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Conserved domains on  [gi|392871570|ref|NP_001257289|]
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C-C motif chemokine 21b precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chemokine super family cl00134
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
 29-91 1.97e-23

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


The actual alignment was detected with superfamily member cd01119:

Pssm-ID: 469625  Cd Length: 61  Bit Score: 85.92  E-value: 1.97e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392871570  29 QDCCLKYSQKKIPYSIVRGYRKQEPSLGCPIPAILFLPRKHSKpeLCANPEEGWVQNLMRRLD 91
Cdd:cd01119    1 EDCCLSYTQHPIPWRVLRGYTYQEISESCDIPAIIFHTRRGRK--VCADPKQDWVKRAIQLLS 61
 
Name Accession Description Interval E-value
Chemokine_CC_DCCL cd01119
Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL ...
 29-91 1.97e-23

Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by blocking progression through the cell cycle; DCCL subgroup contains Exodus-1 (also known as CCL20, MIP-3alpha, LARC, ST38 (mouse)), Exodus-2 (also known as CCL21, SLC, 6-Ckine, TCA4, CKbeta9), and Exodus-3 (also known as CCL-19, ELC, MIP-3beta, CKbeta11). Exodus-3 was shown to inhibit the growth of human breast cancer cells in vivo in a mouse model; Exodus-1, -2, and -3 were all shown to significantly inhibit chronic myelogenous leukemia progenitor cell proliferation; Exodus-2 and -3 show potent immunotherapeutic activity toward solid tumors; chemotatic for T cells, B cells, dendritic cells, macrophage progenitor cells, and NK cells; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates. See CDs: Chemokine_CC (cd00272) for the entire CC subgroup, Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


Pssm-ID: 238539  Cd Length: 61  Bit Score: 85.92  E-value: 1.97e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392871570  29 QDCCLKYSQKKIPYSIVRGYRKQEPSLGCPIPAILFLPRKHSKpeLCANPEEGWVQNLMRRLD 91
Cdd:cd01119    1 EDCCLSYTQHPIPWRVLRGYTYQEISESCDIPAIIFHTRRGRK--VCADPKQDWVKRAIQLLS 61
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 30-90 2.82e-21

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 80.39  E-value: 2.82e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392871570   30 DCCLKYSQKKIPYSIVRGYRKQEPSLGCPIPAILFLPRKHSKpeLCANPEEGWVQNLMRRL 90
Cdd:pfam00048   2 DCCLRYSSKPIPLKRVKSYEIQPASSSCPKPAVIFLTKKGRQ--VCADPKAKWVQRLIKKL 60
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 30-90 2.24e-15

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 65.34  E-value: 2.24e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392871570    30 DCCLKYSQKKIPYSIVRGYRKqePSLGCPIPAILFLPRKHSKpeLCANPEEGWVQNLMRRL 90
Cdd:smart00199   3 RCCLSYTSKKIPLKRIKSYYP--TSSHCPKPAVIFTTKKGRK--VCADPKAKWVQRYIKKL 59
 
Name Accession Description Interval E-value
Chemokine_CC_DCCL cd01119
Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL ...
 29-91 1.97e-23

Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by blocking progression through the cell cycle; DCCL subgroup contains Exodus-1 (also known as CCL20, MIP-3alpha, LARC, ST38 (mouse)), Exodus-2 (also known as CCL21, SLC, 6-Ckine, TCA4, CKbeta9), and Exodus-3 (also known as CCL-19, ELC, MIP-3beta, CKbeta11). Exodus-3 was shown to inhibit the growth of human breast cancer cells in vivo in a mouse model; Exodus-1, -2, and -3 were all shown to significantly inhibit chronic myelogenous leukemia progenitor cell proliferation; Exodus-2 and -3 show potent immunotherapeutic activity toward solid tumors; chemotatic for T cells, B cells, dendritic cells, macrophage progenitor cells, and NK cells; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates. See CDs: Chemokine_CC (cd00272) for the entire CC subgroup, Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


Pssm-ID: 238539  Cd Length: 61  Bit Score: 85.92  E-value: 1.97e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392871570  29 QDCCLKYSQKKIPYSIVRGYRKQEPSLGCPIPAILFLPRKHSKpeLCANPEEGWVQNLMRRLD 91
Cdd:cd01119    1 EDCCLSYTQHPIPWRVLRGYTYQEISESCDIPAIIFHTRRGRK--VCADPKQDWVKRAIQLLS 61
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 30-90 2.82e-21

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 80.39  E-value: 2.82e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392871570   30 DCCLKYSQKKIPYSIVRGYRKQEPSLGCPIPAILFLPRKHSKpeLCANPEEGWVQNLMRRL 90
Cdd:pfam00048   2 DCCLRYSSKPIPLKRVKSYEIQPASSSCPKPAVIFLTKKGRQ--VCADPKAKWVQRLIKKL 60
Chemokine_CC cd00272
Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 31-91 3.00e-18

Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD.


Pssm-ID: 238170  Cd Length: 57  Bit Score: 72.66  E-value: 3.00e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392871570  31 CCLKYSQKKIPYSIVRGYRKQEPSlgCPIPAILFLPRKHSkpELCANPEEGWVQNLMRRLD 91
Cdd:cd00272    1 CCLSYSKKRIPLRVLKSYRRTSSS--CSKPAVIFKTKRGR--EVCADPKQKWVQRYMKLLD 57
Chemokine cd00169
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
 31-91 3.47e-16

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


Pssm-ID: 238098  Cd Length: 59  Bit Score: 67.36  E-value: 3.47e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392871570  31 CCLKYSQKKIPYSIVRGYRKQEPSLGCPIPAILFLPRKHSKpeLCANPEEGWVQNLMRRLD 91
Cdd:cd00169    1 CCLKYTSKPIPPKNIKSYRVQEAGGHCSIPAVIFTTKKGRK--VCADPKEPWVKDLIQKLD 59
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 30-90 2.24e-15

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 65.34  E-value: 2.24e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392871570    30 DCCLKYSQKKIPYSIVRGYRKqePSLGCPIPAILFLPRKHSKpeLCANPEEGWVQNLMRRL 90
Cdd:smart00199   3 RCCLSYTSKKIPLKRIKSYYP--TSSHCPKPAVIFTTKKGRK--VCADPKAKWVQRYIKKL 59
Chemokine_C cd00271
Chemokine_C, C or lymphotactin subgroup, 1 of 4 subgroup designations of chemokines based on ...
 32-91 2.51e-05

Chemokine_C, C or lymphotactin subgroup, 1 of 4 subgroup designations of chemokines based on the arrangement of two N-terminal, conserved cysteine residues. Most of the known chemokines (cd00169) belong to either the CC (cd00272) or CXC (cd00273) subclass. The two other subclasses each have a single known member: fractalkine for the CX3C (cd00274) class and lymphotactin for the C (cd00271) class. Chemokine_Cs differ structurally since they contain only one of the two disulfide bridges that are conserved in all other chemokines and they possess a unique C-terminal extension, which is required for biological activity and thought to play a role in receptor binding. Lymphotactin, a mediator of mucosal immunity, has been found to chemoattract neutrophils and B cells through the XCR1 receptor and thought to be a factor in acute allograft rejection and inflammatory bowel disease.


Pssm-ID: 238169  Cd Length: 72  Bit Score: 39.84  E-value: 2.51e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392871570  32 CLKYSQKKIPYSIVRGYRKQEpslgCPIPAILFLPRKHSKpeLCANPEEGWVQNLMRRLD 91
Cdd:cd00271   11 CVSLTTQRLPVQKIKTYTIKE----GSVRAVIFITKRGLK--ICADPQAKWVKSAVKTID 64
Chemokine_CX3C cd00274
Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 39-95 3.70e-04

Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically cleaved to a freely diffusible form; chemotatic for T cells, monocytes, and natural killer cells; function as monomers and are found only in vertebrates and a few viruses; currently only fractalkine (sometimes called neurotactin) has been identified as a member of this subfamily; the primary source of fractalkine is neurons, and they exhibit cell adhesion and chemoattractive properties in the central nervous system. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_CC (cd00272), and Chemokine_C (cd00271) for the additional chemokine subgroups.


Pssm-ID: 238172  Cd Length: 76  Bit Score: 36.97  E-value: 3.70e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 392871570  39 KIPYSIVRGYRKQEPSlgCPIPAILFLPRKHSKpeLCANPEEGWVQNLMRRLDQPPA 95
Cdd:cd00274   18 KIPVALLIHYQQNQES--CGKRAIILETRQHRL--FCADPKEQWVKDAMQHLDRQAA 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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