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Conserved domains on  [gi|39931107|sp|Q86WA6|]
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RecName: Full=Valacyclovir hydrolase; Short=VACVase; Short=Valacyclovirase; AltName: Full=Biphenyl hydrolase-like protein; AltName: Full=Biphenyl hydrolase-related protein; Short=Bph-rp; AltName: Full=Breast epithelial mucin-associated antigen; Short=MCNAA; Flags: Precursor

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 40-291 1.24e-46

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 155.93  E-value: 1.24e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107  40 TSAKVAVNGVQLHYQQTGEGDHAVLLLPGMLGSGETdFGPQLKNLNKKlFTVVAWDPRGYGHSRPPDRDFPadfFERDAK 119
Cdd:COG0596   3 TPRFVTVDGVRLHYREAGPDGPPVVLLHGLPGSSYE-WRPLIPALAAG-YRVIAPDLRGHGRSDKPAGGYT---LDDLAD 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107 120 DAVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIwganayVTDEDSMIYEGIRDVSKWSERTRKPLEALYGY 199
Cdd:COG0596  78 DLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVL------VDEVLAALAEPLRRPGLAPEALAALLRALART 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107 200 DYfartcekwvdgirqfkhlpdgnicRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNLHLRFA 279
Cdd:COG0596 152 DL------------------------RERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHFPPLEQP 207

                       250
                ....*....|..
gi 39931107 280 DEFNKLAEDFLQ 291
Cdd:COG0596 208 EAFAAALRDFLA 219
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 40-291 1.24e-46

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 155.93  E-value: 1.24e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107  40 TSAKVAVNGVQLHYQQTGEGDHAVLLLPGMLGSGETdFGPQLKNLNKKlFTVVAWDPRGYGHSRPPDRDFPadfFERDAK 119
Cdd:COG0596   3 TPRFVTVDGVRLHYREAGPDGPPVVLLHGLPGSSYE-WRPLIPALAAG-YRVIAPDLRGHGRSDKPAGGYT---LDDLAD 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107 120 DAVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIwganayVTDEDSMIYEGIRDVSKWSERTRKPLEALYGY 199
Cdd:COG0596  78 DLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVL------VDEVLAALAEPLRRPGLAPEALAALLRALART 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107 200 DYfartcekwvdgirqfkhlpdgnicRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNLHLRFA 279
Cdd:COG0596 152 DL------------------------RERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHFPPLEQP 207

                       250
                ....*....|..
gi 39931107 280 DEFNKLAEDFLQ 291
Cdd:COG0596 208 EAFAAALRDFLA 219
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 62-276 1.52e-24

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 98.73  E-value: 1.52e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107    62 AVLLLPGMLGSGEtDFGPQLKNLNKKLFTVVAWDPRGYGHSRPP--DRDFPADFFerdAKDAVDLMKALKFKKVSLLGWS 139
Cdd:pfam00561   2 PVLLLHGLPGSSD-LWRKLAPALARDGFRVIALDLRGFGKSSRPkaQDDYRTDDL---AEDLEYILEALGLEKVNLVGHS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107   140 DGGITALIAAAKYPSYIHKMVIWGANAYVTDEDSMIYEGIRDVSKWSERTR--------KPLEALYGYDYFARTCEK--- 208
Cdd:pfam00561  78 MGGLIALAYAAKYPDRVKALVLLGALDPPHELDEADRFILALFPGFFDGFVadfapnplGRLVAKLLALLLLRLRLLkal 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107   209 -------WVDGIRQFKHLPDGNI----------CRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGK 271
Cdd:pfam00561 158 pllnkrfPSGDYALAKSLVTGALlfietwstelRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDAG 237


                  ....*
gi 39931107   272 HNLHL 276
Cdd:pfam00561 238 HFAFL 242
PLN02578 PLN02578
hydrolase
 30-290 1.57e-03

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 39.44  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107   30 GPAAAFGTSVTSAKVAVNGVQ---------------------LHYQQTGEGDHAVLLLpgmlGSGETDFG-----PQLKn 83
Cdd:PLN02578  36 GGIVASGVSVMGSSSASQSVQglerlpfkkegynfwtwrghkIHYVVQGEGLPIVLIH----GFGASAFHwryniPELA- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107   84 lnkKLFTVVAWDPRGYGHSRPPDRDFPADFFERDAkdaVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIW- 162
Cdd:PLN02578 111 ---KKYKVYALDLLGFGWSDKALIEYDAMVWRDQV---ADFVKEVVKEPAVLVGNSLGGFTALSTAVGYPELVAGVALLn 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107  163 -----------GANAYVTDEDSM---IYEGIRDVSK--------WSERTRKPLEALYGYDYFARTC--EKWVDGIRQ--- 215
Cdd:PLN02578 185 sagqfgsesreKEEAIVVEETVLtrfVVKPLKEWFQrvvlgflfWQAKQPSRIESVLKSVYKDKSNvdDYLVESITEpaa 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107  216 --------------FKHLPDGNICRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRL-HLmpEGKHNLHLRFAD 280
Cdd:PLN02578 265 dpnagevyyrlmsrFLFNQSRYTLDSLLSKLSCPLLLLWGDLDPWVGPAKAEKIKAFYPDTTLvNL--QAGHCPHDEVPE 342

                        330
                 ....*....|
gi 39931107  281 EFNKLAEDFL 290
Cdd:PLN02578 343 QVNKALLEWL 352
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 40-291 1.24e-46

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 155.93  E-value: 1.24e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107  40 TSAKVAVNGVQLHYQQTGEGDHAVLLLPGMLGSGETdFGPQLKNLNKKlFTVVAWDPRGYGHSRPPDRDFPadfFERDAK 119
Cdd:COG0596   3 TPRFVTVDGVRLHYREAGPDGPPVVLLHGLPGSSYE-WRPLIPALAAG-YRVIAPDLRGHGRSDKPAGGYT---LDDLAD 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107 120 DAVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIwganayVTDEDSMIYEGIRDVSKWSERTRKPLEALYGY 199
Cdd:COG0596  78 DLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVL------VDEVLAALAEPLRRPGLAPEALAALLRALART 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107 200 DYfartcekwvdgirqfkhlpdgnicRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNLHLRFA 279
Cdd:COG0596 152 DL------------------------RERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHFPPLEQP 207

                       250
                ....*....|..
gi 39931107 280 DEFNKLAEDFLQ 291
Cdd:COG0596 208 EAFAAALRDFLA 219
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
59-291 1.33e-25

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 101.56  E-value: 1.33e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107  59 GDHAVLLLPGmLGSGETDFGPQLKNLNKKLFTVVAwdPRGYGHSRPPDrDF----PADFFErDAKDAVDLMKAlKFKKVS 134
Cdd:COG1647  14 GRKGVLLLHG-FTGSPAEMRPLAEALAKAGYTVYA--PRLPGHGTSPE-DLlkttWEDWLE-DVEEAYEILKA-GYDKVI 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107 135 LLGWSDGGITALIAAAKYPSyIHKMVIWGANAYVTDEDS----MIYEGIRDVSKWSERTRKPLEALYGYDYFartcekWV 210
Cdd:COG1647  88 VIGLSMGGLLALLLAARYPD-VAGLVLLSPALKIDDPSApllpLLKYLARSLRGIGSDIEDPEVAEYAYDRT------PL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107 211 DGIRQFKHLpdGNICRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGS--RLHLMPEGKHNLHL-RFADEFNKLAE 287
Cdd:COG1647 161 RALAELQRL--IREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPdkELVWLEDSGHVITLdKDREEVAEEIL 238


                ....
gi 39931107 288 DFLQ 291
Cdd:COG1647 239 DFLE 242
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 62-276 1.52e-24

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 98.73  E-value: 1.52e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107    62 AVLLLPGMLGSGEtDFGPQLKNLNKKLFTVVAWDPRGYGHSRPP--DRDFPADFFerdAKDAVDLMKALKFKKVSLLGWS 139
Cdd:pfam00561   2 PVLLLHGLPGSSD-LWRKLAPALARDGFRVIALDLRGFGKSSRPkaQDDYRTDDL---AEDLEYILEALGLEKVNLVGHS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107   140 DGGITALIAAAKYPSYIHKMVIWGANAYVTDEDSMIYEGIRDVSKWSERTR--------KPLEALYGYDYFARTCEK--- 208
Cdd:pfam00561  78 MGGLIALAYAAKYPDRVKALVLLGALDPPHELDEADRFILALFPGFFDGFVadfapnplGRLVAKLLALLLLRLRLLkal 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107   209 -------WVDGIRQFKHLPDGNI----------CRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGK 271
Cdd:pfam00561 158 pllnkrfPSGDYALAKSLVTGALlfietwstelRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDAG 237


                  ....*
gi 39931107   272 HNLHL 276
Cdd:pfam00561 238 HFAFL 242
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
45-291 2.77e-21

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 89.68  E-value: 2.77e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107  45 AVNGVQLHYQQ---TGEGDHAVLLLPGMLGSGETdFGPQLKNLNKKLFTVVAWDPRGYGHSRPPDRDFP-ADFFERDAKD 120
Cdd:COG2267  10 TRDGLRLRGRRwrpAGSPRGTVVLVHGLGEHSGR-YAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDsFDDYVDDLRA 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107 121 AVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIWGAnAYVTDEDSMIYEGirdvskwsertrkplealygyd 200
Cdd:COG2267  89 ALDALRARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAP-AYRADPLLGPSAR---------------------- 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107 201 yfartcekWVDGIRQFKHlpdgnicrhlLPRVQCPALIVHGEKDPLVPRFHA-DFIHKHVKGSRLHLMPEGKHNLHL-RF 278
Cdd:COG2267 146 --------WLRALRLAEA----------LARIDVPVLVLHGGADRVVPPEAArRLAARLSPDVELVLLPGARHELLNePA 207

                       250
                ....*....|...
gi 39931107 279 ADEFNKLAEDFLQ 291
Cdd:COG2267 208 REEVLAAILAWLE 220
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
62-290 9.01e-18

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 80.45  E-value: 9.01e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107  62 AVLLLPGMLGSGETDFGPQLKNLNKKLFTVVAWDPRGYGHSRppdRDFPADFFErDAKDAVDLMKALKF---KKVSLLGW 138
Cdd:COG1506  25 VVVYVHGGPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESA---GDWGGDEVD-DVLAAIDYLAARPYvdpDRIGIYGH 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107 139 SDGGITALIAAAKYPSYIHKMVIWGAnayVTDEDSMiYEGIRDVSKWSERTrkPLEALYGYDyfARTCEKWVDgirqfkh 218
Cdd:COG1506 101 SYGGYMALLAAARHPDRFKAAVALAG---VSDLRSY-YGTTREYTERLMGG--PWEDPEAYA--ARSPLAYAD------- 165

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 39931107 219 lpdgnicrhllpRVQCPALIVHGEKDPLVP-----RFHADFIHKHVKgSRLHLMPEGKHNLHLRFADEFNKLAEDFL 290
Cdd:COG1506 166 ------------KLKTPLLLIHGEADDRVPpeqaeRLYEALKKAGKP-VELLVYPGEGHGFSGAGAPDYLERILDFL 229
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 89-291 8.37e-14

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 69.56  E-value: 8.37e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107  89 FTVVAWDPRGYGHS--RPPDRDFPAdffERDAKDAVDLMKALKF---KKVSLLGWSDGGITALIAAAKYPsyihkmviwG 163
Cdd:COG1073  65 FNVLAFDYRGYGESegEPREEGSPE---RRDARAAVDYLRTLPGvdpERIGLLGISLGGGYALNAAATDP---------R 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107 164 ANAYVTDedSMIYEgIRDVSKwsERTRKPLEALYGYDYFaRTCEKWVDGIR-QFKHLpdgnicrHLLPRVQCPALIVHGE 242
Cdd:COG1073 133 VKAVILD--SPFTS-LEDLAA--QRAKEARGAYLPGVPY-LPNVRLASLLNdEFDPL-------AKIEKISRPLLFIHGE 199

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 39931107 243 KDPLVPRFHADFIHKHVKGS-RLHLMPEGKHN-LHLRFADEFNKLAEDFLQ 291
Cdd:COG1073 200 KDEAVPFYMSEDLYEAAAEPkELLIVPGAGHVdLYDRPEEEYFDKLAEFFK 250
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 63-285 2.67e-10

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 59.02  E-value: 2.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107    63 VLLLPGMlgsgeTDFGPQLKNLNKKLFTVVAWDPRGYGHSRPPDRDFPadfferDAKDAVDLMKALK-FKKVSLLGWSDG 141
Cdd:pfam12697   1 VVLVHGA-----GLSAAPLAALLAAGVAVLAPDLPGHGSSSPPPLDLA------DLADLAALLDELGaARPVVLVGHSLG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107   142 GITALIAAAkypSYIHKMVIWGANAYVTDEDSMIYEGIRDVSKWSERTRKPLEALYGYDYFARTC--EKWVDGIRQFKHL 219
Cdd:pfam12697  70 GAVALAAAA---AALVVGVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPadAEWAAALARLAAL 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 39931107   220 PDGN--ICRHLLPRVQCPALIVHGEkDPLVPRFHADFIHKhVKGSRLHLMPEGKHNLHLRfADEFNKL 285
Cdd:pfam12697 147 LAALalLPLAAWRDLPVPVLVLAEE-DRLVPELAQRLLAA-LAGARLVVLPGAGHLPLDD-PEEVAEA 211
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 62-275 7.70e-09

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 54.91  E-value: 7.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107    62 AVLLLPGMlgsGET-----DFGpqlKNLNKKLFTVVAWDPRGYGHSRPPDRDFPA-DFFERDAKDAVDLMKAL-KFKKVS 134
Cdd:pfam12146   6 VVVLVHGL---GEHsgryaHLA---DALAAQGFAVYAYDHRGHGRSDGKRGHVPSfDDYVDDLDTFVDKIREEhPGLPLF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107   135 LLGWSDGGITALIAAAKYPSYIHKMVIWGAnAYVTDEDSM-----------------IYEGIRDVSKWSERTRKPLEAlY 197
Cdd:pfam12146  80 LLGHSMGGLIAALYALRYPDKVDGLILSAP-ALKIKPYLAppilkllakllgklfprLRVPNNLLPDSLSRDPEVVAA-Y 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107   198 GYDyfartceKWVDG---IRQFKHLPD-GNICRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGS--RLHLMPEGK 271
Cdd:pfam12146 158 AAD-------PLVHGgisARTLYELLDaGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTdkTLKLYPGLY 230


                  ....
gi 39931107   272 HNLH 275
Cdd:pfam12146 231 HELL 234
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
62-286 2.33e-04

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 41.49  E-value: 2.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107  62 AVLLLPGMLGSGET--DFGPQLKNLNkklFTVVAWDPRGYGHSRPPDRD-------FPADFFERDAKDAVDLMKALKF-- 130
Cdd:COG0412  31 GVVVLHEIFGLNPHirDVARRLAAAG---YVVLAPDLYGRGGPGDDPDEaralmgaLDPELLAADLRAALDWLKAQPEvd 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107 131 -KKVSLLGWSDGGITALIAAAKYPsyihkmviwGANAYVtdedsmiyegirdvskwsertrkpleALYGydyfartcekw 209
Cdd:COG0412 108 aGRVGVVGFCFGGGLALLAAARGP---------DLAAAV--------------------------SFYG----------- 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107 210 vdgirqfkhLPDGNICRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGS----RLHLMPEGKHNLHLRFADEFNKL 285
Cdd:COG0412 142 ---------GLPADDLLDLAARIKAPVLLLYGEKDPLVPPEQVAALEAALAAAgvdvELHVYPGAGHGFTNPGRPRYDPA 212


                .
gi 39931107 286 A 286
Cdd:COG0412 213 A 213
YpfH COG0400
Predicted esterase [General function prediction only];
56-164 1.15e-03

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 39.12  E-value: 1.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107  56 TGEGDHAVLLLPGmLGSGETDFGPQLKNLNKKLFTVVAwdPRG-----YGHSRPPDRDFPADFF-ERDAKDAVDLMKA-- 127
Cdd:COG0400   1 GGPAAPLVVLLHG-YGGDEEDLLPLAPELALPGAAVLA--PRApvpegPGGRAWFDLSFLEGREdEEGLAAAAEALAAfi 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 39931107 128 --------LKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIWGA 164
Cdd:COG0400  78 delearygIDPERIVLAGFSQGAAMALSLALRRPELLAGVVALSG 122
PLN02578 PLN02578
hydrolase
 30-290 1.57e-03

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 39.44  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107   30 GPAAAFGTSVTSAKVAVNGVQ---------------------LHYQQTGEGDHAVLLLpgmlGSGETDFG-----PQLKn 83
Cdd:PLN02578  36 GGIVASGVSVMGSSSASQSVQglerlpfkkegynfwtwrghkIHYVVQGEGLPIVLIH----GFGASAFHwryniPELA- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107   84 lnkKLFTVVAWDPRGYGHSRPPDRDFPADFFERDAkdaVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIW- 162
Cdd:PLN02578 111 ---KKYKVYALDLLGFGWSDKALIEYDAMVWRDQV---ADFVKEVVKEPAVLVGNSLGGFTALSTAVGYPELVAGVALLn 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107  163 -----------GANAYVTDEDSM---IYEGIRDVSK--------WSERTRKPLEALYGYDYFARTC--EKWVDGIRQ--- 215
Cdd:PLN02578 185 sagqfgsesreKEEAIVVEETVLtrfVVKPLKEWFQrvvlgflfWQAKQPSRIESVLKSVYKDKSNvdDYLVESITEpaa 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39931107  216 --------------FKHLPDGNICRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRL-HLmpEGKHNLHLRFAD 280
Cdd:PLN02578 265 dpnagevyyrlmsrFLFNQSRYTLDSLLSKLSCPLLLLWGDLDPWVGPAKAEKIKAFYPDTTLvNL--QAGHCPHDEVPE 342

                        330
                 ....*....|
gi 39931107  281 EFNKLAEDFL 290
Cdd:PLN02578 343 QVNKALLEWL 352
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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