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Conserved domains on  [gi|398365913|ref|NP_009848|]
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Snf5p [Saccharomyces cerevisiae S288C]

Protein Classification

SWI/SNF chromatin-remodeling complex subunit SNF5( domain architecture ID 10522086)

SWI/SNF chromatin-remodeling complex subunit SNF5 is a component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SNF5 pfam04855
SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ...
 452-662 6.84e-63

SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes characterized so far. This family consists of the conserved region of SNF5, including a direct repeat motif. SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF complex. SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumours (MRTs).


:

Pssm-ID: 428158  Cd Length: 186  Bit Score: 210.13  E-value: 6.84e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365913  452 ETSEQLVPIRLEFDQDRDRffLRDTLLWNKNDKLIKIEDFVDDMLRDYRFEDATREQHIDTICQSIQEQIQEFQG----- 526
Cdd:pfam04855   1 ELPETLVPIRIDLDIDKYR--LRDTFTWNLHETLITPEQFAQTLCEDLDLPNEPAPAFADQIAKQIREQLEEYAGvalhp 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365913  527 --NPYIELNQDRL--------GGDDLRIRIKLDIVVGQNQLIDQFEWDISNSDNCPEEFAESMCQELELPGEFVTAIAHS 596
Cdd:pfam04855  79 lpYPHVEEEDDPLdpdlpylnPDDDLRILIKLDITIGNHLLTDQFEWDLLSPLNTPEEFAKQTCADLGLSGEFVTAIAHA 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398365913  597 IREQVHMYHKSLallgynfdgsaiedddirsrmlptitlddvyrpaaeskiFTPNLLQISAAELER 662
Cdd:pfam04855 159 IREQVLRYKKSL---------------------------------------CTPKLEELSEEELEK 185
 
Name Accession Description Interval E-value
SNF5 pfam04855
SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ...
 452-662 6.84e-63

SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes characterized so far. This family consists of the conserved region of SNF5, including a direct repeat motif. SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF complex. SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumours (MRTs).


Pssm-ID: 428158  Cd Length: 186  Bit Score: 210.13  E-value: 6.84e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365913  452 ETSEQLVPIRLEFDQDRDRffLRDTLLWNKNDKLIKIEDFVDDMLRDYRFEDATREQHIDTICQSIQEQIQEFQG----- 526
Cdd:pfam04855   1 ELPETLVPIRIDLDIDKYR--LRDTFTWNLHETLITPEQFAQTLCEDLDLPNEPAPAFADQIAKQIREQLEEYAGvalhp 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365913  527 --NPYIELNQDRL--------GGDDLRIRIKLDIVVGQNQLIDQFEWDISNSDNCPEEFAESMCQELELPGEFVTAIAHS 596
Cdd:pfam04855  79 lpYPHVEEEDDPLdpdlpylnPDDDLRILIKLDITIGNHLLTDQFEWDLLSPLNTPEEFAKQTCADLGLSGEFVTAIAHA 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398365913  597 IREQVHMYHKSLallgynfdgsaiedddirsrmlptitlddvyrpaaeskiFTPNLLQISAAELER 662
Cdd:pfam04855 159 IREQVLRYKKSL---------------------------------------CTPKLEELSEEELEK 185
 
Name Accession Description Interval E-value
SNF5 pfam04855
SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ...
 452-662 6.84e-63

SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes characterized so far. This family consists of the conserved region of SNF5, including a direct repeat motif. SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF complex. SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumours (MRTs).


Pssm-ID: 428158  Cd Length: 186  Bit Score: 210.13  E-value: 6.84e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365913  452 ETSEQLVPIRLEFDQDRDRffLRDTLLWNKNDKLIKIEDFVDDMLRDYRFEDATREQHIDTICQSIQEQIQEFQG----- 526
Cdd:pfam04855   1 ELPETLVPIRIDLDIDKYR--LRDTFTWNLHETLITPEQFAQTLCEDLDLPNEPAPAFADQIAKQIREQLEEYAGvalhp 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365913  527 --NPYIELNQDRL--------GGDDLRIRIKLDIVVGQNQLIDQFEWDISNSDNCPEEFAESMCQELELPGEFVTAIAHS 596
Cdd:pfam04855  79 lpYPHVEEEDDPLdpdlpylnPDDDLRILIKLDITIGNHLLTDQFEWDLLSPLNTPEEFAKQTCADLGLSGEFVTAIAHA 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398365913  597 IREQVHMYHKSLallgynfdgsaiedddirsrmlptitlddvyrpaaeskiFTPNLLQISAAELER 662
Cdd:pfam04855 159 IREQVLRYKKSL---------------------------------------CTPKLEELSEEELEK 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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