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Conserved domains on  [gi|398365587|ref|NP_014407|]
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Cse2p [Saccharomyces cerevisiae S288C]

Protein Classification

mediator of RNA polymerase II transcription subunit 9( domain architecture ID 19137921)

mediator of RNA polymerase II transcription subunit 9 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med9-C cd21431
Mediator complex subunit 9 (Med9) C-terminal domain family; Med9 is a member of the Middle ...
 68-149 1.59e-24

Mediator complex subunit 9 (Med9) C-terminal domain family; Med9 is a member of the Middle module transcriptional mediator complex which has a species-specific amino-terminal and a well-conserved carboxy-terminal half. Med9 carboxy-terminal has a fundamental function involved in direct binding to other Med proteins and the assembly of Med9 into the Middle module. Med9 amino terminal plays a regulatory role in transcriptional regulation. Mediator co-activator complex plays an essential role in regulation of RNA polymerase II transcription in all eukaryotes.


:

Pssm-ID: 467847  Cd Length: 82  Bit Score: 90.17  E-value: 1.59e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365587  68 HIFYSLHQIRKDPNNLSNQLETLTGSIRHRLKLCKSLISENEDTKDLLSKSPSEWQDIIHQREQELQIKRDVLDDLYRKL 147
Cdd:cd21431    1 DIFYSLHRLLSFLPLVHNRIMDKTSKIVHQLKNCLKTKFQKARKMESLMPGIDESPEIIQQQEQRLREKVRTLNDLLQKY 80


                 ..
gi 398365587 148 QR 149
Cdd:cd21431   81 KS 82
 
Name Accession Description Interval E-value
Med9-C cd21431
Mediator complex subunit 9 (Med9) C-terminal domain family; Med9 is a member of the Middle ...
 68-149 1.59e-24

Mediator complex subunit 9 (Med9) C-terminal domain family; Med9 is a member of the Middle module transcriptional mediator complex which has a species-specific amino-terminal and a well-conserved carboxy-terminal half. Med9 carboxy-terminal has a fundamental function involved in direct binding to other Med proteins and the assembly of Med9 into the Middle module. Med9 amino terminal plays a regulatory role in transcriptional regulation. Mediator co-activator complex plays an essential role in regulation of RNA polymerase II transcription in all eukaryotes.


Pssm-ID: 467847  Cd Length: 82  Bit Score: 90.17  E-value: 1.59e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365587  68 HIFYSLHQIRKDPNNLSNQLETLTGSIRHRLKLCKSLISENEDTKDLLSKSPSEWQDIIHQREQELQIKRDVLDDLYRKL 147
Cdd:cd21431    1 DIFYSLHRLLSFLPLVHNRIMDKTSKIVHQLKNCLKTKFQKARKMESLMPGIDESPEIIQQQEQRLREKVRTLNDLLQKY 80


                 ..
gi 398365587 148 QR 149
Cdd:cd21431   81 KS 82
Med9 pfam07544
RNA polymerase II transcription mediator complex subunit 9; This family of Med9 proteins is ...
 64-143 9.39e-23

RNA polymerase II transcription mediator complex subunit 9; This family of Med9 proteins is conserved in yeasts. It forms part of the middle region of Mediator. Med9 has two functional domains. The species-specific amino-terminal half (aa 1-63) plays a regulatory role in transcriptional regulation, whereas this well-conserved carboxy-terminal half (aa 64-149) has a more fundamental function involved in direct binding to the amino-terminal portions of Med4 and Med7 and the assembly of Med9 into the Middle module. Also, some unidentified factor(s) in med9 extracts may impact the binding of TFIID to the promoter.


Pssm-ID: 462202  Cd Length: 80  Bit Score: 85.32  E-value: 9.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365587   64 EFIPHIFYSLHQIRKDPNNLSNQLETLTGSIRHRLKLCKSLISENEDtkdlLSKSPSEWQDIIHQREQELQIKRDVLDDL 143
Cdd:pfam07544   1 EFLPLIFDILKSIEKDPNLSSKDLDTATGELRHKLQKARALIRELPG----IDRSVEEQEAEIENLEQQLARKRELLKKY 76
 
Name Accession Description Interval E-value
Med9-C cd21431
Mediator complex subunit 9 (Med9) C-terminal domain family; Med9 is a member of the Middle ...
 68-149 1.59e-24

Mediator complex subunit 9 (Med9) C-terminal domain family; Med9 is a member of the Middle module transcriptional mediator complex which has a species-specific amino-terminal and a well-conserved carboxy-terminal half. Med9 carboxy-terminal has a fundamental function involved in direct binding to other Med proteins and the assembly of Med9 into the Middle module. Med9 amino terminal plays a regulatory role in transcriptional regulation. Mediator co-activator complex plays an essential role in regulation of RNA polymerase II transcription in all eukaryotes.


Pssm-ID: 467847  Cd Length: 82  Bit Score: 90.17  E-value: 1.59e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365587  68 HIFYSLHQIRKDPNNLSNQLETLTGSIRHRLKLCKSLISENEDTKDLLSKSPSEWQDIIHQREQELQIKRDVLDDLYRKL 147
Cdd:cd21431    1 DIFYSLHRLLSFLPLVHNRIMDKTSKIVHQLKNCLKTKFQKARKMESLMPGIDESPEIIQQQEQRLREKVRTLNDLLQKY 80


                 ..
gi 398365587 148 QR 149
Cdd:cd21431   81 KS 82
Med9 pfam07544
RNA polymerase II transcription mediator complex subunit 9; This family of Med9 proteins is ...
 64-143 9.39e-23

RNA polymerase II transcription mediator complex subunit 9; This family of Med9 proteins is conserved in yeasts. It forms part of the middle region of Mediator. Med9 has two functional domains. The species-specific amino-terminal half (aa 1-63) plays a regulatory role in transcriptional regulation, whereas this well-conserved carboxy-terminal half (aa 64-149) has a more fundamental function involved in direct binding to the amino-terminal portions of Med4 and Med7 and the assembly of Med9 into the Middle module. Also, some unidentified factor(s) in med9 extracts may impact the binding of TFIID to the promoter.


Pssm-ID: 462202  Cd Length: 80  Bit Score: 85.32  E-value: 9.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365587   64 EFIPHIFYSLHQIRKDPNNLSNQLETLTGSIRHRLKLCKSLISENEDtkdlLSKSPSEWQDIIHQREQELQIKRDVLDDL 143
Cdd:pfam07544   1 EFLPLIFDILKSIEKDPNLSSKDLDTATGELRHKLQKARALIRELPG----IDRSVEEQEAEIENLEQQLARKRELLKKY 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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