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Conserved domains on  [gi|41281564|ref|NP_054742|]
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WD repeat-containing protein 37 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
147-486 8.00e-45

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.00  E-value: 8.00e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 147 QLVKEYIGHRDGIWDVSVAkTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFS-PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 227 RyavqLPTPQPVAdtSISGEDE----VECSDkdepdlDGD---VSSDCPTIRV-------PLTSLKSHQGVVIASDWLVG 292
Cdd:COG2319 148 D----LATGKLLR--TLTGHSGavtsVAFSP------DGKllaSGSDDGTVRLwdlatgkLLRTLTGHTGAVRSVAFSPD 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 293 GKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTS 372
Cdd:COG2319 216 GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL--LRTLTGHSGGVNS 293

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 373 AVFT-VGDNVVSGSDDRTVKVWDLKNmRSPIATIR-TDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARlprsSR 450
Cdd:COG2319 294 VAFSpDGKLLASGSDDGTVRLWDLAT-GKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR----TL 368

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 41281564 451 QGHRRMVCCSAWSEDHPVcnLFTCGFDRQAIGWNIN 486
Cdd:COG2319 369 TGHTGAVTSVAFSPDGRT--LASGSADGTVRLWDLA 402
DivIVA super family cl34642
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 64-91 1.73e-03

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG3599:

Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 38.30  E-value: 1.73e-03
                        10        20
                ....*....|....*....|....*...
gi 41281564  64 QIEREFENLYIENLELRREIDTLNERLA 91
Cdd:COG3599  31 EVAEDYERLIRENKELKEKLEELEEELE 58
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
147-486 8.00e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.00  E-value: 8.00e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 147 QLVKEYIGHRDGIWDVSVAkTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFS-PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 227 RyavqLPTPQPVAdtSISGEDE----VECSDkdepdlDGD---VSSDCPTIRV-------PLTSLKSHQGVVIASDWLVG 292
Cdd:COG2319 148 D----LATGKLLR--TLTGHSGavtsVAFSP------DGKllaSGSDDGTVRLwdlatgkLLRTLTGHTGAVRSVAFSPD 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 293 GKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTS 372
Cdd:COG2319 216 GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL--LRTLTGHSGGVNS 293

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 373 AVFT-VGDNVVSGSDDRTVKVWDLKNmRSPIATIR-TDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARlprsSR 450
Cdd:COG2319 294 VAFSpDGKLLASGSDDGTVRLWDLAT-GKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR----TL 368

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 41281564 451 QGHRRMVCCSAWSEDHPVcnLFTCGFDRQAIGWNIN 486
Cdd:COG2319 369 TGHTGAVTSVAFSPDGRT--LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 148-484 1.92e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.88  E-value: 1.92e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 148 LVKEYIGHRDGIWDVSVAKTQPVVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWr 227
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 228 yavqlptpqpvadtsisgedevecsdkdepdldgDVSSDCptirvPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANL 307
Cdd:cd00200  79 ----------------------------------DLETGE-----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKV 119

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 308 YDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRdpSIHSVNVFQGHTDTVTSAVFT-VGDNVVSGSD 386
Cdd:cd00200 120 WDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR--TGKCVATLTGHTGEVNSVAFSpDGEKLLSSSS 197

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 387 DRTVKVWDLKnMRSPIATIRT-DSAINRINVCVGQKIIALPHDNRQVRLFDM-SGVRLARLprssrQGHRRMVCCSAWSE 464
Cdd:cd00200 198 DGTIKLWDLS-TGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRVWDLrTGECVQTL-----SGHTNSVTSLAWSP 271

                       330       340
                ....*....|....*....|
gi 41281564 465 DHPVcnLFTCGFDRQAIGWN 484
Cdd:cd00200 272 DGKR--LASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 188-226 1.85e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.85e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 41281564    188 TGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
189-226 4.96e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 4.96e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 41281564   189 GKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 153-408 2.21e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564  153 IGHRDGIWDVSVAKTQPVVLGTASADHTALLWSI-------ETGKCLVKYAGHVGSVNSIKFHPSEQLALTASG-DQTAH 224
Cdd:PTZ00421  72 LGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVN 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564  225 IWryavqlptpqpvadtsisgedevecsdkdepdldgDVSSDcptirVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRT 304
Cdd:PTZ00421 152 VW-----------------------------------DVERG-----KAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKK 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564  305 ANLYDVETSELVHSLTGHDqelthccTHPTQRLVVTSSRDTtfrlwdfrdpsihsvnvfqghtdtvtsaVFTVGdnvVSG 384
Cdd:PTZ00421 192 LNIIDPRDGTIVSSVEAHA-------SAKSQRCLWAKRKDL----------------------------IITLG---CSK 233

                        250       260
                 ....*....|....*....|....
gi 41281564  385 SDDRTVKVWDLKNMRSPIATIRTD 408
Cdd:PTZ00421 234 SQQRQIMLWDTRKMASPYSTVDLD 257
DivIVA COG3599
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 64-91 1.73e-03

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 38.30  E-value: 1.73e-03
                        10        20
                ....*....|....*....|....*...
gi 41281564  64 QIEREFENLYIENLELRREIDTLNERLA 91
Cdd:COG3599  31 EVAEDYERLIRENKELKEKLEELEEELE 58
DivIVA pfam05103
DivIVA protein; The Bacillus subtilis divIVA1 mutation causes misplacement of the septum ...
 60-91 7.06e-03

DivIVA protein; The Bacillus subtilis divIVA1 mutation causes misplacement of the septum during cell division, resulting in the formation of small, circular, anucleate mini-cells. Inactivation of divIVA produces a mini-cell phenotype, whereas overproduction of DivIVA results in a filamentation phenotype. These proteins appear to contain coiled-coils.


Pssm-ID: 428304 [Multi-domain]  Cd Length: 131  Bit Score: 36.78  E-value: 7.06e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 41281564    60 ELFGQIEREFENLYIENLELRREIDTLNERLA 91
Cdd:pfam05103  25 EFLDQVAEDYEALIRENAELKEKIEELEEKLA 56
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
147-486 8.00e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.00  E-value: 8.00e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 147 QLVKEYIGHRDGIWDVSVAkTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFS-PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 227 RyavqLPTPQPVAdtSISGEDE----VECSDkdepdlDGD---VSSDCPTIRV-------PLTSLKSHQGVVIASDWLVG 292
Cdd:COG2319 148 D----LATGKLLR--TLTGHSGavtsVAFSP------DGKllaSGSDDGTVRLwdlatgkLLRTLTGHTGAVRSVAFSPD 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 293 GKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTS 372
Cdd:COG2319 216 GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL--LRTLTGHSGGVNS 293

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 373 AVFT-VGDNVVSGSDDRTVKVWDLKNmRSPIATIR-TDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARlprsSR 450
Cdd:COG2319 294 VAFSpDGKLLASGSDDGTVRLWDLAT-GKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR----TL 368

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 41281564 451 QGHRRMVCCSAWSEDHPVcnLFTCGFDRQAIGWNIN 486
Cdd:COG2319 369 TGHTGAVTSVAFSPDGRT--LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 148-484 1.92e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.88  E-value: 1.92e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 148 LVKEYIGHRDGIWDVSVAKTQPVVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWr 227
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 228 yavqlptpqpvadtsisgedevecsdkdepdldgDVSSDCptirvPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANL 307
Cdd:cd00200  79 ----------------------------------DLETGE-----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKV 119

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 308 YDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRdpSIHSVNVFQGHTDTVTSAVFT-VGDNVVSGSD 386
Cdd:cd00200 120 WDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR--TGKCVATLTGHTGEVNSVAFSpDGEKLLSSSS 197

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 387 DRTVKVWDLKnMRSPIATIRT-DSAINRINVCVGQKIIALPHDNRQVRLFDM-SGVRLARLprssrQGHRRMVCCSAWSE 464
Cdd:cd00200 198 DGTIKLWDLS-TGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRVWDLrTGECVQTL-----SGHTNSVTSLAWSP 271

                       330       340
                ....*....|....*....|
gi 41281564 465 DHPVcnLFTCGFDRQAIGWN 484
Cdd:cd00200 272 DGKR--LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
147-439 2.47e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.15  E-value: 2.47e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 147 QLVKEYIGHRDGIWDVSVAKTQPVVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 227 RyavqLPTPQPVAdtSISGEDE----VECSDkdepdlDGD---VSSDCPTIRV-------PLTSLKSHQGVVIASDWLVG 292
Cdd:COG2319 190 D----LATGKLLR--TLTGHTGavrsVAFSP------DGKllaSGSADGTVRLwdlatgkLLRTLTGHSGSVRSVAFSPD 257

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 293 GKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTS 372
Cdd:COG2319 258 GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRS 335

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41281564 373 AVFT-VGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSG 439
Cdd:COG2319 336 VAFSpDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 128-436 3.29e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 154.42  E-value: 3.29e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 128 ASTSKIVSSFKTTTsraaCQLVKEYIGHRDGIWDVS-VAKTQPVVlgTASADHTALLWSIETGKCLVKYAGHVGSVNSIK 206
Cdd:cd00200  27 GSGDGTIKVWDLET----GELLRTLKGHTGPVRDVAaSADGTYLA--SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVA 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 207 FHPSEQLALTASGDQTAHIWryavQLPTPQPVadtsisgedevecsdkdepdldgdvssdcptirvplTSLKSHQGVVIA 286
Cdd:cd00200 101 FSPDGRILSSSSRDKTIKVW----DVETGKCL------------------------------------TTLRGHTDWVNS 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 287 SDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRdpSIHSVNVFQGH 366
Cdd:cd00200 141 VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS--TGKCLGTLRGH 218

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41281564 367 TDTVTSAVFTVGDN-VVSGSDDRTVKVWDLKNmRSPIATIR-TDSAINRINVC-VGQKIIALPHDNRqVRLFD 436
Cdd:cd00200 219 ENGVNSVAFSPDGYlLASGSEDGTIRVWDLRT-GECVQTLSgHTNSVTSLAWSpDGKRLASGSADGT-IRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 197-493 4.44e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.55  E-value: 4.44e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 197 GHVGSVNSIKFHPSEQLALTASGDQTAHIWryavqlptpqpvadtsisgedevecsdkdepDLDGDVssdcptirvPLTS 276
Cdd:cd00200   7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVW-------------------------------DLETGE---------LLRT 46

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 277 LKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPS 356
Cdd:cd00200  47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 357 IhsVNVFQGHTDTVTSAVFTVGDN-VVSGSDDRTVKVWDLKNMRsPIATIRT-DSAINRINVCVGQKIIALPHDNRQVRL 434
Cdd:cd00200 127 C--LTTLRGHTDWVNSVAFSPDGTfVASSSQDGTIKLWDLRTGK-CVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 41281564 435 FDMSGVRLARLPRssrqGHRRMVCCSAWSEDHPVcnLFTCGFDRQAIGWNINIPALLQE 493
Cdd:cd00200 204 WDLSTGKCLGTLR----GHENGVNSVAFSPDGYL--LASGSEDGTIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
162-493 2.75e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 2.75e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 162 VSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADT 241
Cdd:COG2319  41 SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHT 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 242 S-ISGedeVECSDkdepdlDGD----VSSDcPTIRV-------PLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYD 309
Cdd:COG2319 121 GaVRS---VAFSP------DGKtlasGSAD-GTVRLwdlatgkLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 310 VETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTSAVFTV-GDNVVSGSDDR 388
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL--LRTLTGHSGSVRSVAFSPdGRLLASGSADG 268

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 389 TVKVWDLKNmRSPIATIRTDS-AINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARlprsSRQGHRRMVCCSAWSEDHP 467
Cdd:COG2319 269 TVRLWDLAT-GELLRTLTGHSgGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR----TLTGHTGAVRSVAFSPDGK 343

                       330       340
                ....*....|....*....|....*.
gi 41281564 468 VcnLFTCGFDRQAIGWNINIPALLQE 493
Cdd:COG2319 344 T--LASGSDDGTVRLWDLATGELLRT 367
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 277-492 6.19e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 6.19e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 277 LKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPs 356
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 357 iHSVNVFQGHTDTVTSAVFTVGDN-VVSGSDDRTVKVWDLKNmRSPIATIRT-DSAINRINVCVGQKIIALPHDNRQVRL 434
Cdd:cd00200  84 -ECVRTLTGHTSYVSSVAFSPDGRiLSSSSRDKTIKVWDVET-GKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 41281564 435 FDM-SGVRLARLPrssrqGHRRMVCCSAWSEDHPvcNLFTCGFDRQAIGWNINIPALLQ 492
Cdd:cd00200 162 WDLrTGKCVATLT-----GHTGEVNSVAFSPDGE--KLLSSSSDGTIKLWDLSTGKCLG 213
WD40 COG2319
WD40 repeat [General function prediction only];
258-486 8.10e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 8.10e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 258 DLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRL 337
Cdd:COG2319  13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 338 VVTSSRDTTFRLWDFRDPsiHSVNVFQGHTDTVTSAVFT-VGDNVVSGSDDRTVKVWDLKNmRSPIATIRTDS-AINRIN 415
Cdd:COG2319  93 LASASADGTVRLWDLATG--LLLRTLTGHTGAVRSVAFSpDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSgAVTSVA 169

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41281564 416 VCVGQKIIALPHDNRQVRLFDM-SGVRLARLprssrQGHRRMVCCSAWSEDHPVcnLFTCGFDRQAIGWNIN 486
Cdd:COG2319 170 FSPDGKLLASGSDDGTVRLWDLaTGKLLRTL-----TGHTGAVRSVAFSPDGKL--LASGSADGTVRLWDLA 234
WD40 COG2319
WD40 repeat [General function prediction only];
293-493 5.30e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.08  E-value: 5.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 293 GKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTS 372
Cdd:COG2319   6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGAL--LATLLGHTAAVLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 373 AVFTV-GDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDM-SGVRLARLPrssr 450
Cdd:COG2319  84 VAFSPdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLT---- 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 41281564 451 qGHRRMVCCSAWSEDHPVcnLFTCGFDRQAIGWNINIPALLQE 493
Cdd:COG2319 160 -GHSGAVTSVAFSPDGKL--LASGSDDGTVRLWDLATGKLLRT 199
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 188-226 1.85e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.85e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 41281564    188 TGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
189-226 4.96e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 4.96e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 41281564   189 GKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 312-351 6.06e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 6.06e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 41281564    312 TSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWD 351
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
360-394 7.86e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.86e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 41281564   360 VNVFQGHTDTVTSAVFTV-GDNVVSGSDDRTVKVWD 394
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPdGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
313-351 1.20e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 41281564   313 SELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWD 351
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 356-394 1.88e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.88e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 41281564    356 SIHSVNVFQGHTDTVTSAVFT-VGDNVVSGSDDRTVKVWD 394
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 153-408 2.21e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564  153 IGHRDGIWDVSVAKTQPVVLGTASADHTALLWSI-------ETGKCLVKYAGHVGSVNSIKFHPSEQLALTASG-DQTAH 224
Cdd:PTZ00421  72 LGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVN 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564  225 IWryavqlptpqpvadtsisgedevecsdkdepdldgDVSSDcptirVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRT 304
Cdd:PTZ00421 152 VW-----------------------------------DVERG-----KAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKK 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564  305 ANLYDVETSELVHSLTGHDqelthccTHPTQRLVVTSSRDTtfrlwdfrdpsihsvnvfqghtdtvtsaVFTVGdnvVSG 384
Cdd:PTZ00421 192 LNIIDPRDGTIVSSVEAHA-------SAKSQRCLWAKRKDL----------------------------IITLG---CSK 233

                        250       260
                 ....*....|....*....|....
gi 41281564  385 SDDRTVKVWDLKNMRSPIATIRTD 408
Cdd:PTZ00421 234 SQQRQIMLWDTRKMASPYSTVDLD 257
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 329-416 1.25e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.61  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564  329 CCTH---PTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFqGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLKNMRSPIATI 405
Cdd:PLN00181 621 CCVQfpsESGRSLAFGSADHKVYYYDLRNPKLPLCTMI-GHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGINET 699

                         90
                 ....*....|.
gi 41281564  406 RTDSAINRINV 416
Cdd:PLN00181 700 PLHSFMGHTNV 710
DivIVA COG3599
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 64-91 1.73e-03

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 38.30  E-value: 1.73e-03
                        10        20
                ....*....|....*....|....*...
gi 41281564  64 QIEREFENLYIENLELRREIDTLNERLA 91
Cdd:COG3599  31 EVAEDYERLIRENKELKEKLEELEEELE 58
WD40 COG2319
WD40 repeat [General function prediction only];
333-493 2.85e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 2.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 333 PTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFqGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAIN 412
Cdd:COG2319   4 ADGAALAAASADLALALLAAALGALLLLLLG-LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281564 413 RINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPrssrQGHRRMVCCSAWSEDHPVcnLFTCGFDRQAIGWNINIPALLQ 492
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTL----TGHTGAVRSVAFSPDGKT--LASGSADGTVRLWDLATGKLLR 156


                .
gi 41281564 493 E 493
Cdd:COG2319 157 T 157
DivIVA pfam05103
DivIVA protein; The Bacillus subtilis divIVA1 mutation causes misplacement of the septum ...
 60-91 7.06e-03

DivIVA protein; The Bacillus subtilis divIVA1 mutation causes misplacement of the septum during cell division, resulting in the formation of small, circular, anucleate mini-cells. Inactivation of divIVA produces a mini-cell phenotype, whereas overproduction of DivIVA results in a filamentation phenotype. These proteins appear to contain coiled-coils.


Pssm-ID: 428304 [Multi-domain]  Cd Length: 131  Bit Score: 36.78  E-value: 7.06e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 41281564    60 ELFGQIEREFENLYIENLELRREIDTLNERLA 91
Cdd:pfam05103  25 EFLDQVAEDYEALIRENAELKEKIEELEEKLA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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