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Conserved domains on  [gi|40044480|emb|CAF01016|]
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unnamed protein product, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CR6_interact super family cl25690
Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family ...
 1-100 1.16e-20

Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity.


The actual alignment was detected with superfamily member pfam10147:

Pssm-ID: 431088 [Multi-domain]  Cd Length: 204  Bit Score: 81.44  E-value: 1.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40044480     1 MQESLRVKQLAEEQKRREREQHIAECMAKMPQMIVNWQQQQRENWEKAQADKERRARLQAEAQELLGYQVDPRSARFQEL 80
Cdd:pfam10147  92 MLESNRAQKAEKEARRQAREQEIAKKMAKMPQWIADWNAQKAKREAEAQAAKERKERLVAEAREHFGFKVDPRDERFKEM 171

                          90       100
                  ....*....|....*....|
gi 40044480    81 LQDLEKKERK*LKEEKQKRK 100
Cdd:pfam10147 172 LQQKEKEDKKKVKEAKRKEK 191
 
Name Accession Description Interval E-value
CR6_interact pfam10147
Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family ...
 1-100 1.16e-20

Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity.


Pssm-ID: 431088 [Multi-domain]  Cd Length: 204  Bit Score: 81.44  E-value: 1.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40044480     1 MQESLRVKQLAEEQKRREREQHIAECMAKMPQMIVNWQQQQRENWEKAQADKERRARLQAEAQELLGYQVDPRSARFQEL 80
Cdd:pfam10147  92 MLESNRAQKAEKEARRQAREQEIAKKMAKMPQWIADWNAQKAKREAEAQAAKERKERLVAEAREHFGFKVDPRDERFKEM 171

                          90       100
                  ....*....|....*....|
gi 40044480    81 LQDLEKKERK*LKEEKQKRK 100
Cdd:pfam10147 172 LQQKEKEDKKKVKEAKRKEK 191
 
Name Accession Description Interval E-value
CR6_interact pfam10147
Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family ...
 1-100 1.16e-20

Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity.


Pssm-ID: 431088 [Multi-domain]  Cd Length: 204  Bit Score: 81.44  E-value: 1.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40044480     1 MQESLRVKQLAEEQKRREREQHIAECMAKMPQMIVNWQQQQRENWEKAQADKERRARLQAEAQELLGYQVDPRSARFQEL 80
Cdd:pfam10147  92 MLESNRAQKAEKEARRQAREQEIAKKMAKMPQWIADWNAQKAKREAEAQAAKERKERLVAEAREHFGFKVDPRDERFKEM 171

                          90       100
                  ....*....|....*....|
gi 40044480    81 LQDLEKKERK*LKEEKQKRK 100
Cdd:pfam10147 172 LQQKEKEDKKKVKEAKRKEK 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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