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Conserved domains on  [gi|403225038|ref|NP_001258077|]
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type 2 lactosamine alpha-2,3-sialyltransferase isoform 5 [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 1-175 5.14e-123

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23984:

Pssm-ID: 480271  Cd Length: 206  Bit Score: 345.58  E-value: 5.14e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPY 80
Cdd:cd23984   32 MNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDLRWLLDLLMGKKVSAKGFWKKPALNLIYKPN 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  81 QIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKN 160
Cdd:cd23984  112 QIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNEVHIAGFKYDFSNLNSTLHYYGNETMSVMTKN 191

                        170
                 ....*....|....*
gi 403225038 161 AYHNVTAEQLFLKDI 175
Cdd:cd23984  192 EYHNISAEQKFLKDL 206
 
Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 1-175 5.14e-123

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 345.58  E-value: 5.14e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPY 80
Cdd:cd23984   32 MNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDLRWLLDLLMGKKVSAKGFWKKPALNLIYKPN 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  81 QIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKN 160
Cdd:cd23984  112 QIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNEVHIAGFKYDFSNLNSTLHYYGNETMSVMTKN 191

                        170
                 ....*....|....*
gi 403225038 161 AYHNVTAEQLFLKDI 175
Cdd:cd23984  192 EYHNISAEQKFLKDL 206
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 1-180 2.26e-47

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 155.07  E-value: 2.26e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038    1 MNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHN-------DPNTTVILTAFKPHDLRWLLELLMGDKINT----NGFWK 69
Cdd:pfam00777  73 CNLAPTKGYEKDVGSKTTLRTMNPESAIDSKYGNlgfshprDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRslrvLYTLK 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   70 KPALNLiyKPYQIRILDPFIIRTAAYELLHFPKVfpknqKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYY 149
Cdd:pfam00777 153 EVKIPV--DPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYY 225

                         170       180       190
                  ....*....|....*....|....*....|.
gi 403225038  150 GNATMSLMNKNAYHNVTAEQLFLKDIIEKNL 180
Cdd:pfam00777 226 DNVLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 1-175 5.14e-123

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 345.58  E-value: 5.14e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPY 80
Cdd:cd23984   32 MNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDLRWLLDLLMGKKVSAKGFWKKPALNLIYKPN 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  81 QIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKN 160
Cdd:cd23984  112 QIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNEVHIAGFKYDFSNLNSTLHYYGNETMSVMTKN 191

                        170
                 ....*....|....*
gi 403225038 161 AYHNVTAEQLFLKDI 175
Cdd:cd23984  192 EYHNISAEQKFLKDL 206
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 1-175 4.43e-92

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 267.24  E-value: 4.43e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDLRWLLELLMGDKINTN-GFWKKPALNLIYKP 79
Cdd:cd23967   32 MNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMDLLWLQAVIKGKKPNGKgGFWKKIATSVPKPP 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  80 YQIRILDPFIIRTAAYELLHFPKVFpkNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNK 159
Cdd:cd23967  112 KKIRILNPYILQEAAFDLIGLPMNG--KQGKNVPTTGIIAIVMALHYCDEVDIAGFGYDPSDPNAPLHYYDSLTMKAIKR 189

                        170
                 ....*....|....*.
gi 403225038 160 NAYHNVTAEQLFLKDI 175
Cdd:cd23967  190 SWTHNVTKEKKYLKKL 205
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 1-173 7.39e-61

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 187.95  E-value: 7.39e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESVFSDP-IHNDPNTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKP 79
Cdd:cd23982   32 LNDAPVRGFEKDVGSKTTIRLFYPESAQFDPgIENDPDTLLVLVPFKPLDFYWLYEILSNEKRVRKGFWKQPPRIWDANP 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  80 YQIRILDPFIIRTAAYELLHFPKvfpKNQKPKHPTTGIIAITLAFYICHEVHLAGFKY-NFSDLKSPLHYYGNATMSLMn 158
Cdd:cd23982  112 KQIRILNPYYTYVAATKLLQVPG---QRKKKQKPTTGLLAITLALHLCDEVHIAGFGYpDNGNSNQPIHYYNQITLKSM- 187

                        170
                 ....*....|....*
gi 403225038 159 KNAYHNVTAEQLFLK 173
Cdd:cd23982  188 ANSGHNLNAEAQAIQ 202
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 1-173 9.49e-50

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 159.90  E-value: 9.49e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDLRWLLELLMGDKI---NTNGFWKKPALNLIY 77
Cdd:cd23983   32 LNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVDFAWLKAMVKKEPLsfwSRLFFWKEVADSIPL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  78 KPYQIRILDPFIIRTAAYELLHFPKvfPKN----QKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNAT 153
Cdd:cd23983  112 KPSQFRILNPLIIKETALDILQYPE--PQSrlwgWDKNVPTLGVTAVVLATHLCDEVSLAGFGYDLSQPHAPLHYYDSVC 189

                        170       180
                 ....*....|....*....|
gi 403225038 154 MSLMNKNAYHNVTAEQLFLK 173
Cdd:cd23983  190 MAAMNTQTMHNVTKETKFLK 209
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 1-180 2.26e-47

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 155.07  E-value: 2.26e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038    1 MNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHN-------DPNTTVILTAFKPHDLRWLLELLMGDKINT----NGFWK 69
Cdd:pfam00777  73 CNLAPTKGYEKDVGSKTTLRTMNPESAIDSKYGNlgfshprDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRslrvLYTLK 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   70 KPALNLiyKPYQIRILDPFIIRTAAYELLHFPKVfpknqKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYY 149
Cdd:pfam00777 153 EVKIPV--DPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYY 225

                         170       180       190
                  ....*....|....*....|....*....|.
gi 403225038  150 GNATMSLMNKNAYHNVTAEQLFLKDIIEKNL 180
Cdd:pfam00777 226 DNVLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 1-175 1.08e-41

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 139.29  E-value: 1.08e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDLRWLLELLMGDKIN-TNGFWKKPALNLIYKP 79
Cdd:cd23981   32 LNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDFKWLKYIVYKEKVSaSDGFWKSVATRVPREP 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  80 YQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNK 159
Cdd:cd23981  112 HEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDEVAVAGFGYDMNTPNAPLHYYETIKMSAIKE 191

                        170
                 ....*....|....*.
gi 403225038 160 NAYHNVTAEQLFLKDI 175
Cdd:cd23981  192 SWTHNIQREKEFLRKL 207
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 1-175 3.66e-21

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 85.88  E-value: 3.66e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESV---------FSDPIHNDPNTTVILTAFKPHDLRWLLELlmgdkintngFWKKP 71
Cdd:cd19952   28 FNQAPTKGFEKDVGSKTTFRVLNSKWAgfylrgprcGCHPLPLEEEVVLILSRAAAADFKRLKRR----------KKRHD 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  72 ALNLIYKPYQIRILDPFIirtAAYELLHFPKVFPKNqkpkHPTTGIIAITLAFYICHEVHLAGF-KYNFSDLKSPLHYYG 150
Cdd:cd19952   98 NAVLLLTDPAPDLLSYVR---KRLEKLGLKSFFGGN----APSSGLLAVLLALQLCDSVDLYGFgVDSGHAPKVPYHYYD 170

                        170       180
                 ....*....|....*....|....*
gi 403225038 151 NATMSLMNKnaYHNVTAEQLFLKDI 175
Cdd:cd19952  171 LVEAEEGTA--VHSFDLEAELLRAL 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 8-168 4.33e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 82.31  E-value: 4.33e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   8 GHEEEVGRRTTFRLFYPESVF-SDPIH--NDPNTTVILTAFKPHDLRWLLELLMGDKINT---NGFWKKPALNLIYKPYQ 81
Cdd:cd23964  119 GFEKDVGTKTSFYTFFPESLHnSLLKHvpQDKDTKYLFIPFKIRDYDYLDAVLSGKPVPDgcdKGKRPPPLFGPKLNATN 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  82 IRILDPFIIRtaayellHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYnfsDLKSPLHYYGNATMSLMNKNA 161
Cdd:cd23964  199 VRLLHPDFIR-------YLFNRWLNSSTSYRPTTGALMLLTALHTCDQVSVYGFGY---DPRFSLHYYDKTFVKFTVFYA 268


                 ....*..
gi 403225038 162 YHNVTAE 168
Cdd:cd23964  269 NHDFTNE 275
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 1-178 5.33e-16

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 73.47  E-value: 5.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESVfsdpIHNDPNTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLiyKPY 80
Cdd:cd23966  107 MNKAPTKGFEKDVGSKTTHHFMYPESA----VDLDPGVHLVLVPFKVLDLQWLISALTTGEITRTYTPVKRFIKA--DKD 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  81 QIRILDPFIIRTAAYELLHfpkvfpknQKPKHPTTGIIAITLAFYICHEVHLAGF---KYNFSDlksplHYY-GNATMSL 156
Cdd:cd23966  181 KVLVINPAFIKYVHDNWTE--------HHGRYPSTGFLALIFALHICDEVSVFGFgadSKGNWH-----HYWeKNRSAGA 247

                        170       180
                 ....*....|....*....|..
gi 403225038 157 MNKNAYHNVTAEQlflkDIIEK 178
Cdd:cd23966  248 FRKTGVHDADFES----DIIKK 265
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 1-175 3.34e-13

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 65.76  E-value: 3.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNttviltafkphDLRWLLELLMGDKINTNG----FWKKPALNLI 76
Cdd:cd23968   75 FNDAPTKGFEKDVGSKTTLRLINSQILSKPEFNFLTD-----------PLYRNVTLLVWDPSSYNVnlekWYKKPDFDFF 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  77 --YKPYQIR-------ILDP-FIIRtaAYELLHfpKVFPKNQKPKHPTTGIIAITLAFYICHEVHLagfkYNF--SDLKS 144
Cdd:cd23968  144 pnYIKYRRRhpeepfyLIDPrFLWR--LWDILQ--EYTPEKIKPNPPSSGFIGIVLMLHLCDWVDV----YEYvpSVRQT 215

                        170       180       190
                 ....*....|....*....|....*....|..
gi 403225038 145 PL-HYYGNATMSLMNKNAYHNVTAEQLFLKDI 175
Cdd:cd23968  216 DRcHYYDVEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 1-167 3.04e-12

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 63.36  E-value: 3.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESVFSdpihNDPNTTVILTAFKPHDLRWLLELLMGDKINTNgFWKKPALNLIYKPy 80
Cdd:cd23980  111 MNKAPTEGFEADVGSKTTHHFVYPESFRE----LAQNVSMILVPFKTLDLEWVISATTTGTISHT-YVPVPRKIKVKKE- 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  81 QIRILDPFIIRTaayellhfpkVFPK--NQKPKHPTTGIIAITLAFYICHEVHLAGFKynfSDLKSPLHYY--GNATMSL 156
Cdd:cd23980  185 KILIYHPAFIKY----------VFDRwlQGHGRYPSTGILSVIFSLHVCDEVDLYGFG---ADSKGNWHHYweNNPSAGA 251

                        170
                 ....*....|....*..
gi 403225038 157 MNKNAYH------NVTA 167
Cdd:cd23980  252 FRKTGVHdgdfesNVTT 268
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 1-174 9.74e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 59.20  E-value: 9.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESVFSdpIHNDPNTTVILTAFKpHDLRWLLE-LLMGDKintngFWKKPALNLIYKP 79
Cdd:cd23963   93 CNLPPIKGFEKDVGRKTNLTTLNPSILKR--RYNSLKKNRDRDKFL-NRLKEYNGsILWYPK-----FSFKSSTNLLLKA 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  80 YQIRILDPFIIRTAAYELLHFPKVF---PKNQKPKHPTTGIIAITLAFYICHEVHLAGFkYNFS-DLKS---PLHYYGNA 152
Cdd:cd23963  165 ARALKKNGLNLTVVYSNPEHFLAVQkfwKRRGLEKRPSTGLYLVSLALTFCDEIHLYGF-WPFPtDPNGrpvPYHYYDDL 243

                        170       180
                 ....*....|....*....|..
gi 403225038 153 TMSLMNKNayHNVTAEQLFLKD 174
Cdd:cd23963  244 SPSTKNKV--HNMPEEFKLLRE 263
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 1-149 3.82e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 57.57  E-value: 3.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESVFSDPihndPNTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPY 80
Cdd:cd23979  110 MNQAPTVGFEADVGSRTTHHFMYPESAKNLP----ANVSFVLVPFKTLDLLWITSALSTGQIRFTYAPVKQFLRVDKDKV 185

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 403225038  81 QIrildpfiirtaaYELLHFPKVFPK--NQKPKHPTTGIIAITLAFYICHEVHLAGFKynfSDLKSPLHYY 149
Cdd:cd23979  186 QI------------YNPAFFKYIHDRwtEHHGRYPSTGMLVLFFALHVCDEVNVYGFG---ADSRGNWHHY 241
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 2-175 7.23e-08

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 50.99  E-value: 7.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   2 NNGPVLGHEEEVGRRTTFRLFYPEsVFSDPIHNDPNTT----VILTAFKPHDLrwllellmgdKINTNGFWKKPALNLI- 76
Cdd:cd23986   80 NSAPTRGYEKDVGNKTTIRIINSQ-ILTNPNHHFIDSSlykdVILVAWDPAPY----------SANLHKWYKKPDYNLFt 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  77 -YKPYQIRILD-PFIIRTAAYeLLHFPKVFPKNQK----PKHPTTGIIAITLAFYICHEVHLagFKYNFSDLKSPL-HYY 149
Cdd:cd23986  149 pYVQYRKRNPNqPFYILHPKF-IWQLWDIIQENTQekiqPNPPSSGFIGILIMMSMCREVHV--YEYIPSVRQTDLcHYH 225

                        170       180
                 ....*....|....*....|....*.
gi 403225038 150 GNATMSLMNKNAYHNVTAEQLFLKDI 175
Cdd:cd23986  226 ERYYDAACTLGAYHPLLYEKLLIQRM 251
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 1-150 1.59e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 49.55  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLF-YP--ESVFSDPIHNDPN----TTVILtafkphdlrWLLEllmgDKINTNGFWKKPAL 73
Cdd:cd23965   31 MNDAPTRGYEKDVGRRTTIRVVsHSslPRLLRNAILLLAGtrapTVVVF---------WGPE----TKMNKDGAGKYNLL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  74 NLIYKPYqiRILDPFIIRTAAYEllHFPKVFpKNQ--KPKHPT-----TGIIAITLAFYICHEVHLAGF---KY--NFSD 141
Cdd:cd23965   98 RSLSKKY--PDVEFYSLTPEKMD--YADELF-EKEtgKSRIKSgtwlsTGWFTMLLALDVCDEIKVYGMvpeNYcrEHPN 172


                 ....*....
gi 403225038 142 LKSPLHYYG 150
Cdd:cd23965  173 SKVPYHYYE 181
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 2-173 5.24e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 45.46  E-value: 5.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   2 NNGPVLGHEEEVGRRTTFRLFYPeSVFsDPIHNDPNTTVILTAFKpHDLRWLlellmGDKIntngFWKkPALNLIYKPYQ 81
Cdd:cd23970   99 NFAPTEGFEKDVGRKTNLTTFNP-SIL-EKYYNNLLTIQDRNNFF-LSLKKL-----DGAI----LWI-PAFFFHTSATV 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  82 IRILDPFIIrtaayELLHFPKV---FP-------------KNQKPKHPTTGIIAITLAFYICHEVHLAGFkYNFSDLKS- 144
Cdd:cd23970  166 TRTLVDFFV-----EHRGQLKVqlaWPgnimqhvnrywktKHLSPKRLSTGILMYTLASAICEEIHLYGF-WPFGFDPTg 239

                        170       180       190
                 ....*....|....*....|....*....|...
gi 403225038 145 ---PLHYYGN-ATMSLMNKNAYHNVTAEQLFLK 173
Cdd:cd23970  240 tplPYHYYDKkGTKFTTKWQESHQLPAEFVLLY 272
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 2-159 2.52e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 43.56  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   2 NNGPVLGHEEEVGRRTTFRLFypesvfsdpihndpNTTVILTAFK----PHDLRWLLELL--MGDKIntngFWKkPALNL 75
Cdd:cd23969   95 NLAPVEGYEKDVGTKSNLTTM--------------NPSVIPHAYGdlvnATDKEKFVERLrqLGDSI----LWI-PAFVS 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  76 IYKPYQIRILDPFI------IRTA--AYELLHFPKVFPKNQK--PKHPTTGIIAITLAFYICHEVHLAGFkYNFS-DLK- 143
Cdd:cd23969  156 KGGEEHVQWTNEIIlkhklnVKTAypPLRLNHAIRGYWLTTKfrIKRPSTGLLMYTLATRFCDEIHLYGF-YPFSeDGNg 234

                        170
                 ....*....|....*...
gi 403225038 144 SPL--HYYGNATMSLMNK 159
Cdd:cd23969  235 RAVkyHYYDNRKYLTTAR 252
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 1-149 1.16e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 41.66  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESVFSD------------PIHNDpnTTVILTAFKPHDLRWLLELLMGDKINTNGFW 68
Cdd:cd23973  113 VNGAVIKGYEEDVGTRTSFYVHTAHSITSSlmilqkrgfkniPQDKD--IKYILFPEGPRDYQWLEALLKNKTIPSGAYY 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  69 K---KPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNfSDLKSP 145
Cdd:cd23973  191 GrrpRSYFSGDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYRPTTGAFLLLTALHLCDTVSAYGFITE-DYRKYP 269


                 ....
gi 403225038 146 LHYY 149
Cdd:cd23973  270 DHYY 273
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 1-149 1.53e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 41.07  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESV---FSDPIH--NDPNTTVILTAFKPHDLRwllelLMGDKINTNgFWKKPALNl 75
Cdd:cd23975   31 MNNAPTKGYEEDVGKRTTIRVVSHTSVpllLKNPDYffKETNETIYVIWGPFRNMR-----KDGKGIVYN-MLKKAVES- 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  76 iYKPYQIRIldpfiirTAAYELLHFPKVFPKN------QKPKHPTTGIIAITLAFYICHEVHLAGF---KYNFSD--LKS 144
Cdd:cd23975  104 -YPQAKIYV-------TTEKRMSYCDTVFKKEtgkdrvQSGSYLSTGWFTLILAMDACYGIHVYGMindTYCKTEgyRKV 175


                 ....*
gi 403225038 145 PLHYY 149
Cdd:cd23975  176 PYHYY 180
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 1-149 1.08e-03

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 38.30  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038   1 MNNGPVLGHEEEVGRRTTFRLFYPESVF------SDPIHNDPNTTVIltafkphdlrwllellmgdkintngFW------ 68
Cdd:cd23978   31 MNDAPTTGYEKDVGNKTTLRVVAHSSVYrvlrrpQEFLNRTPETTLI-------------------------FWgppnkm 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403225038  69 KKPALNLIYKPYQ-----IRILDPFIIrtAAYELLHFPKVFP----KNQKPKHP--TTGIIAITLAFYICHEVHLAGF-K 136
Cdd:cd23978   86 QKDGKSNLFRIIQrasmtFPNMSAFVV--SPRRMRQFDDLFRgetgRDRKKSHSwlSTGWFTMVIAVELCDNVHVYGMvP 163

                        170
                 ....*....|....*...
gi 403225038 137 YNF-----SDLKSPLHYY 149
Cdd:cd23978  164 PNYcskrpTPKKMPYHYY 181
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 109-151 4.69e-03

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 36.74  E-value: 4.69e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 403225038 109 KPKHPTTGIIAITLAFYICHEVHLAG---FKYNFSDLKSPLHYYGN 151
Cdd:cd23990  198 RAKRISSGLMLVTAALELCEEVHLYGfwaFPMNPSGIFITHHYYDN 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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