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Conserved domains on  [gi|399125222]
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Chain A, Clathrin heavy chain 1

Protein Classification

clathrin heavy chain( domain architecture ID 10476644)

clathrin heavy chain is a component of clathrin, the major protein of the polyhedral coat of coated pits and vesicles

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 336-359 5.44e-11

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


:

Pssm-ID: 462732  Cd Length: 24  Bit Score: 56.68  E-value: 5.44e-11
                          10        20
                  ....*....|....*....|....
gi 399125222  336 EENIIPYITNVLQNPDLALRMAVR 359
Cdd:pfam09268   1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 203-239 5.03e-07

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 45.48  E-value: 5.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 399125222  203 AASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVG 239
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 261-293 6.28e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 39.71  E-value: 6.28e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 399125222  261 AQNDFPVAMQISEKHDVVFLITKYGYIHLYDLE 293
Cdd:pfam01394   5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 24-61 7.87e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 39.32  E-value: 7.87e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 399125222   24 GINPANIGFSTLTMESDKFICIREKVGeQAQVVIIDMN 61
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 301-335 2.91e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 37.78  E-value: 2.91e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 399125222  301 NRISGETIFVTAPHEATAGIIGVN--RKGQVLSVCVE 335
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 153-192 2.27e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 35.47  E-value: 2.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 399125222  153 LAGCQIINYRTDAKQKWLLLTGISaqqNRVVGAMQLYSVD 192
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
 
Name Accession Description Interval E-value
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 336-359 5.44e-11

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 56.68  E-value: 5.44e-11
                          10        20
                  ....*....|....*....|....
gi 399125222  336 EENIIPYITNVLQNPDLALRMAVR 359
Cdd:pfam09268   1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 203-239 5.03e-07

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 45.48  E-value: 5.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 399125222  203 AASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVG 239
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 261-293 6.28e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 39.71  E-value: 6.28e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 399125222  261 AQNDFPVAMQISEKHDVVFLITKYGYIHLYDLE 293
Cdd:pfam01394   5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 24-61 7.87e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 39.32  E-value: 7.87e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 399125222   24 GINPANIGFSTLTMESDKFICIREKVGeQAQVVIIDMN 61
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 301-335 2.91e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 37.78  E-value: 2.91e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 399125222  301 NRISGETIFVTAPHEATAGIIGVN--RKGQVLSVCVE 335
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 153-192 2.27e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 35.47  E-value: 2.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 399125222  153 LAGCQIINYRTDAKQKWLLLTGISaqqNRVVGAMQLYSVD 192
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
 
Name Accession Description Interval E-value
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 336-359 5.44e-11

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 56.68  E-value: 5.44e-11
                          10        20
                  ....*....|....*....|....
gi 399125222  336 EENIIPYITNVLQNPDLALRMAVR 359
Cdd:pfam09268   1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 203-239 5.03e-07

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 45.48  E-value: 5.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 399125222  203 AASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVG 239
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 261-293 6.28e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 39.71  E-value: 6.28e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 399125222  261 AQNDFPVAMQISEKHDVVFLITKYGYIHLYDLE 293
Cdd:pfam01394   5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 24-61 7.87e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 39.32  E-value: 7.87e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 399125222   24 GINPANIGFSTLTMESDKFICIREKVGeQAQVVIIDMN 61
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 301-335 2.91e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 37.78  E-value: 2.91e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 399125222  301 NRISGETIFVTAPHEATAGIIGVN--RKGQVLSVCVE 335
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 153-192 2.27e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 35.47  E-value: 2.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 399125222  153 LAGCQIINYRTDAKQKWLLLTGISaqqNRVVGAMQLYSVD 192
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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