NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|407914803|gb|EKG08869|]
View 

hypothetical protein MPH_14210, partial [Macrophomina phaseolina MS6]

Protein Classification

NAD(P)-dependent oxidoreductase( domain architecture ID 10591880)

NAD(P)-dependent oxidoreductase similar to Bacillus subtilis precorrin-2 dehydrogenase, which catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin, a precursor in both siroheme and adenosylcobalamin biosynthesis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NAD_binding_7 pfam13241
Putative NAD(P)-binding; This domain is found in fungi, plants, archaea and bacteria.
 1-95 3.39e-30

Putative NAD(P)-binding; This domain is found in fungi, plants, archaea and bacteria.


:

Pssm-ID: 433055 [Multi-domain]  Cd Length: 104  Bit Score: 102.94  E-value: 3.39e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407914803    1 VAAGRILHCLNADANVTVVSPAArlnpevaYRVSQGQVTHVDRNFEpADLDGADMVLVAVDDPDASTAIWTLCKQRRIPV 80
Cdd:pfam13241  18 VAARKARKLLEAGAKVTVVSPEI-------TPFLEGLLDLIRREFE-GDLDGADLVIAATDDPELNERIAALARARGILV 89

                          90
                  ....*....|....*
gi 407914803   81 NVADEIPECDFFFGS 95
Cdd:pfam13241  90 NVADDPELCDFYFPA 104
 
Name Accession Description Interval E-value
NAD_binding_7 pfam13241
Putative NAD(P)-binding; This domain is found in fungi, plants, archaea and bacteria.
 1-95 3.39e-30

Putative NAD(P)-binding; This domain is found in fungi, plants, archaea and bacteria.


Pssm-ID: 433055 [Multi-domain]  Cd Length: 104  Bit Score: 102.94  E-value: 3.39e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407914803    1 VAAGRILHCLNADANVTVVSPAArlnpevaYRVSQGQVTHVDRNFEpADLDGADMVLVAVDDPDASTAIWTLCKQRRIPV 80
Cdd:pfam13241  18 VAARKARKLLEAGAKVTVVSPEI-------TPFLEGLLDLIRREFE-GDLDGADLVIAATDDPELNERIAALARARGILV 89

                          90
                  ....*....|....*
gi 407914803   81 NVADEIPECDFFFGS 95
Cdd:pfam13241  90 NVADDPELCDFYFPA 104
CysG2 COG1648
Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme transport and ...
 1-96 1.12e-28

Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme transport and metabolism]; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 441254 [Multi-domain]  Cd Length: 211  Bit Score: 102.15  E-value: 1.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407914803   1 VAAGRILHCLNADANVTVVSPAarLNPEVAYRVSQGQVTHVDRNFEPADLDGADMVLVAVDDPDASTAIWTLCKQRRIPV 80
Cdd:COG1648   23 VAARKARLLLKAGARVTVVAPE--FSPELAALAEEGRIELIKRAFEPEDLDGAFLVIAATDDEEVNARVAAAARARGILV 100

                         90
                 ....*....|....*.
gi 407914803  81 NVADEIPECDFFFGSV 96
Cdd:COG1648  101 NVVDDPELCDFIVPAI 116
cysG_Nterm TIGR01470
siroheme synthase, N-terminal domain; This model represents a subfamily of CysG N-terminal ...
 1-96 7.86e-15

siroheme synthase, N-terminal domain; This model represents a subfamily of CysG N-terminal region-related sequences. All sequences in the seed alignment for this model are N-terminal regions of known or predicted siroheme synthases. The C-terminal region of each is uroporphyrin-III C-methyltransferase (EC 2.1.1.107), which catalyzes the first step committed to the biosynthesis of either siroheme or cobalamin (vitamin B12) rather than protoheme (heme). The region represented by this model completes the process of oxidation and iron insertion to yield siroheme. Siroheme is a cofactor for nitrite and sulfite reductases, so siroheme synthase is CysG of cysteine biosynthesis in some organisms. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 130536 [Multi-domain]  Cd Length: 205  Bit Score: 66.27  E-value: 7.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407914803    1 VAAGRILHCLNADANVTVVSPaaRLNPEVAYRVSQGQVTHVDRNFEPADLDGADMVLVAVDDPDASTAIWTLCKQRRIPV 80
Cdd:TIGR01470  20 VALRKARLLLKAGAQLRVIAE--ELESELTLLAEQGGITWLARCFDADILEGAFLVIAATDDEELNRRVAHAARARGVPV 97

                          90
                  ....*....|....*.
gi 407914803   81 NVADEIPECDFFFGSV 96
Cdd:TIGR01470  98 NVVDDPELCSFIFPSI 113
PRK06718 PRK06718
NAD(P)-binding protein;
1-69 3.67e-09

NAD(P)-binding protein;


Pssm-ID: 180667 [Multi-domain]  Cd Length: 202  Bit Score: 51.18  E-value: 3.67e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 407914803   1 VAAGRILHCLNADANVTVVSPaaRLNPEVAYRVSQGQVTHVDRNFEPADLDGADMVLVAVDDPDASTAI 69
Cdd:PRK06718  21 VAGRRAITLLKYGAHIVVISP--ELTENLVKLVEEGKIRWKQKEFEPSDIVDAFLVIAATNDPRVNEQV 87
 
Name Accession Description Interval E-value
NAD_binding_7 pfam13241
Putative NAD(P)-binding; This domain is found in fungi, plants, archaea and bacteria.
 1-95 3.39e-30

Putative NAD(P)-binding; This domain is found in fungi, plants, archaea and bacteria.


Pssm-ID: 433055 [Multi-domain]  Cd Length: 104  Bit Score: 102.94  E-value: 3.39e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407914803    1 VAAGRILHCLNADANVTVVSPAArlnpevaYRVSQGQVTHVDRNFEpADLDGADMVLVAVDDPDASTAIWTLCKQRRIPV 80
Cdd:pfam13241  18 VAARKARKLLEAGAKVTVVSPEI-------TPFLEGLLDLIRREFE-GDLDGADLVIAATDDPELNERIAALARARGILV 89

                          90
                  ....*....|....*
gi 407914803   81 NVADEIPECDFFFGS 95
Cdd:pfam13241  90 NVADDPELCDFYFPA 104
CysG2 COG1648
Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme transport and ...
 1-96 1.12e-28

Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme transport and metabolism]; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 441254 [Multi-domain]  Cd Length: 211  Bit Score: 102.15  E-value: 1.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407914803   1 VAAGRILHCLNADANVTVVSPAarLNPEVAYRVSQGQVTHVDRNFEPADLDGADMVLVAVDDPDASTAIWTLCKQRRIPV 80
Cdd:COG1648   23 VAARKARLLLKAGARVTVVAPE--FSPELAALAEEGRIELIKRAFEPEDLDGAFLVIAATDDEEVNARVAAAARARGILV 100

                         90
                 ....*....|....*.
gi 407914803  81 NVADEIPECDFFFGSV 96
Cdd:COG1648  101 NVVDDPELCDFIVPAI 116
cysG_Nterm TIGR01470
siroheme synthase, N-terminal domain; This model represents a subfamily of CysG N-terminal ...
 1-96 7.86e-15

siroheme synthase, N-terminal domain; This model represents a subfamily of CysG N-terminal region-related sequences. All sequences in the seed alignment for this model are N-terminal regions of known or predicted siroheme synthases. The C-terminal region of each is uroporphyrin-III C-methyltransferase (EC 2.1.1.107), which catalyzes the first step committed to the biosynthesis of either siroheme or cobalamin (vitamin B12) rather than protoheme (heme). The region represented by this model completes the process of oxidation and iron insertion to yield siroheme. Siroheme is a cofactor for nitrite and sulfite reductases, so siroheme synthase is CysG of cysteine biosynthesis in some organisms. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 130536 [Multi-domain]  Cd Length: 205  Bit Score: 66.27  E-value: 7.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407914803    1 VAAGRILHCLNADANVTVVSPaaRLNPEVAYRVSQGQVTHVDRNFEPADLDGADMVLVAVDDPDASTAIWTLCKQRRIPV 80
Cdd:TIGR01470  20 VALRKARLLLKAGAQLRVIAE--ELESELTLLAEQGGITWLARCFDADILEGAFLVIAATDDEELNRRVAHAARARGVPV 97

                          90
                  ....*....|....*.
gi 407914803   81 NVADEIPECDFFFGSV 96
Cdd:TIGR01470  98 NVVDDPELCSFIFPSI 113
PRK06718 PRK06718
NAD(P)-binding protein;
1-69 3.67e-09

NAD(P)-binding protein;


Pssm-ID: 180667 [Multi-domain]  Cd Length: 202  Bit Score: 51.18  E-value: 3.67e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 407914803   1 VAAGRILHCLNADANVTVVSPaaRLNPEVAYRVSQGQVTHVDRNFEPADLDGADMVLVAVDDPDASTAI 69
Cdd:PRK06718  21 VAGRRAITLLKYGAHIVVISP--ELTENLVKLVEEGKIRWKQKEFEPSDIVDAFLVIAATNDPRVNEQV 87
cysG PRK10637
siroheme synthase CysG;
10-96 3.43e-07

siroheme synthase CysG;


Pssm-ID: 182606 [Multi-domain]  Cd Length: 457  Bit Score: 46.29  E-value: 3.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407914803  10 LNADANVTVvsPAARLNPEVAYRVSQGQVTHVDRNFEPADLDGADMVLVAVDDPDASTAIWTLCKQRRIPVNVADEIPEC 89
Cdd:PRK10637  32 LDAGARLTV--NALAFIPQFTAWADAGMLTLVEGPFDESLLDTCWLAIAATDDDAVNQRVSEAAEARRIFCNVVDAPKAA 109


                 ....*..
gi 407914803  90 DFFFGSV 96
Cdd:PRK10637 110 SFIMPSI 116
IspG COG0821
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism] ...
 52-84 4.13e-03

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism]; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440583 [Multi-domain]  Cd Length: 363  Bit Score: 34.63  E-value: 4.13e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 407914803  52 GADMVLVAVDDPDASTAIWTLCKQRRIPVnVAD 84
Cdd:COG0821   54 GCEIVRVAVPDEEAAAALPEIKKQLPVPL-VAD 85
ispG PRK00366
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;
52-84 5.35e-03

flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;


Pssm-ID: 234737 [Multi-domain]  Cd Length: 360  Bit Score: 34.28  E-value: 5.35e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 407914803  52 GADMVLVAVDDPDASTAIWTLCKQRRIPVnVAD 84
Cdd:PRK00366  55 GCEIVRVAVPDMEAAAALPEIKKQLPVPL-VAD 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH