NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|42415465|gb|AAS15702|]
View 

AT07779p [Drosophila melanogaster]

Protein Classification

cytochrome b5-like heme/steroid binding domain-containing protein( domain architecture ID 1903536)

cytochrome b5-like heme/steroid binding domain-containing protein similar to Xenopus laevis cytochrome b5 domain-containing protein 1

CATH:  3.10.120.10
Gene Ontology:  GO:0097159
PubMed:  12537557
SCOP:  3000073

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cyt-b5 super family cl44470
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 72-123 7.86e-05

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


The actual alignment was detected with superfamily member pfam00173:

Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 39.91  E-value: 7.86e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 42415465    72 SDGRILVALRGKIYDVsSDFEEF--GLTGTLSHVAGRDFTNYLKSImdTHNSEI 123
Cdd:pfam00173  10 GDGDCWVAINGKVYDV-TKFLKEhpGGEDVILSAAGKDATDAFEAI--GHSEDA 60
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 72-123 7.86e-05

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 39.91  E-value: 7.86e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 42415465    72 SDGRILVALRGKIYDVsSDFEEF--GLTGTLSHVAGRDFTNYLKSImdTHNSEI 123
Cdd:pfam00173  10 GDGDCWVAINGKVYDV-TKFLKEhpGGEDVILSAAGKDATDAFEAI--GHSEDA 60
COG4892 COG4892
Predicted heme/steroid binding protein [General function prediction only];
60-113 3.44e-04

Predicted heme/steroid binding protein [General function prediction only];


Pssm-ID: 443920 [Multi-domain]  Cd Length: 75  Bit Score: 37.88  E-value: 3.44e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 42415465  60 SLDQLLGFDGtrSDGR-ILVALRGKIYDVsSDFEEFGLTGTLSHVAGRDFTNYLK 113
Cdd:COG4892   5 TLEELAKYNG--KDGNpAYVAVNGKVYDV-TNSRLWKNGTHYGHWAGQDLTDELK 56
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 72-123 7.86e-05

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 39.91  E-value: 7.86e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 42415465    72 SDGRILVALRGKIYDVsSDFEEF--GLTGTLSHVAGRDFTNYLKSImdTHNSEI 123
Cdd:pfam00173  10 GDGDCWVAINGKVYDV-TKFLKEhpGGEDVILSAAGKDATDAFEAI--GHSEDA 60
COG4892 COG4892
Predicted heme/steroid binding protein [General function prediction only];
60-113 3.44e-04

Predicted heme/steroid binding protein [General function prediction only];


Pssm-ID: 443920 [Multi-domain]  Cd Length: 75  Bit Score: 37.88  E-value: 3.44e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 42415465  60 SLDQLLGFDGtrSDGR-ILVALRGKIYDVsSDFEEFGLTGTLSHVAGRDFTNYLK 113
Cdd:COG4892   5 TLEELAKYNG--KDGNpAYVAVNGKVYDV-TNSRLWKNGTHYGHWAGQDLTDELK 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH