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Conserved domains on  [gi|41350078|gb|AAS00381|]
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unknown, partial [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-166 5.29e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 56.57  E-value: 5.29e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41350078  46 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRInrAATFVKWSPLENKFAVGSGARLISVcyf 125
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL--- 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 41350078 126 esendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKC 166
Cdd:cd00200  78 -----WDLET--GECVRtltghtSYVSSVAFSPDGRILSSSSRDKTI 117
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-80 3.09e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 36.93  E-value: 3.09e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41350078   9 EPITCHAWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:cd00200 220 NGVNSVAFSPDGYLLASGSEDGTIRVW--DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-166 5.29e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.57  E-value: 5.29e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41350078  46 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRInrAATFVKWSPLENKFAVGSGARLISVcyf 125
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL--- 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 41350078 126 esendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKC 166
Cdd:cd00200  78 -----WDLET--GECVRtltghtSYVSSVAFSPDGRILSSSSRDKTI 117
WD40 COG2319
WD40 repeat [General function prediction only];
15-163 8.80e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 8.80e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41350078  15 AWNRDRTQIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVilR 94
Cdd:COG2319 211 AFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--G 286

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41350078  95 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIRS------TVLSLDWHPNNVLLAAGSCD 163
Cdd:COG2319 287 HSGGVNSVAFSPDGKLLASGSDDGTVRL--------WDLAT--GKLLRTltghtgAVRSVAFSPDGKTLASGSDD 351
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 46-80 7.48e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 7.48e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 41350078     46 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
42-80 4.27e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 4.27e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 41350078    42 WVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-80 3.09e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 36.93  E-value: 3.09e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41350078   9 EPITCHAWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:cd00200 220 NGVNSVAFSPDGYLLASGSEDGTIRVW--DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-166 5.29e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.57  E-value: 5.29e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41350078  46 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRInrAATFVKWSPLENKFAVGSGARLISVcyf 125
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL--- 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 41350078 126 esendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKC 166
Cdd:cd00200  78 -----WDLET--GECVRtltghtSYVSSVAFSPDGRILSSSSRDKTI 117
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-163 8.04e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.80  E-value: 8.04e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41350078  10 PITCHAWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPT 89
Cdd:cd00200 137 WVNSVAFSPDGTFVASSSQDGTIKLW--DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41350078  90 LVilRINRAATFVKWSPLENKFAVGSGARLISVcyfesendW-WVSKHIKKPIR---STVLSLDWHPNNVLLAAGSCD 163
Cdd:cd00200 215 LR--GHENGVNSVAFSPDGYLLASGSEDGTIRV--------WdLRTGECVQTLSghtNSVTSLAWSPDGKRLASGSAD 282
WD40 COG2319
WD40 repeat [General function prediction only];
15-163 8.80e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 8.80e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41350078  15 AWNRDRTQIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVilR 94
Cdd:COG2319 211 AFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--G 286

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41350078  95 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIRS------TVLSLDWHPNNVLLAAGSCD 163
Cdd:COG2319 287 HSGGVNSVAFSPDGKLLASGSDDGTVRL--------WDLAT--GKLLRTltghtgAVRSVAFSPDGKTLASGSDD 351
WD40 COG2319
WD40 repeat [General function prediction only];
15-163 1.77e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 1.77e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41350078  15 AWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILR 94
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTG 202

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41350078  95 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCD 163
Cdd:COG2319 203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAT--GKLLRtltghsGSVRSVAFSPDGRLLASGSAD 267
WD40 COG2319
WD40 repeat [General function prediction only];
15-163 6.47e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 6.47e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41350078  15 AWNRDRTQIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILR 94
Cdd:COG2319 253 AFSPDGRLLASGSADGTVRLWDLATGELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTG 328

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41350078  95 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCD 163
Cdd:COG2319 329 HTGAVRSVAFSPDGKTLASGSDDGTVRL--------WDLAT--GELLRtltghtGAVTSVAFSPDGRTLASGSAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-163 4.58e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 4.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41350078  10 PITCHAWNRDRTQIALSPNNHEVHIYKKNGSQwvKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPT 89
Cdd:cd00200  53 PVRDVAASADGTYLASGSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCL 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41350078  90 LVILRINRAATFVKWSPlENKFAVGSGA-RLISVCYFESEndwwvskhikKPIR------STVLSLDWHPNNVLLAAGSC 162
Cdd:cd00200 129 TTLRGHTDWVNSVAFSP-DGTFVASSSQdGTIKLWDLRTG----------KCVAtltghtGEVNSVAFSPDGEKLLSSSS 197


                .
gi 41350078 163 D 163
Cdd:cd00200 198 D 198
WD40 COG2319
WD40 repeat [General function prediction only];
15-163 1.88e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 1.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41350078  15 AWNRDRTQIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILR 94
Cdd:COG2319  85 AFSPDGRLLASASADGTVRLWDLATGLLL--RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG--KLLRTLTG 160

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41350078  95 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIRS------TVLSLDWHPNNVLLAAGSCD 163
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRL--------WDLAT--GKLLRTltghtgAVRSVAFSPDGKLLASGSAD 225
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 46-80 7.48e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 7.48e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 41350078     46 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
10-116 3.53e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 3.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41350078  10 PITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPT 89
Cdd:COG2319 290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG--ELL 365

                        90       100
                ....*....|....*....|....*..
gi 41350078  90 LVILRINRAATFVKWSPLENKFAVGSG 116
Cdd:COG2319 366 RTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 pfam00400
WD domain, G-beta repeat;
42-80 4.27e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 4.27e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 41350078    42 WVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
15-80 9.83e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 38.35  E-value: 9.83e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41350078  15 AWNRDRTQIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLWDLATGELL--RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-80 3.09e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 36.93  E-value: 3.09e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41350078   9 EPITCHAWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:cd00200 220 NGVNSVAFSPDGYLLASGSEDGTIRVW--DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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