NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|42407906|dbj|BAD09046|]
View 

putative adenylate kinase, chloroplast precursor (ATP-AMP transphosphorylase) [Oryza sativa Japonica Group]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN02459 super family cl33495
probable adenylate kinase
 72-290 1.55e-52

probable adenylate kinase


The actual alignment was detected with superfamily member PLN02459:

Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 172.72  E-value: 1.55e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   72 QWVVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKGET 151
Cdd:PLN02459  31 NWVFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEEGES 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  152 GFILDGIPRTHMQAEILDEIVDIDLVLNFKCADNCFMKRRFGGDICPHCGQLFDFS--KTASSDRNPSLGSCTWPSQVQH 229
Cdd:PLN02459 111 GFILDGFPRTVRQAEILEGVTDIDLVVNLKLREEVLVEKCLGRRICSECGKNFNVAdiDLKGEDGRPGIVMPPLLPPPEC 190

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42407906  230 AAVL-----GLEDSRMEKMRAYAEQTKLLEDYYRKQRKLMELKTSARPGETWQGLVAALHLQHLDA 290
Cdd:PLN02459 191 ASKLitradDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEFELPGGIPETWPRLLQALNLDDEDK 256
 
Name Accession Description Interval E-value
PLN02459 PLN02459
probable adenylate kinase
 72-290 1.55e-52

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 172.72  E-value: 1.55e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   72 QWVVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKGET 151
Cdd:PLN02459  31 NWVFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEEGES 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  152 GFILDGIPRTHMQAEILDEIVDIDLVLNFKCADNCFMKRRFGGDICPHCGQLFDFS--KTASSDRNPSLGSCTWPSQVQH 229
Cdd:PLN02459 111 GFILDGFPRTVRQAEILEGVTDIDLVVNLKLREEVLVEKCLGRRICSECGKNFNVAdiDLKGEDGRPGIVMPPLLPPPEC 190

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42407906  230 AAVL-----GLEDSRMEKMRAYAEQTKLLEDYYRKQRKLMELKTSARPGETWQGLVAALHLQHLDA 290
Cdd:PLN02459 191 ASKLitradDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEFELPGGIPETWPRLLQALNLDDEDK 256
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 72-274 8.55e-48

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 158.17  E-value: 8.55e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  72 QWVVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEgyNKGET 151
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKK--PDCKK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906 152 GFILDGIPRTHMQAEILDEIVD----IDLVLNFKCADNCFMKRRFGGDICPHCGqlfdfsktassdRNPSLGSCTWPsqv 227
Cdd:cd01428  79 GFILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRRICPVSG------------RVYHLGKDDVT--- 143

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 42407906 228 qHAAVLGLEDSRMEK----MRAYAEQTKLLEDYYRKQRKLMELKTSARPGE 274
Cdd:cd01428 144 -GEPLSQRSDDNEETikkrLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDE 193
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 72-284 8.43e-37

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 130.43  E-value: 8.43e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906    72 QWVVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKgET 151
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDN-EN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   152 GFILDGIPRTHMQAEILDEIVD--IDLVLNFKCADNCFMKRRFGGDICPHCGQLFDfsKTASSDRNPSLGSCTWPSQVQH 229
Cdd:TIGR01351  80 GFILDGFPRTLSQAEALDALLEepIDAVIELDVPDEELVERLSGRRICPSCGRVYH--LKFNPPKVPGCDDCTGELLVQR 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 42407906   230 aavlglEDSRMEK----MRAYAEQTKLLEDYYRKQRKLMELKTSARPGETWQGLVAALH 284
Cdd:TIGR01351 158 ------EDDTEEVvkkrLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 74-283 1.22e-35

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 127.55  E-value: 1.22e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  74 VVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEgyNKGETGF 153
Cdd:COG0563   4 ILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQ--PDCANGF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906 154 ILDGIPRTHMQAEILDEIVD-----IDLVLNFKCADNCFMKR---RFggdICPHCGQLF--DFSKTASSDRNPSLGSctw 223
Cdd:COG0563  82 ILDGFPRTVAQAEALDELLAelgikLDAVIELDVDDEELVERlsgRR---VCPNCGATYhvKFNPPKVEGVCDKCGG--- 155

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42407906 224 pSQVQHAavlgleDSRME----KMRAYAEQTKLLEDYYRKQRKLMELKTSARPGETWQGLVAAL 283
Cdd:COG0563 156 -ELVQRA------DDNEEtvrkRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
ADK pfam00406
Adenylate kinase;
75-260 2.68e-31

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 115.10  E-value: 2.68e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906    75 VMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKGetGFI 154
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKN--GFL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   155 LDGIPRTHMQAEILDE----IVDIDLVLNFKCADNCFMKRRFGGDICPHCGQLF--DFSKTASsdrnPSLGSCTWPSQVQ 228
Cdd:pfam00406  79 LDGFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYhlEFNPPKV----PGKDDVTGEPLVQ 154

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 42407906   229 HAavlgleDSRMEKMR----AYAEQTKLLEDYYRKQ 260
Cdd:pfam00406 155 RS------DDNEETVKkrleTYHKQTKPLIDYYKKK 184
 
Name Accession Description Interval E-value
PLN02459 PLN02459
probable adenylate kinase
 72-290 1.55e-52

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 172.72  E-value: 1.55e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   72 QWVVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKGET 151
Cdd:PLN02459  31 NWVFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEEGES 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  152 GFILDGIPRTHMQAEILDEIVDIDLVLNFKCADNCFMKRRFGGDICPHCGQLFDFS--KTASSDRNPSLGSCTWPSQVQH 229
Cdd:PLN02459 111 GFILDGFPRTVRQAEILEGVTDIDLVVNLKLREEVLVEKCLGRRICSECGKNFNVAdiDLKGEDGRPGIVMPPLLPPPEC 190

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42407906  230 AAVL-----GLEDSRMEKMRAYAEQTKLLEDYYRKQRKLMELKTSARPGETWQGLVAALHLQHLDA 290
Cdd:PLN02459 191 ASKLitradDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEFELPGGIPETWPRLLQALNLDDEDK 256
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 72-274 8.55e-48

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 158.17  E-value: 8.55e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  72 QWVVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEgyNKGET 151
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKK--PDCKK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906 152 GFILDGIPRTHMQAEILDEIVD----IDLVLNFKCADNCFMKRRFGGDICPHCGqlfdfsktassdRNPSLGSCTWPsqv 227
Cdd:cd01428  79 GFILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRRICPVSG------------RVYHLGKDDVT--- 143

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 42407906 228 qHAAVLGLEDSRMEK----MRAYAEQTKLLEDYYRKQRKLMELKTSARPGE 274
Cdd:cd01428 144 -GEPLSQRSDDNEETikkrLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDE 193
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 72-284 8.43e-37

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 130.43  E-value: 8.43e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906    72 QWVVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKgET 151
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDN-EN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   152 GFILDGIPRTHMQAEILDEIVD--IDLVLNFKCADNCFMKRRFGGDICPHCGQLFDfsKTASSDRNPSLGSCTWPSQVQH 229
Cdd:TIGR01351  80 GFILDGFPRTLSQAEALDALLEepIDAVIELDVPDEELVERLSGRRICPSCGRVYH--LKFNPPKVPGCDDCTGELLVQR 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 42407906   230 aavlglEDSRMEK----MRAYAEQTKLLEDYYRKQRKLMELKTSARPGETWQGLVAALH 284
Cdd:TIGR01351 158 ------EDDTEEVvkkrLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 74-283 1.22e-35

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 127.55  E-value: 1.22e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  74 VVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEgyNKGETGF 153
Cdd:COG0563   4 ILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQ--PDCANGF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906 154 ILDGIPRTHMQAEILDEIVD-----IDLVLNFKCADNCFMKR---RFggdICPHCGQLF--DFSKTASSDRNPSLGSctw 223
Cdd:COG0563  82 ILDGFPRTVAQAEALDELLAelgikLDAVIELDVDDEELVERlsgRR---VCPNCGATYhvKFNPPKVEGVCDKCGG--- 155

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42407906 224 pSQVQHAavlgleDSRME----KMRAYAEQTKLLEDYYRKQRKLMELKTSARPGETWQGLVAAL 283
Cdd:COG0563 156 -ELVQRA------DDNEEtvrkRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
ADK pfam00406
Adenylate kinase;
75-260 2.68e-31

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 115.10  E-value: 2.68e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906    75 VMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKGetGFI 154
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKN--GFL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   155 LDGIPRTHMQAEILDE----IVDIDLVLNFKCADNCFMKRRFGGDICPHCGQLF--DFSKTASsdrnPSLGSCTWPSQVQ 228
Cdd:pfam00406  79 LDGFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYhlEFNPPKV----PGKDDVTGEPLVQ 154

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 42407906   229 HAavlgleDSRMEKMR----AYAEQTKLLEDYYRKQ 260
Cdd:pfam00406 155 RS------DDNEETVKkrleTYHKQTKPLIDYYKKK 184
adk PRK00279
adenylate kinase; Reviewed
 74-283 1.06e-26

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 104.08  E-value: 1.06e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   74 VVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEgyNKGETGF 153
Cdd:PRK00279   4 ILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQ--PDCKNGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  154 ILDGIPRTHMQAEILDEI-----VDIDLVLNFKCADNCFMKRRFGGDICPHCGQ----LFDFSKTAssdrnpslGSCtwp 224
Cdd:PRK00279  82 LLDGFPRTIPQAEALDEMlkelgIKLDAVIEIDVPDEELVERLSGRRICPACGRtyhvKFNPPKVE--------GKC--- 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42407906  225 sQVQHAAVLGLEDSRME----KMRAYAEQTKLLEDYYRKQRKLMELKTSARPGETWQGLVAAL 283
Cdd:PRK00279 151 -DVCGEELIQRADDNEEtvrkRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKAL 212
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 74-212 4.27e-24

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 97.56  E-value: 4.27e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   74 VVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKGETGF 153
Cdd:PTZ00088  10 VLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVTDDCFKGF 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 42407906  154 ILDGIPRTHMQAEILDEIVDIDLVLNFKCADNCFMKRRFGGDICPHCGQLFDFSKTASS 212
Cdd:PTZ00088  90 ILDGFPRNLKQCKELGKITNIDLFVNIYLPRNILIKKLLGRRICNTCNRNFNIAHIRSD 148
PRK14530 PRK14530
adenylate kinase; Provisional
 71-283 4.93e-20

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 86.38  E-value: 4.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   71 PQWVVMGRPGPQKHAHAARLAEVLAVPYISMGTLVR----QELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGy 146
Cdd:PRK14530   4 PRILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRankqMDISDMDTEYDTPGEYMDAGELVPDAVVNEIVEEALSDA- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  147 nkgeTGFILDGIPRTHMQAEILDEIVDIDLVLNFKCADNCFMKRRFGGDICPHCGQLF--DFSKTASSDRNPSLGSctwp 224
Cdd:PRK14530  83 ----DGFVLDGYPRNLEQAEYLESITDLDVVLYLDVSEEELVDRLTGRRVCPDCGANYhvEFNQPEEEGVCDECGG---- 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 42407906  225 SQVQHAAvlGLEDSRMEKMRAYAEQTKLLEDYYRKQRKLMELKTSARPGETWQGLVAAL 283
Cdd:PRK14530 155 ELIQRDD--DTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAI 211
adk PRK02496
adenylate kinase; Provisional
 74-283 1.33e-19

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 84.42  E-value: 1.33e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   74 VVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKGetGF 153
Cdd:PRK02496   5 IFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAAN--GW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  154 ILDGIPRTHMQAEILDEIVD-----IDLVLNFKCADNCFMKRRFGGdicphcGQLfDFSKTASSDRnpslgsctwpsqvq 228
Cdd:PRK02496  83 ILDGFPRKVTQAAFLDELLQeigqsGERVVNLDVPDDVVVERLLAR------GRK-DDTEEVIRRR-------------- 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 42407906  229 haavlgledsrmekMRAYAEQTKLLEDYYRKQRKLMELKTSARPGETWQGLVAAL 283
Cdd:PRK02496 142 --------------LEVYREQTAPLIDYYRDRQKLLTIDGNQSVEAVTTELKAAL 182
PRK14532 PRK14532
adenylate kinase; Provisional
 74-266 4.40e-18

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 80.25  E-value: 4.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   74 VVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEgyNKGETGF 153
Cdd:PRK14532   4 ILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPE--AEAAGGA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  154 ILDGIPRTHMQAEILDEIVD-----IDLVLNFKCADNCFMKRRFGgdicphcgqlfDFSKTASSDRNPslgsctwpsqvq 228
Cdd:PRK14532  82 IFDGFPRTVAQAEALDKMLAsrgqkIDVVIRLKVDDEALIERIVK-----------RFEEQGRPDDNP------------ 138

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 42407906  229 haavlgleDSRMEKMRAYAEQTKLLEDYYRKQRKLMEL 266
Cdd:PRK14532 139 --------EVFVTRLDAYNAQTAPLLPYYAGQGKLTEV 168
PRK14526 PRK14526
adenylate kinase; Provisional
 74-280 8.25e-18

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 79.90  E-value: 8.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   74 VVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKGEtgF 153
Cdd:PRK14526   4 VFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKNNDN--F 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  154 ILDGIPRTHMQAEILDEIVDIDLVLNFKCADNCFMKRRFGGDICPHCGQLFDFSKTASSDRnpslGSCTWPSQVQHAAVL 233
Cdd:PRK14526  82 ILDGFPRNINQAKALDKFLPNIKIINFLIDEELLIKRLSGRRICKSCNNIFNIYTLPTKEK----GICDVCKGDLYQRKD 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 42407906  234 GLEDSRMEKMRAYAEQTKLLEDYYRKQRKLMELKTSARPGETWQGLV 280
Cdd:PRK14526 158 DKEESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEVKKKLI 204
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 75-269 9.97e-18

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 79.34  E-value: 9.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906    75 VMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKK-IANSVNEGKLVPEDIIFGLLTKRLEE-GYNKgetG 152
Cdd:TIGR01359   4 VLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREGSENGSlIESYIKEGKIVPSEVTVELLKKAIQEdGSSK---K 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   153 FILDGIPRT--HMQA--EILDEIVDIDLVLNFKCADNCFMKRrfggdiCPHCGQlfdfsKTASSDRNpslgsctwpsqvq 228
Cdd:TIGR01359  81 FLIDGFPRNeeNLEAweKLMDNKVNFKFVLFFDCPEETMIKR------LLKRGQ-----TSGRVDDN------------- 136

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 42407906   229 haavlglEDSRMEKMRAYAEQTKLLEDYYRKQRKLMELKTS 269
Cdd:TIGR01359 137 -------IETLKKRFRTYNEETLPIIEHFENKGKVKEINAE 170
PRK14528 PRK14528
adenylate kinase; Provisional
 74-266 5.07e-17

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 77.36  E-value: 5.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   74 VVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKgeTGF 153
Cdd:PRK14528   5 IFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCK--NGF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  154 ILDGIPRTHMQAEILDEIV-----DIDLVLNFKCADNCFMKRRFGGDIcphcgqlfdfsKTASSDRNpslgsctwpsqvq 228
Cdd:PRK14528  83 LLDGFPRTVEQADALDALLknegkSIDKAINLEVPDGELLKRLLGRAE-----------IEGRADDN------------- 138

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 42407906  229 haavlglEDSRMEKMRAYAEQTKLLEDYYRKQRKLMEL 266
Cdd:PRK14528 139 -------EATIKNRLDNYNKKTLPLLDFYAAQKKLSQV 169
PLN02674 PLN02674
adenylate kinase
 74-274 9.12e-17

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 78.00  E-value: 9.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   74 VVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLtkrlEEGYNKG--ET 151
Cdd:PLN02674  35 ILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGII----DEAMKKPscQK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  152 GFILDGIPRTHMQAEILDEIVD-----IDLVLNFKCADNCFMKRRFGGDICPHCGQLFDfSKTASSdRNPSLGSCTWPSQ 226
Cdd:PLN02674 111 GFILDGFPRTVVQAQKLDEMLAkqgakIDKVLNFAIDDAILEERITGRWIHPSSGRTYH-TKFAPP-KVPGVDDVTGEPL 188

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 42407906  227 VQH----AAVLgleDSRMEkmrAYAEQTKLLEDYYRKQRKLMELKTSARPGE 274
Cdd:PLN02674 189 IQRkddtAAVL---KSRLE---AFHKQTEPVIDYYAKKGVVANLHAEKPPKE 234
PLN02200 PLN02200
adenylate kinase family protein
 75-190 3.04e-13

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 67.61  E-value: 3.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   75 VMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKgetGFI 154
Cdd:PLN02200  48 VLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSDNN---KFL 124

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 42407906  155 LDGIPRTHMQAEILDEIV--DIDLVLNFKCADNCFMKR 190
Cdd:PLN02200 125 IDGFPRTEENRIAFERIIgaEPNVVLFFDCPEEEMVKR 162
PLN02842 PLN02842
nucleotide kinase
 74-279 5.98e-13

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 68.73  E-value: 5.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   74 VVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKgETGF 153
Cdd:PLN02842   1 MISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAK-EKGW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  154 ILDGIPRTHMQAEILDEI-VDIDLVLNFKCADNCFMKRRFGGDICPHCGQLFDFSKTASSDRNPSLGSCTWPSQVQH--- 229
Cdd:PLN02842  80 LLDGYPRSFAQAQSLEKLkIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPESEEIKARLITRPDDTEEkvk 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42407906  230 ----------AAVLGLEDSRMEKMRA-------YAEQTKLLEDYYRKQRKLMELKTSARPGETWQGL 279
Cdd:PLN02842 160 arlqiykknaEAILSTYSDIMVKIDGnrpkevvFEEISSLLSQIQKDATKMIKTKKASPVQDKWRGI 226
PRK14527 PRK14527
adenylate kinase; Provisional
 74-284 3.49e-12

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 64.04  E-value: 3.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   74 VVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEgynKGETGF 153
Cdd:PRK14527  10 IFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAG---MEPVRV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  154 ILDGIPRTHMQAEILDEIVD-----IDLVLNFKCADNCFMKRRFGGDicphcgqlfdfSKTASSDRNpslgsctwpsqvq 228
Cdd:PRK14527  87 IFDGFPRTLAQAEALDRLLEelgarLLAVVLLEVPDEELIRRIVERA-----------RQEGRSDDN------------- 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 42407906  229 haavlglEDSRMEKMRAYAEQTKLLEDYYRKQRKLMELKTSARPGETWQGLVAALH 284
Cdd:PRK14527 143 -------EETVRRRQQVYREQTQPLVDYYEARGHLKRVDGLGTPDEVYARILKALG 191
PRK14531 PRK14531
adenylate kinase; Provisional
 76-173 1.69e-11

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 61.75  E-value: 1.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   76 MGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKgetGFIL 155
Cdd:PRK14531   8 LGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQLKALNSG---GWLL 84

                         90
                 ....*....|....*...
gi 42407906  156 DGIPRTHMQAEILDEIVD 173
Cdd:PRK14531  85 DGFPRTVAQAEALEPLLE 102
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 75-283 1.79e-11

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 61.76  E-value: 1.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906    75 VMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKGEtGFI 154
Cdd:TIGR01360   8 IVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALGTSK-GFL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   155 LDGIPRTHMQAEILD-EIVDIDLVLNFKCADNCFMKRrfggdicphcgqLFDFSKT-ASSDRNpslgsctwpsqvqhaav 232
Cdd:TIGR01360  87 IDGYPREVKQGEEFErRIGPPTLVLYFDCSEDTMVKR------------LLKRAETsGRVDDN----------------- 137

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 42407906   233 lglEDSRMEKMRAYAEQTKLLEDYYRKQRKLMELKTSARPGETWQGLVAAL 283
Cdd:TIGR01360 138 ---EKTIKKRLETYYKATEPVIAYYETKGKLRKINAEGTVDDVFLQVCTAI 185
AAA_17 pfam13207
AAA domain;
87-191 4.20e-11

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 59.56  E-value: 4.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906    87 AARLAEVLAVPYISMGTLVRQELSPASslYKKIANSVNEGKLVPEDIIFGLLTKRLEEgyNKGETGFILDGIPRTHMQAE 166
Cdd:pfam13207  12 LKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIAE--EAGEGGVIVDGHPRIKTPAG 87

                          90       100       110
                  ....*....|....*....|....*....|..
gi 42407906   167 ILD-------EIVDIDLVLNFKCADNCFMKRR 191
Cdd:pfam13207  88 YLPglpvevlRELKPDAIILLEADPEEILERR 119
PRK13808 PRK13808
adenylate kinase; Provisional
 74-264 6.70e-11

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 62.21  E-value: 6.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   74 VVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKGetGF 153
Cdd:PRK13808   4 ILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAAN--GF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906  154 ILDGIPRTHMQAEILDEI-----VDIDLVLNFKCADNCFMKRrfggdICPHCGQLFDFSKTASSDRNPSLGSctwpsqvq 228
Cdd:PRK13808  82 ILDGFPRTVPQAEALDALlkdkqLKLDAVVELRVNEGALLAR-----VETRVAEMRARGEEVRADDTPEVLA-------- 148

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 42407906  229 haavlgledsrmEKMRAYAEQTKLLEDYYRKQRKLM 264
Cdd:PRK13808 149 ------------KRLASYRAQTEPLVHYYSEKRKLL 172
PRK14529 PRK14529
adenylate kinase; Provisional
 74-201 9.84e-11

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 60.50  E-value: 9.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42407906   74 VVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEegyNKGETGF 153
Cdd:PRK14529   4 LIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLK---QDGKNGW 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42407906  154 ILDGIPRTHMQAEILDEIVD---------IDLVLNFKCADNCFMKRRF------------------GGDICPHCG 201
Cdd:PRK14529  81 LLDGFPRNKVQAEKLWEALQkegmkldyvIEILLPREVAKNRIMGRRLckndnnhpnnifidaikpDGDVCRVCG 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH