NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|40788332|dbj|BAA31677|]
View 

KIAA0702 protein, partial [Homo sapiens]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
4-949 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 1333.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332      4 MGKLIRMGPQERWLLRTKRLHWSRLLFLLGMLIIGSTYQHLRRPRGLSSLWAAVSSHQPIKLASRDLSSEEMMMMSSSPS 83
Cdd:TIGR00927    1 MGKLIRMGTQERRLLRPKRLHWSRLLFLLGMLIIGSTYQHLRRPQGLPSLWAAVSSQQPIKLASRDLSNDEMMMVSSDPP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332     84 KPSSEMGGKMLVPQASVGSDEATLSMTVENIPSMPKRTAKMIPTTTKNNYSPTAAGTERRKEDTPTS-SRTLTYYTSTSS 162
Cdd:TIGR00927   81 KSSSEMEGEMLAPQATVGRDEATPSIAMENTPSPPRRTAKITPTTPKNNYSPTAAGTERVKEDTPATpSRALNHYISTSG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    163 RQIVKKYTPTPRGEMKSYSPTQVREKV-KYTPSPRGRRVGTYVPSTFMTMETSHAITPRTTVKDSDITATYKILETNSLK 241
Cdd:TIGR00927  161 RQRVKSYTPKPRGEVKSSSPTQTREKVrKYTPSPLGRMVNSYAPSTFMTMPRSHGITPRTTVKDSEITATYKMLETNPSK 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    242 RIMEETTPTTLKGMFDSTPTFLTHEVEANVLTSPRSVMEKNNLFPPRRVESNSSAHPWGLVGKSNPKTPQGTVLLHTPAT 321
Cdd:TIGR00927  241 RTAGKTTPTPLKGMTDNTPTFLTREVETDLLTSPRSVVEKNTLTTPRRVESNSSTNHWGLVGKNNLTTPQGTVLEHTPAT 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    322 SEGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTAPAIVWRLAKKPSTAPSTSTTPTVRAKLTMQVHHCVVVK 401
Cdd:TIGR00927  321 SEGQVTISIMTGSSPAETKASTAAWKIRNPLSRTSAPAVRIASATFRGLEKNPSTAPSTPATPRVRAVLTTQVHHCVVVK 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    402 PTPAMLTTPSPSLTTALLPEELSPSPSVLPPSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFV 481
Cdd:TIGR00927  401 PAPAVPTTPSPSLTTALFPEAPSPSPSALPPGQPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFV 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    482 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPL 561
Cdd:TIGR00927  481 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPL 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    562 FRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKlpslltrg 641
Cdd:TIGR00927  561 FRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVMALGDLSK-------- 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    642 ssstslhnstirstiyqlmlhsldplrevrlakekeeeslnqGARAQPQAKAESKPEEEEPAklpavTVTPAPVPDIKGD 721
Cdd:TIGR00927  633 ------------------------------------------GDVAEAEHTGERTGEEGERP-----TEAEGENGEESGG 665
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    722 QKENPGGQEDVAEAESTGEMPGEEG-ETAGEGETEEKSG--------------GETQPEG---EGETETQGKGEE----- 778
Cdd:TIGR00927  666 EAEQEGETETKGENESEGEIPAERKgEQEGEGEIEAKEAdhkgeteaeeveheGETEAEGtedEGEIETGEEGEEvedeg 745
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    779 ---CEDENEAEGKGDN--------------EGEDEGEIHA-EDGEMKGNEG----------------------------- 811
Cdd:TIGR00927  746 egeAEGKHEVETEGDRketehegeteaegkEDEDEGEIQAgEDGEMKGDEGaegkvehegeteagekdehegqsetqadd 825
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    812 -----ETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEeeeeekgNEEPLSLDW 886
Cdd:TIGR00927  826 tevkdETGEQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEEE-------NEEPLSLEW 898
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40788332    887 PETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVSE 949
Cdd:TIGR00927  899 PETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGE 961
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
4-949 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 1333.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332      4 MGKLIRMGPQERWLLRTKRLHWSRLLFLLGMLIIGSTYQHLRRPRGLSSLWAAVSSHQPIKLASRDLSSEEMMMMSSSPS 83
Cdd:TIGR00927    1 MGKLIRMGTQERRLLRPKRLHWSRLLFLLGMLIIGSTYQHLRRPQGLPSLWAAVSSQQPIKLASRDLSNDEMMMVSSDPP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332     84 KPSSEMGGKMLVPQASVGSDEATLSMTVENIPSMPKRTAKMIPTTTKNNYSPTAAGTERRKEDTPTS-SRTLTYYTSTSS 162
Cdd:TIGR00927   81 KSSSEMEGEMLAPQATVGRDEATPSIAMENTPSPPRRTAKITPTTPKNNYSPTAAGTERVKEDTPATpSRALNHYISTSG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    163 RQIVKKYTPTPRGEMKSYSPTQVREKV-KYTPSPRGRRVGTYVPSTFMTMETSHAITPRTTVKDSDITATYKILETNSLK 241
Cdd:TIGR00927  161 RQRVKSYTPKPRGEVKSSSPTQTREKVrKYTPSPLGRMVNSYAPSTFMTMPRSHGITPRTTVKDSEITATYKMLETNPSK 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    242 RIMEETTPTTLKGMFDSTPTFLTHEVEANVLTSPRSVMEKNNLFPPRRVESNSSAHPWGLVGKSNPKTPQGTVLLHTPAT 321
Cdd:TIGR00927  241 RTAGKTTPTPLKGMTDNTPTFLTREVETDLLTSPRSVVEKNTLTTPRRVESNSSTNHWGLVGKNNLTTPQGTVLEHTPAT 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    322 SEGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTAPAIVWRLAKKPSTAPSTSTTPTVRAKLTMQVHHCVVVK 401
Cdd:TIGR00927  321 SEGQVTISIMTGSSPAETKASTAAWKIRNPLSRTSAPAVRIASATFRGLEKNPSTAPSTPATPRVRAVLTTQVHHCVVVK 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    402 PTPAMLTTPSPSLTTALLPEELSPSPSVLPPSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFV 481
Cdd:TIGR00927  401 PAPAVPTTPSPSLTTALFPEAPSPSPSALPPGQPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFV 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    482 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPL 561
Cdd:TIGR00927  481 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPL 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    562 FRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKlpslltrg 641
Cdd:TIGR00927  561 FRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVMALGDLSK-------- 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    642 ssstslhnstirstiyqlmlhsldplrevrlakekeeeslnqGARAQPQAKAESKPEEEEPAklpavTVTPAPVPDIKGD 721
Cdd:TIGR00927  633 ------------------------------------------GDVAEAEHTGERTGEEGERP-----TEAEGENGEESGG 665
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    722 QKENPGGQEDVAEAESTGEMPGEEG-ETAGEGETEEKSG--------------GETQPEG---EGETETQGKGEE----- 778
Cdd:TIGR00927  666 EAEQEGETETKGENESEGEIPAERKgEQEGEGEIEAKEAdhkgeteaeeveheGETEAEGtedEGEIETGEEGEEvedeg 745
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    779 ---CEDENEAEGKGDN--------------EGEDEGEIHA-EDGEMKGNEG----------------------------- 811
Cdd:TIGR00927  746 egeAEGKHEVETEGDRketehegeteaegkEDEDEGEIQAgEDGEMKGDEGaegkvehegeteagekdehegqsetqadd 825
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    812 -----ETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEeeeeekgNEEPLSLDW 886
Cdd:TIGR00927  826 tevkdETGEQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEEE-------NEEPLSLEW 898
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40788332    887 PETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVSE 949
Cdd:TIGR00927  899 PETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGE 961
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
461-605 3.68e-33

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 125.02  E-value: 3.68e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332   461 HVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNIL 540
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332   541 FVIGTCSLFS-----REILNLTwWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKW 605
Cdd:pfam01699  81 LVLGLSALIGpvkvdSLLLKLD-LGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
478-603 2.67e-25

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 107.14  E-value: 2.67e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332 478 EYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSReiLNLT 557
Cdd:COG0530   2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 40788332 558 WWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTM 603
Cdd:COG0530  80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL 125
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
486-550 7.60e-08

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 55.42  E-value: 7.60e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40788332  486 VITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFS 550
Cdd:PRK10734 199 VLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALIS 263
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
4-949 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 1333.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332      4 MGKLIRMGPQERWLLRTKRLHWSRLLFLLGMLIIGSTYQHLRRPRGLSSLWAAVSSHQPIKLASRDLSSEEMMMMSSSPS 83
Cdd:TIGR00927    1 MGKLIRMGTQERRLLRPKRLHWSRLLFLLGMLIIGSTYQHLRRPQGLPSLWAAVSSQQPIKLASRDLSNDEMMMVSSDPP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332     84 KPSSEMGGKMLVPQASVGSDEATLSMTVENIPSMPKRTAKMIPTTTKNNYSPTAAGTERRKEDTPTS-SRTLTYYTSTSS 162
Cdd:TIGR00927   81 KSSSEMEGEMLAPQATVGRDEATPSIAMENTPSPPRRTAKITPTTPKNNYSPTAAGTERVKEDTPATpSRALNHYISTSG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    163 RQIVKKYTPTPRGEMKSYSPTQVREKV-KYTPSPRGRRVGTYVPSTFMTMETSHAITPRTTVKDSDITATYKILETNSLK 241
Cdd:TIGR00927  161 RQRVKSYTPKPRGEVKSSSPTQTREKVrKYTPSPLGRMVNSYAPSTFMTMPRSHGITPRTTVKDSEITATYKMLETNPSK 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    242 RIMEETTPTTLKGMFDSTPTFLTHEVEANVLTSPRSVMEKNNLFPPRRVESNSSAHPWGLVGKSNPKTPQGTVLLHTPAT 321
Cdd:TIGR00927  241 RTAGKTTPTPLKGMTDNTPTFLTREVETDLLTSPRSVVEKNTLTTPRRVESNSSTNHWGLVGKNNLTTPQGTVLEHTPAT 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    322 SEGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTAPAIVWRLAKKPSTAPSTSTTPTVRAKLTMQVHHCVVVK 401
Cdd:TIGR00927  321 SEGQVTISIMTGSSPAETKASTAAWKIRNPLSRTSAPAVRIASATFRGLEKNPSTAPSTPATPRVRAVLTTQVHHCVVVK 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    402 PTPAMLTTPSPSLTTALLPEELSPSPSVLPPSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFV 481
Cdd:TIGR00927  401 PAPAVPTTPSPSLTTALFPEAPSPSPSALPPGQPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFV 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    482 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPL 561
Cdd:TIGR00927  481 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPL 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    562 FRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKlpslltrg 641
Cdd:TIGR00927  561 FRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVMALGDLSK-------- 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    642 ssstslhnstirstiyqlmlhsldplrevrlakekeeeslnqGARAQPQAKAESKPEEEEPAklpavTVTPAPVPDIKGD 721
Cdd:TIGR00927  633 ------------------------------------------GDVAEAEHTGERTGEEGERP-----TEAEGENGEESGG 665
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    722 QKENPGGQEDVAEAESTGEMPGEEG-ETAGEGETEEKSG--------------GETQPEG---EGETETQGKGEE----- 778
Cdd:TIGR00927  666 EAEQEGETETKGENESEGEIPAERKgEQEGEGEIEAKEAdhkgeteaeeveheGETEAEGtedEGEIETGEEGEEvedeg 745
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    779 ---CEDENEAEGKGDN--------------EGEDEGEIHA-EDGEMKGNEG----------------------------- 811
Cdd:TIGR00927  746 egeAEGKHEVETEGDRketehegeteaegkEDEDEGEIQAgEDGEMKGDEGaegkvehegeteagekdehegqsetqadd 825
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    812 -----ETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEeeeeekgNEEPLSLDW 886
Cdd:TIGR00927  826 tevkdETGEQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEEE-------NEEPLSLEW 898
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40788332    887 PETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVSE 949
Cdd:TIGR00927  899 PETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGE 961
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
460-614 1.02e-45

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 166.73  E-value: 1.02e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332   460 LHVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNI 539
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40788332   540 LFVIGTCSLFSrEILNLTWWpLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYvftMKWNKHIEVWVK 614
Cdd:TIGR00367  81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVY---LLFLVKNERWVK 150
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
461-605 3.68e-33

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 125.02  E-value: 3.68e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332   461 HVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNIL 540
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332   541 FVIGTCSLFS-----REILNLTwWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKW 605
Cdd:pfam01699  81 LVLGLSALIGpvkvdSLLLKLD-LGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
478-603 2.67e-25

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 107.14  E-value: 2.67e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332 478 EYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSReiLNLT 557
Cdd:COG0530   2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 40788332 558 WWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTM 603
Cdd:COG0530  80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL 125
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
465-603 1.76e-18

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 87.11  E-value: 1.76e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332 465 MMYVFVALA--IVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFV 542
Cdd:COG0530 154 LLLLVLGLAllVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLV 233
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 40788332 543 IGTCSLFSReiLNLTWWPLFRDVSFYILDLIMLILFFL-DSLIAWWESLLLLLAYAFYVFTM 603
Cdd:COG0530 234 LGIGALITP--IPVDPAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLALYLAYLALL 293
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
468-589 4.33e-13

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 71.20  E-value: 4.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332   468 VFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCS 547
Cdd:TIGR00367 177 IGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPS 256
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 40788332   548 LFSR-EILNLTwwpLFRDVSFYILDLIMLILFF-LDSLIAWWES 589
Cdd:TIGR00367 257 LFMPiPVEPLA---YNLDAPVMVIVTLLLMLFFkTSMKLGRWEG 297
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
465-546 1.02e-09

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 62.50  E-value: 1.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332   465 MMYVFVALAIVCDEyFVPALGVITDK-----------------LQI-SEDVAGATFMAAGGSAPELFTSLIGV----FIS 522
Cdd:TIGR00845  82 MVYMFLGVSIIADR-FMASIEVITSQekeitikkpngettvttVRIwNETVSNLTLMALGSSAPEILLSVIEVcghnFEA 160
                          90       100
                  ....*....|....*....|....
gi 40788332   523 hSNVGIGTIVGSAVFNILFVIGTC 546
Cdd:TIGR00845 161 -GDLGPSTIVGSAAFNMFIIIAIC 183
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
486-550 7.60e-08

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 55.42  E-value: 7.60e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40788332  486 VITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFS 550
Cdd:PRK10734 199 VLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALIS 263
PLN03151 PLN03151
cation/calcium exchanger; Provisional
456-608 1.05e-06

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 52.84  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332  456 GWVVLHVFgMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSlIGVFISHS--NVGIGTIVG 533
Cdd:PLN03151 139 GYAVLGVW-LVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKDagEVGLNSVLG 216
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332  534 SAVFNILFVIGTCSL-FSREILNLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWN----KH 608
Cdd:PLN03151 217 GAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANeilrKH 296
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
106-363 3.46e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.44  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332   106 TLSMTVENIPSMPK-----RTAKMIPTTT----------KNNYSPTAAGTERRKEDT----PTSSRTLTYYTSTSSR--- 163
Cdd:pfam05109 388 TFDITVSGLGTAPKtliitRTATNATTTThkvifskapeSTTTSPTLNTTGFAAPNTttglPSSTHVPTNLTAPASTgpt 467
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332   164 -QIVKKYTPTPRGEMKSYSPTqvrekvkyTPSPRGRRVGTYVPSTFMTMETSHAITPrtTVKDSDITATYKILETNSLKR 242
Cdd:pfam05109 468 vSTADVTSPTPAGTTSGASPV--------TPSPSPRDNGTESKAPDMTSPTSAVTTP--TPNATSPTPAVTTPTPNATSP 537
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332   243 IMEETTPTTLKgmfdSTPTfltheveanvltsprsvmeKNNLFPPRRVESNSSAHPWGLVGKSNPKTpqgTVLLHTPATS 322
Cdd:pfam05109 538 TLGKTSPTSAV----TTPT-------------------PNATSPTPAVTTPTPNATIPTLGKTSPTS---AVTTPTPNAT 591
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 40788332   323 EGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTA 363
Cdd:pfam05109 592 SPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTG 632
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
493-585 6.79e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 40.36  E-value: 6.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332    493 ISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPLFRDVSFYILDL 572
Cdd:TIGR00927  965 ISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVL 1044
                           90
                   ....*....|...
gi 40788332    573 IMLILFFLDSLIA 585
Cdd:TIGR00927 1045 LFLMLLFVISSIA 1057
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
459-549 8.78e-03

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 39.63  E-value: 8.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40788332  459 VLHVFGMMYVFVALAIVCDEYFVPALgvitdklqisedVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFN 538
Cdd:PRK10734  13 LLLVYGADRLVFAASILCRTFGIPPL------------IIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITN 80
                         90
                 ....*....|.
gi 40788332  539 ILFVIGTCSLF 549
Cdd:PRK10734  81 ILLILGLAALI 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH