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Conserved domains on  [gi|40806223|ref|NP_060667|]
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zinc finger protein 64 isoform a [Homo sapiens]

Protein Classification

zf-H2C2_2 and zf-H2C2_5 domain-containing protein( domain architecture ID 12143203)

zf-H2C2_2 and zf-H2C2_5 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
161-186 1.06e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.06e-05
                          10        20
                  ....*....|....*....|....*.
gi 40806223   161 DMERHLKIHTGDKPHKCEVCGKCFSR 186
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
190-211 6.90e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.90e-05
                          10        20
                  ....*....|....*....|..
gi 40806223   190 LKTHMRCHTGVKPYKCKTCDYA 211
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
371-395 7.06e-05

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 40.23  E-value: 7.06e-05
                          10        20
                  ....*....|....*....|....*
gi 40806223   371 FKCNYCSFDTKQPSNLSKHMKKFHG 395
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
273-292 1.07e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.07e-04
                          10        20
                  ....*....|....*....|
gi 40806223   273 DLKRHMRVHSGEKPFKCEFC 292
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPEC 20
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
203-226 7.01e-04

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.14  E-value: 7.01e-04
                          10        20
                  ....*....|....*....|....
gi 40806223   203 YKCKTCDYAAADSSSLNKHLRIHS 226
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 227-311 1.79e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806223 227 DERPFKCQI--CPYASRNSSQLTVH-LRSHtgdapfqcwlCSAKFKISSDLKRHMRVHSGEKPFKCEFCNVRCTMKGNLK 303
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                ....*...
gi 40806223 304 SHirIKHS 311
Cdd:COG5189 416 YH--RKHS 421
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
315-337 1.98e-03

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 35.99  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|...
gi 40806223   315 FKCPHCDFLGDSKATLRKHSRVH 337
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
161-186 1.06e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.06e-05
                          10        20
                  ....*....|....*....|....*.
gi 40806223   161 DMERHLKIHTGDKPHKCEVCGKCFSR 186
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
190-211 6.90e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.90e-05
                          10        20
                  ....*....|....*....|..
gi 40806223   190 LKTHMRCHTGVKPYKCKTCDYA 211
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
371-395 7.06e-05

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 40.23  E-value: 7.06e-05
                          10        20
                  ....*....|....*....|....*
gi 40806223   371 FKCNYCSFDTKQPSNLSKHMKKFHG 395
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
273-292 1.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.07e-04
                          10        20
                  ....*....|....*....|
gi 40806223   273 DLKRHMRVHSGEKPFKCEFC 292
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPEC 20
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
203-226 7.01e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.14  E-value: 7.01e-04
                          10        20
                  ....*....|....*....|....
gi 40806223   203 YKCKTCDYAAADSSSLNKHLRIHS 226
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 227-311 1.79e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806223 227 DERPFKCQI--CPYASRNSSQLTVH-LRSHtgdapfqcwlCSAKFKISSDLKRHMRVHSGEKPFKCEFCNVRCTMKGNLK 303
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                ....*...
gi 40806223 304 SHirIKHS 311
Cdd:COG5189 416 YH--RKHS 421
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
315-337 1.98e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 35.99  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|...
gi 40806223   315 FKCPHCDFLGDSKATLRKHSRVH 337
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
151-450 2.09e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 2.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806223 151 CQFKTAYGMKDMERHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHSDERP 230
Cdd:COG5048 175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806223 231 FKCQICPYASRNSSQLTVHLRSHtgdapfqcwLCSAKFKISSdlkrhmrvhsgeKPFKCEFCNVRCTMKGNLKSHIRIKH 310
Cdd:COG5048 255 SSASESPRSSLPTASSQSSSPNE---------SDSSSEKGFS------------LPIKSKQCNISFSRSSPLTRHLRSVN 313

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806223 311 sgnnfkcphcdflgdskatlrkHSRVHQSEHPEKCSECSYSCSSKAALRIHERIHCTDRPFKCNYCSFDTKQPSNL---- 386
Cdd:COG5048 314 ----------------------HSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnep 371

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40806223 387 ---------SKHMKKFHGDMVKTEALERKDTGRQSSRQVAKLDAKKSFHCDICDASFMREDSLRSHKRQHSEY 450
Cdd:COG5048 372 pqslqqykdLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-242 4.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.61e-03
                          10        20
                  ....*....|....*....|....*.
gi 40806223   217 SLNKHLRIHSDERPFKCQICPYASRN 242
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
175-197 5.02e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 5.02e-03
                           10        20
                   ....*....|....*....|...
gi 40806223    175 HKCEVCGKCFSRKDKLKTHMRCH 197
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
161-186 1.06e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.06e-05
                          10        20
                  ....*....|....*....|....*.
gi 40806223   161 DMERHLKIHTGDKPHKCEVCGKCFSR 186
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
190-211 6.90e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.90e-05
                          10        20
                  ....*....|....*....|..
gi 40806223   190 LKTHMRCHTGVKPYKCKTCDYA 211
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
371-395 7.06e-05

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 40.23  E-value: 7.06e-05
                          10        20
                  ....*....|....*....|....*
gi 40806223   371 FKCNYCSFDTKQPSNLSKHMKKFHG 395
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
273-292 1.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.07e-04
                          10        20
                  ....*....|....*....|
gi 40806223   273 DLKRHMRVHSGEKPFKCEFC 292
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPEC 20
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
203-226 7.01e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.14  E-value: 7.01e-04
                          10        20
                  ....*....|....*....|....
gi 40806223   203 YKCKTCDYAAADSSSLNKHLRIHS 226
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 175-195 1.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|.
gi 40806223   175 HKCEVCGKCFSRKDKLKTHMR 195
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLR 21
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 227-311 1.79e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806223 227 DERPFKCQI--CPYASRNSSQLTVH-LRSHtgdapfqcwlCSAKFKISSDLKRHMRVHSGEKPFKCEFCNVRCTMKGNLK 303
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                ....*...
gi 40806223 304 SHirIKHS 311
Cdd:COG5189 416 YH--RKHS 421
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
315-337 1.98e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 35.99  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|...
gi 40806223   315 FKCPHCDFLGDSKATLRKHSRVH 337
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
151-450 2.09e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 2.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806223 151 CQFKTAYGMKDMERHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHSDERP 230
Cdd:COG5048 175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806223 231 FKCQICPYASRNSSQLTVHLRSHtgdapfqcwLCSAKFKISSdlkrhmrvhsgeKPFKCEFCNVRCTMKGNLKSHIRIKH 310
Cdd:COG5048 255 SSASESPRSSLPTASSQSSSPNE---------SDSSSEKGFS------------LPIKSKQCNISFSRSSPLTRHLRSVN 313

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806223 311 sgnnfkcphcdflgdskatlrkHSRVHQSEHPEKCSECSYSCSSKAALRIHERIHCTDRPFKCNYCSFDTKQPSNL---- 386
Cdd:COG5048 314 ----------------------HSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnep 371

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40806223 387 ---------SKHMKKFHGDMVKTEALERKDTGRQSSRQVAKLDAKKSFHCDICDASFMREDSLRSHKRQHSEY 450
Cdd:COG5048 372 pqslqqykdLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-290 2.73e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806223 166 LKIHTG--DKPHKC--EVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNK----HLRIHSDERPFKCQICP 237
Cdd:COG5048 311 SVNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETL 390

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806223 238 YASRNS-----SQLTVHLRSHTGDAP--FQCWLCSAKFKISSDLKRHMRVHSGEKPFKCE 290
Cdd:COG5048 391 SNSCIRnfkrdSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-242 4.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.61e-03
                          10        20
                  ....*....|....*....|....*.
gi 40806223   217 SLNKHLRIHSDERPFKCQICPYASRN 242
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
175-197 5.02e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 5.02e-03
                           10        20
                   ....*....|....*....|...
gi 40806223    175 HKCEVCGKCFSRKDKLKTHMRCH 197
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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