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Conserved domains on  [gi|41819539|gb|AAS13286|]
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flagellar hook assembly scaffolding protein [Treponema denticola ATCC 35405]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
flgD super family cl44301
flagellar hook assembly protein FlgD;
26-169 7.51e-52

flagellar hook assembly protein FlgD;


The actual alignment was detected with superfamily member PRK09618:

Pssm-ID: 236594 [Multi-domain]  Cd Length: 142  Bit Score: 162.09  E-value: 7.51e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41819539   26 SEMSPEEKALlglqvdTLNKQNFAETRVPKQQLGKDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNF 105
Cdd:PRK09618   1 MTMTGIDSSL------WLANSKKAERRTGNQNLGKDDFLKLLITQLQNQDPTNPMEDKEFIAQMAQFSSLEQMTNMNKSM 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41819539  106 AAL-NELMTGSSAVNAVGKKVD-LDLGSSQVSGYISAA--TRGINPEVMVNGNWYNWSAVKTVYADNN 169
Cdd:PRK09618  75 EKLvSSSDGLTKYSELIGKEVEwEGEDGEIVSGTVTSVkqKDGDYPLVLDNGTWIVADNVTSVGLKEK 142
 
Name Accession Description Interval E-value
flgD PRK09618
flagellar hook assembly protein FlgD;
26-169 7.51e-52

flagellar hook assembly protein FlgD;


Pssm-ID: 236594 [Multi-domain]  Cd Length: 142  Bit Score: 162.09  E-value: 7.51e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41819539   26 SEMSPEEKALlglqvdTLNKQNFAETRVPKQQLGKDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNF 105
Cdd:PRK09618   1 MTMTGIDSSL------WLANSKKAERRTGNQNLGKDDFLKLLITQLQNQDPTNPMEDKEFIAQMAQFSSLEQMTNMNKSM 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41819539  106 AAL-NELMTGSSAVNAVGKKVD-LDLGSSQVSGYISAA--TRGINPEVMVNGNWYNWSAVKTVYADNN 169
Cdd:PRK09618  75 EKLvSSSDGLTKYSELIGKEVEwEGEDGEIVSGTVTSVkqKDGDYPLVLDNGTWIVADNVTSVGLKEK 142
FlgD COG1843
Flagellar hook-capping protein FlgD [Cell motility];
41-125 4.16e-29

Flagellar hook-capping protein FlgD [Cell motility];


Pssm-ID: 441448 [Multi-domain]  Cd Length: 223  Bit Score: 106.63  E-value: 4.16e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41819539  41 DTLNKQNFAETRVPKQQLGKDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNFAALNELMTGSSAVNA 120
Cdd:COG1843  11 SSLSTSSTSSSSSSSSSLGKDDFLKLLVAQLQNQDPLNPMDNTEFIAQLAQFSTVEQIENLNTTLESLASSLTSSQALQA 90


                ....*...
gi 41819539 121 ---VGKKV 125
Cdd:COG1843  91 sslIGKEV 98
FlgD pfam03963
Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required ...
 51-105 3.39e-19

Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required for hook assembly, yet it has not been detected in the mature flagellum. It appears to act as a hook-capping protein to enable assembly of hook protein subunits. FlgD regulates the assembly of the hook cap structure to prevent leakage of hook monomers into the medium and hook monomer polymerization and also plays a role in determination of the correct hook length, with the help of the FliK protein. This family represents the N-terminal conserved region of FlgD. A recent crystal structure showed that this region was likely to be flexible and was cleaved off during crystallization.


Pssm-ID: 427619 [Multi-domain]  Cd Length: 75  Bit Score: 76.90  E-value: 3.39e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 41819539    51 TRVPKQQLGKDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNF 105
Cdd:pfam03963  19 SAKSSSTLGKDDFLKLLTTQLQNQDPLNPMDNTQFTSQLAQFSSVEQIEKLNKTL 73
 
Name Accession Description Interval E-value
flgD PRK09618
flagellar hook assembly protein FlgD;
26-169 7.51e-52

flagellar hook assembly protein FlgD;


Pssm-ID: 236594 [Multi-domain]  Cd Length: 142  Bit Score: 162.09  E-value: 7.51e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41819539   26 SEMSPEEKALlglqvdTLNKQNFAETRVPKQQLGKDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNF 105
Cdd:PRK09618   1 MTMTGIDSSL------WLANSKKAERRTGNQNLGKDDFLKLLITQLQNQDPTNPMEDKEFIAQMAQFSSLEQMTNMNKSM 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41819539  106 AAL-NELMTGSSAVNAVGKKVD-LDLGSSQVSGYISAA--TRGINPEVMVNGNWYNWSAVKTVYADNN 169
Cdd:PRK09618  75 EKLvSSSDGLTKYSELIGKEVEwEGEDGEIVSGTVTSVkqKDGDYPLVLDNGTWIVADNVTSVGLKEK 142
FlgD COG1843
Flagellar hook-capping protein FlgD [Cell motility];
41-125 4.16e-29

Flagellar hook-capping protein FlgD [Cell motility];


Pssm-ID: 441448 [Multi-domain]  Cd Length: 223  Bit Score: 106.63  E-value: 4.16e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41819539  41 DTLNKQNFAETRVPKQQLGKDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNFAALNELMTGSSAVNA 120
Cdd:COG1843  11 SSLSTSSTSSSSSSSSSLGKDDFLKLLVAQLQNQDPLNPMDNTEFIAQLAQFSTVEQIENLNTTLESLASSLTSSQALQA 90


                ....*...
gi 41819539 121 ---VGKKV 125
Cdd:COG1843  91 sslIGKEV 98
flgD PRK06655
flagellar hook assembly protein FlgD;
56-125 3.45e-20

flagellar hook assembly protein FlgD;


Pssm-ID: 235847 [Multi-domain]  Cd Length: 225  Bit Score: 83.46  E-value: 3.45e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41819539   56 QQLGKDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNFAALNELMTGSSAVNA---VGKKV 125
Cdd:PRK06655  28 AADLQDDFLTLLVAQLKNQDPLNPMDNSQMTSQLAQFSTVSGIEKLNTTLGSLSSQMTSSQALQAsslVGRGV 100
FlgD pfam03963
Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required ...
 51-105 3.39e-19

Flagellar hook capping protein - N-terminal region; FlgD is known to be absolutely required for hook assembly, yet it has not been detected in the mature flagellum. It appears to act as a hook-capping protein to enable assembly of hook protein subunits. FlgD regulates the assembly of the hook cap structure to prevent leakage of hook monomers into the medium and hook monomer polymerization and also plays a role in determination of the correct hook length, with the help of the FliK protein. This family represents the N-terminal conserved region of FlgD. A recent crystal structure showed that this region was likely to be flexible and was cleaved off during crystallization.


Pssm-ID: 427619 [Multi-domain]  Cd Length: 75  Bit Score: 76.90  E-value: 3.39e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 41819539    51 TRVPKQQLGKDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNF 105
Cdd:pfam03963  19 SAKSSSTLGKDDFLKLLTTQLQNQDPLNPMDNTQFTSQLAQFSSVEQIEKLNKTL 73
flgD PRK06009
flagellar hook assembly protein FlgD;
54-142 4.93e-17

flagellar hook assembly protein FlgD;


Pssm-ID: 235670 [Multi-domain]  Cd Length: 140  Bit Score: 73.20  E-value: 4.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41819539   54 PKQQLGKDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNFAALNELMTGSSAVNAVGKKVDLDLGSsq 133
Cdd:PRK06009  29 NKASVNYDSFLQLLIAQMKNQDPTDPMDATQYVSQLATFSQVEQSIQTNSKLDTLLASSSLTQAEGLIGRTVTSADGS-- 106


                 ....*....
gi 41819539  134 VSGYISAAT 142
Cdd:PRK06009 107 ITGVVKSVT 115
flgD PRK12634
flagellar basal body rod modification protein; Reviewed
 49-142 1.61e-13

flagellar basal body rod modification protein; Reviewed


Pssm-ID: 183639 [Multi-domain]  Cd Length: 221  Bit Score: 65.72  E-value: 1.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41819539   49 AETRVPKQQ--LGKDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNFAALNELMTGSSAV---NAVGK 123
Cdd:PRK12634  16 TSSKTAKKEeaLGQADFLKLMTEQLQHQDPLKPMENSAFLGQLAQFSTVQGIGDLNTKVSNFSDSMSSDQVLkgaALVGH 95

                         90       100
                 ....*....|....*....|....
gi 41819539  124 KV-----DLDLGSSQVSGYISAAT 142
Cdd:PRK12634  96 NVlvpsaQVAIDATGSAKGVVAAT 119
flgD PRK11911
flagellar basal body rod modification protein; Provisional
 56-146 1.30e-11

flagellar basal body rod modification protein; Provisional


Pssm-ID: 138812 [Multi-domain]  Cd Length: 140  Bit Score: 59.08  E-value: 1.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41819539   56 QQLGKDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNFAALNELMTGS---SAVNAVGKKVD-LDLGS 131
Cdd:PRK11911  24 KTLGKDDFMKLFLTSLQYQDPSSPLDTNEMMSQMAQLSLMEQVANMTTAVDKLSEQAQNSalqSAVNFIGKDIKgVSLNG 103

                         90
                 ....*....|....*
gi 41819539  132 SQVSGYISAATRGIN 146
Cdd:PRK11911 104 EVISGKVESVQQTTN 118
flgD PRK12812
flagellar basal body rod modification protein; Reviewed
 54-127 1.54e-11

flagellar basal body rod modification protein; Reviewed


Pssm-ID: 139245 [Multi-domain]  Cd Length: 259  Bit Score: 60.66  E-value: 1.54e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41819539   54 PKQQLGKDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNFAALNELMTGS---SAVNAVGKKVDL 127
Cdd:PRK12812  40 PNSQLDKDAFLKLLLIELQHQDPTDPMDSDKMLTQTSQLAALEMQENTNTTMQKLVEQMQSSmstSALSALGKMATV 116
flgD PRK12633
flagellar basal body rod modification protein; Provisional
 60-125 6.14e-11

flagellar basal body rod modification protein; Provisional


Pssm-ID: 183638 [Multi-domain]  Cd Length: 230  Bit Score: 58.83  E-value: 6.14e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41819539   60 KDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNFAALNELMTGSSAVNAV---GKKV 125
Cdd:PRK12633  28 QDQFLTLLVTQLRNQDPLNPMENAELTSQLAQISTVEGINNLKNTMLAISGQIDVSQSMDAVsmiGKGV 96
flgD PRK09619
flagellar hook assembly protein FlgD;
60-138 2.51e-10

flagellar hook assembly protein FlgD;


Pssm-ID: 181996 [Multi-domain]  Cd Length: 218  Bit Score: 56.72  E-value: 2.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41819539   60 KDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNK----NFAALNELMTGSSAvNAVGKKV-----DLDLG 130
Cdd:PRK09619  30 NNQFMTLLVAQIQNQDPLNPADGTEFVSQLAQLSQVQSTENMAKlmksNTVLMDNMQTLATA-NLVGQQVmveshEITLG 108


                 ....*...
gi 41819539  131 SSQVSGYI 138
Cdd:PRK09619 109 EDPVAGRL 116
flgD PRK06792
flagellar basal body rod modification protein; Validated
 58-149 6.94e-10

flagellar basal body rod modification protein; Validated


Pssm-ID: 180695 [Multi-domain]  Cd Length: 190  Bit Score: 55.41  E-value: 6.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41819539   58 LGKDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNFAALNELMTGSS---AVNAVGKKV-DLDLGSSQ 133
Cdd:PRK06792  51 MDKDDFLKLFLASFQHQDPFNAMDMNQMMNQTAQLSLMEQVQNMTKAVDKLQSTMYSTAldgGMKFLGKYVrGVSNDGKQ 130

                         90
                 ....*....|....*.
gi 41819539  134 VSGYISAATRGINPEV 149
Cdd:PRK06792 131 VTGQVETVRLAENNDV 146
flgD PRK12813
flagellar basal body rod modification protein; Reviewed
 61-116 5.39e-09

flagellar basal body rod modification protein; Reviewed


Pssm-ID: 237214 [Multi-domain]  Cd Length: 223  Bit Score: 53.19  E-value: 5.39e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 41819539   61 DDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNFAALNELMTGSS 116
Cdd:PRK12813  33 ETFLRMLTTQLQNQDPLNPMDSSDYAAQLATFSGVEQQVKTNDLLTGLGASLGVMG 88
flgD PRK05842
flagellar hook assembly protein FlgD;
58-119 4.61e-06

flagellar hook assembly protein FlgD;


Pssm-ID: 235621 [Multi-domain]  Cd Length: 295  Bit Score: 45.37  E-value: 4.61e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41819539   58 LGKDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNFAALNELMTGSSAVN 119
Cdd:PRK05842  28 LDKNAFMKLFLEQLKNQDPTAPMETDKIITQTAQLTQVEMQEENKKTMQEVASAMKSNKETN 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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