NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|401405448|ref|XP_003882174|]
View 

putative GMC oxidoreductase [Neospora caninum Liverpool]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN02785 super family cl33566
Protein HOTHEAD
 122-648 1.06e-23

Protein HOTHEAD


The actual alignment was detected with superfamily member PLN02785:

Pssm-ID: 215420 [Multi-domain]  Cd Length: 587  Bit Score: 106.81  E-value: 1.06e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 122 EVFDYIVVGAGAAGCPFARTMADAGKrVLVIERGHAR-SRAQTPAAMDLNGAGRGINDDSISQPVITTQGVRTHIGKVTG 200
Cdd:PLN02785  54 SAYDYIVVGGGTAGCPLAATLSQNFS-VLLLERGGVPfGNANVSFLENFHIGLADTSPTSASQAFISTDGVINARARVLG 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 201 GGTSVNVGIMVRELDEYFHflndQYGhsWDTKTLRKASTWIEDKVsCPMPQENAFSRAICQGLADQGFTPHGGFdatgkn 280
Cdd:PLN02785 133 GGTCINAGFYSRASTRFIQ----KAG--WDAKLVNESYPWVERQI-VHWPKVAPWQAALRDSLLEVGVSPFNGF------ 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 281 yTYPipvsaELRHGEFWGamSLFNSSasGFRN-AADLFlvdefsgAESIENftpakNIELLTDHIVLKVLFDRSGNRPRA 359
Cdd:PLN02785 200 -TYD-----HVYGTKVGG--TIFDEF--GRRHtAAELL-------AAGNPN-----KLRVLLHATVQKIVFDTSGKRPRA 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 360 RCVNYrrtqesdlaslgegpprRRENnigARPAETLLSKvgsffaprvyhacvKEDGEIVMSSGAILSAVNLFKSGVGPA 439
Cdd:PLN02785 258 TGVIF-----------------KDEN---GNQHQAFLSN--------------NKGSEIILSAGAIGSPQMLLLSGIGPK 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 440 EQIKALGLPLVLDVPQLGQRFSDR----IAVPigvflTRR--QQQTFSKPRISDvigFRAFGPDCSDFKIGERTLKCTQV 513
Cdd:PLN02785 304 KELKKHKIPVVLHNEHVGKGMADNpmnsIFVP-----SKApvEQSLIQTVGITK---MGVYIEASSGFGQSPDSIHCHHG 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 514 IVETMYGphamdgpiyaARALVPPHLRNTRVIEAtfqifsrcaqLSRRERFLkpvclvlnrgiecaSRTAVQFSFTSE-- 591
Cdd:PLN02785 376 IMSAEIG----------QLSTIPPKQRTPEAIQA----------YIHRKKNL--------------PHEAFNGGFILEki 421

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 401405448 592 --PKSRGYVSL---DKDGKVTVEANYLKDPQDFFDAVRGVQLAIERVNGDAFRGLIDSVGKT 648
Cdd:PLN02785 422 agPISTGHLSLintNVDDNPSVTFNYFKHPQDLQRCVYGIRTIEKIVKTNHFTNFTQCDKQT 483
GMC_oxred_C pfam05199
GMC oxidoreductase; This domain found associated with pfam00732.
 849-933 8.26e-17

GMC oxidoreductase; This domain found associated with pfam00732.


:

Pssm-ID: 398739 [Multi-domain]  Cd Length: 143  Bit Score: 78.21  E-value: 8.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448  849 VLKRDVPAFLSSASAPDDpkEIAEYVLTYMSSIWHHAGTAEMGT-----VVDDLFRVKGLDGLSIVDASVLPQITRGNPT 923
Cdd:pfam05199  56 LTPGPVPEVSDAAVTSDD--ELLAYIRAAASTSYHPMGTCRMGAdpddaVVDPDLRVHGVDNLRVVDASVFPSSPSGNPT 133

                          90
                  ....*....|
gi 401405448  924 ATLLLMGRYA 933
Cdd:pfam05199 134 LTIYALAERA 143
 
Name Accession Description Interval E-value
PLN02785 PLN02785
Protein HOTHEAD
 122-648 1.06e-23

Protein HOTHEAD


Pssm-ID: 215420 [Multi-domain]  Cd Length: 587  Bit Score: 106.81  E-value: 1.06e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 122 EVFDYIVVGAGAAGCPFARTMADAGKrVLVIERGHAR-SRAQTPAAMDLNGAGRGINDDSISQPVITTQGVRTHIGKVTG 200
Cdd:PLN02785  54 SAYDYIVVGGGTAGCPLAATLSQNFS-VLLLERGGVPfGNANVSFLENFHIGLADTSPTSASQAFISTDGVINARARVLG 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 201 GGTSVNVGIMVRELDEYFHflndQYGhsWDTKTLRKASTWIEDKVsCPMPQENAFSRAICQGLADQGFTPHGGFdatgkn 280
Cdd:PLN02785 133 GGTCINAGFYSRASTRFIQ----KAG--WDAKLVNESYPWVERQI-VHWPKVAPWQAALRDSLLEVGVSPFNGF------ 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 281 yTYPipvsaELRHGEFWGamSLFNSSasGFRN-AADLFlvdefsgAESIENftpakNIELLTDHIVLKVLFDRSGNRPRA 359
Cdd:PLN02785 200 -TYD-----HVYGTKVGG--TIFDEF--GRRHtAAELL-------AAGNPN-----KLRVLLHATVQKIVFDTSGKRPRA 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 360 RCVNYrrtqesdlaslgegpprRRENnigARPAETLLSKvgsffaprvyhacvKEDGEIVMSSGAILSAVNLFKSGVGPA 439
Cdd:PLN02785 258 TGVIF-----------------KDEN---GNQHQAFLSN--------------NKGSEIILSAGAIGSPQMLLLSGIGPK 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 440 EQIKALGLPLVLDVPQLGQRFSDR----IAVPigvflTRR--QQQTFSKPRISDvigFRAFGPDCSDFKIGERTLKCTQV 513
Cdd:PLN02785 304 KELKKHKIPVVLHNEHVGKGMADNpmnsIFVP-----SKApvEQSLIQTVGITK---MGVYIEASSGFGQSPDSIHCHHG 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 514 IVETMYGphamdgpiyaARALVPPHLRNTRVIEAtfqifsrcaqLSRRERFLkpvclvlnrgiecaSRTAVQFSFTSE-- 591
Cdd:PLN02785 376 IMSAEIG----------QLSTIPPKQRTPEAIQA----------YIHRKKNL--------------PHEAFNGGFILEki 421

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 401405448 592 --PKSRGYVSL---DKDGKVTVEANYLKDPQDFFDAVRGVQLAIERVNGDAFRGLIDSVGKT 648
Cdd:PLN02785 422 agPISTGHLSLintNVDDNPSVTFNYFKHPQDLQRCVYGIRTIEKIVKTNHFTNFTQCDKQT 483
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 120-644 2.59e-20

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 95.67  E-value: 2.59e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 120 PQEVFDYIVVGAGAAGCPFARTMA-DAGKRVLVIERGHARSR--AQTPAAM--DLNGAGRGINDDSISQPVITTQGVRTH 194
Cdd:COG2303    1 MLEEYDYVIVGAGSAGCVLANRLSeDAGLRVLLLEAGGRDDDplIRMPAGYakLLGNPRYDWRYETEPQPGLNGRRLYWP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 195 IGKVTGGGTSVNVGIMVR--------------------ELDEYF------HFLNDQY-GHS--WDTKTLRKAS----TWI 241
Cdd:COG2303   81 RGKVLGGSSSINGMIYVRgqpedfdlwaqlgnqgwgydDVLPYFkraednERGADAYhGRSgpLPVSDPPLPNplsdAFI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 242 EDKVSCPMPQENAFSRAICQGLadqgftphGGFDATGKNytypipvsaelrhgefwGAMSlfnSSASGFRNAADlflvde 321
Cdd:COG2303  161 EAAEELGIPRADDFNGGACEGC--------GFCQVTCRN-----------------GARW---SAARAYLPPAL------ 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 322 fsgaesienftPAKNIELLTDHIVLKVLFDrsGNrpRARCVNYRRtqesdlaslgEGppRRREnnigARPAetllskvgs 401
Cdd:COG2303  207 -----------KRPNLTVRTGALVTRILFD--GG--RATGVEYRD----------DG--EEHT----VRAA--------- 246

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 402 ffaprvyhacvkedGEIVMSSGAILSAVNLFKSGVGPAEQIKALGLPLVLDVPQLGQRFSDRIAVPIGVFLTRRQQQTFS 481
Cdd:COG2303  247 --------------REVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLPGVGRNLQDHLEVSVVFRFKEPVTLNKS 312

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 482 KPRISDVIGFRAF--GP------DCSDFKIGERTLkcTQVIVETMYGPHAMDgPIYAARALVPPHlrntrvieaTFQIFs 553
Cdd:COG2303  313 LRKARIGLQYLLTrsGPltsnvaEAGGFFRSDPGL--ERPDLQFHFLPLGLT-PRWGKKALHDGH---------GFTAH- 379

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 554 rcaqlsrrerflkpVCLVlnrgiecasrtavqfsftsEPKSRGYVSL---DKDGKVTVEANYLKDPQDFFDAVRGVQLAI 630
Cdd:COG2303  380 --------------VEQL-------------------RPESRGRVTLdsaDPLGAPLIRPNYLSDENDRRVLVAGVRLAR 426

                        570
                 ....*....|....
gi 401405448 631 ERVNGDAFRGLIDS 644
Cdd:COG2303  427 EIAAQPALAPYRGE 440
GMC_oxred_C pfam05199
GMC oxidoreductase; This domain found associated with pfam00732.
 849-933 8.26e-17

GMC oxidoreductase; This domain found associated with pfam00732.


Pssm-ID: 398739 [Multi-domain]  Cd Length: 143  Bit Score: 78.21  E-value: 8.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448  849 VLKRDVPAFLSSASAPDDpkEIAEYVLTYMSSIWHHAGTAEMGT-----VVDDLFRVKGLDGLSIVDASVLPQITRGNPT 923
Cdd:pfam05199  56 LTPGPVPEVSDAAVTSDD--ELLAYIRAAASTSYHPMGTCRMGAdpddaVVDPDLRVHGVDNLRVVDASVFPSSPSGNPT 133

                          90
                  ....*....|
gi 401405448  924 ATLLLMGRYA 933
Cdd:pfam05199 134 LTIYALAERA 143
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 869-934 5.81e-14

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 75.63  E-value: 5.81e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 869 EIAEYVLTYMSSIWHHAGTAEMGT----VVDDLFRVKGLDGLSIVDASVLPQITRGNPTATLLLMGRYAA 934
Cdd:COG2303  452 EELAFIRARAYTIYHPVGTCRMGTdpdsVVDPRLRVHGVENLRVVDASVMPTITSGNTNAPTIMLAEKAA 521
PRK02106 PRK02106
choline dehydrogenase; Validated
 869-934 1.37e-10

choline dehydrogenase; Validated


Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 64.85  E-value: 1.37e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 869 EIAEYVLTYMSSIWHHAGTAEMGT----VVDDLFRVKGLDGLSIVDASVLPQITRGNPTATLLLMGRYAA 934
Cdd:PRK02106 459 EIDAFVREHAETAYHPSCTCKMGTdpmaVVDPEGRVHGVEGLRVVDASIMPTITNGNLNAPTIMIAEKAA 528
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 124-244 1.46e-06

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 51.17  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448  124 FDYIVVGAGAAGCPFARTMADAGKRVLVIERgHARSR------AQTPAAMDLNgagrGINDDSISQPVIttqGVRTHIgk 197
Cdd:TIGR02032   1 YDVVVVGAGPAGASAAYRLADKGLRVLLLEK-KSFPRykpcggALSPRALEEL----DLPGELIVNLVR---GARFFS-- 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 401405448  198 vtGGGTSVNVGI-----MVRELDEYFHFLNDQ---YGHSWDTKTlRKASTWIEDK 244
Cdd:TIGR02032  71 --PNGDSVEIPIetelaYVIDRDAFDEQLAERaqeAGAELRLGT-RVLDVEIHDD 122
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
128-161 3.53e-05

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 42.52  E-value: 3.53e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 401405448  128 VVGAGAAGCPFARTMADAGKRVLVIER-----GHARSRA 161
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKrdrlgGNAYSYR 39
 
Name Accession Description Interval E-value
PLN02785 PLN02785
Protein HOTHEAD
 122-648 1.06e-23

Protein HOTHEAD


Pssm-ID: 215420 [Multi-domain]  Cd Length: 587  Bit Score: 106.81  E-value: 1.06e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 122 EVFDYIVVGAGAAGCPFARTMADAGKrVLVIERGHAR-SRAQTPAAMDLNGAGRGINDDSISQPVITTQGVRTHIGKVTG 200
Cdd:PLN02785  54 SAYDYIVVGGGTAGCPLAATLSQNFS-VLLLERGGVPfGNANVSFLENFHIGLADTSPTSASQAFISTDGVINARARVLG 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 201 GGTSVNVGIMVRELDEYFHflndQYGhsWDTKTLRKASTWIEDKVsCPMPQENAFSRAICQGLADQGFTPHGGFdatgkn 280
Cdd:PLN02785 133 GGTCINAGFYSRASTRFIQ----KAG--WDAKLVNESYPWVERQI-VHWPKVAPWQAALRDSLLEVGVSPFNGF------ 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 281 yTYPipvsaELRHGEFWGamSLFNSSasGFRN-AADLFlvdefsgAESIENftpakNIELLTDHIVLKVLFDRSGNRPRA 359
Cdd:PLN02785 200 -TYD-----HVYGTKVGG--TIFDEF--GRRHtAAELL-------AAGNPN-----KLRVLLHATVQKIVFDTSGKRPRA 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 360 RCVNYrrtqesdlaslgegpprRRENnigARPAETLLSKvgsffaprvyhacvKEDGEIVMSSGAILSAVNLFKSGVGPA 439
Cdd:PLN02785 258 TGVIF-----------------KDEN---GNQHQAFLSN--------------NKGSEIILSAGAIGSPQMLLLSGIGPK 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 440 EQIKALGLPLVLDVPQLGQRFSDR----IAVPigvflTRR--QQQTFSKPRISDvigFRAFGPDCSDFKIGERTLKCTQV 513
Cdd:PLN02785 304 KELKKHKIPVVLHNEHVGKGMADNpmnsIFVP-----SKApvEQSLIQTVGITK---MGVYIEASSGFGQSPDSIHCHHG 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 514 IVETMYGphamdgpiyaARALVPPHLRNTRVIEAtfqifsrcaqLSRRERFLkpvclvlnrgiecaSRTAVQFSFTSE-- 591
Cdd:PLN02785 376 IMSAEIG----------QLSTIPPKQRTPEAIQA----------YIHRKKNL--------------PHEAFNGGFILEki 421

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 401405448 592 --PKSRGYVSL---DKDGKVTVEANYLKDPQDFFDAVRGVQLAIERVNGDAFRGLIDSVGKT 648
Cdd:PLN02785 422 agPISTGHLSLintNVDDNPSVTFNYFKHPQDLQRCVYGIRTIEKIVKTNHFTNFTQCDKQT 483
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 120-644 2.59e-20

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 95.67  E-value: 2.59e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 120 PQEVFDYIVVGAGAAGCPFARTMA-DAGKRVLVIERGHARSR--AQTPAAM--DLNGAGRGINDDSISQPVITTQGVRTH 194
Cdd:COG2303    1 MLEEYDYVIVGAGSAGCVLANRLSeDAGLRVLLLEAGGRDDDplIRMPAGYakLLGNPRYDWRYETEPQPGLNGRRLYWP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 195 IGKVTGGGTSVNVGIMVR--------------------ELDEYF------HFLNDQY-GHS--WDTKTLRKAS----TWI 241
Cdd:COG2303   81 RGKVLGGSSSINGMIYVRgqpedfdlwaqlgnqgwgydDVLPYFkraednERGADAYhGRSgpLPVSDPPLPNplsdAFI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 242 EDKVSCPMPQENAFSRAICQGLadqgftphGGFDATGKNytypipvsaelrhgefwGAMSlfnSSASGFRNAADlflvde 321
Cdd:COG2303  161 EAAEELGIPRADDFNGGACEGC--------GFCQVTCRN-----------------GARW---SAARAYLPPAL------ 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 322 fsgaesienftPAKNIELLTDHIVLKVLFDrsGNrpRARCVNYRRtqesdlaslgEGppRRREnnigARPAetllskvgs 401
Cdd:COG2303  207 -----------KRPNLTVRTGALVTRILFD--GG--RATGVEYRD----------DG--EEHT----VRAA--------- 246

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 402 ffaprvyhacvkedGEIVMSSGAILSAVNLFKSGVGPAEQIKALGLPLVLDVPQLGQRFSDRIAVPIGVFLTRRQQQTFS 481
Cdd:COG2303  247 --------------REVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLPGVGRNLQDHLEVSVVFRFKEPVTLNKS 312

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 482 KPRISDVIGFRAF--GP------DCSDFKIGERTLkcTQVIVETMYGPHAMDgPIYAARALVPPHlrntrvieaTFQIFs 553
Cdd:COG2303  313 LRKARIGLQYLLTrsGPltsnvaEAGGFFRSDPGL--ERPDLQFHFLPLGLT-PRWGKKALHDGH---------GFTAH- 379

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 554 rcaqlsrrerflkpVCLVlnrgiecasrtavqfsftsEPKSRGYVSL---DKDGKVTVEANYLKDPQDFFDAVRGVQLAI 630
Cdd:COG2303  380 --------------VEQL-------------------RPESRGRVTLdsaDPLGAPLIRPNYLSDENDRRVLVAGVRLAR 426

                        570
                 ....*....|....
gi 401405448 631 ERVNGDAFRGLIDS 644
Cdd:COG2303  427 EIAAQPALAPYRGE 440
GMC_oxred_C pfam05199
GMC oxidoreductase; This domain found associated with pfam00732.
 849-933 8.26e-17

GMC oxidoreductase; This domain found associated with pfam00732.


Pssm-ID: 398739 [Multi-domain]  Cd Length: 143  Bit Score: 78.21  E-value: 8.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448  849 VLKRDVPAFLSSASAPDDpkEIAEYVLTYMSSIWHHAGTAEMGT-----VVDDLFRVKGLDGLSIVDASVLPQITRGNPT 923
Cdd:pfam05199  56 LTPGPVPEVSDAAVTSDD--ELLAYIRAAASTSYHPMGTCRMGAdpddaVVDPDLRVHGVDNLRVVDASVFPSSPSGNPT 133

                          90
                  ....*....|
gi 401405448  924 ATLLLMGRYA 933
Cdd:pfam05199 134 LTIYALAERA 143
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 869-934 5.81e-14

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 75.63  E-value: 5.81e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 869 EIAEYVLTYMSSIWHHAGTAEMGT----VVDDLFRVKGLDGLSIVDASVLPQITRGNPTATLLLMGRYAA 934
Cdd:COG2303  452 EELAFIRARAYTIYHPVGTCRMGTdpdsVVDPRLRVHGVENLRVVDASVMPTITSGNTNAPTIMLAEKAA 521
PRK02106 PRK02106
choline dehydrogenase; Validated
 121-462 3.26e-12

choline dehydrogenase; Validated


Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 70.25  E-value: 3.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 121 QEVFDYIVVGAGAAGCPFA-RTMADAGKRVLVIERGHARSRA----QTPAAMDLNGAGRGINDDSISQPVITTQGVRTHI 195
Cdd:PRK02106   3 TMEYDYIIIGAGSAGCVLAnRLSEDPDVSVLLLEAGGPDYRWdffiQMPAALAFPLQGKRYNWAYETEPEPHMNNRRMEC 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 196 --GKVTGGGTSVNVGIMVR--ELDeYfhflnDQYGHS-----WDTKT----LRKASTWI--ED---------KVSCPMPQ 251
Cdd:PRK02106  83 prGKVLGGSSSINGMVYIRgnAMD-Y-----DNWAELpglegWSYADclpyFKKAETRDggEDdyrggdgplSVTRGKPG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 252 EN----AFSRAICQ----------GLADQGFTPhggFDATGKNytypipvsaelrhGEFWgamslfnSSASGFrnaadlf 317
Cdd:PRK02106 157 TNplfqAFVEAGVQagyprtddlnGYQQEGFGP---MDRTVTN-------------GRRW-------SAARAY------- 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 318 lvdefsgaesienFTPAK---NIELLTDHIVLKVLFDrsGNrpRARCVNYRRtqesdlaslGEGPPRRRENNigarpaet 394
Cdd:PRK02106 207 -------------LDPALkrpNLTIVTHALTDRILFE--GK--RAVGVEYER---------GGGRETARARR-------- 252

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 401405448 395 llskvgsffaprvyhacvkedgEIVMSSGAILSAVNLFKSGVGPAEQIKALGLPLVLDVPQLGQRFSD 462
Cdd:PRK02106 253 ----------------------EVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPGVGENLQD 298
PRK02106 PRK02106
choline dehydrogenase; Validated
 869-934 1.37e-10

choline dehydrogenase; Validated


Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 64.85  E-value: 1.37e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 869 EIAEYVLTYMSSIWHHAGTAEMGT----VVDDLFRVKGLDGLSIVDASVLPQITRGNPTATLLLMGRYAA 934
Cdd:PRK02106 459 EIDAFVREHAETAYHPSCTCKMGTdpmaVVDPEGRVHGVEGLRVVDASIMPTITNGNLNAPTIMIAEKAA 528
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 124-244 1.46e-06

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 51.17  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448  124 FDYIVVGAGAAGCPFARTMADAGKRVLVIERgHARSR------AQTPAAMDLNgagrGINDDSISQPVIttqGVRTHIgk 197
Cdd:TIGR02032   1 YDVVVVGAGPAGASAAYRLADKGLRVLLLEK-KSFPRykpcggALSPRALEEL----DLPGELIVNLVR---GARFFS-- 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 401405448  198 vtGGGTSVNVGI-----MVRELDEYFHFLNDQ---YGHSWDTKTlRKASTWIEDK 244
Cdd:TIGR02032  71 --PNGDSVEIPIetelaYVIDRDAFDEQLAERaqeAGAELRLGT-RVLDVEIHDD 122
PTZ00367 PTZ00367
squalene epoxidase; Provisional
 119-154 5.83e-06

squalene epoxidase; Provisional


Pssm-ID: 240384 [Multi-domain]  Cd Length: 567  Bit Score: 50.23  E-value: 5.83e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 401405448 119 RPQEVFDYIVVGAGAAGCPFARTMADAGKRVLVIER 154
Cdd:PTZ00367  29 RTNYDYDVIIVGGSIAGPVLAKALSKQGRKVLMLER 64
PRK06370 PRK06370
FAD-containing oxidoreductase;
119-156 8.46e-06

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 49.43  E-value: 8.46e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 401405448 119 RPQEVFDYIVVGAGAAGCPFARTMADAGKRVLVIERGH 156
Cdd:PRK06370   1 TPAQRYDAIVIGAGQAGPPLAARAAGLGMKVALIERGL 38
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 124-156 1.48e-05

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 48.54  E-value: 1.48e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 401405448 124 FDYIVVGAGAAGCPFARTMADAGKRVLVIERGH 156
Cdd:COG1249    4 YDLVVIGAGPGGYVAAIRAAQLGLKVALVEKGR 36
PRK10015 PRK10015
oxidoreductase; Provisional
 121-157 2.11e-05

oxidoreductase; Provisional


Pssm-ID: 182194 [Multi-domain]  Cd Length: 429  Bit Score: 48.05  E-value: 2.11e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 401405448 121 QEVFDYIVVGAGAAGCPFARTMADAGKRVLVIERGHA 157
Cdd:PRK10015   3 DDKFDAIVVGAGVAGSVAALVMARAGLDVLVIERGDS 39
PRK09126 PRK09126
FAD-dependent hydroxylase;
124-165 2.30e-05

FAD-dependent hydroxylase;


Pssm-ID: 236385 [Multi-domain]  Cd Length: 392  Bit Score: 47.63  E-value: 2.30e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 401405448 124 FDYIVVGAGAAGCPFARTMADAGKRVLVIERgHARSRAQTPA 165
Cdd:PRK09126   4 SDIVVVGAGPAGLSFARSLAGSGLKVTLIER-QPLAALADPA 44
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
128-161 3.53e-05

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 42.52  E-value: 3.53e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 401405448  128 VVGAGAAGCPFARTMADAGKRVLVIER-----GHARSRA 161
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKrdrlgGNAYSYR 39
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
125-161 1.01e-04

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 45.67  E-value: 1.01e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 401405448 125 DYIVVGAGAAGCPFARTMADAGKRVLVIERGHARSRA 161
Cdd:COG0665    4 DVVVIGGGIAGLSTAYHLARRGLDVTVLERGRPGSGA 40
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 124-155 1.70e-04

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 44.62  E-value: 1.70e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 401405448  124 FDYIVVGAGAAGCPFARTMADAGKRVLVIERG 155
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIEDE 32
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 124-156 5.07e-04

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 43.63  E-value: 5.07e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 401405448 124 FDYIVVGAGAAGCPFARTMADAGKRVLVIERGH 156
Cdd:PRK06292   4 YDVIVIGAGPAGYVAARRAAKLGKKVALIEKGP 36
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 124-181 6.19e-04

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 43.28  E-value: 6.19e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 401405448 124 FDYIVVGAGAAGCPFARTMADAGKRVLVIE-----RGH-ARSRAQTPAAMdlNGAGRGINDDSI 181
Cdd:COG1053    4 YDVVVVGSGGAGLRAALEAAEAGLKVLVLEkvpprGGHtAAAQGGINAAG--TNVQKAAGEDSP 65
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 125-161 7.56e-04

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 43.05  E-value: 7.56e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 401405448  125 DYIVVGAGAAGCPFARTMADAGKRVLVIERGHARSRA 161
Cdd:pfam00890   1 DVLVIGGGLAGLAAALAAAEAGLKVAVVEKGQPFGGA 37
PRK10157 PRK10157
putative oxidoreductase FixC; Provisional
 121-157 9.98e-04

putative oxidoreductase FixC; Provisional


Pssm-ID: 182273 [Multi-domain]  Cd Length: 428  Bit Score: 42.59  E-value: 9.98e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 401405448 121 QEVFDYIVVGAGAAGCPFARTMADAGKRVLVIERGHA 157
Cdd:PRK10157   3 EDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNS 39
HI0933_like pfam03486
HI0933-like protein;
124-155 1.35e-03

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 42.18  E-value: 1.35e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 401405448  124 FDYIVVGAGAAGCPFARTMADAGKRVLVIERG 155
Cdd:pfam03486   1 FDVIVIGGGAAGLMAAISAAKRGRRVLLIEKG 32
GMC_oxred_C pfam05199
GMC oxidoreductase; This domain found associated with pfam00732.
 592-640 1.56e-03

GMC oxidoreductase; This domain found associated with pfam00732.


Pssm-ID: 398739 [Multi-domain]  Cd Length: 143  Bit Score: 40.07  E-value: 1.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 401405448  592 PKSRGYVSL---DKDGKVTVEANYLKDPQDFFDAVRGVQLAIERVNGDAFRG 640
Cdd:pfam05199   1 PRSRGRVTLsssDPTGLPVIDPNYLSDPADLAALRAALRLARRILAAAGLVL 52
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
117-161 1.73e-03

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 41.83  E-value: 1.73e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 401405448 117 ARRPQEVfDYIVVGAGAAG--CpfARTMADAGKRVLVIErghARSRA 161
Cdd:COG1231    2 SRRARGK-DVVIVGAGLAGlaA--ARELRKAGLDVTVLE---ARDRV 42
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
125-251 2.35e-03

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 41.76  E-value: 2.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401405448 125 DYIVVGAGAAGCPFARTMADAGKRVLVIERGHARSRAQTPAAMD-LNGA---GRGINDDSISQPVITTQGVrthIGKVTG 200
Cdd:PRK13800  15 DVLVIGGGTAGTMAALTAAEHGANVLLLEKAHVRHSGALAMGMDgVNNAvipGKAEPEDYVAEITRANDGI---VNQRTV 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 401405448 201 GGTSVNVGIMVRELDEY-FHFLNDQYGHSWDTKTLRKASTWIedkvscPMPQ 251
Cdd:PRK13800  92 YQTATRGFAMVQRLERYgVKFEKDEHGEYAVRRVHRSGSYVL------PMPE 137
COG2509 COG2509
FAD-dependent dehydrogenase [General function prediction only];
127-160 4.36e-03

FAD-dependent dehydrogenase [General function prediction only];


Pssm-ID: 441999 [Multi-domain]  Cd Length: 466  Bit Score: 40.48  E-value: 4.36e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 401405448 127 IVVGAGAAGCPFARTMADAGKRVLVIERGHA-RSR 160
Cdd:COG2509   34 VIVGAGPAGLFAALELAEAGLKPLVLERGKDvEER 68
COG3573 COG3573
Predicted oxidoreductase [General function prediction only];
125-154 7.81e-03

Predicted oxidoreductase [General function prediction only];


Pssm-ID: 442794 [Multi-domain]  Cd Length: 551  Bit Score: 39.78  E-value: 7.81e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 401405448 125 DYIVVGAGAAGCPFARTMADAGKRVLVIER 154
Cdd:COG3573    7 DVIVVGAGLAGLVAAAELADAGRRVLLLDQ 36
PRK12834 PRK12834
putative FAD-binding dehydrogenase; Reviewed
 125-153 7.90e-03

putative FAD-binding dehydrogenase; Reviewed


Pssm-ID: 183782 [Multi-domain]  Cd Length: 549  Bit Score: 39.88  E-value: 7.90e-03
                         10        20
                 ....*....|....*....|....*....
gi 401405448 125 DYIVVGAGAAGCPFARTMADAGKRVLVIE 153
Cdd:PRK12834   6 DVIVVGAGLAGLVAAAELADAGKRVLLLD 34
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 124-159 8.09e-03

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 39.83  E-value: 8.09e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 401405448 124 FDYIVVGAG----AAGCpfarTMADAGKRVLVIER-----GHARS 159
Cdd:COG1233    4 YDVVVIGAGigglAAAA----LLARAGYRVTVLEKndtpgGRART 44
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
127-155 8.75e-03

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 39.65  E-value: 8.75e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 401405448 127 IVVGAGAAG--CpfARTMADAGKRVLVIERG 155
Cdd:COG2081    1 IVIGAGAAGlmA--AITAAERGARVLLLEKN 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH