|
Name |
Accession |
Description |
Interval |
E-value |
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
181-932 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1278.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 181 SKKKKIAVMTSGGDSQGMNAAVRAVVRSSIYYGCDVYAVYEGYEGLVKGGDYLRKMEWKDVRGWLSEGGTLIGTARSKEF 260
Cdd:cd00764 1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 261 RERWGRKQACSNLIDQGIDALVVIGGDGSLTGADLFRSEWPSLVEELVKDGKFTEDEVALYQNLTIVGMVGSIDNDMSGT 340
Cdd:cd00764 81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 341 DSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPERAAPhGKWQDELKRVCQRHR 420
Cdd:cd00764 161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPE-DGWEDQMCRRLSEHR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 421 EKGRRNNTVIVAEGALDDQLNPITAEQVKDVLVE-LGLDTKITTLGHVQRGGTAVAHDRWLATLQGVDAVKAILNMTPET 499
Cdd:cd00764 240 SRGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVErLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDT 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 500 PSPLIGILENKVIRMPLVESVKLTKQV-----------AAAIEAKDFDKAISLRDTEFIELYsnfmsttvnddgsQLLPE 568
Cdd:cd00764 320 PACVVSLNGNKAVRLPLMECVQLTKDVqkamdekrfdeAAALRGKSFDKNWNLYKLLAIELP-------------QPLPE 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 569 ADRLNIAIVHVGAPSAALNAATRAATLYCLAHGHRPYAITNGFSGLIQtGQVKELSWIDVEDWHNLGGSEIGTNRSVAAE 648
Cdd:cd00764 387 KTNLNIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAK-GQIVELGWIDVGGWTGRGGSELGTKRTLPKK 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 649 DMGTIAYHFQKNKFDGVIILGGFEGFKSLKQLRDGRDQYPIFNIPMCLIPATVSNNVPGTEYSLGSDTCLNALVKYTDAI 728
Cdd:cd00764 466 DLETIAYNFQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRI 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 729 KQSASSTRRRVFVVEVQGGHSGYVASFTGLVTGAVSVYTPENAINLKTIQEDLALLKESFKHEQGETRNGKLVIRNEMAS 808
Cdd:cd00764 546 KQSASGTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYT 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 809 DVYTTELLADIIteqsNDRFGVRTAIPGHVQQGGVPSSKDRVIASRFAVKCVKFIEQWNKKNTAADNEDFKILRFNYVNG 888
Cdd:cd00764 626 TVFTYELYSEEG----KGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNG 701
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 417201 889 VKQYTVLD-----------------EDLSAAVICVNGSKISFKPIAHIWENETNIELRKGQ 932
Cdd:cd00764 702 VKKYAVLFepveelkqttfehripkEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
184-949 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1184.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 184 KKIAVMTSGGDSQGMNAAVRAVVRSSIYYGCDVYAVYEGYEGLVKGGDYLRKMEWKDVRGWLSEGGTLIGTARSKEFRER 263
Cdd:TIGR02478 1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 264 WGRKQACSNLIDQGIDALVVIGGDGSLTGADLFRSEWPSLVEELVKDGKFTEDEVALYQNLTIVGMVGSIDNDMSGTDST 343
Cdd:TIGR02478 81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 344 IGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPERaAPHGKWQDELKRVCQRHREKG 423
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPER-PPEEGWEDQLCHKLKRNRKAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 424 RRNNTVIVAEGALDDQLNPITAEQVKDVLVE-LGLDTKITTLGHVQRGGTAVAHDRWLATLQGVDAVKAILNMTPETPSP 502
Cdd:TIGR02478 240 KRKTIVIVAEGAIDRDLNPITSEDVKDVLVErLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 503 LIGILENKVIRMPLVESVKLTKQVAAAIEAKDFDKAISLRDTEFIELYSNFMSTTVNDDGSQLLP-EADRLNIAIVHVGA 581
Cdd:TIGR02478 320 VISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPsEASRLRIAIIHVGA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 582 PSAALNAATRAATLYCLAHGHRPYAITNGFSGLIqTGQVKELSWIDVEDWHNLGGSEIGTNRSVAAEDMGTIAYHFQKNK 661
Cdd:TIGR02478 400 PAGGMNAATRSAVRYALARGHTVIAIHNGFSGLA-RHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHK 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 662 FDGVIILGGFEGFKSLKQLRDGRDQYPIFNIPMCLIPATVSNNVPGTEYSLGSDTCLNALVKYTDAIKQSASSTRRRVFV 741
Cdd:TIGR02478 479 IDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFV 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 742 VEVQGGHSGYVASFTGLVTGAVSVYTPENAINLKTIQEDLALLKESFKHEqgetRNGKLVIRNEMASDVYTTELLADIIT 821
Cdd:TIGR02478 559 VETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEG----RAGKLILRNEKASKVYTTDFIARIIS 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 822 EQSNDRFGVRTAIPGHVQQGGVPSSKDRVIASRFAVKCVKFIEQWNKKNTAADNedfkilrfnyvngvkqytVLDEDLSA 901
Cdd:TIGR02478 635 EEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADK------------------LSADDTSA 696
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 417201 902 AVICVNGSKISFKPIAHIWENETNIELRKGQEIHWEEYNEIGDILSGR 949
Cdd:TIGR02478 697 VVIGIRGSNVLFTPVKQLLANETDFEHRRPKNQWWLQLRPLVRILAGR 744
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
185-490 |
4.52e-135 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 406.73 E-value: 4.52e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 185 KIAVMTSGGDSQGMNAAVRAVVRSSIYYGCDVYAVYEGYEGLVKGGdyLRKMEWKDVRGWLSEGGTLIGTARSKEFRERW 264
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 265 GRKQACSNLIDQGIDALVVIGGDGSLTGADLFRSEWpslveelvkdgkftedevalyqNLTIVGMVGSIDNDMSGTDSTI 344
Cdd:pfam00365 79 GREKIAENLKKLGIDALVVIGGDGSLTGANKLSEER----------------------GIPVVGIPKTIDNDIPGTDYTI 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 345 GAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPERAAphgkwqdELKRVCQ--RHREK 422
Cdd:pfam00365 137 GFDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPF-------DIEELCEkiKELRK 209
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 417201 423 GRRNNTVIVAEGAlddqlnpITAEQVKDVLVE-LGLDTKITTLGHVQRGGTAVAHDRWLATLQGVDAVK 490
Cdd:pfam00365 210 GKRFSIIVVAEGA-------SDGEFLAKLIEEgTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
184-526 |
6.60e-112 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 348.22 E-value: 6.60e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 184 KKIAVMTSGGDSQGMNAAVRAVVRSSIYYGCDVYAVYEGYEGLVKGgDYlRKMEWKDVRGWLSEGGTLIGTARSKEFRER 263
Cdd:PRK03202 2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG-DI-VKLDLKSVSDIINRGGTILGSARFPEFKDE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 264 WGRKQACSNLIDQGIDALVVIGGDGSLTGADlfrsewpslveelvkdgKFTEdevalyQNLTIVGMVGSIDNDMSGTDST 343
Cdd:PRK03202 80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAK-----------------RLTE------HGIPVIGLPGTIDNDIAGTDYT 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 344 IGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPERAAPHgkwqDELKRVCQRHREKG 423
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDI----EELCAKIKKGRERG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 424 RRNNTVIVAEGALD-DQLnpitAEQVKDvlvELGLDTKITTLGHVQRGGTAVAHDRWLATLQGVDAVKAILN-----Mtp 497
Cdd:PRK03202 213 KKHAIIVVAEGVMPaEEL----AKEIEE---RTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEgkggrM-- 283
|
330 340
....*....|....*....|....*....
gi 417201 498 etpsplIGILENKVIRMPLVESVKLTKQV 526
Cdd:PRK03202 284 ------VGIQNNKIVHVPIEEAVENMKHP 306
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
183-526 |
5.06e-111 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 346.68 E-value: 5.06e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 183 KKKIAVMTSGGDSQGMNAAVRAVVRSSIYYGCDVYAVYEGYEGLVKGgDYlRKMEWKDVRGWLSEGGTLIGTARSKEFRE 262
Cdd:COG0205 1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG-DI-IDLTREDVSGILQRGGTILGSSRSKPFKT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 263 RWGRKQACSNLIDQGIDALVVIGGDGSLTGADlfrsewpslveelvkdgKFTEdevalYQNLTIVGMVGSIDNDMSGTDS 342
Cdd:COG0205 79 EEGREKALENLKKLGIDALVVIGGDGSLDGAA-----------------KLAE-----EYGIPVVGIPKTIDNDLPGTDY 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 343 TIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPERAAPhgkwQDELKRVCQRHREK 422
Cdd:COG0205 137 TIGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD----LDKLLEKLKERRKR 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 423 GRRNNTVIVAEGALDDQLNPI---------------TAEQVKDVLVE-LGLDTKITTLGHVQRGGTAVAHDRWLATLQGV 486
Cdd:COG0205 213 GKGYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEErTGIETRVTVLGHLQRGGSPSAFDRVLASRLGA 292
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 417201 487 DAVKAILN-----MtpetpsplIGILENKVIRMPLVESVKLTKQV 526
Cdd:COG0205 293 AAVELLLEgktgvM--------VGIRRGEIVLVPLEEVANKEKPV 329
|
|
| Pfk_N |
pfam18468 |
Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal ... |
6-99 |
1.11e-30 |
|
Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal domain found in yeast ATP-dependent 6-phosphofructokinase subunit alpha. ATP-dependent 6-phosphofructokinases (Pfks, EC 2.7.1.11) catalyze the phosphorylation of fructose 6-phosphate (F-6-P) to fructose 1,6-bisphosphate, a key control step of glycolysis in most organizms. The N-terminal domain contains the active site and is related to glyoxalase I (E.C. 4.4.1.5).
Pssm-ID: 408261 Cd Length: 98 Bit Score: 116.08 E-value: 1.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 6 YGVAFRSLSTGDEKLYKEATRFYHSLGFQTVKLYDNFKNHDDSnlIVGTSKNSVKECWLESFKLSELDSQGFRVPQQEAS 85
Cdd:pfam18468 1 SGLSFISFVTNDPDKFEATIKFYTKLGFSATKSYSKDTNNDFE--LIGVSTDSIKEIWLESFPLSEVDSHGFRIPWQESP 78
|
90 100
....*....|....*....|
gi 417201 86 NQL------QTDGVMIKLRL 99
Cdd:pfam18468 79 GYQgdyspkLSDGVVIKLRL 98
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
181-932 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1278.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 181 SKKKKIAVMTSGGDSQGMNAAVRAVVRSSIYYGCDVYAVYEGYEGLVKGGDYLRKMEWKDVRGWLSEGGTLIGTARSKEF 260
Cdd:cd00764 1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 261 RERWGRKQACSNLIDQGIDALVVIGGDGSLTGADLFRSEWPSLVEELVKDGKFTEDEVALYQNLTIVGMVGSIDNDMSGT 340
Cdd:cd00764 81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 341 DSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPERAAPhGKWQDELKRVCQRHR 420
Cdd:cd00764 161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPE-DGWEDQMCRRLSEHR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 421 EKGRRNNTVIVAEGALDDQLNPITAEQVKDVLVE-LGLDTKITTLGHVQRGGTAVAHDRWLATLQGVDAVKAILNMTPET 499
Cdd:cd00764 240 SRGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVErLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDT 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 500 PSPLIGILENKVIRMPLVESVKLTKQV-----------AAAIEAKDFDKAISLRDTEFIELYsnfmsttvnddgsQLLPE 568
Cdd:cd00764 320 PACVVSLNGNKAVRLPLMECVQLTKDVqkamdekrfdeAAALRGKSFDKNWNLYKLLAIELP-------------QPLPE 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 569 ADRLNIAIVHVGAPSAALNAATRAATLYCLAHGHRPYAITNGFSGLIQtGQVKELSWIDVEDWHNLGGSEIGTNRSVAAE 648
Cdd:cd00764 387 KTNLNIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAK-GQIVELGWIDVGGWTGRGGSELGTKRTLPKK 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 649 DMGTIAYHFQKNKFDGVIILGGFEGFKSLKQLRDGRDQYPIFNIPMCLIPATVSNNVPGTEYSLGSDTCLNALVKYTDAI 728
Cdd:cd00764 466 DLETIAYNFQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRI 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 729 KQSASSTRRRVFVVEVQGGHSGYVASFTGLVTGAVSVYTPENAINLKTIQEDLALLKESFKHEQGETRNGKLVIRNEMAS 808
Cdd:cd00764 546 KQSASGTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYT 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 809 DVYTTELLADIIteqsNDRFGVRTAIPGHVQQGGVPSSKDRVIASRFAVKCVKFIEQWNKKNTAADNEDFKILRFNYVNG 888
Cdd:cd00764 626 TVFTYELYSEEG----KGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNG 701
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 417201 889 VKQYTVLD-----------------EDLSAAVICVNGSKISFKPIAHIWENETNIELRKGQ 932
Cdd:cd00764 702 VKKYAVLFepveelkqttfehripkEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
184-949 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1184.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 184 KKIAVMTSGGDSQGMNAAVRAVVRSSIYYGCDVYAVYEGYEGLVKGGDYLRKMEWKDVRGWLSEGGTLIGTARSKEFRER 263
Cdd:TIGR02478 1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 264 WGRKQACSNLIDQGIDALVVIGGDGSLTGADLFRSEWPSLVEELVKDGKFTEDEVALYQNLTIVGMVGSIDNDMSGTDST 343
Cdd:TIGR02478 81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 344 IGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPERaAPHGKWQDELKRVCQRHREKG 423
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPER-PPEEGWEDQLCHKLKRNRKAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 424 RRNNTVIVAEGALDDQLNPITAEQVKDVLVE-LGLDTKITTLGHVQRGGTAVAHDRWLATLQGVDAVKAILNMTPETPSP 502
Cdd:TIGR02478 240 KRKTIVIVAEGAIDRDLNPITSEDVKDVLVErLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 503 LIGILENKVIRMPLVESVKLTKQVAAAIEAKDFDKAISLRDTEFIELYSNFMSTTVNDDGSQLLP-EADRLNIAIVHVGA 581
Cdd:TIGR02478 320 VISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPsEASRLRIAIIHVGA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 582 PSAALNAATRAATLYCLAHGHRPYAITNGFSGLIqTGQVKELSWIDVEDWHNLGGSEIGTNRSVAAEDMGTIAYHFQKNK 661
Cdd:TIGR02478 400 PAGGMNAATRSAVRYALARGHTVIAIHNGFSGLA-RHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHK 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 662 FDGVIILGGFEGFKSLKQLRDGRDQYPIFNIPMCLIPATVSNNVPGTEYSLGSDTCLNALVKYTDAIKQSASSTRRRVFV 741
Cdd:TIGR02478 479 IDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFV 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 742 VEVQGGHSGYVASFTGLVTGAVSVYTPENAINLKTIQEDLALLKESFKHEqgetRNGKLVIRNEMASDVYTTELLADIIT 821
Cdd:TIGR02478 559 VETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEG----RAGKLILRNEKASKVYTTDFIARIIS 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 822 EQSNDRFGVRTAIPGHVQQGGVPSSKDRVIASRFAVKCVKFIEQWNKKNTAADNedfkilrfnyvngvkqytVLDEDLSA 901
Cdd:TIGR02478 635 EEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADK------------------LSADDTSA 696
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 417201 902 AVICVNGSKISFKPIAHIWENETNIELRKGQEIHWEEYNEIGDILSGR 949
Cdd:TIGR02478 697 VVIGIRGSNVLFTPVKQLLANETDFEHRRPKNQWWLQLRPLVRILAGR 744
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
184-540 |
1.07e-174 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 511.84 E-value: 1.07e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 184 KKIAVMTSGGDSQGMNAAVRAVVRSSIYYGCDVYAVYEGYEGLVKGgdYLRKMEWKDVRGWLSEGGTLIGTARSKEFRER 263
Cdd:cd00363 1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 264 WGRKQACSNLIDQGIDALVVIGGDGSLTGADLFRSEWPSLveelvkdgkftedevalYQNLTIVGMVGSIDNDMSGTDST 343
Cdd:cd00363 79 EGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSK-----------------YQGFNVIGLPGTIDNDIKGTDYT 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 344 IGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPERAAPhGKWQDELKRVCQRHREKG 423
Cdd:cd00363 142 IGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAA-DEWEEEMVDVIKKRRERG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 424 RRNNTVIVAEGALDDQLNPITAEQVKDVLVE-LGLDTKITTLGHVQRGGTAVAHDRWLATLQGVDAVKAILNMTPETPSP 502
Cdd:cd00363 221 KRHGIVIVAEGAIDFIPKPITEKLLAKLVEErLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVG 300
|
330 340 350
....*....|....*....|....*....|....*...
gi 417201 503 LIGILENKVIRMPLVESVKLTKQVAAAIEAKDFDKAIS 540
Cdd:cd00363 301 IQNLNENQVVRHPLTEAVNMTKRVGVDLEGRPFKKFAK 338
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
185-490 |
4.52e-135 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 406.73 E-value: 4.52e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 185 KIAVMTSGGDSQGMNAAVRAVVRSSIYYGCDVYAVYEGYEGLVKGGdyLRKMEWKDVRGWLSEGGTLIGTARSKEFRERW 264
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 265 GRKQACSNLIDQGIDALVVIGGDGSLTGADLFRSEWpslveelvkdgkftedevalyqNLTIVGMVGSIDNDMSGTDSTI 344
Cdd:pfam00365 79 GREKIAENLKKLGIDALVVIGGDGSLTGANKLSEER----------------------GIPVVGIPKTIDNDIPGTDYTI 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 345 GAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPERAAphgkwqdELKRVCQ--RHREK 422
Cdd:pfam00365 137 GFDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPF-------DIEELCEkiKELRK 209
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 417201 423 GRRNNTVIVAEGAlddqlnpITAEQVKDVLVE-LGLDTKITTLGHVQRGGTAVAHDRWLATLQGVDAVK 490
Cdd:pfam00365 210 GKRFSIIVVAEGA-------SDGEFLAKLIEEgTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
184-526 |
6.60e-112 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 348.22 E-value: 6.60e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 184 KKIAVMTSGGDSQGMNAAVRAVVRSSIYYGCDVYAVYEGYEGLVKGgDYlRKMEWKDVRGWLSEGGTLIGTARSKEFRER 263
Cdd:PRK03202 2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG-DI-VKLDLKSVSDIINRGGTILGSARFPEFKDE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 264 WGRKQACSNLIDQGIDALVVIGGDGSLTGADlfrsewpslveelvkdgKFTEdevalyQNLTIVGMVGSIDNDMSGTDST 343
Cdd:PRK03202 80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAK-----------------RLTE------HGIPVIGLPGTIDNDIAGTDYT 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 344 IGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPERAAPHgkwqDELKRVCQRHREKG 423
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDI----EELCAKIKKGRERG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 424 RRNNTVIVAEGALD-DQLnpitAEQVKDvlvELGLDTKITTLGHVQRGGTAVAHDRWLATLQGVDAVKAILN-----Mtp 497
Cdd:PRK03202 213 KKHAIIVVAEGVMPaEEL----AKEIEE---RTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEgkggrM-- 283
|
330 340
....*....|....*....|....*....
gi 417201 498 etpsplIGILENKVIRMPLVESVKLTKQV 526
Cdd:PRK03202 284 ------VGIQNNKIVHVPIEEAVENMKHP 306
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
183-526 |
5.06e-111 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 346.68 E-value: 5.06e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 183 KKKIAVMTSGGDSQGMNAAVRAVVRSSIYYGCDVYAVYEGYEGLVKGgDYlRKMEWKDVRGWLSEGGTLIGTARSKEFRE 262
Cdd:COG0205 1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG-DI-IDLTREDVSGILQRGGTILGSSRSKPFKT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 263 RWGRKQACSNLIDQGIDALVVIGGDGSLTGADlfrsewpslveelvkdgKFTEdevalYQNLTIVGMVGSIDNDMSGTDS 342
Cdd:COG0205 79 EEGREKALENLKKLGIDALVVIGGDGSLDGAA-----------------KLAE-----EYGIPVVGIPKTIDNDLPGTDY 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 343 TIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPERAAPhgkwQDELKRVCQRHREK 422
Cdd:COG0205 137 TIGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD----LDKLLEKLKERRKR 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 423 GRRNNTVIVAEGALDDQLNPI---------------TAEQVKDVLVE-LGLDTKITTLGHVQRGGTAVAHDRWLATLQGV 486
Cdd:COG0205 213 GKGYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEErTGIETRVTVLGHLQRGGSPSAFDRVLASRLGA 292
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 417201 487 DAVKAILN-----MtpetpsplIGILENKVIRMPLVESVKLTKQV 526
Cdd:COG0205 293 AAVELLLEgktgvM--------VGIRRGEIVLVPLEEVANKEKPV 329
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
573-861 |
2.82e-95 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 302.34 E-value: 2.82e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 573 NIAIVHVGAPSaalnaatraaTLYCLAHGHRPYAITNGFSGLIQtGQVKELSWIDVEDWHNLGGSEIGTNRSV---AAED 649
Cdd:pfam00365 1 RIGILTSGGDApgmnaairavVRTAIYRGHEVYGIRNGYEGLVE-GDIDELTWRDVSGILNRGGTILGTSRSKpfkTEEG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 650 MGTIAYHFQKNKFDGVIILGGFEGFKSLKQLRDGRdqypifNIPMCLIPATVSNNVPGTEYSLGSDTCLNALVKYTDAIK 729
Cdd:pfam00365 80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEER------GIPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 730 QSASSTrRRVFVVEVQGGHSGYVASFTGLVTGAVSVYTPENAINLKTIQEDLALLKESfkheqgetRNGKLVIRNEMASD 809
Cdd:pfam00365 154 DTASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELRKG--------KRFSIIVVAEGASD 224
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 417201 810 vytTELLADIITEQSNdrFGVRTAIPGHVQQGGVPSSKDRVIASRFAVKCVK 861
Cdd:pfam00365 225 ---GEFLAKLIEEGTG--IETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
185-520 |
4.66e-95 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 302.73 E-value: 4.66e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 185 KIAVMTSGGDSQGMNAAVRAVVRSSIYYGCDVYAVYEGYEGLVKGgdYLRKMEWKDVRGWLSEGGTLIGTARSKEFRERW 264
Cdd:TIGR02482 1 KIGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 265 GRKQACSNLIDQGIDALVVIGGDGSLTGADLFRSEwpslveelvkdgkftedevalyQNLTIVGMVGSIDNDMSGTDSTI 344
Cdd:TIGR02482 79 VREKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEE----------------------GGIPVIGLPGTIDNDIPGTDYTI 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 345 GAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPERAAPHgkwqDELKRVCQRHREKGR 424
Cdd:TIGR02482 137 GFDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDI----DELIQRLKEQHEAGK 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 425 RNNTVIVAEGALDDQLNPItAEQVKDvlvELGLDTKITTLGHVQRGGTAVAHDRWLATLQGVDAVKAILNMTPETpspLI 504
Cdd:TIGR02482 213 KHSIIIVAEGNIVGSAKEV-AKKIEE---KTGIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGV---MI 285
|
330
....*....|....*.
gi 417201 505 GILENKVIRMPLVESV 520
Cdd:TIGR02482 286 GIQNNKIVTHPIEEAL 301
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
184-539 |
7.47e-82 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 268.12 E-value: 7.47e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 184 KKIAVMTSGGDSQGMNAAVRAVVRSSIYYGCDVYAVYEGYEGLVKGgdYLRKMEWKDVRGWLSEGGTLIGTARSKEFRER 263
Cdd:cd00763 1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 264 WGRKQACSNLIDQGIDALVVIGGDGSLTGADLfrsewpsLVEElvkdgkftedevalyqNLTIVGMVGSIDNDMSGTDST 343
Cdd:cd00763 79 EGQAKAIEQLKKHGIDALVVIGGDGSYMGAMR-------LTEH----------------GFPCVGLPGTIDNDIPGTDYT 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 344 IGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPERAAPhgkwQDELKRVCQRHREKG 423
Cdd:cd00763 136 IGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD----REEVANRIKAGIERG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 424 RRNNTVIVAEGALD-DQLnpitAEQVKDvlvELGLDTKITTLGHVQRGGTAVAHDRWLATLQGVDAVKAILnmtpETPSP 502
Cdd:cd00763 212 KKHAIVVVAEGVYDvDEL----AKEIEE---ATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLL----AGKGG 280
|
330 340 350
....*....|....*....|....*....|....*...
gi 417201 503 L-IGILENKVIRMPLVEsvkltkqvaAAIEAKDFDKAI 539
Cdd:cd00763 281 LaVGIQNEQLVHHDIID---------AIENMKPFKKDW 309
|
|
| PFK_mixed |
TIGR02483 |
phosphofructokinase; Members of this family that are characterized, save one, are ... |
185-520 |
1.26e-75 |
|
phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 274155 [Multi-domain] Cd Length: 324 Bit Score: 251.45 E-value: 1.26e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 185 KIAVMTSGGDSQGMNAAVRAVVRSSIY-YGCDVYAVYEGYEGLVKGgDYLRKMEWKDVRGWLSEGGTLIGTARSKEFR-E 262
Cdd:TIGR02483 1 RIGVLTGGGDCPGLNAVIRGVVRRAIAeYGWEVIGIRDGWRGLLEG-DTVPLLDLEDVRGILPRGGTILGSSRTNPFKyE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 263 RWGRKQACSNLIDQGIDALVVIGGDGSLTGAdlfrsewpslvEELVKDGkftedevalyqnLTIVGMVGSIDNDMSGTDS 342
Cdd:TIGR02483 80 EDGDDKIVANLKELGLDALIAIGGDGTLGIA-----------RRLADKG------------LPVVGVPKTIDNDLEATDY 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 343 TIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPERaapHGKWQDELKRVCQRhREK 422
Cdd:TIGR02483 137 TFGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEI---PFDIDSVCEKVRER-FAR 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 423 GRRNNTVIVAEGAL------------DDQLNPIT----AEQVKDVLVE-LGLDTKITTLGHVQRGGTAVAHDRWLATLQG 485
Cdd:TIGR02483 213 GKRFAIVVVAEGAKpkggemvvqegvKDAFGHVRlggiGNWLAEEIERrTGIETRATVLGHLQRGGSPSAFDRVLATRFG 292
|
330 340 350
....*....|....*....|....*....|....*
gi 417201 486 VDAVKAILNMTPETPSPLIGileNKVIRMPLVESV 520
Cdd:TIGR02483 293 VAAVDLVHEGQFGHMVALRG---TDIVYVPIAEAV 324
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
181-492 |
1.12e-51 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 185.66 E-value: 1.12e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 181 SKKKKIAVMTSGGDSQGMNAAVRAVVRSSI-YYGCDVYAVYEGYEGLVKGGDYLRKMEWKDVRGWLSEGGTLIGTA---- 255
Cdd:PRK14071 2 GEKKRIGILTSGGDCAGLNAVIRAVVHRARgTYGWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTnkgd 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 256 -------------RSKEFRErwGRKQAcsnlidqGIDALVVIGGDGSLtgadlfrsewpSLVEELVKDGkftedevalyq 322
Cdd:PRK14071 82 pfafpmpdgslrdRSQEIID--GYHSL-------GLDALIGIGGDGSL-----------AILRRLAQQG----------- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 323 NLTIVGMVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPEra 402
Cdd:PRK14071 131 GINLVGIPKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPE-- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 403 APHgKWQDELKRVCQRhREKGRRNNTVIVAEGALDDQLNPIT-----------------AEQVKDvlvELGLDTKITTLG 465
Cdd:PRK14071 209 IPY-TLENVCKKIRER-QEEGKNFCLVVVSEAVRTEEGEQVTktqalgedryggigqylAEQIAE---RTGAETRVTVLG 283
|
330 340
....*....|....*....|....*..
gi 417201 466 HVQRGGTAVAHDRWLATLQGVDAVKAI 492
Cdd:PRK14071 284 HIQRGGIPSPRDRLLASAFGVAAVDLI 310
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
175-502 |
2.39e-47 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 181.77 E-value: 2.39e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 175 ELVDKDSKKKKIAVMTSGGDSQGMNAAVRAVVRSSIYYGCDVYAVYEGYEGLVKGGdyLRKMEWKDVRGWLSEGGTLIGT 254
Cdd:TIGR02478 381 KLVPSEASRLRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD--VRELTWSDVEGWVGEGGSELGT 458
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 255 ARSKEFRErwgRKQACSNLIDQGIDALVVIGGDGSLTGA---DLFRSEWPSLveelvkdgkftedevalyqNLTIVGMVG 331
Cdd:TIGR02478 459 NRSLPGDD---LGTIAYYFQQHKIDGLIIIGGFEAFEALyqlDAAREKYPAF-------------------RIPMVVIPA 516
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 332 SIDNDMSGTDSTIGAYSALERICEMVDYIDATAK-SHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPEraapHGKWQD 410
Cdd:TIGR02478 517 TISNNVPGTEYSLGSDTALNEITEYCDNIKQSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPE----EGISLK 592
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 411 ELKRVCQRHREK---GRRNNTVIVAEGALDDqlnpITAEQVKDVLVELG---LDTKITTLGHVQRGGTAVAHDRWLATLQ 484
Cdd:TIGR02478 593 DLQEDIEHLKETfaeGRAGKLILRNEKASKV----YTTDFIARIISEEGkgrFDARTAVLGHMQQGGSPSPFDRVRATRL 668
|
330
....*....|....*...
gi 417201 485 GVDAVKAILNMTPETPSP 502
Cdd:TIGR02478 669 AIRAVDFIEEKIKANKHA 686
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
594-865 |
6.11e-43 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 159.86 E-value: 6.11e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 594 TLYCLAHGHRPYAITNGFSGLIqTGQVKELSWIDVEDWHNLGGSEIGTNRS---VAAEDMGTIAYHFQKNKFDGVIILGG 670
Cdd:COG0205 24 VRTAIKYGIEVYGIRDGYEGLL-EGDIIDLTREDVSGILQRGGTILGSSRSkpfKTEEGREKALENLKKLGIDALVVIGG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 671 fEG-FKSLKQLRDgrdqypIFNIPMCLIPATVSNNVPGTEYSLGSDTCLNALVKYTDAIKQSASSTrRRVFVVEVQGGHS 749
Cdd:COG0205 103 -DGsLDGAAKLAE------EYGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRDTAASH-ERVFVVEVMGRHA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 750 GYVASFTGLVTGAVSVYTPENAINLKTIqedLALLKESFKHEQG----------ETRNGKLVIRNEMASDVY-----TTE 814
Cdd:COG0205 175 GWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGysiivvaegaGDEDGEAVLEADTDAFGHvrlggIGE 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 417201 815 LLADIITEQSNdrFGVRTAIPGHVQQGGVPSSKDRVIASRFAVKCVKFIEQ 865
Cdd:COG0205 252 YLAKEIEERTG--IETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLE 300
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
596-865 |
2.17e-38 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 145.99 E-value: 2.17e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 596 YCLAHGHRPYAITNGFSGLIQtGQVKELSWIDVEDWHNLGGSEIGTNRSV--AAEDMGTIAY-HFQKNKFDGVIILGGfE 672
Cdd:PRK03202 26 TAISEGLEVYGIYDGYAGLLE-GDIVKLDLKSVSDIINRGGTILGSARFPefKDEEGRAKAIeNLKKLGIDALVVIGG-D 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 673 G-FKSLKQLRDGrdqypifNIPMCLIPATVSNNVPGTEYSLGSDTCLNALVKYTDAIKQSASStRRRVFVVEVQGGHSGY 751
Cdd:PRK03202 104 GsYMGAKRLTEH-------GIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTASS-HERVFIVEVMGRHAGD 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 752 VASFTGLVTGAVSVYTPENainLKTIQEDLALLKESFKHeqgeTRNGKLVIrneMASDVYTTELLADIITEQSNdrFGVR 831
Cdd:PRK03202 176 LALHAGIAGGAEVILIPEV---PFDIEELCAKIKKGRER----GKKHAIIV---VAEGVMPAEELAKEIEERTG--LETR 243
|
250 260 270
....*....|....*....|....*....|....
gi 417201 832 TAIPGHVQQGGVPSSKDRVIASRFAVKCVKFIEQ 865
Cdd:PRK03202 244 VTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE 277
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
598-863 |
3.93e-33 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 131.27 E-value: 3.93e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 598 LAHGHRPYAITNGFSGLIQtGQVKELSWIDVEDWHNLGGSEIGTNRSVAAED---MGTIAYHFQKNKFDGVIILGGFEGF 674
Cdd:cd00363 27 IAEGLEVYGIYEGYAGLVE-GDIKELDWESVSDIINRGGTIIGSARCKEFRTeegRAKAAENLKKHGIDALVVIGGDGSY 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 675 KSLKQLRD-GRDQYPifNIPMCLIPATVSNNVPGTEYSLGSDTCLNALVKYTDAIKQSASStRRRVFVVEVQGGHSGYVA 753
Cdd:cd00363 106 TGADLLTEeWPSKYQ--GFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIRDTASS-HQRTFVVEVMGRHCGDIA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 754 SFTGLVTGAVSVYTPENAINLKTIQEDLALLKESfkHEQGEtRNGkLVIRNEMASD----VYTTELLADIITEQSNdrFG 829
Cdd:cd00363 183 LEAGLATGADIIFIPEEPAADEWEEEMVDVIKKR--RERGK-RHG-IVIVAEGAIDfipkPITEKLLAKLVEERLG--FD 256
|
250 260 270
....*....|....*....|....*....|....
gi 417201 830 VRTAIPGHVQQGGVPSSKDRVIASRFAVKCVKFI 863
Cdd:cd00363 257 TRATVLGHVQRGGTPTAFDRILASRLGAEAVELL 290
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
598-863 |
7.78e-32 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 126.76 E-value: 7.78e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 598 LAHGHRPYAITNGFSGLIQtGQVKELSWIDVEDWHNLGGSEIGTNRS--VAAEDMGTIAY-HFQKNKFDGVIILGGFEGF 674
Cdd:cd00763 27 IAEGLEVYGIRDGYAGLIA-GDIVPLDRYSVSDIINRGGTFLGSARFpeFKDEEGQAKAIeQLKKHGIDALVVIGGDGSY 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 675 KSLKQLRDgrdqypiFNIPMCLIPATVSNNVPGTEYSLGSDTCLNALVKYTDAIKQSASStRRRVFVVEVQGGHSGYVAS 754
Cdd:cd00763 106 MGAMRLTE-------HGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRDTSSS-HQRISVVEVMGRHCGDIAL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 755 FTGLVTGAVSVYTPENAINLKTIQEDLALLkesfkHEQGetRNGKLVIRNEMasdVYTTELLADIITEQSNdrFGVRTAI 834
Cdd:cd00763 178 AAGIAGGAEFIVIPEAEFDREEVANRIKAG-----IERG--KKHAIVVVAEG---VYDVDELAKEIEEATG--FETRATV 245
|
250 260
....*....|....*....|....*....
gi 417201 835 PGHVQQGGVPSSKDRVIASRFAVKCVKFI 863
Cdd:cd00763 246 LGHIQRGGSPTAFDRILASRMGAYAVELL 274
|
|
| Pfk_N |
pfam18468 |
Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal ... |
6-99 |
1.11e-30 |
|
Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal domain found in yeast ATP-dependent 6-phosphofructokinase subunit alpha. ATP-dependent 6-phosphofructokinases (Pfks, EC 2.7.1.11) catalyze the phosphorylation of fructose 6-phosphate (F-6-P) to fructose 1,6-bisphosphate, a key control step of glycolysis in most organizms. The N-terminal domain contains the active site and is related to glyoxalase I (E.C. 4.4.1.5).
Pssm-ID: 408261 Cd Length: 98 Bit Score: 116.08 E-value: 1.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 6 YGVAFRSLSTGDEKLYKEATRFYHSLGFQTVKLYDNFKNHDDSnlIVGTSKNSVKECWLESFKLSELDSQGFRVPQQEAS 85
Cdd:pfam18468 1 SGLSFISFVTNDPDKFEATIKFYTKLGFSATKSYSKDTNNDFE--LIGVSTDSIKEIWLESFPLSEVDSHGFRIPWQESP 78
|
90 100
....*....|....*....|
gi 417201 86 NQL------QTDGVMIKLRL 99
Cdd:pfam18468 79 GYQgdyspkLSDGVVIKLRL 98
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
180-440 |
5.60e-25 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 109.36 E-value: 5.60e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 180 DSKKKKIAVMTSGGDSQGMNAAVRAVVRSSIY-YGC-DVYAVYEGYEGLVKGGdyLRKMEWKDVRGWLSEGGTLIGTARS 257
Cdd:PTZ00286 84 NPKEVKAGIVTCGGLCPGLNVVIRELVMNLINnYGVkTIYGAKYGYKGLYKED--WIKLDPKDVKTIHRLGGTILGSSRG 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 258 KEfrerwGRKQACSNLIDQGIDALVVIGGDGSLTGADlfrsewpSLVEELVKDGkftedevalyQNLTIVGMVGSIDNDM 337
Cdd:PTZ00286 162 GF-----DPKVMVDTLIRHGINILFTLGGDGTHRGAL-------AIYKELRRRK----------LNISVVGIPKTIDNDI 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 338 SGTDSTIGAYSALERICEMVDYIDATAKSHSRAF-VVEVMGRHCGWLGLMSGIATA-ADYIFIPEraaphgkWQDELKRV 415
Cdd:PTZ00286 220 PIIDESFGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPE-------FDIPLEGV 292
|
250 260
....*....|....*....|....*..
gi 417201 416 CQ--RHREKGRRNNTVIVAEGALDDQL 440
Cdd:PTZ00286 293 LEyiEQRLQKKGHCVIVVAEGAGQSLK 319
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
605-865 |
2.65e-21 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 96.68 E-value: 2.65e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 605 YAITNGFSGLIQTG-QVKELSWIDVEDWHNLGGSEIGT-----------------NRSvaaEDMGTiAYHfqKNKFDGVI 666
Cdd:PRK14071 39 IGIRDATQGLMARPpQYIELDLDQVDDLLRMGGTILGTtnkgdpfafpmpdgslrDRS---QEIID-GYH--SLGLDALI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 667 ILGGFEGFKSLKQLRDgrdqypIFNIPMCLIPATVSNNVPGTEYSLGSDTCLNALVKYTDAIKQSASStRRRVFVVEVQG 746
Cdd:PRK14071 113 GIGGDGSLAILRRLAQ------QGGINLVGIPKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAAS-HNRVMILEVMG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 747 GHSGYVASFTGLVTGAVSVYTPENAINLKTIQEDLallkesfKHEQGETRNGKLVI-----RNEMASDVYTTELL----- 816
Cdd:PRK14071 186 RDAGHIALAAGIAGGADVILIPEIPYTLENVCKKI-------RERQEEGKNFCLVVvseavRTEEGEQVTKTQALgedry 258
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 417201 817 ---ADIITEQSNDRFGV--RTAIPGHVQQGGVPSSKDRVIASRFAVKCVKFIEQ 865
Cdd:PRK14071 259 ggiGQYLAEQIAERTGAetRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDLIAQ 312
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
183-468 |
3.68e-15 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 78.90 E-value: 3.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 183 KKKIAVMTSGGDSQGMNAAVRAVVR--SSIYYGCDVYAVYEGYEGLVKGgDYLRKMEwkDVRG----WLSEGGTLIGTAR 256
Cdd:PRK06555 3 VKKVALLTAGGLAPCLSSAVGGLIEryTEIAPEVEIIAYRSGYQGLLLG-DSIEITP--AVRAnaglLHRYGGSPIGNSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 257 SK--EFRERWGR----------KQACSNLIDQGIDALVVIGGDGS-LTGADLFRSewpslveeLVKDGkftedevalYqN 323
Cdd:PRK06555 80 VKltNVADCVKRglvkegenplKVAAERLAADGVDILHTIGGDDTnTTAADLAAY--------LAENG---------Y-D 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 324 LTIVGMVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVV-EVMGRHCGWLglmsGIATAADYI------ 396
Cdd:PRK06555 142 LTVVGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWL----TAATARAYRewldrq 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 397 -FIP------ERAAPHGKWQDEL--------KRVCQRHREKGrrNNTVIVAEGA-LDDqlnpITAEQVKDvlvelGLDTK 460
Cdd:PRK06555 218 eYVPgfglsaERWDIHAVYLPEMafdleaeaERLKAVMDEVG--NVNIFLSEGAgLDA----IVAEMEAA-----GEEVK 286
|
....*...
gi 417201 461 ITTLGHVQ 468
Cdd:PRK06555 287 RDAFGHVK 294
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
324-473 |
1.64e-14 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 76.82 E-value: 1.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 324 LTIVGMVGSIDNDMSGTDSTIGAYSALERICE--MVDYIDATA-KSHSRAFVVEVMGRHCGWLGLMSGIAT-----AADY 395
Cdd:PRK14072 133 IRCIGIPKTIDNDLPGTDHCPGFGSAAKYIATsvLEAALDVAAmANTSKVFILEVMGRHAGWLAAAAALAKqnpddAPHL 212
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 417201 396 IFIPERAAPHGKWQDELKRVCQRHrekGRrnNTVIVAEGALDDQLNPItAEQVkdvlvelgldTKITTLGHVQRGGTA 473
Cdd:PRK14072 213 IYLPERPFDEEKFLADVRAIVKRY---GY--CVVVVSEGIRDADGKFI-AEAG----------LAEDAFGHAQLGGVA 274
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
185-526 |
2.04e-14 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 76.39 E-value: 2.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 185 KIAVMTSGGDSQGMNAAVRAVVRSSIYYGC-DVYAVYEGYEGLVKGGDYLRKMEWKDVRGWLSEGGTLIGTARSkefrer 263
Cdd:PLN02884 55 KAAIVTCGGLCPGLNDVIRQIVFTLEIYGVkNIVGIPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLGVSRG------ 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 264 wGRKqaCSNLID----QGIDALVVIGGDGSLTGADLFRsewpslvEELVKDGkftedevalyQNLTIVGMVGSIDNDMSG 339
Cdd:PLN02884 129 -GAK--TSDIVDsieaRGINMLFVLGGNGTHAGANAIH-------NECRKRK----------MKVSVVGVPKTIDNDILL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 340 TDSTIGAYSALERICEMVD--YIDATAKSHSRAfVVEVMGRHCGWLGLMSGIATA-ADYIFIPERA----APHGKWQdEL 412
Cdd:PLN02884 189 MDKTFGFDTAVEEAQRAINsaYIEAHSAYHGIG-LVKLMGRSSGFIAMHASLASGqVDICLIPEVPftldGPNGVLR-HL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 413 KRVCQRhreKGRrnNTVIVAEGALDDQLNPITA-----------------EQVKDVLVELGL--DTKITTLGHVQRGGTA 473
Cdd:PLN02884 267 EHLIET---KGS--AVVCVAEGAGQDLLQKTNAtdasgnpvlgdigvhlqQEIKKHFKDIGVpaDVKYIDPTYMIRACRA 341
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 417201 474 VAHDRWLATLQGVDAVK-AILNMTPETpsplIGILENKVIRMPLVESVKLTKQV 526
Cdd:PLN02884 342 NASDAILCTVLGQNAVHgAFAGFSGIT----VGICNTHYVYLPIPEVIAYPRRV 391
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
605-790 |
5.61e-14 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 75.46 E-value: 5.61e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 605 YAITNGFSGLIQTGQVKeLSWIDVEDWHNLGGSEIGTNRSvaAEDMGTIAYHFQKNKFDGVIILGGFEGFKSLKQLrdgr 684
Cdd:PTZ00286 123 YGAKYGYKGLYKEDWIK-LDPKDVKTIHRLGGTILGSSRG--GFDPKVMVDTLIRHGINILFTLGGDGTHRGALAI---- 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 685 dQYPI----FNIPMCLIPATVSNNVPGTEYSLGSDTCLNALVKYTDAIKQSASSTRRRVFVVEVQGGHSGYVASFTGLVT 760
Cdd:PTZ00286 196 -YKELrrrkLNISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYVEAKSAKNGVGIVKLMGRDSGFIALHASVAS 274
|
170 180 190
....*....|....*....|....*....|.
gi 417201 761 GAVSV-YTPENAINLKTIqedLALLKESFKH 790
Cdd:PTZ00286 275 ADVNVcLIPEFDIPLEGV---LEYIEQRLQK 302
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
180-435 |
5.67e-14 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 75.29 E-value: 5.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 180 DSKKKKIAVMTSGGDSQGMNAAVRAVVRSsIYYGCDVYAVY---EGYEGLVKggDY-LRKMEW--KDVRGWLSEGGTLIG 253
Cdd:PRK06830 77 DPSKVKAAIVTCGGLCPGLNDVIRAIVLE-LHHHYGVRRILgirYGYQGLIP--RYgHDPVELtpEVVADIHEFGGTILG 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 254 TARSKefrerwgrkQACSNLID----QGIDALVVIGGDGSLTGADlfrsewpSLVEELVKDGkftedevalyQNLTIVGM 329
Cdd:PRK06830 154 SSRGP---------QDPEEIVDtlerMNINILFVIGGDGTLRGAS-------AIAEEIERRG----------LKISVIGI 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 330 VGSIDNDMSGTDSTIGAYSALERICEmvdyidATAKSHSRAF-------VVEVMGRHCGWLGLMSGIATA-ADYIFIPER 401
Cdd:PRK06830 208 PKTIDNDINFIQKSFGFETAVEKATE------AIRCAHVEANgapngigLVKLMGRHSGFIAAYAALASKdVNFVLIPEV 281
|
250 260 270
....*....|....*....|....*....|....*...
gi 417201 402 ----AAPHGKWQDeLKRvcqrhREKGRRNNTVIVAEGA 435
Cdd:PRK06830 282 pfdlEGPNGLLAA-LEK-----RLAERGHAVIVVAEGA 313
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
160-435 |
4.28e-11 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 66.31 E-value: 4.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 160 FIAPKDSsVEQKITV----------------ELVDKDSKKKKIAVMTSGGDSQGMNAAVRAVVRSSIY-YGC-DVYAVYE 221
Cdd:PLN02564 49 FVNEDDT-VAQKIVVhkdsprgthfrragprQKVYFESDEVRACIVTCGGLCPGLNTVIREIVCGLSYmYGVtRILGIDG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 222 GYEGLvkggdYLRK---MEWKDVRGWLSEGGTLIGTARSKEfrerwGRKQACSNLIDQGIDALVVIGGDGSLTGADLfrs 298
Cdd:PLN02564 128 GYRGF-----YSRNtipLTPKVVNDIHKRGGTILGTSRGGH-----DTSKIVDSIQDRGINQVYIIGGDGTQKGASV--- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 299 ewpsLVEELVKDGKftedEVAlyqnltIVGMVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKS-HSRAFVVEVMG 377
Cdd:PLN02564 195 ----IYEEIRRRGL----KVA------VAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESvENGIGLVKLMG 260
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 417201 378 RHCGWLGLMSGIATA-ADYIFIPEraAP---HGKwQDELKRVCQRHREKGrrNNTVIVAEGA 435
Cdd:PLN02564 261 RYSGFIAMYATLASRdVDCCLIPE--SPfylEGK-GGLFEFIEKRLKENG--HMVIVVAEGA 317
|
|
| PTZ00468 |
PTZ00468 |
phosphofructokinase family protein; Provisional |
184-437 |
1.42e-06 |
|
phosphofructokinase family protein; Provisional
Pssm-ID: 185647 [Multi-domain] Cd Length: 1328 Bit Score: 52.67 E-value: 1.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 184 KKIAVMTSGGDSQGMNAAVRAVVrsSIYYGCDVYAVYEGYEGLVKG--GDYLRKMEWKDVRGWLSEGG-TLIGTARSKEF 260
Cdd:PTZ00468 103 RRIGVVLSGGQASGGHNVIAGLM--SYIKLCNQSSQLFGFLGGPEGvySERYRELTEDDINGILNQGGfNIICSGRHKIE 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 261 RERwgRKQACSNLIDQ-GIDALVVIGGDGSLTGADLfrsewpsLVEELVKDGkftedevalyQNLTIVGMVGSIDNDMSG 339
Cdd:PTZ00468 181 TEE--QMRASLEICEKlKLHGLVVIGGDDSNTNAAV-------LAEYFKRNS----------SSTVVVGCPKTIDGDLKN 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 340 --TDSTIGAYSALERICEMVDYI-DATAKSHSRAFVVEVMGRHCGWLGLMSGIATAADYIFIPERAAPHGKWQ----DEL 412
Cdd:PTZ00468 242 evIETSFGYDTAVKTYSEQIGSImDAIKTEGYGYYFVRLMGRSASHITLECGLQTRANMILIGEEIKEENRSLmsivDEI 321
|
250 260
....*....|....*....|....*
gi 417201 413 KRVCQRHREKGRRNNTVIVAEGALD 437
Cdd:PTZ00468 322 VEMILKRDSLGKKHGIVLLPEGLIE 346
|
|
| Pyrophosphate_PFK |
cd00765 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
181-460 |
6.62e-06 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.
Pssm-ID: 238390 Cd Length: 550 Bit Score: 49.87 E-value: 6.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 181 SKKKKIAVMTSGGDSQGMNAAVRAVV-------RSSIYYGcdvyavYEGYEGLVKGGDYLRKMEwKDVRGWLSEGG-TLI 252
Cdd:cd00765 70 APKLKIGIVLSGGQAPGGHNVISGLFdylkeraKGSTLYG------FKGGPAGILKCDYIELNA-EYIQPYRNTGGfDMI 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 253 GTARSK-EFRERWgrKQACSNLIDQGIDALVVIGGDGSLTGADLfrsewpsLVEELVKDGkftedevalyQNLTIVGMVG 331
Cdd:cd00765 143 CSGRTKiETEDQF--KQAEETAKKLDLDALVVIGGDDSNTNAAL-------LAENFRSKG----------LKTRVIGVPK 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 332 SIDNDM--SGTDSTIGAYSALERICEMVDYIDATAKSHSRAF-VVEVMGRHCGWLGLMSGIATAADYIFIPERAAPHGKW 408
Cdd:cd00765 204 TIDGDLknKEIETSFGFDTATKIYSELIGNVMRDARSTGKYWhFVKLMGRSASHIALECALKTHPNICIISEEVSAQKQT 283
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 417201 409 ----QDELKRVCQRHREKGRRNNTVIVAEG---------ALDDQLNPITAEQVKDvlvELGLDTK 460
Cdd:cd00765 284 lkniTDYMVDVICKRAELGYNFGVVLVPEGliefipevkELIAELNEILANEVVE---FNGLWKK 345
|
|
| PRK07085 |
PRK07085 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional |
178-434 |
7.10e-05 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
Pssm-ID: 235930 Cd Length: 555 Bit Score: 46.45 E-value: 7.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 178 DKDSKKKKIAVMTSGGDS-------QGMNAAVRAVVRSSIYYGcdvyaVYEGYEGLVKGgdylRKMEWKD--VRGWLSEG 248
Cdd:PRK07085 65 ESSSKPLKVGVILSGGQApgghnviAGLFDGLKKLNPDSKLFG-----FIGGPLGLLNG----KYIEITEevIDEYRNTG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 249 G-TLIGTARSK-EFRERwgrKQAC-SNLIDQGIDALVVIGGDGSLTGADLfrsewpsLVEELVKDGkftedevalyQNLT 325
Cdd:PRK07085 136 GfDMIGSGRTKiETEEQ---KEAClETVKKLKLDGLVIIGGDDSNTNAAI-------LAEYFAKHG----------CKTQ 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 326 IVGMVGSIDNDMSGT--DSTIGAYSALERICEMVDYI--DA-TAKSHSraFVVEVMGRHCGWLGLMSGIATAADYIFIPE 400
Cdd:PRK07085 196 VIGVPKTIDGDLKNEfiETSFGFDTATKTYSEMIGNIsrDAlSAKKYW--HFIKLMGRSASHIALECALQTHPNICLISE 273
|
250 260 270
....*....|....*....|....*....|....*....
gi 417201 401 RAAPHGKWQDEL-----KRVCQRhREKGRRNNTVIVAEG 434
Cdd:PRK07085 274 EVAEKKMSLQDIvhyiaSVIADR-AAKGKNYGVILIPEG 311
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
602-758 |
1.06e-04 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 45.89 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 602 HRPYAITNGFSGLIQTGQVkELSWIDVEDWHNLGGSEIGTNRsvAAEDMGTIAYHFQKNKFDGVIILGGfegfkslkqlr 681
Cdd:PLN02564 120 TRILGIDGGYRGFYSRNTI-PLTPKVVNDIHKRGGTILGTSR--GGHDTSKIVDSIQDRGINQVYIIGG----------- 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 682 DG--RDQYPIF--------NIPMCLIPATVSNNVPGTEYSLGSDTCLNALVKYTDAIKQSASSTRRRVFVVEVQGGHSGY 751
Cdd:PLN02564 186 DGtqKGASVIYeeirrrglKVAVAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESVENGIGLVKLMGRYSGF 265
|
....*..
gi 417201 752 VASFTGL 758
Cdd:PLN02564 266 IAMYATL 272
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
697-858 |
1.53e-04 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 45.24 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 697 IPATVSNNVPGTEYSLGsdtclnalvkYTDAIKQSASSTR------------RRVFVVEVQGGHSGYVASFTGLVT---- 760
Cdd:PRK14072 138 IPKTIDNDLPGTDHCPG----------FGSAAKYIATSVLeaaldvaamantSKVFILEVMGRHAGWLAAAAALAKqnpd 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 417201 761 -GAVSVYTPENAINLKTIQEDlalLKESFKheqgetRNGKLVIrneMASDVYTTE---LLADIITeqSNDRFgvrtaipG 836
Cdd:PRK14072 208 dAPHLIYLPERPFDEEKFLAD---VRAIVK------RYGYCVV---VVSEGIRDAdgkFIAEAGL--AEDAF-------G 266
|
170 180
....*....|....*....|..
gi 417201 837 HVQQGGVPSSKDRVIASRFAVK 858
Cdd:PRK14072 267 HAQLGGVAPVLANLIKEKLGKK 288
|
|
| |
