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Conserved domains on  [gi|41017276|sp|O95372|]
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RecName: Full=Acyl-protein thioesterase 2; Short=APT-2; AltName: Full=Lysophospholipase II; Short=LPL-II; Short=LysoPLA II; AltName: Full=Palmitoyl-protein hydrolase

Protein Classification

alpha/beta hydrolase( domain architecture ID 10491393)

alpha/beta hydrolase similar to acyl-protein thioesterase that hydrolyzes fatty acids from S-acylated cysteine residues in proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Abhydrolase_2 pfam02230
Phospholipase/Carboxylesterase; This family consists of both phospholipases and ...
 11-228 3.79e-113

Phospholipase/Carboxylesterase; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.


:

Pssm-ID: 396693 [Multi-domain]  Cd Length: 217  Bit Score: 322.79  E-value: 3.79e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276    11 LTDAATVSGAERETAAVIFLHGLGDTGHSWADALST-IRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDE 89
Cdd:pfam02230   1 NGCAEVVSPRDPAQATVIFLHGLGDSGHGWADAAKTeAPLPNIKFIFPHGPEIPVTLNGGMRMPAWFDLVGLSPNAKEDE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276    90 AGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAIL 169
Cdd:pfam02230  81 AGIKNSAETIEELIDAEQKKGIPSSRIIIGGFSQGAMLALYSALTLPLPLGGIVAFSGFLPLPTKFPSHPNLVTKKTPIF 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 41017276   170 QCHGELDPMVPVRFGALTAEKLRSVVTpaRVQFKTYPGVMHSSCPQEMAAVKEFLEKLL 228
Cdd:pfam02230 161 LIHGEEDPVVPLALGKLAKEYLKTSLN--KVELKIYEGLAHSICGREMQDIKKFLSKHI 217
 
Name Accession Description Interval E-value
Abhydrolase_2 pfam02230
Phospholipase/Carboxylesterase; This family consists of both phospholipases and ...
 11-228 3.79e-113

Phospholipase/Carboxylesterase; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.


Pssm-ID: 396693 [Multi-domain]  Cd Length: 217  Bit Score: 322.79  E-value: 3.79e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276    11 LTDAATVSGAERETAAVIFLHGLGDTGHSWADALST-IRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDE 89
Cdd:pfam02230   1 NGCAEVVSPRDPAQATVIFLHGLGDSGHGWADAAKTeAPLPNIKFIFPHGPEIPVTLNGGMRMPAWFDLVGLSPNAKEDE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276    90 AGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAIL 169
Cdd:pfam02230  81 AGIKNSAETIEELIDAEQKKGIPSSRIIIGGFSQGAMLALYSALTLPLPLGGIVAFSGFLPLPTKFPSHPNLVTKKTPIF 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 41017276   170 QCHGELDPMVPVRFGALTAEKLRSVVTpaRVQFKTYPGVMHSSCPQEMAAVKEFLEKLL 228
Cdd:pfam02230 161 LIHGEEDPVVPLALGKLAKEYLKTSLN--KVELKIYEGLAHSICGREMQDIKKFLSKHI 217
YpfH COG0400
Predicted esterase [General function prediction only];
20-229 9.37e-53

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 168.93  E-value: 9.37e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276  20 AERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVtlnmkMVMPSWFDLMGLSPDapEDEAGIKKAAENI 99
Cdd:COG0400   1 GGPAAPLVVLLHGYGGDEEDLLPLAPELALPGAAVLAPRAPVPEG-----PGGRAWFDLSFLEGR--EDEEGLAAAAEAL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276 100 KALIEHEMKN-GIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLhRAFPQAANGSAKDLAILQCHGELDPM 178
Cdd:COG0400  74 AAFIDELEARyGIDPERIVLAGFSQGAAMALSLALRRPELLAGVVALSGYLPG-EEALPAPEAALAGTPVFLAHGTQDPV 152

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 41017276 179 VPVRFGALTAEKLRSvvTPARVQFKTYPGvMHSSCPQEMAAVKEFLEKLLP 229
Cdd:COG0400 153 IPVERAREAAEALEA--AGADVTYREYPG-GHEISPEELADARAWLAERLA 200
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
 19-146 1.70e-03

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 39.45  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276    19 GAERETAAVIFLHGLGDTGHSWadalstirLPHVKYICPHAPRIPVtlnmkmvmpswfDLMG---------LSPDAPEDE 89
Cdd:PLN02980 1366 GQNAEGSVVLFLHGFLGTGEDW--------IPIMKAISGSARCISI------------DLPGhggskiqnhAKETQTEPT 1425

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 41017276    90 AGIKKAAENIKALIEHemkngIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALS 146
Cdd:PLN02980 1426 LSVELVADLLYKLIEH-----ITPGKVTLVGYSMGARIALYMALRFSDKIEGAVIIS 1477
 
Name Accession Description Interval E-value
Abhydrolase_2 pfam02230
Phospholipase/Carboxylesterase; This family consists of both phospholipases and ...
 11-228 3.79e-113

Phospholipase/Carboxylesterase; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.


Pssm-ID: 396693 [Multi-domain]  Cd Length: 217  Bit Score: 322.79  E-value: 3.79e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276    11 LTDAATVSGAERETAAVIFLHGLGDTGHSWADALST-IRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDE 89
Cdd:pfam02230   1 NGCAEVVSPRDPAQATVIFLHGLGDSGHGWADAAKTeAPLPNIKFIFPHGPEIPVTLNGGMRMPAWFDLVGLSPNAKEDE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276    90 AGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAIL 169
Cdd:pfam02230  81 AGIKNSAETIEELIDAEQKKGIPSSRIIIGGFSQGAMLALYSALTLPLPLGGIVAFSGFLPLPTKFPSHPNLVTKKTPIF 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 41017276   170 QCHGELDPMVPVRFGALTAEKLRSVVTpaRVQFKTYPGVMHSSCPQEMAAVKEFLEKLL 228
Cdd:pfam02230 161 LIHGEEDPVVPLALGKLAKEYLKTSLN--KVELKIYEGLAHSICGREMQDIKKFLSKHI 217
YpfH COG0400
Predicted esterase [General function prediction only];
20-229 9.37e-53

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 168.93  E-value: 9.37e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276  20 AERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVtlnmkMVMPSWFDLMGLSPDapEDEAGIKKAAENI 99
Cdd:COG0400   1 GGPAAPLVVLLHGYGGDEEDLLPLAPELALPGAAVLAPRAPVPEG-----PGGRAWFDLSFLEGR--EDEEGLAAAAEAL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276 100 KALIEHEMKN-GIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLhRAFPQAANGSAKDLAILQCHGELDPM 178
Cdd:COG0400  74 AAFIDELEARyGIDPERIVLAGFSQGAAMALSLALRRPELLAGVVALSGYLPG-EEALPAPEAALAGTPVFLAHGTQDPV 152

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 41017276 179 VPVRFGALTAEKLRSvvTPARVQFKTYPGvMHSSCPQEMAAVKEFLEKLLP 229
Cdd:COG0400 153 IPVERAREAAEALEA--AGADVTYREYPG-GHEISPEELADARAWLAERLA 200
COG4099 COG4099
Predicted peptidase [General function prediction only];
27-212 8.55e-16

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 73.46  E-value: 8.55e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276  27 VIFLHGLGDTGHswaDALSTIRLPHVKYICP-HAPRIPVtlnmkMVmpswfdlmgLSPDAPEDEA-GIKKAAENIKALIE 104
Cdd:COG4099  52 VLFLHGAGERGT---DNEKQLTHGAPKFINPeNQAKFPA-----IV---------LAPQCPEDDYwSDTKALDAVLALLD 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276 105 HEMKN-GIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWlplhrAFPQAANgSAKDLAILQCHGELDPMVPVRF 183
Cdd:COG4099 115 DLIAEyRIDPDRIYLTGLSMGGYGTWDLAARYPDLFAAAVPICGG-----GDPANAA-NLKKVPVWIFHGAKDDVVPVEE 188

                       170       180
                ....*....|....*....|....*....
gi 41017276 184 GALTAEKLRSVvtPARVQFKTYPGVMHSS 212
Cdd:COG4099 189 SRAMVEALKAA--GADVKYTEYPGVGHNS 215
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
20-226 5.51e-13

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 65.79  E-value: 5.51e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276  20 AERETAAVIFLHGLGDTGHSW---ADALstirlphvkyicpHAPRIPVTLnmkmvmpswFDL--MGLSPDAPEDEAGIKK 94
Cdd:COG2267  24 AGSPRGTVVLVHGLGEHSGRYaelAEAL-------------AAAGYAVLA---------FDLrgHGRSDGPRGHVDSFDD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276  95 AAENIKALIEHEMKNgiPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALS---CWLPLH-------RAFPQAANGSAK 164
Cdd:COG2267  82 YVDDLRAALDALRAR--PGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLApayRADPLLgpsarwlRALRLAEALARI 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41017276 165 DLAILQCHGELDPMVPVRFGALTAEKLrsvvtPARVQFKTYPG----VMHSSCPQE-MAAVKEFLEK 226
Cdd:COG2267 160 DVPVLVLHGGADRVVPPEAARRLAARL-----SPDVELVLLPGarheLLNEPAREEvLAAILAWLER 221
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 26-227 2.28e-11

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 61.17  E-value: 2.28e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276  26 AVIFLHGLGDTGHSW---ADALStirlPHVKYICPhapripvtlnmkmvmpswfDL--MGLSpDAPEDEAGIKKAAENIK 100
Cdd:COG0596  25 PVVLLHGLPGSSYEWrplIPALA----AGYRVIAP-------------------DLrgHGRS-DKPAGGYTLDDLADDLA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276 101 ALIEHEmknGIPanRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWL---------------PLHRAFPQAANGSAKD 165
Cdd:COG0596  81 ALLDAL---GLE--RVVLVGHSMGGMVALELAARHPERVAGLVLVDEVLaalaeplrrpglapeALAALLRALARTDLRE 155

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41017276 166 LA------ILQCHGELDPMVPVRFGALTAEKLRsvvtpaRVQFKTYPGV---MHSSCPQEMA-AVKEFLEKL 227
Cdd:COG0596 156 RLaritvpTLVIWGEKDPIVPPALARRLAELLP------NAELVVLPGAghfPPLEQPEAFAaALRDFLARL 221
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
83-228 5.25e-09

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 54.11  E-value: 5.25e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276  83 PDAPED-EAGIKKAAENIKALiehemknGIPANRIVLGGFSQGGALSLYTALTCPHP----LAGIVALSCWLPLhRAFPq 157
Cdd:COG0657  61 PAALEDaYAALRWLRANAAEL-------GIDPDRIAVAGDSAGGHLAAALALRARDRggprPAAQVLIYPVLDL-TASP- 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276 158 aANGSAKDLA-ILQCHGELDPMvpVRFGALTAEKLRSVVTParVQFKTYPGVMHSSC--------PQEMAAVKEFLEKLL 228
Cdd:COG0657 132 -LRADLAGLPpTLIVTGEADPL--VDESEALAAALRAAGVP--VELHVYPGGGHGFGllaglpeaRAALAEIAAFLRRAL 206
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
71-211 1.24e-08

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 53.43  E-value: 1.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276  71 VMPSWFDlmGLSPDAPEDEAG-------IKKAAENIKALIEHEMKN-GIPANRIVLGGFSQGGALSLYTALTCPhPLAGI 142
Cdd:COG0412  60 LAPDLYG--RGGPGDDPDEARalmgaldPELLAADLRAALDWLKAQpEVDAGRVGVVGFCFGGGLALLAAARGP-DLAAA 136

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41017276 143 VALSCWLPLHRAFPQAANGSAKdlaILQCHGELDPMVPVRFGALTAEKLRSvvTPARVQFKTYPGVMHS 211
Cdd:COG0412 137 VSFYGGLPADDLLDLAARIKAP---VLLLYGEKDPLVPPEQVAALEAALAA--AGVDVELHVYPGAGHG 200
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
99-229 1.51e-07

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 50.40  E-value: 1.51e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276  99 IKALIEHemkNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSC------WLPLHRAFPQAANGSAKDLAI---- 168
Cdd:COG1506  81 IDYLAAR---PYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGvsdlrsYYGTTREYTERLMGGPWEDPEayaa 157

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41017276 169 ---------LQC-----HGELDPMVPVRFGALTAEKLRSvvTPARVQFKTYPGVMH----SSCPQEMAAVKEFLEKLLP 229
Cdd:COG1506 158 rsplayadkLKTpllliHGEADDRVPPEQAERLYEALKK--AGKPVELLVYPGEGHgfsgAGAPDYLERILDFLDRHLK 234
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
27-207 7.61e-07

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 48.70  E-value: 7.61e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276  27 VIFLHGLGDTGHSWADALstiRLPHV--KYIcpHAPRIPVTLnmkMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIE 104
Cdd:COG2382 115 LYLLDGGGGDEQDWFDQG---RLPTIldNLI--AAGKIPPMI---VVMPDGGDGGDRGTEGPGNDAFERFLAEELIPFVE 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276 105 HEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALS---CWLPLHRAFPQ-----AANGSAKDLAILQCHGELD 176
Cdd:COG2382 187 KNYRVSADPEHRAIAGLSMGGLAALYAALRHPDLFGYVGSFSgsfWWPPGDADRGGwaellAAGAPKKPLRFYLDVGTED 266

                       170       180       190
                ....*....|....*....|....*....|...
gi 41017276 177 PMVPvrfgalTAEKLRSVVTPA--RVQFKTYPG 207
Cdd:COG2382 267 DLLE------ANRALAAALKAKgyDVEYREFPG 293
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 25-194 1.46e-06

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 47.69  E-value: 1.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276  25 AAVIFLHGLGDTG---------HSWADALSTIrlphVKYicPHAPRipvtlnmKMVMPSWFDLMGLSPDAPEDEAGIkka 95
Cdd:COG3509  54 PLVVALHGCGGSAadfaagtglNALADREGFI----VVY--PEGTG-------RAPGRCWNWFDGRDQRRGRDDVAF--- 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276  96 aenIKALIEHEMKN-GIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCwLPLHRAFPQAANgSAKDLAILQCHGE 174
Cdd:COG3509 118 ---IAALVDDLAARyGIDPKRVYVTGLSAGGAMAYRLACEYPDVFAAVAPVAG-LPYGAASDAACA-PGRPVPVLVIHGT 192

                       170       180
                ....*....|....*....|
gi 41017276 175 LDPMVPVRFGALTAEKLRSV 194
Cdd:COG3509 193 ADPTVPYAGAEETLAQWAAL 212
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 26-146 1.99e-06

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 47.11  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276    26 AVIFLHGLGDTGHSWADALSTIRLPHVKYICphapripvtlnmkmvmpswFDLMGL--SPDAPEDEAGIKKA-AENIKAL 102
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDGFRVIA-------------------LDLRGFgkSSRPKAQDDYRTDDlAEDLEYI 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 41017276   103 IEHemkNGIPanRIVLGGFSQGGALSLYTALTCPHPLAGIVALS 146
Cdd:pfam00561  63 LEA---LGLE--KVNLVGHSMGGLIALAYAAKYPDRVKALVLLG 101
FSH1 pfam03959
Serine hydrolase (FSH1); This is a family of serine hydrolases.
 27-180 4.19e-04

Serine hydrolase (FSH1); This is a family of serine hydrolases.


Pssm-ID: 461110  Cd Length: 208  Bit Score: 39.96  E-value: 4.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276    27 VIFLHGLGDTGHSWADALSTIRlPHVK------------YICPHAPRIPVTLNMKMVMP------SWFdlmgLSPDAPED 88
Cdd:pfam03959   6 VLCLHGFGQSGEIFRAKTGALR-KLLKklgvefvyldapFELAEPADLPGSESEKDEGEddepyrAWF----FGDDDTNE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276    89 EAGIKKAaenIKALIEHEMKNGiPANRIVlgGFSQGGALSLYTA------LTCPHP-LAGIVALSCWLPLHRAFPQAANG 161
Cdd:pfam03959  81 YLGLDES---LDYVRDYIKENG-PFDGIL--GFSQGAALAAILAslleegLPLSHPpLKFAILFSGFRPRPPIYQEYYSE 154

                         170
                  ....*....|....*....
gi 41017276   162 SAKDLAILQCHGELDPMVP 180
Cdd:pfam03959 155 DPIQTPSLHVIGELDTVVP 173
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
26-227 5.71e-04

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 39.92  E-value: 5.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276  26 AVIFLHGLGDTGHS---WADAL-------STIRLP-HvkyicphapripvtlnmkmvmpswfdlmGLSPDAPEdEAGIKK 94
Cdd:COG1647  17 GVLLLHGFTGSPAEmrpLAEALakagytvYAPRLPgH----------------------------GTSPEDLL-KTTWED 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276  95 AAENIKALIEhEMKNGipANRIVLGGFSQGGALSLYTALTCPHpLAGIVALS-------------CWLPLHRAFPQAANG 161
Cdd:COG1647  68 WLEDVEEAYE-ILKAG--YDKVIVIGLSMGGLLALLLAARYPD-VAGLVLLSpalkiddpsapllPLLKYLARSLRGIGS 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276 162 SAKD------------------LAILQC----------------HGELDPMVPVRFGALTAEKLRSvvtpARVQFKTYPG 207
Cdd:COG1647 144 DIEDpevaeyaydrtplralaeLQRLIRevrrdlpkitaptliiQSRKDEVVPPESARYIYERLGS----PDKELVWLED 219

                       250       260
                ....*....|....*....|....*
gi 41017276 208 ---VMHSSCPQE--MAAVKEFLEKL 227
Cdd:COG1647 220 sghVITLDKDREevAEEILDFLERL 244
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
 19-146 1.70e-03

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 39.45  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41017276    19 GAERETAAVIFLHGLGDTGHSWadalstirLPHVKYICPHAPRIPVtlnmkmvmpswfDLMG---------LSPDAPEDE 89
Cdd:PLN02980 1366 GQNAEGSVVLFLHGFLGTGEDW--------IPIMKAISGSARCISI------------DLPGhggskiqnhAKETQTEPT 1425

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 41017276    90 AGIKKAAENIKALIEHemkngIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALS 146
Cdd:PLN02980 1426 LSVELVADLLYKLIEH-----ITPGKVTLVGYSMGARIALYMALRFSDKIEGAVIIS 1477
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 81-134 8.24e-03

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 36.39  E-value: 8.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 41017276    81 LSPDAP-----EDeagIKKAaenIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALT 134
Cdd:pfam20434  57 LSTDAKfpaqiQD---VKAA---IRFLRANAAKYGIDTNKIALMGFSAGGHLALLAGLS 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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