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Conserved domains on  [gi|394338888|gb|AFN28388|]
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pleiomorphic adenoma protein-like 2 protein, partial [Microctenopoma nanum]

Protein Classification

zinc finger family protein( domain architecture ID 706824)

zinc finger family protein may be involved in transcriptional regulation; similar to Schizosaccharomyces pombe E3 ubiquitin-protein ligase hel2, which that plays a key role in the ribosome quality control (RQC), and Homo sapiens histone H4 transcription factor

Gene Ontology:  GO:0008270
PubMed:  11179890

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5236 super family cl28715
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
5-120 7.30e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5236:

Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 40.00  E-value: 7.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394338888   5 FKCEECGKHYNTKlGYKRHVAMHSATAGDLTCKVCMQSYESTPVLLE-----HLKSHSGKSSGGAKEKKHP-CDHCDRRF 78
Cdd:COG5236  152 FKCPKSKCHRRCG-SLKELKKHYKAQHGFVLCSECIGNKKDFWNEIRlfrssTLRDHKNGGLEEEGFKGHPlCIFCKIYF 230

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 394338888  79 YTRKDVRRHMVVHTGRkdflCQYC-------AQRFGRKDHLTRHVKKSH 120
Cdd:COG5236  231 YDDDELRRHCRLRHEA----CHICdmvgpirYQYFKSYEDLEAHFRNAH 275
 
Name Accession Description Interval E-value
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
5-120 7.30e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 40.00  E-value: 7.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394338888   5 FKCEECGKHYNTKlGYKRHVAMHSATAGDLTCKVCMQSYESTPVLLE-----HLKSHSGKSSGGAKEKKHP-CDHCDRRF 78
Cdd:COG5236  152 FKCPKSKCHRRCG-SLKELKKHYKAQHGFVLCSECIGNKKDFWNEIRlfrssTLRDHKNGGLEEEGFKGHPlCIFCKIYF 230

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 394338888  79 YTRKDVRRHMVVHTGRkdflCQYC-------AQRFGRKDHLTRHVKKSH 120
Cdd:COG5236  231 YDDDELRRHCRLRHEA----CHICdmvgpirYQYFKSYEDLEAHFRNAH 275
 
Name Accession Description Interval E-value
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
5-120 7.30e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 40.00  E-value: 7.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394338888   5 FKCEECGKHYNTKlGYKRHVAMHSATAGDLTCKVCMQSYESTPVLLE-----HLKSHSGKSSGGAKEKKHP-CDHCDRRF 78
Cdd:COG5236  152 FKCPKSKCHRRCG-SLKELKKHYKAQHGFVLCSECIGNKKDFWNEIRlfrssTLRDHKNGGLEEEGFKGHPlCIFCKIYF 230

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 394338888  79 YTRKDVRRHMVVHTGRkdflCQYC-------AQRFGRKDHLTRHVKKSH 120
Cdd:COG5236  231 YDDDELRRHCRLRHEA----CHICdmvgpirYQYFKSYEDLEAHFRNAH 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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