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Conserved domains on  [gi|394298806|gb|EJE42368|]
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methyltransferase small domain protein [Staphylococcus epidermidis NIH05003]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11457987)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Methanocaldococcus jannaschii S-adenosylmethionine-dependent methyltransferase MJ0882

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 8-201 2.27e-80

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


:

Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 237.40  E-value: 2.27e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806   8 QPDVKSNPKRISYQIKNAQLELTTDAGVFSKDNVDFGSDLLIKTFlkehPPGPSKTIADVGCGYGPIGLAIGKVSPHHQI 87
Cdd:COG2813    1 APAASDWPRTITVRLAGRDLTFVTLPGVFSRDRLDIGTRLLLEHL----PEPLGGRVLDLGCGYGVIGLALAKRNPEARV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  88 TMLDINNRALALAEMNKTKNQVDNVTIIESDCLSAVNHQCFDYILTNPPIRAG----KDIVHRIFEQAFDRLKTTGELYV 163
Cdd:COG2813   77 TLVDVNARAVELARANAAANGLENVEVLWSDGLSGVPDGSFDLILSNPPFHAGravdKEVAHALIADAARHLRPGGELWL 156

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 394298806 164 VIQKKQgmpSAKKKIEELFGNVEIIAKSKGYYILKSIK 201
Cdd:COG2813  157 VANRHL---PYERKLEELFGNVEVLARNKGFKVLRAVK 191
 
Name Accession Description Interval E-value
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 8-201 2.27e-80

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 237.40  E-value: 2.27e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806   8 QPDVKSNPKRISYQIKNAQLELTTDAGVFSKDNVDFGSDLLIKTFlkehPPGPSKTIADVGCGYGPIGLAIGKVSPHHQI 87
Cdd:COG2813    1 APAASDWPRTITVRLAGRDLTFVTLPGVFSRDRLDIGTRLLLEHL----PEPLGGRVLDLGCGYGVIGLALAKRNPEARV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  88 TMLDINNRALALAEMNKTKNQVDNVTIIESDCLSAVNHQCFDYILTNPPIRAG----KDIVHRIFEQAFDRLKTTGELYV 163
Cdd:COG2813   77 TLVDVNARAVELARANAAANGLENVEVLWSDGLSGVPDGSFDLILSNPPFHAGravdKEVAHALIADAARHLRPGGELWL 156

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 394298806 164 VIQKKQgmpSAKKKIEELFGNVEIIAKSKGYYILKSIK 201
Cdd:COG2813  157 VANRHL---PYERKLEELFGNVEVLARNKGFKVLRAVK 191
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 26-198 4.14e-68

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 205.52  E-value: 4.14e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806   26 QLELTTDAGVFSKDNVDFGSDLLIKTFlkehPPGPSKTIADVGCGYGPIGLAIGKVSPHHQITMLDINNRALALAEMNKT 105
Cdd:pfam05175   1 ELTFKTLPGVFSHGRLDIGSRLLLEHL----PKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  106 KNQVDNVTIIESDCLSAVNHQCFDYILTNPPIRAGK----DIVHRIFEQAFDRLKTTGELYVVIQKKQGMPSAkkkIEEL 181
Cdd:pfam05175  77 ANGLENGEVVASDVYSGVEDGKFDLIISNPPFHAGLattyNVAQRFIADAKRHLRPGGELWIVANRFLGYPPL---LEEL 153

                         170
                  ....*....|....*..
gi 394298806  182 FGNVEIIAKSKGYYILK 198
Cdd:pfam05175 154 FGNVEVVAKTNGFKVLK 170
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
19-191 2.64e-22

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 92.31  E-value: 2.64e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  19 SYQIKNaqLELTTDAGVFSKDNVDFGSDLLIKTFlkehPPGPSKTIADVGCGYGPIGLAIGKVSPHHQITMLDINNRALA 98
Cdd:PRK09489 161 EYQVDG--LTVKTLPGVFSRDGLDVGSQLLLSTL----TPHTKGKVLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALE 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  99 LAEMNKTKNQVDNvTIIESDCLSAVNHQcFDYILTNPPIRAGKDI----VHRIFEQAFDRLKTTGELYVVIQKKQGMPsa 174
Cdd:PRK09489 235 SSRATLAANGLEG-EVFASNVFSDIKGR-FDMIISNPPFHDGIQTsldaAQTLIRGAVRHLNSGGELRIVANAFLPYP-- 310

                        170
                 ....*....|....*..
gi 394298806 175 kKKIEELFGNVEIIAKS 191
Cdd:PRK09489 311 -DLLDETFGSHEVLAQT 326
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 63-165 3.31e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 68.23  E-value: 3.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  63 TIADVGCGYGPIGLAIGKvSPHHQITMLDINNRALALAEMNKTKNQVDNVTIIESDCLSAV--NHQCFDYILTNPPIRAG 140
Cdd:cd02440    1 RVLDLGCGTGALALALAS-GPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPpeADESFDVIISDPPLHHL 79

                         90       100
                 ....*....|....*....|....*
gi 394298806 141 KDIVHRIFEQAFDRLKTTGELYVVI 165
Cdd:cd02440   80 VEDLARFLEEARRLLKPGGVLVLTL 104
 
Name Accession Description Interval E-value
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 8-201 2.27e-80

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 237.40  E-value: 2.27e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806   8 QPDVKSNPKRISYQIKNAQLELTTDAGVFSKDNVDFGSDLLIKTFlkehPPGPSKTIADVGCGYGPIGLAIGKVSPHHQI 87
Cdd:COG2813    1 APAASDWPRTITVRLAGRDLTFVTLPGVFSRDRLDIGTRLLLEHL----PEPLGGRVLDLGCGYGVIGLALAKRNPEARV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  88 TMLDINNRALALAEMNKTKNQVDNVTIIESDCLSAVNHQCFDYILTNPPIRAG----KDIVHRIFEQAFDRLKTTGELYV 163
Cdd:COG2813   77 TLVDVNARAVELARANAAANGLENVEVLWSDGLSGVPDGSFDLILSNPPFHAGravdKEVAHALIADAARHLRPGGELWL 156

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 394298806 164 VIQKKQgmpSAKKKIEELFGNVEIIAKSKGYYILKSIK 201
Cdd:COG2813  157 VANRHL---PYERKLEELFGNVEVLARNKGFKVLRAVK 191
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 26-198 4.14e-68

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 205.52  E-value: 4.14e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806   26 QLELTTDAGVFSKDNVDFGSDLLIKTFlkehPPGPSKTIADVGCGYGPIGLAIGKVSPHHQITMLDINNRALALAEMNKT 105
Cdd:pfam05175   1 ELTFKTLPGVFSHGRLDIGSRLLLEHL----PKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  106 KNQVDNVTIIESDCLSAVNHQCFDYILTNPPIRAGK----DIVHRIFEQAFDRLKTTGELYVVIQKKQGMPSAkkkIEEL 181
Cdd:pfam05175  77 ANGLENGEVVASDVYSGVEDGKFDLIISNPPFHAGLattyNVAQRFIADAKRHLRPGGELWIVANRFLGYPPL---LEEL 153

                         170
                  ....*....|....*..
gi 394298806  182 FGNVEIIAKSKGYYILK 198
Cdd:pfam05175 154 FGNVEVVAKTNGFKVLK 170
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
19-191 2.64e-22

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 92.31  E-value: 2.64e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  19 SYQIKNaqLELTTDAGVFSKDNVDFGSDLLIKTFlkehPPGPSKTIADVGCGYGPIGLAIGKVSPHHQITMLDINNRALA 98
Cdd:PRK09489 161 EYQVDG--LTVKTLPGVFSRDGLDVGSQLLLSTL----TPHTKGKVLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALE 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  99 LAEMNKTKNQVDNvTIIESDCLSAVNHQcFDYILTNPPIRAGKDI----VHRIFEQAFDRLKTTGELYVVIQKKQGMPsa 174
Cdd:PRK09489 235 SSRATLAANGLEG-EVFASNVFSDIKGR-FDMIISNPPFHDGIQTsldaAQTLIRGAVRHLNSGGELRIVANAFLPYP-- 310

                        170
                 ....*....|....*..
gi 394298806 175 kKKIEELFGNVEIIAKS 191
Cdd:PRK09489 311 -DLLDETFGSHEVLAQT 326
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 47-201 8.54e-21

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 87.14  E-value: 8.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  47 LLIKTFLKEHPPGPSKTIADVGCGYGPIGLAIGKVSPHHQITMLDINNRALALAEMNKTKNQVDNVTIIESDCLSAVNHQ 126
Cdd:PRK09328  95 ELVEWALEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGDWFEPLPGG 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806 127 CFDYILTNPP-IRA------------------------GKDIVHRIFEQAFDRLKTTGELYVVIQKKQGmpsakKKIEEL 181
Cdd:PRK09328 175 RFDLIVSNPPyIPEadihllqpevrdhephlalfggedGLDFYRRIIEQAPRYLKPGGWLLLEIGYDQG-----EAVRAL 249

                        170       180
                 ....*....|....*....|
gi 394298806 182 FgnveiiaKSKGYYILKSIK 201
Cdd:PRK09328 250 L-------AAAGFADVETRK 262
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 47-188 3.33e-20

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 85.59  E-value: 3.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  47 LLIKTFLKEHPPGPSKTIADVGCGYGPIGLAIGKVSPHHQITMLDINNRALALAEMNKTKNQVDN-VTIIESDCLSAV-N 124
Cdd:COG2890   99 ELVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLGLEDrVRFLQGDLFEPLpG 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806 125 HQCFDYILTNPP-IRA------------------------GKDIVHRIFEQAFDRLKTTGELYVVIqkkqgMPSAKKKIE 179
Cdd:COG2890  179 DGRFDLIVSNPPyIPEdeiallppevrdheprlaldggedGLDFYRRIIAQAPRLLKPGGWLLLEI-----GEDQGEAVR 253

                        170
                 ....*....|....
gi 394298806 180 EL-----FGNVEII 188
Cdd:COG2890  254 ALleaagFADVETH 267
PRK15001 PRK15001
23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;
8-201 9.68e-19

23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;


Pssm-ID: 184963 [Multi-domain]  Cd Length: 378  Bit Score: 82.77  E-value: 9.68e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806   8 QPDVKSNPKRISYQIKNAQLELTTDAGVFSKDNVDFGSdlliKTFLKEHPPGPSKTIADVGCGYGPIGLAIGKVSPHHQI 87
Cdd:PRK15001 180 EPPLADAPQTVSWKLEGTDWTIHNHANVFSRTGLDIGA----RFFMQHLPENLEGEIVDLGCGNGVIGLTLLDKNPQAKV 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  88 TMLDINNRALALAEMNKTKN---QVDNVTIIESDCLSAVNHQCFDYILTNPPIRA----GKDIVHRIFEQAFDRLKTTGE 160
Cdd:PRK15001 256 VFVDESPMAVASSRLNVETNmpeALDRCEFMINNALSGVEPFRFNAVLCNPPFHQqhalTDNVAWEMFHHARRCLKINGE 335

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 394298806 161 LYVVIQKKQGMPSAKKKIeelFGNVEIIAKSKGYYILKSIK 201
Cdd:PRK15001 336 LYIVANRHLDYFHKLKKI---FGNCTTIATNNKFVVLKAVK 373
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 63-165 3.31e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 68.23  E-value: 3.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  63 TIADVGCGYGPIGLAIGKvSPHHQITMLDINNRALALAEMNKTKNQVDNVTIIESDCLSAV--NHQCFDYILTNPPIRAG 140
Cdd:cd02440    1 RVLDLGCGTGALALALAS-GPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPpeADESFDVIISDPPLHHL 79

                         90       100
                 ....*....|....*....|....*
gi 394298806 141 KDIVHRIFEQAFDRLKTTGELYVVI 165
Cdd:cd02440   80 VEDLARFLEEARRLLKPGGVLVLTL 104
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 57-165 3.73e-11

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 60.16  E-value: 3.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  57 PPGPSKTIADVGCGYGPIGLAIGKVSPHHQITMLDINNRALALAEMNKTKNQVDN-VTIIESDCLSAVNH---QCFDYIL 132
Cdd:COG4123   34 PVKKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDLKEFAAElppGSFDLVV 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 394298806 133 TNPP----------IRAGKDIVH--------RIFEQAFDRLKTTGELYVVI 165
Cdd:COG4123  114 SNPPyfkagsgrksPDEARAIARhedaltleDLIRAAARLLKPGGRFALIH 164
PRK14968 PRK14968
putative methyltransferase; Provisional
 45-192 2.48e-10

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 57.22  E-value: 2.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  45 SDLLIKTFLKEhppgPSKTIADVGCGYGPIGLAIGKVSphHQITMLDINNRALALAEMNKTKNQVDN--VTIIESDCLSA 122
Cdd:PRK14968  12 SFLLAENAVDK----KGDRVLEVGTGSGIVAIVAAKNG--KKVVGVDINPYAVECAKCNAKLNNIRNngVEVIRSDLFEP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806 123 VNHQCFDYILTNPPI--------------------RAGKDIVHRIFEQAFDRLKTTGELYVVIQKKQGMPSAKKKIEELF 182
Cdd:PRK14968  86 FRGDKFDVILFNPPYlpteeeeewddwlnyalsggKDGREVIDRFLDEVGRYLKPGGRILLLQSSLTGEDEVLEYLEKLG 165

                        170
                 ....*....|
gi 394298806 183 GNVEIIAKSK 192
Cdd:PRK14968 166 FEAEVVAEEK 175
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 58-195 2.46e-09

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 53.57  E-value: 2.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806   58 PGPSKTIADVGCGYGPIG-LAIGKVSPHHQITMLDINNRALALAEMNKTKNQVDNVTIIESDCLS---AVNHQCFDYILT 133
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSfELAEELGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEElpeLLEDDKFDVVIS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 394298806  134 NPPIRAGKDIVhRIFEQAFDRLKTTGELYVV-IQKKQGMPSAKKKIEELFGNVEIIAKSKGYY 195
Cdd:pfam13847  81 NCVLNHIPDPD-KVLQEILRVLKPGGRLIISdPDSLAELPAHVKEDSTYYAGCVGGAILKKKL 142
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 53-169 1.18e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 52.61  E-value: 1.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  53 LKEHPPGPSkTIADVGCGYGPIGLAIGKvSPHHQITMLDINNRALALAEMNKTKNQVDNVTIIESDC--LSAVNHQCFDY 130
Cdd:COG0500   20 LLERLPKGG-RVLDLGCGTGRNLLALAA-RFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLaeLDPLPAESFDL 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 394298806 131 IL-------TNPPIRAgkdivhRIFEQAFDRLKTTGELYVVIQKKQ 169
Cdd:COG0500   98 VVafgvlhhLPPEERE------ALLRELARALKPGGVLLLSASDAA 137
PRK14967 PRK14967
putative methyltransferase; Provisional
 45-164 3.72e-07

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 48.90  E-value: 3.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  45 SDLLIKTfLKEHPPGPSKTIADVGCGYGPIGLAIGKVSPHHqITMLDINNRALALAEMNKTKNQVDnVTIIESDCLSAVN 124
Cdd:PRK14967  22 TQLLADA-LAAEGLGPGRRVLDLCTGSGALAVAAAAAGAGS-VTAVDISRRAVRSARLNALLAGVD-VDVRRGDWARAVE 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806 125 HQCFDYILTNPPI-----------------RAGKD---IVHRIFEQAFDRLKTTGELYVV 164
Cdd:PRK14967  99 FRPFDVVVSNPPYvpappdappsrgparawDAGPDgraVLDRLCDAAPALLAPGGSLLLV 158
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 63-196 7.07e-07

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 48.32  E-value: 7.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  63 TIADVGCGYGPIGLAIGKVSPHHqITMLDINNRALALAEMNKTKNQV-DNVTIIESDCLSAVNHQC--FDYILTNPPIRA 139
Cdd:COG2520  183 RVLDMFAGVGPFSIPIAKRSGAK-VVAIDINPDAVEYLKENIRLNKVeDRVTPILGDAREVAPELEgkADRIIMNLPHSA 261

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 394298806 140 gkdivHRIFEQAFDRLKTTGEL--YVVIQKKQGMPSAKKKIEELFG----NVEIIAK------SKGYYI 196
Cdd:COG2520  262 -----DEFLDAALRALKPGGVIhyYEIVPEEDPFERAEERIEEAAEeagyEVEILEKrrvksySPGVYH 325
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 46-163 2.48e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 45.01  E-value: 2.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  46 DLLIKTFLKEHPPgPSKTIADVGCGYGPIGLAIGKVSphHQITMLDINNRALALAemnKTKNQVDNVTIIESDCLS-AVN 124
Cdd:COG2227   11 DRRLAALLARLLP-AGGRVLDVGCGTGRLALALARRG--ADVTGVDISPEALEIA---RERAAELNVDFVQGDLEDlPLE 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 394298806 125 HQCFDYILTNppiragkDIVH------RIFEQAFDRLKTTGELYV 163
Cdd:COG2227   85 DGSFDLVICS-------EVLEhlpdpaALLRELARLLKPGGLLLL 122
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 61-136 1.66e-05

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 44.47  E-value: 1.66e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 394298806  61 SKTIADVGCGYGPIGLAIGKVSPHHQITMLDINNRALALAEMNKTKNQV-DNVTIIESDCLSAVNHQCFDYILTNPP 136
Cdd:PRK01544 139 FLNILELGTGSGCIAISLLCELPNANVIATDISLDAIEVAKSNAIKYEVtDRIQIIHSNWFENIEKQKFDFIVSNPP 215
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 50-164 2.95e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 42.29  E-value: 2.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  50 KTFLKEHPPGPSKTIADVGCGYGPIGLAIGKvsPHHQITMLDINNRALALAEmNKTKNQVDNVTIIESDCLS-AVNHQCF 128
Cdd:COG2226   12 EALLAALGLRPGARVLDLGCGTGRLALALAE--RGARVTGVDISPEMLELAR-ERAAEAGLNVEFVVGDAEDlPFPDGSF 88

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 394298806 129 DYILTNPPIRAGKDIvHRIFEQAFDRLKTTGELYVV 164
Cdd:COG2226   89 DLVISSFVLHHLPDP-ERALAEIARVLKPGGRLVVV 123
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 64-156 3.39e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 41.01  E-value: 3.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806   64 IADVGCGYGPIGLAIGKvSPHHQITMLDINNRALALAEMNKTKNQVdNVTIIESDCLS-AVNHQCFDYILTNPPIRA-GK 141
Cdd:pfam13649   1 VLDLGCGTGRLTLALAR-RGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDlPFPDGSFDLVVSSGVLHHlPD 78

                          90
                  ....*....|....*
gi 394298806  142 DIVHRIFEQAFDRLK 156
Cdd:pfam13649  79 PDLEAALREIARVLK 93
PRK07402 PRK07402
precorrin-6Y C5,15-methyltransferase subunit CbiT;
47-161 4.61e-05

precorrin-6Y C5,15-methyltransferase subunit CbiT;


Pssm-ID: 180961  Cd Length: 196  Bit Score: 42.29  E-value: 4.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  47 LLIKTFLKehpPGPSKTIADVGCGYGPIGLAIGKVSPHHQITMLDINNRALALAEMNKTKNQVDNVTIIESdclSAvnHQ 126
Cdd:PRK07402  30 LLLISQLR---LEPDSVLWDIGAGTGTIPVEAGLLCPKGRVIAIERDEEVVNLIRRNCDRFGVKNVEVIEG---SA--PE 101

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 394298806 127 CFDYILTNPP---IRAGKDIvHRIFEQAFDRLKTTGEL 161
Cdd:PRK07402 102 CLAQLAPAPDrvcIEGGRPI-KEILQAVWQYLKPGGRL 138
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
47-170 5.58e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 41.91  E-value: 5.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  47 LLIKTFLKEHPPGPSKTIADVGCGYGPIGLAIGKVspHHQITMLDINNRALALAemnKTKNQVDNVTIIESDCLSAVNHQ 126
Cdd:COG4976   33 LLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPR--GYRLTGVDLSEEMLAKA---REKGVYDRLLVADLADLAEPDGR 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 394298806 127 cFDYILTN---PPIRAgkdiVHRIFEQAFDRLKTTGELYVVIQKKQG 170
Cdd:COG4976  108 -FDLIVAAdvlTYLGD----LAAVFAGVARALKPGGLFIFSVEDADG 149
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 58-116 5.98e-05

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 42.85  E-value: 5.98e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 394298806  58 PGPSKTIADVGCGYGPIGLAIGKVSPHHQITMLDINNRALALAEMNKTKNQVDNVTIIE 116
Cdd:COG2242  245 LRPGDVLWDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRFGVPNVEVVE 303
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
60-134 6.91e-05

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 40.19  E-value: 6.91e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 394298806  60 PSKTIADVGCGYGPIGLAIGKVSPHHQITMLDINNRALALAemnktKNQVDNVTIIESDCLSAVNHQCFDYILTN 134
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARA-----RARLPNVRFVVADLRDLDPPEPFDLVVSN 70
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
61-116 7.66e-04

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 38.83  E-value: 7.66e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 394298806  61 SKTIADVGCGYGPIGLAIGKVSPHHQITMLDINNRALALAEMNKTKNQVDNVTIIE 116
Cdd:PRK08287  32 AKHLIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGCGNIDIIP 87
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
58-136 2.46e-03

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 37.47  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  58 PGPSKTIADVGCGYGpiGLAI----------GKVSPHHQITMLDINNRALALAEMNKTKNQVDNVTIIESDCLSA--VNH 125
Cdd:COG0286   41 PKPGETVYDPACGSG--GFLVeaaeylkehgGDERKKLSLYGQEINPTTYRLAKMNLLLHGIGDPNIELGDTLSNdgDEL 118

                         90
                 ....*....|.
gi 394298806 126 QCFDYILTNPP 136
Cdd:COG0286  119 EKFDVVLANPP 129
PLN02672 PLN02672
methionine S-methyltransferase
 62-121 6.36e-03

methionine S-methyltransferase


Pssm-ID: 215360 [Multi-domain]  Cd Length: 1082  Bit Score: 37.06  E-value: 6.36e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 394298806   62 KTIADVGCGYGPIGLAIG-KVSPhHQITMLDINNRALALAEMN----------------KTKNQVDNVTIIESDCLS 121
Cdd:PLN02672  120 KTVAELGCGNGWISIAIAeKWLP-SKVYGLDINPRAVKVAWINlylnaldddglpvydgEGKTLLDRVEFYESDLLG 195
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 63-199 9.20e-03

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 35.93  E-value: 9.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394298806  63 TIADVGCGYGPI----GLAIGKVSphhQITMLDINNRALALAEMNKTKNQV-DNVTIIESDCLSAVNH--QCFDYILtnp 135
Cdd:PRK00377  43 MILDIGCGTGSVtveaSLLVGETG---KVYAVDKDEKAINLTRRNAEKFGVlNNIVLIKGEAPEILFTinEKFDRIF--- 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 394298806 136 pIRAGKDIVHRIFEQAFDRLKTTGELYVVIQKKQGMPSAKKKIEELFGNVEIIA-------KSKGYYILKS 199
Cdd:PRK00377 117 -IGGGSEKLKEIISASWEIIKKGGRIVIDAILLETVNNALSALENIGFNLEITEviiakgmKTKVGTAMMT 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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