NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|398365699|ref|NP_010403|]
View 

anaphase promoting complex subunit 4 [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANAPC4 super family cl15150
Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of ...
 223-411 1.19e-19

Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Results in C.elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle. the APC/C is likely to be required for all metaphase-to-anaphase transitions in a multicellular organizm.


The actual alignment was detected with superfamily member pfam12896:

Pssm-ID: 463744  Cd Length: 203  Bit Score: 87.65  E-value: 1.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365699  223 LLQSKSS--VNLLNYIM-VIKELIGYMLTHLEFINRelatpYLDFVKRLCDEAYGYGKLKSELEALFLLGEISCDLEDWL 299
Cdd:pfam12896  19 LLASKSSqlQSLLRYINqTLKEMQEEWKNARELPDR-----KLRNLEDLLKEQGGESSIVQELYHLLLTGHPSPPLKEFL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365699  300 CNSVGEKNFKRWKYLGCEAYQKTVQILTLIFVPACERIIIYVEKLRAIlqafSIQNKLSYTSDLTA--VEVLLKSSQKLL 377
Cdd:pfam12896  94 VNQLGERGLKRWEKAVESSYENIRKLVHEHLLPALERLIILLSELRGL----AKWHERYEILGLDPelIDELLDTAGSLL 169

                         170       180       190
                  ....*....|....*....|....*....|....
gi 398365699  378 TMTLNSIIGLGRDETLFEKFFIWFNDRLHEALDE 411
Cdd:pfam12896 170 LKAHELLQVINEELKLFKAFFRWLRYVIDRLADE 203
 
Name Accession Description Interval E-value
ANAPC4 pfam12896
Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of ...
 223-411 1.19e-19

Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Results in C.elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle. the APC/C is likely to be required for all metaphase-to-anaphase transitions in a multicellular organizm.


Pssm-ID: 463744  Cd Length: 203  Bit Score: 87.65  E-value: 1.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365699  223 LLQSKSS--VNLLNYIM-VIKELIGYMLTHLEFINRelatpYLDFVKRLCDEAYGYGKLKSELEALFLLGEISCDLEDWL 299
Cdd:pfam12896  19 LLASKSSqlQSLLRYINqTLKEMQEEWKNARELPDR-----KLRNLEDLLKEQGGESSIVQELYHLLLTGHPSPPLKEFL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365699  300 CNSVGEKNFKRWKYLGCEAYQKTVQILTLIFVPACERIIIYVEKLRAIlqafSIQNKLSYTSDLTA--VEVLLKSSQKLL 377
Cdd:pfam12896  94 VNQLGERGLKRWEKAVESSYENIRKLVHEHLLPALERLIILLSELRGL----AKWHERYEILGLDPelIDELLDTAGSLL 169

                         170       180       190
                  ....*....|....*....|....*....|....
gi 398365699  378 TMTLNSIIGLGRDETLFEKFFIWFNDRLHEALDE 411
Cdd:pfam12896 170 LKAHELLQVINEELKLFKAFFRWLRYVIDRLADE 203
 
Name Accession Description Interval E-value
ANAPC4 pfam12896
Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of ...
 223-411 1.19e-19

Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Results in C.elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle. the APC/C is likely to be required for all metaphase-to-anaphase transitions in a multicellular organizm.


Pssm-ID: 463744  Cd Length: 203  Bit Score: 87.65  E-value: 1.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365699  223 LLQSKSS--VNLLNYIM-VIKELIGYMLTHLEFINRelatpYLDFVKRLCDEAYGYGKLKSELEALFLLGEISCDLEDWL 299
Cdd:pfam12896  19 LLASKSSqlQSLLRYINqTLKEMQEEWKNARELPDR-----KLRNLEDLLKEQGGESSIVQELYHLLLTGHPSPPLKEFL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365699  300 CNSVGEKNFKRWKYLGCEAYQKTVQILTLIFVPACERIIIYVEKLRAIlqafSIQNKLSYTSDLTA--VEVLLKSSQKLL 377
Cdd:pfam12896  94 VNQLGERGLKRWEKAVESSYENIRKLVHEHLLPALERLIILLSELRGL----AKWHERYEILGLDPelIDELLDTAGSLL 169

                         170       180       190
                  ....*....|....*....|....*....|....
gi 398365699  378 TMTLNSIIGLGRDETLFEKFFIWFNDRLHEALDE 411
Cdd:pfam12896 170 LKAHELLQVINEELKLFKAFFRWLRYVIDRLADE 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH