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Conserved domains on  [gi|395825442|ref|XP_003785942|]
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baculoviral IAP repeat-containing protein 1 [Otolemur garnettii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NLRC4_HD pfam17889
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and ...
 766-872 1.80e-52

NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).


:

Pssm-ID: 436120  Cd Length: 106  Bit Score: 179.02  E-value: 1.80e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442   766 ADQDLGLYYLKQINSSMMALKPYNNFLNYiSNCPLTKAGPKIVSHLLHLVDDKESLENVSENDDYLKHRPEISQEMVFIR 845
Cdd:pfam17889    1 EDQDLGLYYLKQINSILKAVSRYNNFLLY-TCHSSTKAGPKIVSHLLHLVDHKESLENLSENDDYLKHHPETSLLMQNIR 79

                           90       100
                   ....*....|....*....|....*..
gi 395825442   846 RFWQMAPQAYFSLVSNHLLGLALKIAY 872
Cdd:pfam17889   80 SLWQLSPELYLSSVSEHLLSLALEIAY 106
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 464-617 5.13e-38

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


:

Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 140.13  E-value: 5.13e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442   464 SVMCVEGEAGSGKTIFLKKIAFLWASGCCPflNRFQLVFYLSLSATR---PGQGLADIISDQLLEKEGSVTEmcLRNIIQ 540
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLP--QGFDFVFFLPCRELSrsgNARSLADLLFSQWPEPAAPVSE--VWAVIL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442   541 QLRNQVLFLLDDYKEMGSVPQDVER----------LIQKNHSSRTCLLIAVRTNRARDIRRYLDT--ILEIKAFPFYNTI 608
Cdd:pfam05729   77 ELPERLLLILDGLDELVSDLGQLDGpcpvltllssLLRKKLLPGASLLLTVRPDALRDLRRGLEEprYLEVRGFSESDRK 156


                   ....*....
gi 395825442   609 CILRKLFSH 617
Cdd:pfam05729  157 QYVRKYFSD 165
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 162-228 1.39e-32

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


:

Pssm-ID: 459891  Cd Length: 68  Bit Score: 120.84  E-value: 1.39e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 395825442   162 RLESFKNWPFYAQAT-SPRALSAAGFVFTGERDTVQCFSCSGCLGNWEEGDDPWKEHAKWFPKCEFLQ 228
Cdd:pfam00653    1 RLATFENWPHSNKSPpTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 279-347 8.22e-32

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


:

Pssm-ID: 237989  Cd Length: 69  Bit Score: 118.91  E-value: 8.22e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 395825442  279 ELRLDSFKNWPQESSAGVAALAKAGLFYTGIKDIVQCFSCGGCLENWKEGDDPLEDHTKYFPNCQFIQN 347
Cdd:cd00022     1 EARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 61-129 1.56e-22

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


:

Pssm-ID: 237989  Cd Length: 69  Bit Score: 92.33  E-value: 1.56e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 395825442   61 ARRLKTFETHPQDGSWTPQEMAAAGFYFTGVKTGIQCFCCSLILFGTSLRRVPIEDHKTFHQDCEFLLS 129
Cdd:cd00022     1 EARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
450-764 1.08e-20

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


:

Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 99.11  E-value: 1.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442  450 QEPLVLPEVFTKLNSVMCVEGEAGSGKTIFLKKIAFLWASGCCPFLNRfqLVFYLSLSATRPGQGLADIISDQLLEKEGS 529
Cdd:COG5635   167 IESLKRLELLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAEDP--IPILIELRDLAEEASLEDLLAEALEKRGGE 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442  530 VTEmclrNIIQQLRN-QVLFLLDDYKEMgSVPQDVERLIQK-----NHSSRTCLLIAVRTNRARDIRRYLDTILEIKAFP 603
Cdd:COG5635   245 PED----ALERLLRNgRLLLLLDGLDEV-PDEADRDEVLNQlrrflERYPKARVIITSRPEGYDSSELEGFEVLELAPLS 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442  604 FYNTICILRKLFSHNMARLLKFRIYFGRQKNLQESHKTPLFVAAVCANWFQYPFDPSfDDVAVFKSYMECLFLRHKTTIE 683
Cdd:COG5635   320 DEQIEEFLKKWFEATERKAERLLEALEENPELRELARNPLLLTLLALLLRERGELPD-TRAELYEQFVELLLERWDEQRG 398

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442  684 LLQATVSS-------CGELALKGFFSSCFEFSDDDLEEagvdedgDLTMCLMSKFTAQRL---------------RPVYQ 741
Cdd:COG5635   399 LTIYRELSreelrelLSELALAMQENGRTEFAREELEE-------ILREYLGRRKDAEALldelllrtgllvergEGRYS 471

                         330       340
                  ....*....|....*....|...
gi 395825442  742 FLSPPFQEFLAARRLIELLDSDR 764
Cdd:COG5635   472 FAHRSFQEYLAARALVEELDEEL 494
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1064-1275 1.01e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1064 ELSVAEQELLLTLPSLESLELTGT-IQAQVRLIQNSPNLHVFHLKCNffsDFESLMTVLSSCKKLKEVKFSGSFFQSIPf 1142
Cdd:COG4886   100 ELDLSGNEELSNLTNLESLDLSGNqLTDLPEELANLTNLKELDLSNN---QLTDLPEPLGNLTNLKSLDLSNNQLTDLP- 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1143 vAILPNFISLKILNVGNQQFPDketsekFAYTLGSLKNLEELILpTGDGIHQVAKLIvQQCRQLQRLRvlsffqtLDDDS 1222
Cdd:COG4886   176 -EELGNLTNLKELDLSNNQITD------LPEPLGNLTNLEELDL-SGNQLTDLPEPL-ANLTNLETLD-------LSNNQ 239

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 395825442 1223 VMEIAKVavdGGFQKLENLNLSINhKITEegyrnfFQALDNLPNLQELSITRN 1275
Cdd:COG4886   240 LTDLPEL---GNLTNLEELDLSNN-QLTD------LPPLANLTNLKTLDLSNN 282
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1236-1333 6.19e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 6.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1236 QKLENLNLSINHkITEEGYRNFFQALDNLPNLQELSITRNYTHCIKAQAttvksLSQCVLRLPSLTTLHMLSWLLDAEDI 1315
Cdd:cd00116   165 RDLKELNLANNG-IGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASA-----LAETLASLKSLEVLNLGDNNLTDAGA 238

                          90
                  ....*....|....*....
gi 395825442 1316 A-LLNVMKERHPQSKHLNI 1333
Cdd:cd00116   239 AaLASALLSPNISLLTLSL 257
 
Name Accession Description Interval E-value
NLRC4_HD pfam17889
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and ...
 766-872 1.80e-52

NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).


Pssm-ID: 436120  Cd Length: 106  Bit Score: 179.02  E-value: 1.80e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442   766 ADQDLGLYYLKQINSSMMALKPYNNFLNYiSNCPLTKAGPKIVSHLLHLVDDKESLENVSENDDYLKHRPEISQEMVFIR 845
Cdd:pfam17889    1 EDQDLGLYYLKQINSILKAVSRYNNFLLY-TCHSSTKAGPKIVSHLLHLVDHKESLENLSENDDYLKHHPETSLLMQNIR 79

                           90       100
                   ....*....|....*....|....*..
gi 395825442   846 RFWQMAPQAYFSLVSNHLLGLALKIAY 872
Cdd:pfam17889   80 SLWQLSPELYLSSVSEHLLSLALEIAY 106
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 464-617 5.13e-38

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 140.13  E-value: 5.13e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442   464 SVMCVEGEAGSGKTIFLKKIAFLWASGCCPflNRFQLVFYLSLSATR---PGQGLADIISDQLLEKEGSVTEmcLRNIIQ 540
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLP--QGFDFVFFLPCRELSrsgNARSLADLLFSQWPEPAAPVSE--VWAVIL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442   541 QLRNQVLFLLDDYKEMGSVPQDVER----------LIQKNHSSRTCLLIAVRTNRARDIRRYLDT--ILEIKAFPFYNTI 608
Cdd:pfam05729   77 ELPERLLLILDGLDELVSDLGQLDGpcpvltllssLLRKKLLPGASLLLTVRPDALRDLRRGLEEprYLEVRGFSESDRK 156


                   ....*....
gi 395825442   609 CILRKLFSH 617
Cdd:pfam05729  157 QYVRKYFSD 165
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 162-228 1.39e-32

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 120.84  E-value: 1.39e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 395825442   162 RLESFKNWPFYAQAT-SPRALSAAGFVFTGERDTVQCFSCSGCLGNWEEGDDPWKEHAKWFPKCEFLQ 228
Cdd:pfam00653    1 RLATFENWPHSNKSPpTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 159-229 3.50e-32

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 119.73  E-value: 3.50e-32
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 395825442    159 EEARLESFKNWPFYAQATsPRALSAAGFVFTGERDTVQCFSCSGCLGNWEEGDDPWKEHAKWFPKCEFLQR 229
Cdd:smart00238    2 EEARLKTFQNWPYNSKCT-PEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 279-347 8.22e-32

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 118.91  E-value: 8.22e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 395825442  279 ELRLDSFKNWPQESSAGVAALAKAGLFYTGIKDIVQCFSCGGCLENWKEGDDPLEDHTKYFPNCQFIQN 347
Cdd:cd00022     1 EARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 160-228 1.55e-31

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 117.75  E-value: 1.55e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 395825442  160 EARLESFKNWPFYAQATsPRALSAAGFVFTGERDTVQCFSCSGCLGNWEEGDDPWKEHAKWFPKCEFLQ 228
Cdd:cd00022     1 EARLKTFKNWPISLKVT-PEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVL 68
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 277-347 1.92e-31

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 117.80  E-value: 1.92e-31
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 395825442    277 NEELRLDSFKNWPQESSAGVAALAKAGLFYTGIKDIVQCFSCGGCLENWKEGDDPLEDHTKYFPNCQFIQN 347
Cdd:smart00238    1 SEEARLKTFQNWPYNSKCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 281-346 2.46e-28

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 108.90  E-value: 2.46e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 395825442   281 RLDSFKNWP--QESSAGVAALAKAGLFYTGIKDIVQCFSCGGCLENWKEGDDPLEDHTKYFPNCQFIQ 346
Cdd:pfam00653    1 RLATFENWPhsNKSPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 61-129 1.56e-22

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 92.33  E-value: 1.56e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 395825442   61 ARRLKTFETHPQDGSWTPQEMAAAGFYFTGVKTGIQCFCCSLILFGTSLRRVPIEDHKTFHQDCEFLLS 129
Cdd:cd00022     1 EARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 63-127 7.24e-22

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 90.41  E-value: 7.24e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 395825442    63 RLKTFET--HPQDGSWTPQEMAAAGFYFTGVKTGIQCFCCSLILFGTSLRRVPIEDHKTFHQDCEFL 127
Cdd:pfam00653    1 RLATFENwpHSNKSPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFL 67
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 59-129 6.20e-21

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 87.76  E-value: 6.20e-21
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 395825442     59 SEARRLKTFETHPQDGSWTPQEMAAAGFYFTGVKTGIQCFCCSLILFGTSLRRVPIEDHKTFHQDCEFLLS 129
Cdd:smart00238    1 SEEARLKTFQNWPYNSKCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
450-764 1.08e-20

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 99.11  E-value: 1.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442  450 QEPLVLPEVFTKLNSVMCVEGEAGSGKTIFLKKIAFLWASGCCPFLNRfqLVFYLSLSATRPGQGLADIISDQLLEKEGS 529
Cdd:COG5635   167 IESLKRLELLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAEDP--IPILIELRDLAEEASLEDLLAEALEKRGGE 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442  530 VTEmclrNIIQQLRN-QVLFLLDDYKEMgSVPQDVERLIQK-----NHSSRTCLLIAVRTNRARDIRRYLDTILEIKAFP 603
Cdd:COG5635   245 PED----ALERLLRNgRLLLLLDGLDEV-PDEADRDEVLNQlrrflERYPKARVIITSRPEGYDSSELEGFEVLELAPLS 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442  604 FYNTICILRKLFSHNMARLLKFRIYFGRQKNLQESHKTPLFVAAVCANWFQYPFDPSfDDVAVFKSYMECLFLRHKTTIE 683
Cdd:COG5635   320 DEQIEEFLKKWFEATERKAERLLEALEENPELRELARNPLLLTLLALLLRERGELPD-TRAELYEQFVELLLERWDEQRG 398

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442  684 LLQATVSS-------CGELALKGFFSSCFEFSDDDLEEagvdedgDLTMCLMSKFTAQRL---------------RPVYQ 741
Cdd:COG5635   399 LTIYRELSreelrelLSELALAMQENGRTEFAREELEE-------ILREYLGRRKDAEALldelllrtgllvergEGRYS 471

                         330       340
                  ....*....|....*....|...
gi 395825442  742 FLSPPFQEFLAARRLIELLDSDR 764
Cdd:COG5635   472 FAHRSFQEYLAARALVEELDEEL 494
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1064-1275 1.01e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1064 ELSVAEQELLLTLPSLESLELTGT-IQAQVRLIQNSPNLHVFHLKCNffsDFESLMTVLSSCKKLKEVKFSGSFFQSIPf 1142
Cdd:COG4886   100 ELDLSGNEELSNLTNLESLDLSGNqLTDLPEELANLTNLKELDLSNN---QLTDLPEPLGNLTNLKSLDLSNNQLTDLP- 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1143 vAILPNFISLKILNVGNQQFPDketsekFAYTLGSLKNLEELILpTGDGIHQVAKLIvQQCRQLQRLRvlsffqtLDDDS 1222
Cdd:COG4886   176 -EELGNLTNLKELDLSNNQITD------LPEPLGNLTNLEELDL-SGNQLTDLPEPL-ANLTNLETLD-------LSNNQ 239

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 395825442 1223 VMEIAKVavdGGFQKLENLNLSINhKITEegyrnfFQALDNLPNLQELSITRN 1275
Cdd:COG4886   240 LTDLPEL---GNLTNLEELDLSNN-QLTD------LPPLANLTNLKTLDLSNN 282
NOD2_WH pfam17779
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ...
 687-742 1.16e-05

NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.


Pssm-ID: 465501  Cd Length: 57  Bit Score: 44.09  E-value: 1.16e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 395825442   687 ATVSSCGELALKGFFSSCFEFSDDDLEEAGVDEDgDLTMCLMSKFTAQRL--RPVYQF 742
Cdd:pfam17779    1 KLLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDES-DLSSGLLTEILQKDLgcEKVYSF 57
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1025-1276 1.44e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1025 PASQHIELHLTHSSGIIESIRPALE-------LHKASVTKCSIdkCELSVAEQELLLTLPSLESLELT--GTIQAQVRLI 1095
Cdd:cd00116    51 PSLKELCLSLNETGRIPRGLQSLLQgltkgcgLQELDLSDNAL--GPDGCGVLESLLRSSSLQELKLNnnGLGDRGLRLL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1096 Q-----NSPNLHVFHLKCNFFSD--FESLMTVLSSCKKLKEVKFS--GSFFQSIPFVA-ILPNFISLKILNVGNQQFPDK 1165
Cdd:cd00116   129 AkglkdLPPALEKLVLGRNRLEGasCEALAKALRANRDLKELNLAnnGIGDAGIRALAeGLKANCNLEVLDLNNNGLTDE 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1166 ETSeKFAYTLGSLKNLEELILptgdgihqvaklivQQCRqlqrlrvlsffqtLDDDSVMEIAKvAVDGGFQKLENLNLSI 1245
Cdd:cd00116   209 GAS-ALAETLASLKSLEVLNL--------------GDNN-------------LTDAGAAALAS-ALLSPNISLLTLSLSC 259

                         250       260       270
                  ....*....|....*....|....*....|.
gi 395825442 1246 NHkITEEGYRNFFQALDNLPNLQELSITRNY 1276
Cdd:cd00116   260 ND-ITDDGAKDLAEVLAEKESLLELDLRGNK 289
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1236-1333 6.19e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 6.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1236 QKLENLNLSINHkITEEGYRNFFQALDNLPNLQELSITRNYTHCIKAQAttvksLSQCVLRLPSLTTLHMLSWLLDAEDI 1315
Cdd:cd00116   165 RDLKELNLANNG-IGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASA-----LAETLASLKSLEVLNLGDNNLTDAGA 238

                          90
                  ....*....|....*....
gi 395825442 1316 A-LLNVMKERHPQSKHLNI 1333
Cdd:cd00116   239 AaLASALLSPNISLLTLSL 257
 
Name Accession Description Interval E-value
NLRC4_HD pfam17889
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and ...
 766-872 1.80e-52

NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).


Pssm-ID: 436120  Cd Length: 106  Bit Score: 179.02  E-value: 1.80e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442   766 ADQDLGLYYLKQINSSMMALKPYNNFLNYiSNCPLTKAGPKIVSHLLHLVDDKESLENVSENDDYLKHRPEISQEMVFIR 845
Cdd:pfam17889    1 EDQDLGLYYLKQINSILKAVSRYNNFLLY-TCHSSTKAGPKIVSHLLHLVDHKESLENLSENDDYLKHHPETSLLMQNIR 79

                           90       100
                   ....*....|....*....|....*..
gi 395825442   846 RFWQMAPQAYFSLVSNHLLGLALKIAY 872
Cdd:pfam17889   80 SLWQLSPELYLSSVSEHLLSLALEIAY 106
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 464-617 5.13e-38

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 140.13  E-value: 5.13e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442   464 SVMCVEGEAGSGKTIFLKKIAFLWASGCCPflNRFQLVFYLSLSATR---PGQGLADIISDQLLEKEGSVTEmcLRNIIQ 540
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLP--QGFDFVFFLPCRELSrsgNARSLADLLFSQWPEPAAPVSE--VWAVIL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442   541 QLRNQVLFLLDDYKEMGSVPQDVER----------LIQKNHSSRTCLLIAVRTNRARDIRRYLDT--ILEIKAFPFYNTI 608
Cdd:pfam05729   77 ELPERLLLILDGLDELVSDLGQLDGpcpvltllssLLRKKLLPGASLLLTVRPDALRDLRRGLEEprYLEVRGFSESDRK 156


                   ....*....
gi 395825442   609 CILRKLFSH 617
Cdd:pfam05729  157 QYVRKYFSD 165
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 162-228 1.39e-32

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 120.84  E-value: 1.39e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 395825442   162 RLESFKNWPFYAQAT-SPRALSAAGFVFTGERDTVQCFSCSGCLGNWEEGDDPWKEHAKWFPKCEFLQ 228
Cdd:pfam00653    1 RLATFENWPHSNKSPpTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 159-229 3.50e-32

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 119.73  E-value: 3.50e-32
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 395825442    159 EEARLESFKNWPFYAQATsPRALSAAGFVFTGERDTVQCFSCSGCLGNWEEGDDPWKEHAKWFPKCEFLQR 229
Cdd:smart00238    2 EEARLKTFQNWPYNSKCT-PEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 279-347 8.22e-32

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 118.91  E-value: 8.22e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 395825442  279 ELRLDSFKNWPQESSAGVAALAKAGLFYTGIKDIVQCFSCGGCLENWKEGDDPLEDHTKYFPNCQFIQN 347
Cdd:cd00022     1 EARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 160-228 1.55e-31

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 117.75  E-value: 1.55e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 395825442  160 EARLESFKNWPFYAQATsPRALSAAGFVFTGERDTVQCFSCSGCLGNWEEGDDPWKEHAKWFPKCEFLQ 228
Cdd:cd00022     1 EARLKTFKNWPISLKVT-PEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVL 68
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 277-347 1.92e-31

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 117.80  E-value: 1.92e-31
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 395825442    277 NEELRLDSFKNWPQESSAGVAALAKAGLFYTGIKDIVQCFSCGGCLENWKEGDDPLEDHTKYFPNCQFIQN 347
Cdd:smart00238    1 SEEARLKTFQNWPYNSKCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 281-346 2.46e-28

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 108.90  E-value: 2.46e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 395825442   281 RLDSFKNWP--QESSAGVAALAKAGLFYTGIKDIVQCFSCGGCLENWKEGDDPLEDHTKYFPNCQFIQ 346
Cdd:pfam00653    1 RLATFENWPhsNKSPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 61-129 1.56e-22

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 92.33  E-value: 1.56e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 395825442   61 ARRLKTFETHPQDGSWTPQEMAAAGFYFTGVKTGIQCFCCSLILFGTSLRRVPIEDHKTFHQDCEFLLS 129
Cdd:cd00022     1 EARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 63-127 7.24e-22

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 90.41  E-value: 7.24e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 395825442    63 RLKTFET--HPQDGSWTPQEMAAAGFYFTGVKTGIQCFCCSLILFGTSLRRVPIEDHKTFHQDCEFL 127
Cdd:pfam00653    1 RLATFENwpHSNKSPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFL 67
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 59-129 6.20e-21

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 87.76  E-value: 6.20e-21
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 395825442     59 SEARRLKTFETHPQDGSWTPQEMAAAGFYFTGVKTGIQCFCCSLILFGTSLRRVPIEDHKTFHQDCEFLLS 129
Cdd:smart00238    1 SEEARLKTFQNWPYNSKCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
450-764 1.08e-20

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 99.11  E-value: 1.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442  450 QEPLVLPEVFTKLNSVMCVEGEAGSGKTIFLKKIAFLWASGCCPFLNRfqLVFYLSLSATRPGQGLADIISDQLLEKEGS 529
Cdd:COG5635   167 IESLKRLELLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAEDP--IPILIELRDLAEEASLEDLLAEALEKRGGE 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442  530 VTEmclrNIIQQLRN-QVLFLLDDYKEMgSVPQDVERLIQK-----NHSSRTCLLIAVRTNRARDIRRYLDTILEIKAFP 603
Cdd:COG5635   245 PED----ALERLLRNgRLLLLLDGLDEV-PDEADRDEVLNQlrrflERYPKARVIITSRPEGYDSSELEGFEVLELAPLS 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442  604 FYNTICILRKLFSHNMARLLKFRIYFGRQKNLQESHKTPLFVAAVCANWFQYPFDPSfDDVAVFKSYMECLFLRHKTTIE 683
Cdd:COG5635   320 DEQIEEFLKKWFEATERKAERLLEALEENPELRELARNPLLLTLLALLLRERGELPD-TRAELYEQFVELLLERWDEQRG 398

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442  684 LLQATVSS-------CGELALKGFFSSCFEFSDDDLEEagvdedgDLTMCLMSKFTAQRL---------------RPVYQ 741
Cdd:COG5635   399 LTIYRELSreelrelLSELALAMQENGRTEFAREELEE-------ILREYLGRRKDAEALldelllrtgllvergEGRYS 471

                         330       340
                  ....*....|....*....|...
gi 395825442  742 FLSPPFQEFLAARRLIELLDSDR 764
Cdd:COG5635   472 FAHRSFQEYLAARALVEELDEEL 494
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1064-1275 1.01e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1064 ELSVAEQELLLTLPSLESLELTGT-IQAQVRLIQNSPNLHVFHLKCNffsDFESLMTVLSSCKKLKEVKFSGSFFQSIPf 1142
Cdd:COG4886   100 ELDLSGNEELSNLTNLESLDLSGNqLTDLPEELANLTNLKELDLSNN---QLTDLPEPLGNLTNLKSLDLSNNQLTDLP- 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1143 vAILPNFISLKILNVGNQQFPDketsekFAYTLGSLKNLEELILpTGDGIHQVAKLIvQQCRQLQRLRvlsffqtLDDDS 1222
Cdd:COG4886   176 -EELGNLTNLKELDLSNNQITD------LPEPLGNLTNLEELDL-SGNQLTDLPEPL-ANLTNLETLD-------LSNNQ 239

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 395825442 1223 VMEIAKVavdGGFQKLENLNLSINhKITEegyrnfFQALDNLPNLQELSITRN 1275
Cdd:COG4886   240 LTDLPEL---GNLTNLEELDLSNN-QLTD------LPPLANLTNLKTLDLSNN 282
NOD2_WH pfam17779
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ...
 687-742 1.16e-05

NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.


Pssm-ID: 465501  Cd Length: 57  Bit Score: 44.09  E-value: 1.16e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 395825442   687 ATVSSCGELALKGFFSSCFEFSDDDLEEAGVDEDgDLTMCLMSKFTAQRL--RPVYQF 742
Cdd:pfam17779    1 KLLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDES-DLSSGLLTEILQKDLgcEKVYSF 57
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1025-1276 1.44e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1025 PASQHIELHLTHSSGIIESIRPALE-------LHKASVTKCSIdkCELSVAEQELLLTLPSLESLELT--GTIQAQVRLI 1095
Cdd:cd00116    51 PSLKELCLSLNETGRIPRGLQSLLQgltkgcgLQELDLSDNAL--GPDGCGVLESLLRSSSLQELKLNnnGLGDRGLRLL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1096 Q-----NSPNLHVFHLKCNFFSD--FESLMTVLSSCKKLKEVKFS--GSFFQSIPFVA-ILPNFISLKILNVGNQQFPDK 1165
Cdd:cd00116   129 AkglkdLPPALEKLVLGRNRLEGasCEALAKALRANRDLKELNLAnnGIGDAGIRALAeGLKANCNLEVLDLNNNGLTDE 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1166 ETSeKFAYTLGSLKNLEELILptgdgihqvaklivQQCRqlqrlrvlsffqtLDDDSVMEIAKvAVDGGFQKLENLNLSI 1245
Cdd:cd00116   209 GAS-ALAETLASLKSLEVLNL--------------GDNN-------------LTDAGAAALAS-ALLSPNISLLTLSLSC 259

                         250       260       270
                  ....*....|....*....|....*....|.
gi 395825442 1246 NHkITEEGYRNFFQALDNLPNLQELSITRNY 1276
Cdd:cd00116   260 ND-ITDDGAKDLAEVLAEKESLLELDLRGNK 289
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 1048-1324 1.20e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1048 LELHKASVTKCSIDKCELSVAEQELLlTLPSLEsLELTGTIQAQVRLIQNsPNLHVFHLKCNFFSD--FESLMTVLSSCK 1125
Cdd:COG5238   160 GLAARLGLLAAISMAKALQNNSVETV-YLGCNQ-IGDEGIEELAEALTQN-TTVTTLWLKRNPIGDegAEILAEALKGNK 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1126 KLKEVKFSGSFFQSIPFVAI---LPNFISLKILNVGNQQFpDKETSEKFAYTLGSLKNLEELIL---PTGDgihQVAKLI 1199
Cdd:COG5238   237 SLTTLDLSNNQIGDEGVIALaeaLKNNTTVETLYLSGNQI-GAEGAIALAKALQGNTTLTSLDLsvnRIGD---EGAIAL 312

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1200 VQQCRQLQRLRVLSFFQT-LDDDSVMEIAKvAVDGGfQKLENLNLSINhKITEEGYRNFFQALDNLPNLQELSITRNYTH 1278
Cdd:COG5238   313 AEGLQGNKTLHTLNLAYNgIGAQGAIALAK-ALQEN-TTLHSLDLSDN-QIGDEGAIALAKYLEGNTTLRELNLGKNNIG 389

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 395825442 1279 CIKAQAttvksLSQcVLRLPSLTTLHMLSWLLDAEDIALLNVMKER 1324
Cdd:COG5238   390 KQGAEA-----LID-ALQTNRLHTLILDGNLIGAEAQQRLEQLLER 429
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1145-1304 3.85e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.46  E-value: 3.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1145 ILPNFISLKILNVGNQQFPDKETSEKFAYTLGSLKNLEELILPTGDGIHQVAKL------------IVQQCRQLQRLRVL 1212
Cdd:COG4886    62 LSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLesldlsgnqltdLPEELANLTNLKEL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1213 SffqtLDDDSVMEIAKVAvdGGFQKLENLNLSINhKITEegyrnFFQALDNLPNLQELSITRNYthcikaqattVKSLSQ 1292
Cdd:COG4886   142 D----LSNNQLTDLPEPL--GNLTNLKSLDLSNN-QLTD-----LPEELGNLTNLKELDLSNNQ----------ITDLPE 199

                         170
                  ....*....|..
gi 395825442 1293 CVLRLPSLTTLH 1304
Cdd:COG4886   200 PLGNLTNLEELD 211
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1236-1333 6.19e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 6.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395825442 1236 QKLENLNLSINHkITEEGYRNFFQALDNLPNLQELSITRNYTHCIKAQAttvksLSQCVLRLPSLTTLHMLSWLLDAEDI 1315
Cdd:cd00116   165 RDLKELNLANNG-IGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASA-----LAETLASLKSLEVLNLGDNNLTDAGA 238

                          90
                  ....*....|....*....
gi 395825442 1316 A-LLNVMKERHPQSKHLNI 1333
Cdd:cd00116   239 AaLASALLSPNISLLTLSL 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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