGNSSQYSPSTLSSTPQRSYWTRHPLV--KKNWKVVLAAFLLLLLGLVLLFTGIFIFINPHE---GVSSAV 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 42476068    82 VLIIGILVFLPGFYHLRIAYYASKGYRGYSYDDIPDF 118
Cdd:pfam05915  79 FFVPGFLCFIPGFYHVRYIYCAVRGRRGYRFFYLPYF 115
 
Name Accession Description Interval E-value
TMEM_230_134 pfam05915
Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins ...
 2-118 1.25e-16

Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins 230 and 134 (TMEM230 and 134). TMEM134 function is unknown, but it has been shown to interact with E virus ORF2. TMEM 230 is involved in trafficking and recycling of synaptic vesicles.


Pssm-ID: 399128  Cd Length: 115  Bit Score: 69.77  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476068     2 MPSRTNLATGIPSSKVKYSRLSSTDDGYIDLQFKKTppKIPYKAIALATVLFLIGAFLIIIGSLLLSGYISkggADRAVP 81
Cdd:pfam05915   4 LENEDDDSLYGNSSQYSPSTLSSTPQRSYWTRHPLV--KKNWKVVLAAFLLLLLGLVLLFTGIFIFINPHE---GVSSAV 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 42476068    82 VLIIGILVFLPGFYHLRIAYYASKGYRGYSYDDIPDF 118
Cdd:pfam05915  79 FFVPGFLCFIPGFYHVRYIYCAVRGRRGYRFFYLPYF 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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