NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|40385867|ref|NP_954697|]
View 

methionine aminopeptidase 1D, mitochondrial isoform 1 precursor [Homo sapiens]

Protein Classification

methionyl aminopeptidase( domain architecture ID 10099531)

methionyl aminopeptidase catalyzes the hydrolytic removal of N-terminal methionine residues

CATH:  3.90.230.10
EC:  3.4.11.18
Gene Ontology:  GO:0070006|GO:0046872|GO:0006508
PubMed:  7674922

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 94-330 7.36e-131

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


:

Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 372.60  E-value: 7.36e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  94 IQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGD 173
Cdd:cd01086   1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 174 IINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQVCPHFVGHG 253
Cdd:cd01086  81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 40385867 254 IGSYFHGHPEIWHHA-NDSDLPMEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSRGAQILTK 330
Cdd:cd01086 161 IGRKFHEEPQIPNYGrPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILTL 238
 
Name Accession Description Interval E-value
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 94-330 7.36e-131

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 372.60  E-value: 7.36e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  94 IQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGD 173
Cdd:cd01086   1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 174 IINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQVCPHFVGHG 253
Cdd:cd01086  81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 40385867 254 IGSYFHGHPEIWHHA-NDSDLPMEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSRGAQILTK 330
Cdd:cd01086 161 IGRKFHEEPQIPNYGrPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILTL 238
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
86-334 5.80e-117

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 337.75  E-value: 5.80e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  86 IEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPD 165
Cdd:COG0024   1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 166 SRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQV 245
Cdd:COG0024  81 DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 246 CPHFVGHGIGSYFHGHPEIWHH-ANDSDLPMEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSRG 324
Cdd:COG0024 161 VREFVGHGIGREMHEEPQVPNYgRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDG 240

                       250
                ....*....|
gi 40385867 325 AQILTKLPHE 334
Cdd:COG0024 241 PEILTLPDGG 250
PRK05716 PRK05716
methionine aminopeptidase; Validated
 85-334 5.44e-111

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 322.85  E-value: 5.44e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   85 SIEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIP 164
Cdd:PRK05716   2 AITIKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIPAPLGYHGFPKSICTSVNEVVCHGIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  165 DSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQ 244
Cdd:PRK05716  82 SDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  245 VCPHFVGHGIGSYFHGHPEIWHHANDSDLP-MEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSR 323
Cdd:PRK05716 162 VVREYCGHGIGRKFHEEPQIPHYGAPGDGPvLKEGMVFTIEPMINAGKREVKTLKDGWTVVTKDGSLSAQYEHTVAVTED 241

                        250
                 ....*....|.
gi 40385867  324 GAQILTKLPHE 334
Cdd:PRK05716 242 GPEILTLRPEE 252
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 86-331 6.28e-92

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 274.23  E-value: 6.28e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867    86 IEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPD 165
Cdd:TIGR00500   1 ISLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   166 SRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQV 245
Cdd:TIGR00500  81 KKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   246 CPHFVGHGIGSYFHGHPEIWHHANDSDLP-MEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSRG 324
Cdd:TIGR00500 161 VREYCGHGIGRKFHEEPQIPNYGKKFTNVrLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITDNG 240


                  ....*..
gi 40385867   325 AQILTKL 331
Cdd:TIGR00500 241 PEILTER 247
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 95-321 7.95e-55

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 178.20  E-value: 7.95e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867    95 QGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYpsplGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGDI 174
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA----RGPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   175 INIDVTVYYN-GYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGF-QVCPHFVGH 252
Cdd:pfam00557  77 VLIDVGAEYDgGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLgEYFPHGLGH 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 40385867   253 GIGSYFHGHPEIWHhaNDSDLPMEEGMAFTIEPIITEgspefkvledawtvvsLDNQRSAQFEHTVLIT 321
Cdd:pfam00557 157 GIGLEVHEGPYISR--GGDDRVLEPGMVFTIEPGIYF----------------IPGWGGVRIEDTVLVT 207
 
Name Accession Description Interval E-value
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 94-330 7.36e-131

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 372.60  E-value: 7.36e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  94 IQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGD 173
Cdd:cd01086   1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 174 IINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQVCPHFVGHG 253
Cdd:cd01086  81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 40385867 254 IGSYFHGHPEIWHHA-NDSDLPMEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSRGAQILTK 330
Cdd:cd01086 161 IGRKFHEEPQIPNYGrPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILTL 238
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
86-334 5.80e-117

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 337.75  E-value: 5.80e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  86 IEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPD 165
Cdd:COG0024   1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 166 SRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQV 245
Cdd:COG0024  81 DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 246 CPHFVGHGIGSYFHGHPEIWHH-ANDSDLPMEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSRG 324
Cdd:COG0024 161 VREFVGHGIGREMHEEPQVPNYgRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDG 240

                       250
                ....*....|
gi 40385867 325 AQILTKLPHE 334
Cdd:COG0024 241 PEILTLPDGG 250
PRK05716 PRK05716
methionine aminopeptidase; Validated
 85-334 5.44e-111

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 322.85  E-value: 5.44e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   85 SIEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIP 164
Cdd:PRK05716   2 AITIKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIPAPLGYHGFPKSICTSVNEVVCHGIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  165 DSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQ 244
Cdd:PRK05716  82 SDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  245 VCPHFVGHGIGSYFHGHPEIWHHANDSDLP-MEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSR 323
Cdd:PRK05716 162 VVREYCGHGIGRKFHEEPQIPHYGAPGDGPvLKEGMVFTIEPMINAGKREVKTLKDGWTVVTKDGSLSAQYEHTVAVTED 241

                        250
                 ....*....|.
gi 40385867  324 GAQILTKLPHE 334
Cdd:PRK05716 242 GPEILTLRPEE 252
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 55-332 1.90e-106

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 316.78  E-value: 1.90e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   55 PAAVSSAHPVPKHIKKPDYVTTGI-----VPDWGDSIEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVH 129
Cdd:PLN03158  99 PYPISPRRVVPDHIPKPDWALDGTpkiepNSDLQHSVEIKTPEQIQRMRETCRIAREVLDAAARAIKPGVTTDEIDRVVH 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  130 REIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEV 209
Cdd:PLN03158 179 EATIAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPDARKLEDGDIVNVDVTVYYKGCHGDLNETFFVGNVDEASRQLVKC 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  210 ARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQVCPHFVGHGIGSYFHGHPEIWHHA-NDSDLPMEEGMAFTIEPIIT 288
Cdd:PLN03158 259 TYECLEKAIAIVKPGVRYREVGEVINRHATMSGLSVVKSYCGHGIGELFHCAPNIPHYArNKAVGVMKAGQVFTIEPMIN 338

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 40385867  289 EGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSRGAQILT-KLP 332
Cdd:PLN03158 339 AGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETGVEVLTaRLP 383
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 83-329 3.84e-99

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 292.90  E-value: 3.84e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   83 GDSIEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHG 162
Cdd:PRK12896   5 GRGMEIKSPRELEKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEKRLEEHGAIPSPEGYYGFPGSTCISVNEEVAHG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  163 IPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNG 242
Cdd:PRK12896  85 IPGPRVIKDGDLVNIDVSAYLDGYHGDTGITFAVGPVSEEAEKLCRVAEEALWAGIKQVKAGRPLNDIGRAIEDFAKKNG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  243 FQVCPHFVGHGIGSYFHGHP-EIWHHANDSD-LPMEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLI 320
Cdd:PRK12896 165 YSVVRDLTGHGVGRSLHEEPsVILTYTDPLPnRLLRPGMTLAVEPFLNLGAKDAETLDDGWTVVTPDKSLSAQFEHTVVV 244


                 ....*....
gi 40385867  321 TSRGAQILT 329
Cdd:PRK12896 245 TRDGPEILT 253
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 86-331 6.28e-92

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 274.23  E-value: 6.28e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867    86 IEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPD 165
Cdd:TIGR00500   1 ISLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   166 SRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQV 245
Cdd:TIGR00500  81 KKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   246 CPHFVGHGIGSYFHGHPEIWHHANDSDLP-MEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSRG 324
Cdd:TIGR00500 161 VREYCGHGIGRKFHEEPQIPNYGKKFTNVrLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITDNG 240


                  ....*..
gi 40385867   325 AQILTKL 331
Cdd:TIGR00500 241 PEILTER 247
PRK12318 PRK12318
methionyl aminopeptidase;
86-331 4.96e-80

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 245.50  E-value: 4.96e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   86 IEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGG--FPKSVCTSVNNVLCHGI 163
Cdd:PRK12318  41 IIIKTPEQIEKIRKACQVTARILDALCEAAKEGVTTNELDELSRELHKEYNAIPAPLNYGSppFPKTICTSLNEVICHGI 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  164 PDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGF 243
Cdd:PRK12318 121 PNDIPLKNGDIMNIDVSCIVDGYYGDCSRMVMIGEVSEIKKKVCQASLECLNAAIAILKPGIPLYEIGEVIENCADKYGF 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  244 QVCPHFVGHGIGSYFHGHPEIWHHANDSDLPMEEGMAFTIEPIITEGSPE-FKVLEDAWTVVSLDNQRSAQFEHTVLITS 322
Cdd:PRK12318 201 SVVDQFVGHGVGIKFHENPYVPHHRNSSKIPLAPGMIFTIEPMINVGKKEgVIDPINHWEARTCDNQPSAQWEHTILITE 280


                 ....*....
gi 40385867  323 RGAQILTKL 331
Cdd:PRK12318 281 TGYEILTLL 289
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 95-321 7.95e-55

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 178.20  E-value: 7.95e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867    95 QGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYpsplGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGDI 174
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA----RGPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   175 INIDVTVYYN-GYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGF-QVCPHFVGH 252
Cdd:pfam00557  77 VLIDVGAEYDgGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLgEYFPHGLGH 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 40385867   253 GIGSYFHGHPEIWHhaNDSDLPMEEGMAFTIEPIITEgspefkvledawtvvsLDNQRSAQFEHTVLIT 321
Cdd:pfam00557 157 GIGLEVHEGPYISR--GGDDRVLEPGMVFTIEPGIYF----------------IPGWGGVRIEDTVLVT 207
PRK12897 PRK12897
type I methionyl aminopeptidase;
86-331 3.79e-53

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 175.22  E-value: 3.79e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   86 IEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPD 165
Cdd:PRK12897   2 ITIKTKNEIDLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEKHGATSEQKGYNGYPYAICASVNDEMCHAFPA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  166 SRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQV 245
Cdd:PRK12897  82 DVPLTEGDIVTIDMVVNLNGGLSDSAWTYRVGKVSDEAEKLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGFSV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  246 CPHFVGHGIGSYFHGHPEIWHHANDSDLP-MEEGMAFTIEPIITEGSPEFKVLEDAWTVVSLDNQRSAQFEHTVLITSRG 324
Cdd:PRK12897 162 ARDFTGHGIGKEIHEEPAIFHFGKQGQGPeLQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTIAITKDG 241


                 ....*..
gi 40385867  325 AQILTKL 331
Cdd:PRK12897 242 PIILTKL 248
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 94-325 2.16e-40

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 140.67  E-value: 2.16e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  94 IQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPlgyggfpkSVCTSVNNV--LCHGIPDSRPLQD 171
Cdd:cd01066   1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGGYPAG--------PTIVGSGARtaLPHYRPDDRRLQE 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 172 GDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGF-QVCPHFV 250
Cdd:cd01066  73 GDLVLVDLGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLgPNFGHRT 152

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40385867 251 GHGIGSYFHGHPEIwhhANDSDLPMEEGMAFTIEPIItegspefkvledawtvvSLDNQRSAQFEHTVLITSRGA 325
Cdd:cd01066 153 GHGIGLEIHEPPVL---KAGDDTVLEPGMVFAVEPGL-----------------YLPGGGGVRIEDTVLVTEDGP 207
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
88-334 1.18e-39

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 141.50  E-value: 1.18e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  88 VKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYpsplgYGGFPKSVCTSVNNVLCHGIPDSR 167
Cdd:COG0006  73 IKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGAE-----GPSFDTIVASGENAAIPHYTPTDR 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 168 PLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQVC- 246
Cdd:COG0006 148 PLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYf 227

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 247 PHFVGHGIGSYFHGHPEIwhhANDSDLPMEEGMAFTIEPIITegspefkvLEDAWTVvsldnqRSaqfEHTVLITSRGAQ 326
Cdd:COG0006 228 PHGTGHGVGLDVHEGPQI---SPGNDRPLEPGMVFTIEPGIY--------IPGIGGV------RI---EDTVLVTEDGAE 287


                ....*...
gi 40385867 327 ILTKLPHE 334
Cdd:COG0006 288 VLTRLPRE 295
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 94-287 4.18e-29

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 111.06  E-value: 4.18e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  94 IQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAY-PSplgyggFPKSVCTSVNNVLCHGIPDSRPLQDG 172
Cdd:cd01092   1 IELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLGAEgPS------FDTIVASGPNSALPHGVPSDRKIEEG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 173 DIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGF-QVCPHFVG 251
Cdd:cd01092  75 DLVLIDFGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDVIEEAGYgEYFIHRTG 154

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 40385867 252 HGIGSYFHGHPEIwhhANDSDLPMEEGMAFTIEPII 287
Cdd:cd01092 155 HGVGLEVHEAPYI---SPGSDDVLEEGMVFTIEPGI 187
PRK07281 PRK07281
methionyl aminopeptidase;
117-329 6.52e-25

methionyl aminopeptidase;


Pssm-ID: 180918  Cd Length: 286  Bit Score: 101.85  E-value: 6.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  117 VDMTteEIDALVHREIISHNAYPSPLGYGG----FPKSVCTSVNNVLCHGIPDSRPLQDGDIINIDVTV----------- 181
Cdd:PRK07281  35 VDMW--EVEEYVRRRCKEENVLPLQIGVDGammdYPYATCCGLNDEVAHAFPRHYILKEGDLLKVDMVLsepldksivdv 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  182 -------------YYNGYHG---DTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQV 245
Cdd:PRK07281 113 sklnfdnveqmkkYTESYRGglaDSCWAYAVGTPSDEVKNLMDVTKEAMYRGIEQAVVGNRIGDIGAAIQEYAESRGYGV 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  246 CPHFVGHGIGSYFHGHPEIWHHANDS-DLPMEEGMAFTIEPIITEGSPEFKV-LEDAWTVVSLDNQRSAQFEHTVLITSR 323
Cdd:PRK07281 193 VRDLVGHGVGPTMHEEPMVPNYGTAGrGLRLREGMVLTIEPMINTGTWEIDTdMKTGWAHKTLDGGLSCQYEHQFVITKD 272


                 ....*.
gi 40385867  324 GAQILT 329
Cdd:PRK07281 273 GPVILT 278
met_pdase_II TIGR00501
methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. ...
 99-330 7.95e-19

methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. The role of this protein in general is to produce the mature amino end of cytosolic proteins by removing the N-terminal methionine. This model describes type II, among which the eukaryotic members typically have an N-terminal extension not present in archaeal members. It can act cotranslationally. The enzyme from rat has been shown to associate with translation initiation factor 2 (IF-2) and may have a role in translational regulation. [Protein fate, Protein modification and repair]


Pssm-ID: 129592  Cd Length: 295  Bit Score: 85.22  E-value: 7.95e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867    99 QACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPsplgygGFPKSVctSVNNVLCHGIP---DSRPLQDGDII 175
Cdd:TIGR00501  10 EAGKIHSKVRREAADRIVPGVKLLEVAEFVENRIRELGAEP------AFPCNI--SINECAAHFTPkagDKTVFKDGDVV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   176 NIDVTVYYNGYHGDTSETFLVGNVdecGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQVCPHFVGHGIG 255
Cdd:TIGR00501  82 KLDLGAHVDGYIADTAITVDLGDQ---YDNLVKAAKDALYTAIKEIRAGVRVGEIGKAIQEVIESYGVKPISNLTGHSMA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   256 SY-FHGHPEIWHHANDSDLPMEEGMAFTIEPIITEG---------------------------------SPEFKVL---- 297
Cdd:TIGR00501 159 PYrLHGGKSIPNVKERDTTKLEEGDVVAIEPFATDGvgyvtdggevsiyaflaerpvrldsarnllktiDENYGTLpfar 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 40385867   298 ------EDAWTVVSLD--------------NQRS----AQFEHTVLITSRGAQILTK 330
Cdd:TIGR00501 239 rwldklGDEKYLFALNnlirhgliydypvlNEISggyvAQWEHTILVEEHGKEVTTK 295
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 94-290 7.73e-16

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 76.52  E-value: 7.73e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  94 IQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPsplgygGFPKSVctSVNNVLCHGIP---DSRPLQ 170
Cdd:cd01088   1 LEKYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGAGP------AFPVNL--SINECAAHYTPnagDDTVLK 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 171 DGDIINIDVTVYYNGYHGDTSETFLVGNVdecGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQVCPHFV 250
Cdd:cd01088  73 EGDVVKLDFGAHVDGYIADSAFTVDFDPK---YDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNLT 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 40385867 251 GHGIGSY-FHGHPEIWHHANDSDLPMEEGMAFTIEPIITEG 290
Cdd:cd01088 150 GHSIERYrLHAGKSIPNVKGGEGTRLEEGDVYAIEPFATTG 190
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 94-330 1.38e-13

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 69.14  E-value: 1.38e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  94 IQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAypsPLGYGgfPKSVCTSVNNVLcHGIPDSRPLQDGD 173
Cdd:cd01087   1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGA---RLAYS--YIVAAGSNAAIL-HYVHNDQPLKDGD 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 174 IINIDVTVYYNGYHGDTSETFLV-GNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIgNTISHITHQNGFQV------- 245
Cdd:cd01087  75 LVLIDAGAEYGGYASDITRTFPVnGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDI-HLLAHRVLAEGLKElgilkgd 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 246 -------------CPHFVGHGIGSYFH--GHPeiwHHANDSDLPMEEGMAFTIEP---IItegsPEFKVLEDAWTVVSL- 306
Cdd:cd01087 154 vdeivesgayakfFPHGLGHYLGLDVHdvGGY---LRYLRRARPLEPGMVITIEPgiyFI----PDLLDVPEYFRGGGIr 226

                       250       260
                ....*....|....*....|....*.
gi 40385867 307 --DNqrsaqfehtVLITSRGAQILTK 330
Cdd:cd01087 227 ieDD---------VLVTEDGPENLTR 243
PRK09795 PRK09795
aminopeptidase; Provisional
 87-334 1.21e-08

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 55.71  E-value: 1.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   87 EVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSplgygGFPKSVCTSVNNVLCHGIPDS 166
Cdd:PRK09795 126 QIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKA-----SFDTIVASGWRGALPHGKASD 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  167 RPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKK-----LVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQN 241
Cdd:PRK09795 201 KIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAEShplfnVYQIVLQAQLAAISAIRPGVRCQQVDDAARRVITEA 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  242 GF-QVCPHFVGHGIGSYFHGHPEIwhhANDSDLPMEEGMAFTIEPIITegspefkvledawtvvsLDNQRSAQFEHTVLI 320
Cdd:PRK09795 281 GYgDYFGHNTGHAIGIEVHEDPRF---SPRDTTTLQPGMLLTVEPGIY-----------------LPGQGGVRIEDVVLV 340

                        250
                 ....*....|....
gi 40385867  321 TSRGAQILTKLPHE 334
Cdd:PRK09795 341 TPQGAEVLYAMPKT 354
PRK15173 PRK15173
peptidase; Provisional
 88-334 6.24e-08

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 53.57  E-value: 6.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   88 VKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHnaypSPLGYGGFPK-SVCTSVNNVLchgIPDS 166
Cdd:PRK15173  95 IKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSK----SETHFSRFHLiSVGADFSPKL---IPSN 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  167 RPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFqvc 246
Cdd:PRK15173 168 TKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVIKKSGL--- 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  247 PHF----VGHGIGSY--FHGHPEIWHHANDSdlpMEEGMAFTIEpiitegSPEFKVledawtvvsldNQRSAQFEHTVLI 320
Cdd:PRK15173 245 PNYnrghLGHGNGVFlgLEESPFVSTHATES---FTSGMVLSLE------TPYYGY-----------NLGSIMIEDMILI 304

                        250
                 ....*....|....
gi 40385867  321 TSRGAQILTKLPHE 334
Cdd:PRK15173 305 NKEGIEFLSKLPRD 318
PRK14575 PRK14575
putative peptidase; Provisional
 88-334 1.28e-07

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 52.79  E-value: 1.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   88 VKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHnaypSPLGYGGFPK-SVCTSVNNVLchgIPDS 166
Cdd:PRK14575 178 IKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSK----SETHFSRFHLiSVGADFSPKL---IPSN 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  167 RPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFqvc 246
Cdd:PRK14575 251 TKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVIKKSGL--- 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  247 PHF----VGHGIGSY--FHGHPEIWHHANDSdlpMEEGMAFTIEpiitegSPEFKVledawtvvsldNQRSAQFEHTVLI 320
Cdd:PRK14575 328 PNYnrghLGHGNGVFlgLEESPFVSTHATES---FTSGMVLSLE------TPYYGY-----------NLGSIMIEDMILI 387

                        250
                 ....*....|....
gi 40385867  321 TSRGAQILTKLPHE 334
Cdd:PRK14575 388 NKEGIEFLSKLPRD 401
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 147-329 4.34e-07

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 50.02  E-value: 4.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 147 FPksVCTSVNNVLCHGIP----DSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGK--KLVEVARRCRDEAIAA 220
Cdd:cd01089  59 FP--TCISVNNCVCHFSPlksdATYTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAETPVtgKKADVIAAAHYALEAA 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867 221 CRAGAPfsviGNTISHIThQNGFQVCPHFVGHGIGSyfhghpeIWHHAndsdlpMEEGMAFtiepiiTEGSPEFKVLED- 299
Cdd:cd01089 137 LRLLRP----GNQNSDIT-EAIQKVIVDYGCTPVEG-------VLSHQ------LKRVVSS------GEGKAKLVECVKh 192

                       170       180       190
                ....*....|....*....|....*....|....*
gi 40385867 300 ----AWTVV-SLDNQRSAQFEHTVLITSRGAQILT 329
Cdd:cd01089 193 gllfPYPVLyEKEGEVVAQFKLTVLLTPNGVTVLT 227
PRK14576 PRK14576
putative endopeptidase; Provisional
 88-331 9.00e-07

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 50.01  E-value: 9.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   88 VKNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIIShnaYPSPlgygGFPKSVCTSV-NNVLCHGIPDS 166
Cdd:PRK14576 177 IKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVMS---FPET----NFSRFNLISVgDNFSPKIIADT 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  167 RPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFqvc 246
Cdd:PRK14576 250 TPAKVGDLIKFDCGIDVAGYGADLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFDSTMAVIKTSGL--- 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  247 PHF----VGHGIGSY--FHGHPEIWHHANDSDLPmeeGMAFTIEpiitegSPEFKVledawtvvsldNQRSAQFEHTVLI 320
Cdd:PRK14576 327 PHYnrghLGHGDGVFlgLEEVPFVSTQATETFCP---GMVLSLE------TPYYGI-----------GVGSIMLEDMILI 386

                        250
                 ....*....|.
gi 40385867  321 TSRGAQILTKL 331
Cdd:PRK14576 387 TDSGFEFLSKL 397
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 63-284 1.08e-06

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 50.10  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   63 PVPKHIKKPDYVTTGIVPDWGDSIEVKNEDQIQGLHQACQLARHV------LLLAGKSLkVDMTtEEIDALVhREIISHN 136
Cdd:PTZ00053 127 PVGEIQEYPGENSSRTSSEEKRELEKLSEEQYQDLRRAAEVHRQVrryaqsVIKPGVKL-IDIC-ERIESKS-RELIEAD 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  137 AypspLGYG-GFPKSVctSVNNVLCHGIP---DSRPLQDGDIINIDVTVYYNGYHGDTSET--FlvgnvDECGKKLVEVA 210
Cdd:PTZ00053 204 G----LKCGwAFPTGC--SLNHCAAHYTPntgDKTVLTYDDVCKLDFGTHVNGRIIDCAFTvaF-----NPKYDPLLQAT 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  211 RRCRDEAIAACRAGAPFSVIGNTI-----SHITHQNGfQVCP-----HFVGHGIGSY-FHGH---PEIwhHANDSDLpME 276
Cdd:PTZ00053 273 KDATNTGIKEAGIDVRLSDIGAAIqevieSYEVEIKG-KTYPiksirNLNGHSIGPYiIHGGksvPIV--KGGENTR-ME 348


                 ....*...
gi 40385867  277 EGMAFTIE 284
Cdd:PTZ00053 349 EGELFAIE 356
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 147-303 6.31e-05

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 44.49  E-value: 6.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   147 FPksVCTSVNNVLCHGIP----DSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDE---CGKK--LVEVARRCRDEA 217
Cdd:TIGR00495  78 FP--TCISVNNCVGHFSPlksdQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEepvTGRKadVIAAAHLAAEAA 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   218 IAACRAGAPFSVIGNTISHITHQNGFQVCPHFVGHGIGSY-FHGHPEIWHHANDSD------LPMEEGMAFTIEPIITEG 290
Cdd:TIGR00495 156 LRLVKPGNTNTQVTEAINKVAHSYGCTPVEGMLSHQLKQHvIDGEKVIISNPSDSQkkdhdtAEFEENEVYAVDILVSTG 235

                         170
                  ....*....|...
gi 40385867   291 SPEFKVLEDAWTV 303
Cdd:TIGR00495 236 EGKAKDADQRTTI 248
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 89-285 7.42e-05

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 44.33  E-value: 7.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867   89 KNEDQIQGLHQACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNA-YPSplgyggFPKSVCTSVNNVLCHGIPDSR 167
Cdd:PRK10879 174 KSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHEFNRHGArYPS------YNTIVGSGENGCILHYTENES 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40385867  168 PLQDGDIINIDVTVYYNGYHGDTSETFLV-GNVDECGKKLVEVARRCRDEAIAACRAGAPFS------------------ 228
Cdd:PRK10879 248 EMRDGDLVLIDAGCEYKGYAGDITRTFPVnGKFTPAQREIYDIVLESLETSLRLYRPGTSIRevtgevvrimvsglvklg 327

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 40385867  229 VIGNTISHITHQNGF-QVCPHFVGHGIGSYFHghpEIWHHANDSDLPMEEGMAFTIEP 285
Cdd:PRK10879 328 ILKGDVDQLIAENAHrPFFMHGLSHWLGLDVH---DVGVYGQDRSRILEPGMVLTVEP 382
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH