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Conserved domains on  [gi|40254554|ref|NP_061221|]
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sulfotransferase 1C1 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
46-297 1.41e-114

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 330.84  E-value: 1.41e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554    46 PDDLLIATYAKAGTTWTQEIVDMIQNDGDVQKCQRA---NTYDRHPFIEWTLP---PPLNSGLDLANKMPSPRTLKTHLP 119
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPhlfNNHNRSPFLEWYPGdtyFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554   120 VQMLPPSFWKENSKIIYVARNAKDCLVSYYYFSRMNKMLPDPGTLGEYIETFKAGKVLWGSWYDHVKGWWDVKDKHRILY 199
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554   200 LFYEDMKEDPKREIKKIVKFLEKDISEEVLNKIIHHTSFDVMKQNPMANYTTLPSsimdhSISPFMRKGMPGDWKNYFTV 279
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPK-----EVSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 40254554   280 AQSEDFDEDYRKKMAGST 297
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
46-297 1.41e-114

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 330.84  E-value: 1.41e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554    46 PDDLLIATYAKAGTTWTQEIVDMIQNDGDVQKCQRA---NTYDRHPFIEWTLP---PPLNSGLDLANKMPSPRTLKTHLP 119
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPhlfNNHNRSPFLEWYPGdtyFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554   120 VQMLPPSFWKENSKIIYVARNAKDCLVSYYYFSRMNKMLPDPGTLGEYIETFKAGKVLWGSWYDHVKGWWDVKDKHRILY 199
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554   200 LFYEDMKEDPKREIKKIVKFLEKDISEEVLNKIIHHTSFDVMKQNPMANYTTLPSsimdhSISPFMRKGMPGDWKNYFTV 279
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPK-----EVSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 40254554   280 AQSEDFDEDYRKKMAGST 297
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 42-296 5.27e-29

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 113.48  E-value: 5.27e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554   42 FQAKPDDLLIATYAKAGTTWTQEIVDMIQN----DGDVQKCQRANTYDRHPFIEWTLP--PPLNSGLDLANKMPSprtlk 115
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANrsrfDDSSNPLLKRNPHEFVPYIEIDFPffPSVDVLKDKGNTLFS----- 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554  116 THLPVQMLPPSFWKENSKIIYVARNAKDCLVSYYYFSRMNKMLPDP-GTLGEYIETFKAGKVLWGSWYDHVKGWWDV--K 192
Cdd:PLN02164 150 THIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAyqE 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554  193 DKHRILYLFYEDMKEDPKREIKKIVKFLEKDISEE-----VLNKIIHHTSFDVMKqNPMAN-----YTTLPSSimdHSIS 262
Cdd:PLN02164 230 NPDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANkgekdREDRPAV---YANS 305

                        250       260       270
                 ....*....|....*....|....*....|....
gi 40254554  263 PFMRKGMPGDWKNYFTVAQSEDFDEDYRKKMAGS 296
Cdd:PLN02164 306 AYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGT 339
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
46-297 1.41e-114

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 330.84  E-value: 1.41e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554    46 PDDLLIATYAKAGTTWTQEIVDMIQNDGDVQKCQRA---NTYDRHPFIEWTLP---PPLNSGLDLANKMPSPRTLKTHLP 119
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPhlfNNHNRSPFLEWYPGdtyFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554   120 VQMLPPSFWKENSKIIYVARNAKDCLVSYYYFSRMNKMLPDPGTLGEYIETFKAGKVLWGSWYDHVKGWWDVKDKHRILY 199
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554   200 LFYEDMKEDPKREIKKIVKFLEKDISEEVLNKIIHHTSFDVMKQNPMANYTTLPSsimdhSISPFMRKGMPGDWKNYFTV 279
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPK-----EVSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 40254554   280 AQSEDFDEDYRKKMAGST 297
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 42-296 5.27e-29

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 113.48  E-value: 5.27e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554   42 FQAKPDDLLIATYAKAGTTWTQEIVDMIQN----DGDVQKCQRANTYDRHPFIEWTLP--PPLNSGLDLANKMPSprtlk 115
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANrsrfDDSSNPLLKRNPHEFVPYIEIDFPffPSVDVLKDKGNTLFS----- 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554  116 THLPVQMLPPSFWKENSKIIYVARNAKDCLVSYYYFSRMNKMLPDP-GTLGEYIETFKAGKVLWGSWYDHVKGWWDV--K 192
Cdd:PLN02164 150 THIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAyqE 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554  193 DKHRILYLFYEDMKEDPKREIKKIVKFLEKDISEE-----VLNKIIHHTSFDVMKqNPMAN-----YTTLPSSimdHSIS 262
Cdd:PLN02164 230 NPDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANkgekdREDRPAV---YANS 305

                        250       260       270
                 ....*....|....*....|....*....|....
gi 40254554  263 PFMRKGMPGDWKNYFTVAQSEDFDEDYRKKMAGS 296
Cdd:PLN02164 306 AYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGT 339
Sulfotransfer_3 pfam13469
Sulfotransferase family;
104-221 2.77e-05

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 43.82  E-value: 2.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254554   104 LANKMPSP----RTLKTHLPvqmlppsfwkeNSKIIYVARNAKDC----LVSYYYFSRMNKMLPDPGTLGEYIETfkagk 175
Cdd:pfam13469  61 LCDKSPSHlfhlDLLLKAFP-----------DAKFIHLHRDPVDTvissYCSLFGFTLSSYSTAFLRDIGLALAR----- 124

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 40254554   176 vlwgsWYDHVKGW---WDVKDKHRILYLFYEDMKEDPKREIKKIVKFLE 221
Cdd:pfam13469 125 -----WSRAYERLmaaRARVPPGRFLDVRYEDLVADPEGTLRRILEFLG 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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