|
Name |
Accession |
Description |
Interval |
E-value |
| Adenylsucc_synt |
pfam00709 |
Adenylosuccinate synthetase; |
108-497 |
0e+00 |
|
Adenylosuccinate synthetase;
Pssm-ID: 459912 Cd Length: 417 Bit Score: 684.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLVFDFHQAV 187
Cdd:pfam00709 31 GGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIEELEERGI-DVPDRLFISDRAHLILPYHKAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 188 DGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTL---EIDIEGQLKRL 264
Cdd:pfam00709 110 DGLRE---EARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVFREKLEALLELKNKLLEKLygePLDVEEELEEL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 265 KGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAY 344
Cdd:pfam00709 186 LEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPYVTSSNTTAGGACTGLGIGPTKIDEVIGVVKAY 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 345 TTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKL 424
Cdd:pfam00709 265 TTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRINGVTGLALTKLDVLDGLDEIKVCVAYEL 344
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40316944 425 NGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 497
Cdd:pfam00709 345 DGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEELLGVPIKIISVGPDREQTI 417
|
|
| Adenylsucc_synt |
smart00788 |
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ... |
108-497 |
0e+00 |
|
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.
Pssm-ID: 197875 Cd Length: 417 Bit Score: 614.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLVFDFHQAV 187
Cdd:smart00788 33 GGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKEIEELEAKGV-DVKDRLFISDRAHLILPYHIAL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 188 DglqevqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTL----EIDIEGQLKR 263
Cdd:smart00788 112 D-------KAREKARIGTTGRGIGPAYEDKVARRGIRVGDLF-DEEVLREKLEELLDYKNFLLKKLygaePVDVEEILEE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 264 LKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKA 343
Cdd:smart00788 184 LLEYAERLRPYVTDVSELLNEALKAG-KKVLFEGAQGTLLDIDHGTYPYVTSSNTTAGGAATGAGIGPTRIDRVIGVVKA 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 344 YTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYK 423
Cdd:smart00788 263 YTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRINGITGLALTKLDVLDGLDEIKVCVAYK 342
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40316944 424 LNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 497
Cdd:smart00788 343 LDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERIEELVGVPVSIISTGPDREQTI 416
|
|
| PTZ00350 |
PTZ00350 |
adenylosuccinate synthetase; Provisional |
108-497 |
0e+00 |
|
adenylosuccinate synthetase; Provisional
Pssm-ID: 240376 Cd Length: 436 Bit Score: 581.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGlKDWEKRLIISDRAHLVFDFHQAV 187
Cdd:PTZ00350 46 GGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSLLEEIEQLTKKG-INLLGRLYISDRAHLVFDLHQAI 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 188 DGLQEvQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKGF 267
Cdd:PTZ00350 125 DGIQE-SEKGKGGTQIGTTKRGIGPCYSTKASRTGLRVGDLL-NFETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGY 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 268 AERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTR 347
Cdd:PTZ00350 203 AEKLKDMIVDTVYFMNKAIK-EGKRVLVEGANATMLDIDFGTYPYVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTR 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 348 VGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGK 427
Cdd:PTZ00350 282 VGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALRYVQMINGFDSINLTKLDVLSGLKEIKICVNYKNKGT 361
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 40316944 428 --RIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 497
Cdd:PTZ00350 362 glEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENAQKYVLFIEELLGVPIVWIGVGPNRENMI 433
|
|
| PurA |
COG0104 |
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ... |
108-499 |
0e+00 |
|
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439874 Cd Length: 423 Bit Score: 568.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLVFDFHQAV 187
Cdd:COG0104 33 GGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEEIDGLEARGV-DVRSRLRISERAHLILPYHRAL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 188 DGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTL----EIDIEGQLKR 263
Cdd:COG0104 112 DKARE---EARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPEVLREKLEELLEYKNFLLEKLygaePLDFEELLEE 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 264 LKGFAERIRPMVRDGVYFMYEALH-GppKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVK 342
Cdd:COG0104 188 YLEYAERLKPYVADTSELLNEALKaG--KKVLFEGAQGTLLDIDHGTYPYVTSSNTTAGGACTGSGVGPTKIDRVIGVVK 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 343 AYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSY 422
Cdd:COG0104 266 AYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVRINGLTGLALTKLDVLDGLDEIKVCVAY 345
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 40316944 423 KLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 499
Cdd:COG0104 346 ELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVERIEELLGVPISIVSVGPDREQTIVR 422
|
|
| AdSS |
cd03108 |
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ... |
108-497 |
3.83e-164 |
|
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.
Pssm-ID: 349762 Cd Length: 316 Bit Score: 466.98 E-value: 3.83e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLVFDFHQAV 187
Cdd:cd03108 34 GGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFEEIEELEKKGI-DVKGRLLISDRAHLVFPYHQEL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 188 DGLQEVQRQaqeGKNIGTTKKGIGPTYSSKAARTGLRICDllsdfdefssrfknlahqhqsmfptleidiegqlkrlkgf 267
Cdd:cd03108 113 DGLEEKERG---GKKIGTTKRGIGPAYADKAARTGIRVGD---------------------------------------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 268 aerirPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTR 347
Cdd:cd03108 150 -----PYVVDTVELLNEALK-AGKKVLFEGAQGTLLDIDFGTYPYVTSSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTTR 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 348 VGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDIldvlgevkvgvsyklngk 427
Cdd:cd03108 224 VGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRINGLTELALTKLDV------------------ 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 428 ripyfpanqemlqkveveyetlpgwkadttgarrwedlppQAQNYIRFVENHVGVAVKWVGVGKSRESMI 497
Cdd:cd03108 286 ----------------------------------------NAQKYIERIEELLGVPITYISVGPDREQTI 315
|
|
| purA |
TIGR00184 |
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ... |
108-499 |
3.11e-161 |
|
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 272949 Cd Length: 425 Bit Score: 463.94 E-value: 3.11e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKkGLKDWEKRLIISDRAHLVFDFHQAV 187
Cdd:TIGR00184 31 GGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEMEYLEK-RGISVRDRLFVSYRCHLILPYHKKL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 188 DGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSD---FDEFSSRFKNLAHQHQSMFPTLEIDIEGQLKRL 264
Cdd:TIGR00184 110 DKARE---KSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDeafAEKAKNILEYLNEQLVKYYKDEGVDYEKKLDEY 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 265 KGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAY 344
Cdd:TIGR00184 187 MKYAEELKPFVVDVSVELNEALDEG-EKVLFEGAQGTMLDIDYGTYPYVTSSNTTAGGVATGVGIGPTKVDEVIGVFKAY 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 345 TTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKL 424
Cdd:TIGR00184 266 TTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNGATQLALTKLDVLDGIDEIKVCVAYRM 345
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40316944 425 NGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 499
Cdd:TIGR00184 346 KGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEELTGVPVTIISTGPEREQTIDL 420
|
|
| amino_Aden_PurZ |
NF038379 |
succino-amino-deoxyadenylate synthase PurZ; |
108-398 |
1.23e-19 |
|
succino-amino-deoxyadenylate synthase PurZ;
Pssm-ID: 468496 Cd Length: 292 Bit Score: 88.97 E-value: 1.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVD-GKEYDFHLLPSGI-INTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLVfdfhq 185
Cdd:NF038379 34 AGPNAGHTYIDDeGRKFVHRMLPNGIvSPPLKQVLIGPGSEIDLEVLREEIEELEDAGH-DVGKRLLIHEQATVI----- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 186 avDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTglricdllsdfdefssrfknlahqhqsmfPTLEIDIEGQLKRLK 265
Cdd:NF038379 108 --ELHKHVEEEAGPMTKIGSTKKGIGAARAAKIRRN-----------------------------PSTLGDAEGDFGEGA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 266 GFAERIRPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNI--GDVYGVVKA 343
Cdd:NF038379 157 VRDQPWEIAERVVDNALYDFALQAAERIQIEGTQGYSLGLHAGFYPYCTSRDCTPADFLADAGIPLPNVdaFKVVGTART 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40316944 344 YTTRVGIGAFPT---------EQIneigGLLQtrghEWGVTTGRKRRCGWLDLMILRYAHMVNG 398
Cdd:NF038379 237 YPIRVAGWSGNSypdqgettwEEL----GLPE----ELTTVTKKVRRVGTFSAEQVREAVQANG 292
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Adenylsucc_synt |
pfam00709 |
Adenylosuccinate synthetase; |
108-497 |
0e+00 |
|
Adenylosuccinate synthetase;
Pssm-ID: 459912 Cd Length: 417 Bit Score: 684.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLVFDFHQAV 187
Cdd:pfam00709 31 GGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIEELEERGI-DVPDRLFISDRAHLILPYHKAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 188 DGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTL---EIDIEGQLKRL 264
Cdd:pfam00709 110 DGLRE---EARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVFREKLEALLELKNKLLEKLygePLDVEEELEEL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 265 KGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAY 344
Cdd:pfam00709 186 LEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPYVTSSNTTAGGACTGLGIGPTKIDEVIGVVKAY 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 345 TTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKL 424
Cdd:pfam00709 265 TTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRINGVTGLALTKLDVLDGLDEIKVCVAYEL 344
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40316944 425 NGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 497
Cdd:pfam00709 345 DGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEELLGVPIKIISVGPDREQTI 417
|
|
| Adenylsucc_synt |
smart00788 |
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ... |
108-497 |
0e+00 |
|
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.
Pssm-ID: 197875 Cd Length: 417 Bit Score: 614.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLVFDFHQAV 187
Cdd:smart00788 33 GGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKEIEELEAKGV-DVKDRLFISDRAHLILPYHIAL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 188 DglqevqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTL----EIDIEGQLKR 263
Cdd:smart00788 112 D-------KAREKARIGTTGRGIGPAYEDKVARRGIRVGDLF-DEEVLREKLEELLDYKNFLLKKLygaePVDVEEILEE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 264 LKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKA 343
Cdd:smart00788 184 LLEYAERLRPYVTDVSELLNEALKAG-KKVLFEGAQGTLLDIDHGTYPYVTSSNTTAGGAATGAGIGPTRIDRVIGVVKA 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 344 YTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYK 423
Cdd:smart00788 263 YTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRINGITGLALTKLDVLDGLDEIKVCVAYK 342
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40316944 424 LNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 497
Cdd:smart00788 343 LDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERIEELVGVPVSIISTGPDREQTI 416
|
|
| PTZ00350 |
PTZ00350 |
adenylosuccinate synthetase; Provisional |
108-497 |
0e+00 |
|
adenylosuccinate synthetase; Provisional
Pssm-ID: 240376 Cd Length: 436 Bit Score: 581.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGlKDWEKRLIISDRAHLVFDFHQAV 187
Cdd:PTZ00350 46 GGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSLLEEIEQLTKKG-INLLGRLYISDRAHLVFDLHQAI 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 188 DGLQEvQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKGF 267
Cdd:PTZ00350 125 DGIQE-SEKGKGGTQIGTTKRGIGPCYSTKASRTGLRVGDLL-NFETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGY 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 268 AERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTR 347
Cdd:PTZ00350 203 AEKLKDMIVDTVYFMNKAIK-EGKRVLVEGANATMLDIDFGTYPYVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTR 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 348 VGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGK 427
Cdd:PTZ00350 282 VGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALRYVQMINGFDSINLTKLDVLSGLKEIKICVNYKNKGT 361
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 40316944 428 --RIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 497
Cdd:PTZ00350 362 glEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENAQKYVLFIEELLGVPIVWIGVGPNRENMI 433
|
|
| PurA |
COG0104 |
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ... |
108-499 |
0e+00 |
|
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439874 Cd Length: 423 Bit Score: 568.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLVFDFHQAV 187
Cdd:COG0104 33 GGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEEIDGLEARGV-DVRSRLRISERAHLILPYHRAL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 188 DGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTL----EIDIEGQLKR 263
Cdd:COG0104 112 DKARE---EARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPEVLREKLEELLEYKNFLLEKLygaePLDFEELLEE 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 264 LKGFAERIRPMVRDGVYFMYEALH-GppKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVK 342
Cdd:COG0104 188 YLEYAERLKPYVADTSELLNEALKaG--KKVLFEGAQGTLLDIDHGTYPYVTSSNTTAGGACTGSGVGPTKIDRVIGVVK 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 343 AYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSY 422
Cdd:COG0104 266 AYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVRINGLTGLALTKLDVLDGLDEIKVCVAY 345
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 40316944 423 KLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 499
Cdd:COG0104 346 ELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVERIEELLGVPISIVSVGPDREQTIVR 422
|
|
| PRK01117 |
PRK01117 |
adenylosuccinate synthetase; Provisional |
108-499 |
0e+00 |
|
adenylosuccinate synthetase; Provisional
Pssm-ID: 234904 Cd Length: 430 Bit Score: 555.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLVFDFHQAV 187
Cdd:PRK01117 35 GGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALLKEIDELEARGV-DVRERLRISERAHLILPYHRAL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 188 DGLQEVQRqaqeGKN-IGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQH----QSMFPTLEIDIEGQLK 262
Cdd:PRK01117 114 DKAREKAR----GKKkIGTTGRGIGPAYEDKVARRGIRVGDLL-DPETFAEKLEENLEYKnfllTKYYGAEAVDFEEILD 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 263 RLKGFAERIRPMVRDGVYFMYEALH-GppKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVV 341
Cdd:PRK01117 189 EYLEYAERLKPYVTDTSLLLNDALKaG--KRVLFEGAQGTLLDIDHGTYPFVTSSNTTAGGAATGSGVGPTKIDYVLGIA 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 342 KAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVS 421
Cdd:PRK01117 267 KAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYAVRVNGLTGLALTKLDVLDGLEEIKICVA 346
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 40316944 422 YKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 499
Cdd:PRK01117 347 YELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYIKRIEELTGVPISIISTGPDRDQTIIL 424
|
|
| PLN02513 |
PLN02513 |
adenylosuccinate synthase |
108-497 |
0e+00 |
|
adenylosuccinate synthase
Pssm-ID: 178129 Cd Length: 427 Bit Score: 540.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVV-VDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLVFDFHQA 186
Cdd:PLN02513 36 GGANAGHTIYnDEGKKFALHLVPSGILNEKTTCVIGNGVVVHLPGLFEEIDGLESNGV-SCEGRLLVSDRAHLLFDFHQE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 187 VDGLQEVQRqaqEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTLEID---IEGQLKR 263
Cdd:PLN02513 115 VDGLREAEL---AGSKIGTTKRGIGPAYSSKATRNGLRVGDLR-HMDTFAEKLRELLADAAARFEGFEYDasmVEEEVEA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 264 LKGFAERIRPMVRDGVYFMYEAlHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKA 343
Cdd:PLN02513 191 YKKFAERLEPFITDTVHYLNEA-IQAGKKILVEGAQATMLDIDFGTYPFVTSSNPSAGGICTGLGIAPRKLGDIIGVVKA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 344 YTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYK 423
Cdd:PLN02513 270 YTTRVGSGPFPTELFGELGDLLREAGQEFGTTTGRPRRCGWLDIVALKYSCQINGFTSLNLTKLDVLSGLPEIKIGVAYK 349
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40316944 424 L-NGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 497
Cdd:PLN02513 350 TpDGKVVKSFPADLDTLEQVEVVYEVLPGWQEDISSVRNYDDLPAAAQAYVERIEELVGVPVHYIGVGPGRDALI 424
|
|
| AdSS |
cd03108 |
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ... |
108-497 |
3.83e-164 |
|
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.
Pssm-ID: 349762 Cd Length: 316 Bit Score: 466.98 E-value: 3.83e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLVFDFHQAV 187
Cdd:cd03108 34 GGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFEEIEELEKKGI-DVKGRLLISDRAHLVFPYHQEL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 188 DGLQEVQRQaqeGKNIGTTKKGIGPTYSSKAARTGLRICDllsdfdefssrfknlahqhqsmfptleidiegqlkrlkgf 267
Cdd:cd03108 113 DGLEEKERG---GKKIGTTKRGIGPAYADKAARTGIRVGD---------------------------------------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 268 aerirPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTR 347
Cdd:cd03108 150 -----PYVVDTVELLNEALK-AGKKVLFEGAQGTLLDIDFGTYPYVTSSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTTR 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 348 VGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDIldvlgevkvgvsyklngk 427
Cdd:cd03108 224 VGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRINGLTELALTKLDV------------------ 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 428 ripyfpanqemlqkveveyetlpgwkadttgarrwedlppQAQNYIRFVENHVGVAVKWVGVGKSRESMI 497
Cdd:cd03108 286 ----------------------------------------NAQKYIERIEELLGVPITYISVGPDREQTI 315
|
|
| purA |
TIGR00184 |
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ... |
108-499 |
3.11e-161 |
|
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 272949 Cd Length: 425 Bit Score: 463.94 E-value: 3.11e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKkGLKDWEKRLIISDRAHLVFDFHQAV 187
Cdd:TIGR00184 31 GGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEMEYLEK-RGISVRDRLFVSYRCHLILPYHKKL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 188 DGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSD---FDEFSSRFKNLAHQHQSMFPTLEIDIEGQLKRL 264
Cdd:TIGR00184 110 DKARE---KSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDeafAEKAKNILEYLNEQLVKYYKDEGVDYEKKLDEY 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 265 KGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAY 344
Cdd:TIGR00184 187 MKYAEELKPFVVDVSVELNEALDEG-EKVLFEGAQGTMLDIDYGTYPYVTSSNTTAGGVATGVGIGPTKVDEVIGVFKAY 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 345 TTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKL 424
Cdd:TIGR00184 266 TTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNGATQLALTKLDVLDGIDEIKVCVAYRM 345
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40316944 425 NGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 499
Cdd:TIGR00184 346 KGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEELTGVPVTIISTGPEREQTIDL 420
|
|
| PRK13787 |
PRK13787 |
adenylosuccinate synthetase; Provisional |
107-499 |
1.70e-110 |
|
adenylosuccinate synthetase; Provisional
Pssm-ID: 172324 Cd Length: 423 Bit Score: 334.23 E-value: 1.70e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 107 RGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKrLIISDRAHLVFDFHQA 186
Cdd:PRK13787 34 QGGANAGHTVVVHGKKYVFHLVPSGVIYDQTICVIGNGVVLDPLFFIEECDRLQKEGFPVKDK-LLLSDACHLLFPYHSQ 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 187 VDGLQEVQrQAQEGKnIGTTKKGIGPTYSSKAARTGLRICDLLSDfdEFSSRFKNLAH-------QHQSMFPTLEIDIEg 259
Cdd:PRK13787 113 IDSARETT-SSQEHK-IGTTKKGIGICYADKMMRTGLRVGDLLDK--SYKRRLKHLVDeknreldKLYGMPPVSYNDIN- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 260 qlKRLKGFAERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYG 339
Cdd:PRK13787 188 --DGLKFFLSKVGKNIINTAYYLDTELK-KGKRVLLEGAQGTGLDVDFGTYPYVTSSNPTTGGALIGTGISFQHLKHVIG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 340 VVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVG 419
Cdd:PRK13787 265 ITKAYTTRVGEGPFPTELLGEAGEVLRQKGGEFGATTGRPRRCGWFDVEMLKHSVRINGITSIALTKIDILSDYDTIPVA 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 420 VSYKLNGKRIPYFPAnqEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 499
Cdd:PRK13787 345 VGYKLNGKTLDCFPS--QGLEKVEPLYEEFPGWKDDISGINEFQKLPEKCKNYISALEKWIGVKINLVSTGPDRKDTIIG 422
|
|
| PRK13783 |
PRK13783 |
adenylosuccinate synthetase; Provisional |
108-499 |
7.51e-104 |
|
adenylosuccinate synthetase; Provisional
Pssm-ID: 237505 Cd Length: 404 Bit Score: 316.27 E-value: 7.51e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGlKDWEKRLIISDRAHLVFDFHQAV 187
Cdd:PRK13783 34 GGANAGHTVNYGDFKVVHHLLPSADFKKNVGAAIGNGVVLDLEVLVEELEELKEKF-PDYSGRIFISELAHVVLPVHKEL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 188 DGLQEVQRqaqeGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDfDEFSSRFKNLAHQHQSMFpTLEIDIEGQLKRLKGF 267
Cdd:PRK13783 113 DEIIESVR----KNAIGTTKRGIGPAYADKVMRVGVRLADLFDE-EKLREFLEKILSLYKKLY-GIEFDVEKMMEDLLTF 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 268 AERIRPMVRDGVYfMYEALHGppKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQnIGDVYGVVKAYTTR 347
Cdd:PRK13783 187 YEKIKDLVVSPVE-IKRILEE--KSVLFEGTQGVLLDLDVGTYPYVTSSNCSTTGVSAGMGFPVK-VDEVIGVFKAYTTR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 348 VGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGK 427
Cdd:PRK13783 263 VGEGPFPTELFGEEGEKLRKAGHEYGATTGRPRRCGWLDLPLLRYAIEVSGVDSLVMTKADVLNGFEKIKVCVRYEIGGK 342
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 40316944 428 RIPYfPANQEMLQKVEVEYETLPGWKadTTGARRWEDlppqaqnYIRFVENHVGVAVKWVGVGKSRESMIQL 499
Cdd:PRK13783 343 EVRD-PSSLRDLEKAEPVYEEFDGWK--SLEDKNFLK-------FVDFIERETGRKIAYISTGPKIEEIVEV 404
|
|
| PRK13786 |
PRK13786 |
adenylosuccinate synthetase; Provisional |
107-498 |
1.41e-101 |
|
adenylosuccinate synthetase; Provisional
Pssm-ID: 184325 Cd Length: 424 Bit Score: 311.35 E-value: 1.41e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 107 RGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVsFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLVFDFHQA 186
Cdd:PRK13786 33 QGGDNAGHTVKVGDEVYKLHLIPSGFLLDARV-LIGPGVVLNPEVLAEEIDMLEKHGVKVDAEKLGIDAKTSIIMPYHIE 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 187 VDGLQEVQRQAQegknIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTLEIDI-----EGQL 261
Cdd:PRK13786 112 LDGLRESARTEK----IGTTKRGIGFAYIDKIARDEVRMSDLV-DKERLMRRLEELAPQKEKEIKELGGDPsivrdEALI 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 262 KRLKGFAERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVV 341
Cdd:PRK13786 187 DKYLELGRQLAPYITDVSYEINKALD-EGKSVLAEGAQGTHLDVIHGTQKFVTSSSTIAGSACANLGVGPTRVDNVLGIV 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 342 KAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVS 421
Cdd:PRK13786 266 KAYITRVGEGPLPTELKDEAGEHLQDVGGEFGTTTGRPRRCGWFDLPLLKKAIYLNGYTEIALTKLDVLTGLDPIKICVG 345
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 40316944 422 YKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQ 498
Cdd:PRK13786 346 YELDGEILDYPPELTSDLARCVPVYEELEGWSTDLTEVKAYEDLPENARNYVERLEELMGVPIKYISVGPGREQTFK 422
|
|
| PRK13788 |
PRK13788 |
adenylosuccinate synthetase; Provisional |
107-494 |
2.68e-97 |
|
adenylosuccinate synthetase; Provisional
Pssm-ID: 184326 [Multi-domain] Cd Length: 404 Bit Score: 299.80 E-value: 2.68e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 107 RGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkdwEKRLIISDRAHLVFDFHQA 186
Cdd:PRK13788 34 QGGANAGHTVVAKGKTFKLNLLPSGVLHPHATSVLGDGMVIDPFRFAEERENLRAGGL---NPKLLISERAHLVLPHHKY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 187 VDGlqevqrqaqeGKN-IGTTKKGIGPTYSSKAARTGLRICDLLSD--FDEFSSRFknLAHQHQSMFPTLEIDIEGQLKR 263
Cdd:PRK13788 111 VDG----------RKNfVGTTGRGIGPAYSDRARRVGIRFGDLLDEavLRERVERL--LEAKPNSTREAGWDTVEKALAD 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 264 LKGFAERIRPMVRDGVYFMYEAL-HGppKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVK 342
Cdd:PRK13788 179 LAPMREILLPFIADTGSLLREAIrEG--KRVLFEGAQATLLDLNYGTYPYVTSSHPTVGGILVGAGVNHKAINKVYGVAK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 343 AYTTRVGIGAFPTEQINEIGGLLQTRG----HEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKV 418
Cdd:PRK13788 257 AFTTRVGHGPFPTEVFGEMAIRLRGKGgnpwDEFGTTTGRARRVGWLDLVLLKYACEVNGFDGLVLTKLDVLSGLEKVKV 336
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 40316944 419 GVSYKLNGKripyfpanqemlqkveVEYETLPGWkADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRE 494
Cdd:PRK13788 337 CVEYDDDGQ----------------PVYKELPGW-GDLDGVKSREALPKEAQAYLELIEETTGVPVVMFSTSPRRE 395
|
|
| PRK13785 |
PRK13785 |
adenylosuccinate synthetase; Provisional |
107-499 |
4.86e-94 |
|
adenylosuccinate synthetase; Provisional
Pssm-ID: 237506 Cd Length: 454 Bit Score: 292.82 E-value: 4.86e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 107 RGGNNAGHTVVVDGKEYDFHLLPSGIINTKaVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRliISDRAHLVFDFHQA 186
Cdd:PRK13785 33 QGGDNAGHTVVHGGEEYKLSLVPSGAVRGK-IGVLGNGCVVNPETLFDEIDALRERGL-DPDVR--VAERAHVILPYHRV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 187 VDGLQEvQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMFPTL----------EID 256
Cdd:PRK13785 109 LDGIEE-EAKSDSDLEVGTTGRGIGPTYEDKAGRRGVRVGDLL-DPDVLRDRLEYVVPQKRALAEDVygldasetpeAFD 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 257 IEGQLKRLKGFAERIRP--MVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNI 334
Cdd:PRK13785 187 VDALFEEYREYGERLAEedMTVNAGDFLAERIDDG-DNVMLEGAQGTSIDIDHGNYPYVTSSNPTAGGAATGTGLGPTVV 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 335 GD--VYGVVKAYTTRVGIGAFPTE---------------QINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVN 397
Cdd:PRK13785 266 GQgeVVGIVKAYLSRVGSGPLPTElggvegdtpdeggrpDEEELATYIREEGGEYGTVTGRPRRVGWLDMPMLRHAARAS 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 398 GFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKA---DTTGARRWEDLPPQAQNYIR 474
Cdd:PRK13785 346 GFTGLAINHIDVLAGLDEVKVGHSYELDGEELLTMPATTERWARCEPNFRSFDGWPEvdwAAVAEEGYDALPENARTYLE 425
|
410 420
....*....|....*....|....*
gi 40316944 475 FVENHVGVAVKWVGVGKSRESMIQL 499
Cdd:PRK13785 426 YVSDELDTPIYAVGVGPGREETVVL 450
|
|
| PRK13784 |
PRK13784 |
adenylosuccinate synthetase; Provisional |
107-497 |
3.66e-78 |
|
adenylosuccinate synthetase; Provisional
Pssm-ID: 172322 Cd Length: 428 Bit Score: 251.09 E-value: 3.66e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 107 RGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLVFDFHQA 186
Cdd:PRK13784 34 QGGNNAGHTLVVNGKKTFLHLIPSGVLHQHTKCVIGHGVVLDPVALDEEITRLQAKGIAISAENLFVSESCTIITSYHKL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 187 VDGLqevqRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSSRFKNLAHQHQSMF--------PTLEIDIE 258
Cdd:PRK13784 114 LDAV----RESNTSEKIGTTGKGIGPAYEDKVSRKGIKFKHLF-DKDLLRSRLAISLAEKETLFrdlykveyPTLEQEFD 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 259 gqlkRLKGFAERIRPMVRDGVYFMYEALhGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVY 338
Cdd:PRK13784 189 ----KLFALGQKLKQYAADTFSIIDQAI-AAGKNVVYEGAQGVLLDVDYGTYPFVTSSNTSVAGVYSGATTAGHGLDHVI 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 339 GVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKV 418
Cdd:PRK13784 264 GITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWLDLPLLKYSAKCSNLTSIALTKVDVLSDMDTLKV 343
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 40316944 419 GVSYKLNGKRIpYFPANQEMLQKVEVEYETLPGWKADTTGARrwEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMI 497
Cdd:PRK13784 344 CIGYKYEGKEI-YCAYPGIDLYKVEPILVEMEPFSIDETVTK--DNMPAALKTYLKTIENHVGIPISSLAYGPSREQIL 419
|
|
| PRK04293 |
PRK04293 |
adenylosuccinate synthetase; Provisional |
107-499 |
1.55e-51 |
|
adenylosuccinate synthetase; Provisional
Pssm-ID: 179812 Cd Length: 333 Bit Score: 178.15 E-value: 1.55e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 107 RGGN--NAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGlkdwekRLIISDRAHLVFDFH 184
Cdd:PRK04293 34 RGGVgpNAGHTVEYNGKKYGLRMIPSGFVNKDAKLAIGAGVLVDPEVLLKEVEELNVGG------RVFVDYRCGIIEEKH 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 185 QAVDglqevQRQAQEGKNIGTTKKGIGPTYSSKAARTGlricDLLSDFDEfssrfknlahqhqsmfptleidiegqlkrl 264
Cdd:PRK04293 108 VEED-----RSDEHLSKKIGSTGTGCGPANADRVLRRL----KLAKDVEE------------------------------ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 265 kgfaerIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAY 344
Cdd:PRK04293 149 ------LEKYLTDVPEEVNEALDRG-ENVLIEGTQGFGLSLYYGTYPYVTSKDTTASGIASDVGVGPTKVDEVIVVFKSY 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 345 TTRVGIGAFPTEQINEIGgllQTRG-HEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDvlgevkvgvsyk 423
Cdd:PRK04293 222 PTRVGEGPFPTELSLEEA---EKLGlVEYGTVTGRRRRVGPFDFELARRAARINGATQIAITKLDKLD------------ 286
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 40316944 424 lngkripyfpanqemlqkveveyetlpgwkADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 499
Cdd:PRK04293 287 ------------------------------KEAYGVTEYDKLPPEAKKFIEEIEEELGVPVTLISTGPELEDTIDL 332
|
|
| amino_Aden_PurZ |
NF038379 |
succino-amino-deoxyadenylate synthase PurZ; |
108-398 |
1.23e-19 |
|
succino-amino-deoxyadenylate synthase PurZ;
Pssm-ID: 468496 Cd Length: 292 Bit Score: 88.97 E-value: 1.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 108 GGNNAGHTVVVD-GKEYDFHLLPSGI-INTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLkDWEKRLIISDRAHLVfdfhq 185
Cdd:NF038379 34 AGPNAGHTYIDDeGRKFVHRMLPNGIvSPPLKQVLIGPGSEIDLEVLREEIEELEDAGH-DVGKRLLIHEQATVI----- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 186 avDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTglricdllsdfdefssrfknlahqhqsmfPTLEIDIEGQLKRLK 265
Cdd:NF038379 108 --ELHKHVEEEAGPMTKIGSTKKGIGAARAAKIRRN-----------------------------PSTLGDAEGDFGEGA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 266 GFAERIRPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNI--GDVYGVVKA 343
Cdd:NF038379 157 VRDQPWEIAERVVDNALYDFALQAAERIQIEGTQGYSLGLHAGFYPYCTSRDCTPADFLADAGIPLPNVdaFKVVGTART 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40316944 344 YTTRVGIGAFPT---------EQIneigGLLQtrghEWGVTTGRKRRCGWLDLMILRYAHMVNG 398
Cdd:NF038379 237 YPIRVAGWSGNSypdqgettwEEL----GLPE----ELTTVTKKVRRVGTFSAEQVREAVQANG 292
|
|
| PTZ00351 |
PTZ00351 |
adenylosuccinate synthetase; Provisional |
109-240 |
3.97e-05 |
|
adenylosuccinate synthetase; Provisional
Pssm-ID: 173544 Cd Length: 710 Bit Score: 46.20 E-value: 3.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40316944 109 GNNAGHTVVVD-GKEYDFHLLPSGIINTKAVSFIGNGVVIHlPGLFEEAEKNE--KKGLkDWEKRLIISDRAhLVFDFHQ 185
Cdd:PTZ00351 206 GENAGHTVYDKaGRKFVFNLAPSGLLLPGKRNYIGPECVMD-PVSFMEKEIIQliDAGI-DYRDRLFIGNVC-IVTPYHK 282
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 40316944 186 AVDGLQEVQRQaqegknigTTKKGIGPTYSSKAARTGLRICDLLSDFDEFSSRFK 240
Cdd:PTZ00351 283 LLDLLGSAANS--------STLKGMAPVHGSKVMKRGIRLDHIFNDDETLRKRLE 329
|
|
| |
