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Conserved domains on  [gi|394267997|gb|EJE12573|]
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hypothetical protein HMPREF9981_00965, partial [Staphylococcus epidermidis NIHLM020]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 1-59 1.44e-11

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member COG0763:

Pssm-ID: 471961  Cd Length: 378  Bit Score: 57.77  E-value: 1.44e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 394267997   1 GEVERLLPMLLGAANILHTKYPDIQFLIPAINDARKQQIeqgvEQLAPQLKAKIHILEN 59
Cdd:COG0763  197 SEIKRLLPVFLEAAKLLAARRPDLQFVVPLAPSLRRELI----EAALADWPLPVTLVDG 251
 
Name Accession Description Interval E-value
LpxB COG0763
Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis]; Lipid A disaccharide ...
 1-59 1.44e-11

Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis]; Lipid A disaccharide synthetase is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 440526  Cd Length: 378  Bit Score: 57.77  E-value: 1.44e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 394267997   1 GEVERLLPMLLGAANILHTKYPDIQFLIPAINDARKQQIeqgvEQLAPQLKAKIHILEN 59
Cdd:COG0763  197 SEIKRLLPVFLEAAKLLAARRPDLQFVVPLAPSLRRELI----EAALADWPLPVTLVDG 251
 
Name Accession Description Interval E-value
LpxB COG0763
Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis]; Lipid A disaccharide ...
 1-59 1.44e-11

Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis]; Lipid A disaccharide synthetase is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 440526  Cd Length: 378  Bit Score: 57.77  E-value: 1.44e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 394267997   1 GEVERLLPMLLGAANILHTKYPDIQFLIPAINDARKQQIeqgvEQLAPQLKAKIHILEN 59
Cdd:COG0763  197 SEIKRLLPVFLEAAKLLAARRPDLQFVVPLAPSLRRELI----EAALADWPLPVTLVDG 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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