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FAST kinase domain-containing protein 4 isoform 2 [Homo sapiens]
FAST kinase domain-containing protein( domain architecture ID 10535844)
FAST kinase domain-containing protein similar to human Fas-activated serine/threonine (FAST) kinase that phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
TBRG4-like_N | cd23739 | transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted ... |
96-271 | 1.66e-61 | ||||
transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted alpha-helical domain N-terminal to FAST kinase-like protein, subdomain 1 (FAST_1); TBRG4 also called cell cycle progression restoration protein 2 or Fas-activated serine-threonine (FAST) kinase domain-containing protein 4, is a regulator of TGFbeta and is implicated in numerous types of cancer. It serves a role in the tumorigenesis of lung cancer via deregulation of DNA damage-inducible transcript 3 (DDIT3), caveolin 1 (CAV1), and ribonucleotide reductase regulatory subunit M2 (RRM2). This domain lies N-terminal to the FAST_1 domain, and is predicted (by AlphaFold) to be alpha-helical, with similarity to structures of members of the 6-hairpin (6 helical hairpin) clan. : Pssm-ID: 467932 [Multi-domain] Cd Length: 249 Bit Score: 202.11 E-value: 1.66e-61
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FAST_2 | pfam08368 | FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ... |
341-426 | 6.98e-29 | ||||
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2. : Pssm-ID: 462448 Cd Length: 89 Bit Score: 109.19 E-value: 6.98e-29
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FAST_1 | pfam06743 | FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ... |
259-330 | 9.17e-23 | ||||
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2. : Pssm-ID: 461999 [Multi-domain] Cd Length: 72 Bit Score: 91.78 E-value: 9.17e-23
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RAP | smart00952 | This domain is found in various eukaryotic species, particularly in apicomplexans; In ... |
453-510 | 1.67e-13 | ||||
This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. : Pssm-ID: 214932 Cd Length: 58 Bit Score: 64.95 E-value: 1.67e-13
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Name | Accession | Description | Interval | E-value | ||||
TBRG4-like_N | cd23739 | transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted ... |
96-271 | 1.66e-61 | ||||
transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted alpha-helical domain N-terminal to FAST kinase-like protein, subdomain 1 (FAST_1); TBRG4 also called cell cycle progression restoration protein 2 or Fas-activated serine-threonine (FAST) kinase domain-containing protein 4, is a regulator of TGFbeta and is implicated in numerous types of cancer. It serves a role in the tumorigenesis of lung cancer via deregulation of DNA damage-inducible transcript 3 (DDIT3), caveolin 1 (CAV1), and ribonucleotide reductase regulatory subunit M2 (RRM2). This domain lies N-terminal to the FAST_1 domain, and is predicted (by AlphaFold) to be alpha-helical, with similarity to structures of members of the 6-hairpin (6 helical hairpin) clan. Pssm-ID: 467932 [Multi-domain] Cd Length: 249 Bit Score: 202.11 E-value: 1.66e-61
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FAST_2 | pfam08368 | FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ... |
341-426 | 6.98e-29 | ||||
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2. Pssm-ID: 462448 Cd Length: 89 Bit Score: 109.19 E-value: 6.98e-29
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FAST_1 | pfam06743 | FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ... |
259-330 | 9.17e-23 | ||||
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2. Pssm-ID: 461999 [Multi-domain] Cd Length: 72 Bit Score: 91.78 E-value: 9.17e-23
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RAP | smart00952 | This domain is found in various eukaryotic species, particularly in apicomplexans; In ... |
453-510 | 1.67e-13 | ||||
This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. Pssm-ID: 214932 Cd Length: 58 Bit Score: 64.95 E-value: 1.67e-13
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RAP | pfam08373 | RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ... |
456-510 | 2.45e-11 | ||||
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection. Pssm-ID: 429953 Cd Length: 58 Bit Score: 58.75 E-value: 2.45e-11
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Name | Accession | Description | Interval | E-value | ||||
TBRG4-like_N | cd23739 | transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted ... |
96-271 | 1.66e-61 | ||||
transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted alpha-helical domain N-terminal to FAST kinase-like protein, subdomain 1 (FAST_1); TBRG4 also called cell cycle progression restoration protein 2 or Fas-activated serine-threonine (FAST) kinase domain-containing protein 4, is a regulator of TGFbeta and is implicated in numerous types of cancer. It serves a role in the tumorigenesis of lung cancer via deregulation of DNA damage-inducible transcript 3 (DDIT3), caveolin 1 (CAV1), and ribonucleotide reductase regulatory subunit M2 (RRM2). This domain lies N-terminal to the FAST_1 domain, and is predicted (by AlphaFold) to be alpha-helical, with similarity to structures of members of the 6-hairpin (6 helical hairpin) clan. Pssm-ID: 467932 [Multi-domain] Cd Length: 249 Bit Score: 202.11 E-value: 1.66e-61
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FAST_2 | pfam08368 | FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ... |
341-426 | 6.98e-29 | ||||
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2. Pssm-ID: 462448 Cd Length: 89 Bit Score: 109.19 E-value: 6.98e-29
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FAST_1 | pfam06743 | FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ... |
259-330 | 9.17e-23 | ||||
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2. Pssm-ID: 461999 [Multi-domain] Cd Length: 72 Bit Score: 91.78 E-value: 9.17e-23
|
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RAP | smart00952 | This domain is found in various eukaryotic species, particularly in apicomplexans; In ... |
453-510 | 1.67e-13 | ||||
This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. Pssm-ID: 214932 Cd Length: 58 Bit Score: 64.95 E-value: 1.67e-13
|
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RAP | pfam08373 | RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ... |
456-510 | 2.45e-11 | ||||
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection. Pssm-ID: 429953 Cd Length: 58 Bit Score: 58.75 E-value: 2.45e-11
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Blast search parameters | ||||
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