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Conserved domains on  [gi|3891387]
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Chain B, 6-PHOSPHOGLUCONATE DEHYDROGENASE

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gnd super family cl33850
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 14-468 2.75e-171

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


The actual alignment was detected with superfamily member COG0362:

Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 489.97  E-value: 2.75e-171
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   14 ANLALNIAEKGFKVAVFNRTYSKSEEFMKAnasAPFAGNLKAFETMEAFAASLKKPRKALILVQAGAATDSTIEQLKKVF 93
Cdd:COG0362  15 RNLALNIADHGFSVAVYNRTAEKTDAFLAE---HGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPVDAVIEQLLPLL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   94 EKGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKAdDGRPCVT 173
Cdd:COG0362  92 EPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIAAKV-DGEPCVT 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387  174 MNGSGGAGSCVKMYHNSGEYAILQIWGEVFDILR-AMGLNNDEVAAVLEDWkSKNFLKSYMLDISIAAARAKD-KDGSYL 251
Cdd:COG0362 171 YIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRdGLGLSNDEIAEVFAEW-NKGELDSYLIEITADILRKKDpETGKPL 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387  252 TEHVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQANASNAPGITQSPGYTLKNKSpsgpeIKQLYD 331
Cdd:COG0362 250 VDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEGDKEAF-----IEDLRD 324

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387  332 SVCIAIISCYAQMFQCLREMDKVHNFGLNLpATIAT-FRAGCILQGYLLKPMTEAFEKNPNISNLMCA--FQTEIRAGLQ 408
Cdd:COG0362 325 ALYASKIVSYAQGFALLRAASKEYGWNLDL-GEIARiWRGGCIIRARFLDDITEAYDKNPDLPNLLLDpyFADALKKAQP 403

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387  409 NYRDMVALITsKLEVSIPVLSASLNYVTAMFTPTLKyGQLVSLQRDVFGRHGYERVDKDG 468
Cdd:COG0362 404 AWRRVVATAA-LAGIPVPAFSSALAYYDSYRSARLP-ANLIQAQRDYFGAHTYERVDKEG 461
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 14-468 2.75e-171

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 489.97  E-value: 2.75e-171
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   14 ANLALNIAEKGFKVAVFNRTYSKSEEFMKAnasAPFAGNLKAFETMEAFAASLKKPRKALILVQAGAATDSTIEQLKKVF 93
Cdd:COG0362  15 RNLALNIADHGFSVAVYNRTAEKTDAFLAE---HGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPVDAVIEQLLPLL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   94 EKGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKAdDGRPCVT 173
Cdd:COG0362  92 EPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIAAKV-DGEPCVT 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387  174 MNGSGGAGSCVKMYHNSGEYAILQIWGEVFDILR-AMGLNNDEVAAVLEDWkSKNFLKSYMLDISIAAARAKD-KDGSYL 251
Cdd:COG0362 171 YIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRdGLGLSNDEIAEVFAEW-NKGELDSYLIEITADILRKKDpETGKPL 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387  252 TEHVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQANASNAPGITQSPGYTLKNKSpsgpeIKQLYD 331
Cdd:COG0362 250 VDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEGDKEAF-----IEDLRD 324

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387  332 SVCIAIISCYAQMFQCLREMDKVHNFGLNLpATIAT-FRAGCILQGYLLKPMTEAFEKNPNISNLMCA--FQTEIRAGLQ 408
Cdd:COG0362 325 ALYASKIVSYAQGFALLRAASKEYGWNLDL-GEIARiWRGGCIIRARFLDDITEAYDKNPDLPNLLLDpyFADALKKAQP 403

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387  409 NYRDMVALITsKLEVSIPVLSASLNYVTAMFTPTLKyGQLVSLQRDVFGRHGYERVDKDG 468
Cdd:COG0362 404 AWRRVVATAA-LAGIPVPAFSSALAYYDSYRSARLP-ANLIQAQRDYFGAHTYERVDKEG 461
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
15-468 6.78e-167

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 478.46  E-value: 6.78e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    15 NLALNIAEKGFKVAVFNRTYSKSEEFMKANASApfaGNLKAFETMEAFAASLKKPRKALILVQAGAATDSTIEQLKKVFE 94
Cdd:PRK09287   4 NLALNIASHGYTVAVYNRTPEKTDEFLAEEGKG---KKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    95 KGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKADDGRPCVTM 174
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   175 NGSGGAGSCVKMYHNSGEYAILQIWGEVFDILR-AMGLNNDEVAAVLEDWkSKNFLKSYMLDISIAAARAKD-KDGSYLT 252
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKdGLGLSAEEIADVFAEW-NKGELNSYLIEITADILRQKDeETGKPLV 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   253 EHVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQANASNAPGITQSPGYTLKNkspsgpEIKQLYDS 332
Cdd:PRK09287 240 DVILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAAKFEGDKAE------FIEDVRQA 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   333 VCIAIISCYAQMFQCLREMDKVHNFGLNLPATIATFRAGCILQGYLLKPMTEAFEKNPNISNLMCA--FQTEIRAGLQNY 410
Cdd:PRK09287 314 LYASKIVSYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDpyFKDILEEYQDAL 393

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 3891387   411 RDMVALiTSKLEVSIPVLSASLNYVTAMFTPTLKyGQLVSLQRDVFGRHGYERVDKDG 468
Cdd:PRK09287 394 RRVVAL-AVQAGIPVPAFSSALSYYDSYRTARLP-ANLIQAQRDYFGAHTYERTDKEG 449
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 15-472 2.21e-141

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 413.72  E-value: 2.21e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387     15 NLALNIAEKGFKVAVFNRTYSKSEEFMKANASApfaGNLKAFETMEAFAASLKKPRKALILVQAGAATDSTIEQLKKVFE 94
Cdd:TIGR00873  13 NLALNMEDHGFTVSVYNRTPSKTDEFLAEEAKG---KSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAVIDSLLPLLE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387     95 KGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKADdGRPCVTM 174
Cdd:TIGR00873  90 KGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKVD-GEPCCTW 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    175 NGSGGAGSCVKMYHNSGEYAILQIWGEVFDILR-AMGLNNDEVAAVLEDWKSKNfLKSYMLDISIAAARAKDKDGSYLTE 253
Cdd:TIGR00873 169 VGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKrGLGLSNEEIAEIFTEWNNGE-LDSYLIEITADILAKKDEDGNPLVD 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    254 HVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQANASNAPGitqspgyTLKNKSPSGPE--IKQLYD 331
Cdd:TIGR00873 248 KILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPG-------PEAPKKGVDKEefIEDVRQ 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    332 SVCIAIISCYAQMFQCLREMDKVHNFGLNLPATIATFRAGCILQGYLLKPMTEAFEKNPNISNLMCA--FQTEIRAGLQN 409
Cdd:TIGR00873 321 ALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLApyFKQALTDAQSG 400

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3891387    410 YRDMVALITSKlEVSIPVLSASLNYVTAMFTPTLKyGQLVSLQRDVFGRHGYERVDKDGRESF 472
Cdd:TIGR00873 401 WRKVVALAITY-GIPVPAFSAALSFYDGYRTARLP-ANLLQAQRDYFGAHTYERTDKPRGEFF 461
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 181-474 4.24e-108

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 322.48  E-value: 4.24e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    181 GSCVKMYHNSGEYAILQIWGEVFDILR-AMGLNNDEVAAVLEDWKsKNFLKSYMLDISIAAARAKDK-DGSYLTEHVMDR 258
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKrGLGLSNDEIADVFEEWN-KGELDSYLIEITADILRKKDPeDGKPLVDKILDK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    259 IGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQANASNAPGITQSPGYTLKNKSpsgpeIKQLYDSVCIAII 338
Cdd:pfam00393  80 AGQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPPPALFEGDKEAF-----IEDLRQALYASKI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    339 SCYAQMFQCLREMDKVHNFGLNLPATIATFRAGCILQGYLLKPMTEAFEKNPNISNLMCA--FQTEIRAGLQNYRDMVAL 416
Cdd:pfam00393 155 ISYAQGFALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDpyFAKELKEAQPSWRRVVAL 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 3891387    417 iTSKLEVSIPVLSASLNYVTAMFTPTLKyGQLVSLQRDVFGRHGYERVDKDGRESFQW 474
Cdd:pfam00393 235 -AVEAGIPVPALSAALSYYDGYRSERLP-ANLIQAQRDYFGAHTYERIDKEGFFHTEW 290
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 14-468 2.75e-171

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 489.97  E-value: 2.75e-171
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   14 ANLALNIAEKGFKVAVFNRTYSKSEEFMKAnasAPFAGNLKAFETMEAFAASLKKPRKALILVQAGAATDSTIEQLKKVF 93
Cdd:COG0362  15 RNLALNIADHGFSVAVYNRTAEKTDAFLAE---HGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPVDAVIEQLLPLL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   94 EKGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKAdDGRPCVT 173
Cdd:COG0362  92 EPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIAAKV-DGEPCVT 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387  174 MNGSGGAGSCVKMYHNSGEYAILQIWGEVFDILR-AMGLNNDEVAAVLEDWkSKNFLKSYMLDISIAAARAKD-KDGSYL 251
Cdd:COG0362 171 YIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRdGLGLSNDEIAEVFAEW-NKGELDSYLIEITADILRKKDpETGKPL 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387  252 TEHVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQANASNAPGITQSPGYTLKNKSpsgpeIKQLYD 331
Cdd:COG0362 250 VDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEGDKEAF-----IEDLRD 324

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387  332 SVCIAIISCYAQMFQCLREMDKVHNFGLNLpATIAT-FRAGCILQGYLLKPMTEAFEKNPNISNLMCA--FQTEIRAGLQ 408
Cdd:COG0362 325 ALYASKIVSYAQGFALLRAASKEYGWNLDL-GEIARiWRGGCIIRARFLDDITEAYDKNPDLPNLLLDpyFADALKKAQP 403

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387  409 NYRDMVALITsKLEVSIPVLSASLNYVTAMFTPTLKyGQLVSLQRDVFGRHGYERVDKDG 468
Cdd:COG0362 404 AWRRVVATAA-LAGIPVPAFSSALAYYDSYRSARLP-ANLIQAQRDYFGAHTYERVDKEG 461
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
15-468 6.78e-167

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 478.46  E-value: 6.78e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    15 NLALNIAEKGFKVAVFNRTYSKSEEFMKANASApfaGNLKAFETMEAFAASLKKPRKALILVQAGAATDSTIEQLKKVFE 94
Cdd:PRK09287   4 NLALNIASHGYTVAVYNRTPEKTDEFLAEEGKG---KKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    95 KGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKADDGRPCVTM 174
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   175 NGSGGAGSCVKMYHNSGEYAILQIWGEVFDILR-AMGLNNDEVAAVLEDWkSKNFLKSYMLDISIAAARAKD-KDGSYLT 252
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKdGLGLSAEEIADVFAEW-NKGELNSYLIEITADILRQKDeETGKPLV 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   253 EHVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQANASNAPGITQSPGYTLKNkspsgpEIKQLYDS 332
Cdd:PRK09287 240 DVILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAAKFEGDKAE------FIEDVRQA 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   333 VCIAIISCYAQMFQCLREMDKVHNFGLNLPATIATFRAGCILQGYLLKPMTEAFEKNPNISNLMCA--FQTEIRAGLQNY 410
Cdd:PRK09287 314 LYASKIVSYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDpyFKDILEEYQDAL 393

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 3891387   411 RDMVALiTSKLEVSIPVLSASLNYVTAMFTPTLKyGQLVSLQRDVFGRHGYERVDKDG 468
Cdd:PRK09287 394 RRVVAL-AVQAGIPVPAFSSALSYYDSYRTARLP-ANLIQAQRDYFGAHTYERTDKEG 449
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 15-472 2.21e-141

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 413.72  E-value: 2.21e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387     15 NLALNIAEKGFKVAVFNRTYSKSEEFMKANASApfaGNLKAFETMEAFAASLKKPRKALILVQAGAATDSTIEQLKKVFE 94
Cdd:TIGR00873  13 NLALNMEDHGFTVSVYNRTPSKTDEFLAEEAKG---KSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAVIDSLLPLLE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387     95 KGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKADdGRPCVTM 174
Cdd:TIGR00873  90 KGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKVD-GEPCCTW 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    175 NGSGGAGSCVKMYHNSGEYAILQIWGEVFDILR-AMGLNNDEVAAVLEDWKSKNfLKSYMLDISIAAARAKDKDGSYLTE 253
Cdd:TIGR00873 169 VGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKrGLGLSNEEIAEIFTEWNNGE-LDSYLIEITADILAKKDEDGNPLVD 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    254 HVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQANASNAPGitqspgyTLKNKSPSGPE--IKQLYD 331
Cdd:TIGR00873 248 KILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPG-------PEAPKKGVDKEefIEDVRQ 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    332 SVCIAIISCYAQMFQCLREMDKVHNFGLNLPATIATFRAGCILQGYLLKPMTEAFEKNPNISNLMCA--FQTEIRAGLQN 409
Cdd:TIGR00873 321 ALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLApyFKQALTDAQSG 400

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3891387    410 YRDMVALITSKlEVSIPVLSASLNYVTAMFTPTLKyGQLVSLQRDVFGRHGYERVDKDGRESF 472
Cdd:TIGR00873 401 WRKVVALAITY-GIPVPAFSAALSFYDGYRTARLP-ANLLQAQRDYFGAHTYERTDKPRGEFF 461
PTZ00142 PTZ00142
6-phosphogluconate dehydrogenase; Provisional
 15-474 2.44e-127

6-phosphogluconate dehydrogenase; Provisional


Pssm-ID: 240287 [Multi-domain]  Cd Length: 470  Bit Score: 377.98  E-value: 2.44e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    15 NLALNIAEKGFKVAVFNRTYSKSEEFMKANASAPFagNLKAFETMEAFAASLKKPRKALILVQAGAATDSTIEQLKKVFE 94
Cdd:PTZ00142  15 NLALNIASRGFKISVYNRTYEKTEEFVKKAKEGNT--RVKGYHTLEELVNSLKKPRKVILLIKAGEAVDETIDNLLPLLE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    95 KGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKADDgRPCVTM 174
Cdd:PTZ00142  93 KGDIIIDGGNEWYLNTERRIKRCEEKGILYLGMGVSGGEEGARYGPSLMPGGNKEAYDHVKDILEKCSAKVGD-SPCVTY 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   175 NGSGGAGSCVKMYHNSGEYAILQIWGEVFDILR-AMGLNNDEVAAVLEDWKSKNfLKSYMLDISIAAARAKDKDG-SYLT 252
Cdd:PTZ00142 172 VGPGSSGHYVKMVHNGIEYGDMQLISESYKLMKhILGMSNEELSEVFNKWNEGI-LNSYLIEITAKILAKKDDLGeEHLV 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   253 EHVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQANASNAPGITQSpgytlkNKSPSGPEiKQLYDS 332
Cdd:PTZ00142 251 DKILDIAGSKGTGKWTVQEALERGIPVPTMAASVDARNISALKEERTKASSHLAGPNPA------NKTETEDK-KYFIDD 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   333 VCIAI----ISCYAQMFQCLREMDKVHNFGLNLPATIATFRAGCILQGYLLKPMTEAFEKNPNISNLM--CAFQTEIRAG 406
Cdd:PTZ00142 324 LKNALycskIISYTQGFFLIKEASKEFGWNLNLGEIARIWRGGCIIRAVFLDRIKNAFKKNPQLDLLFldPDFNDELKNK 403

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3891387   407 LQNYRdMVALITSKLEVSIPVLSASLNYVTaMFTPTLKYGQLVSLQRDVFGRHGYERVDKDGRESFQW 474
Cdd:PTZ00142 404 QPSWR-KVVSMATKNGIPTPAFSASLAYYQ-MYRSQNLPANLVQAQRDYFGAHTYKRLDRPGAFHTNW 469
PLN02350 PLN02350
phosphogluconate dehydrogenase (decarboxylating)
 15-477 6.32e-125

phosphogluconate dehydrogenase (decarboxylating)


Pssm-ID: 215200 [Multi-domain]  Cd Length: 493  Bit Score: 372.90  E-value: 6.32e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    15 NLALNIAEKGFKVAVFNRTYSKSEEFMKanaSAPFAGNLK--AFETMEAFAASLKKPRKALILVQAGAATDSTIEQLKKV 92
Cdd:PLN02350  20 NLALNIAEKGFPISVYNRTTSKVDETVE---RAKKEGNLPlyGFKDPEDFVLSIQKPRSVIILVKAGAPVDQTIKALSEY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    93 FEKGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKADDGrPCV 172
Cdd:PLN02350  97 MEPGDCIIDGGNEWYENTERRIKEAAEKGLLYLGMGVSGGEEGARNGPSLMPGGSFEAYKNIEDILEKVAAQVDDG-PCV 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   173 TMNGSGGAGSCVKMYHNSGEYAILQIWGEVFDILRAMG-LNNDEVAAVLEDWkSKNFLKSYMLDI-SIAAARAKDKDGSY 250
Cdd:PLN02350 176 TYIGPGGAGNFVKMVHNGIEYGDMQLISEAYDVLKSVGgLSNEELAEVFAEW-NKGELESFLIEItADIFSVKDDKGDGY 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   251 LTEHVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQAnasnAPGITQSPGYTLKNKSPSGPEIKQLY 330
Cdd:PLN02350 255 LVDKILDKTGMKGTGKWTVQQAAELSVAAPTIAASLDARYLSGLKEERVA----AAKVFKEAGLEDILSADSGVDKKQLI 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   331 DSVCIAI----ISCYAQMFQCLREMDKVHNFGLNLPATIATFRAGCILQGYLLKPMTEAFEKNPNISNLMC--AFQTEIR 404
Cdd:PLN02350 331 DDVRQALyaskICSYAQGMNLIRAKSVEKGWNLNLGELARIWKGGCIIRAVFLDRIKKAYDRNPDLASLLVdpEFAKEMV 410

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3891387   405 AGLQNYRDMVAL-ITSKleVSIPVLSASLNYVTAMFTPTLKyGQLVSLQRDVFGRHGYERVDKDGRESFQWPEL 477
Cdd:PLN02350 411 ERQAAWRRVVSLaINAG--ISTPGMSASLAYFDTYRRARLP-ANLVQAQRDYFGAHTYERVDRPGSFHTEWTKL 481
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 181-474 4.24e-108

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 322.48  E-value: 4.24e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    181 GSCVKMYHNSGEYAILQIWGEVFDILR-AMGLNNDEVAAVLEDWKsKNFLKSYMLDISIAAARAKDK-DGSYLTEHVMDR 258
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKrGLGLSNDEIADVFEEWN-KGELDSYLIEITADILRKKDPeDGKPLVDKILDK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    259 IGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQANASNAPGITQSPGYTLKNKSpsgpeIKQLYDSVCIAII 338
Cdd:pfam00393  80 AGQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPPPALFEGDKEAF-----IEDLRQALYASKI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    339 SCYAQMFQCLREMDKVHNFGLNLPATIATFRAGCILQGYLLKPMTEAFEKNPNISNLMCA--FQTEIRAGLQNYRDMVAL 416
Cdd:pfam00393 155 ISYAQGFALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDpyFAKELKEAQPSWRRVVAL 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 3891387    417 iTSKLEVSIPVLSASLNYVTAMFTPTLKyGQLVSLQRDVFGRHGYERVDKDGRESFQW 474
Cdd:pfam00393 235 -AVEAGIPVPALSAALSYYDGYRSERLP-ANLIQAQRDYFGAHTYERIDKEGFFHTEW 290
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
14-289 6.20e-59

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 196.12  E-value: 6.20e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    14 ANLALNIAEKGFKVAVFNRTYSKSEEFMKANAsapfagnlKAFETMEAFAASLKKPRKALILVQAGAATDSTIEQLKKVF 93
Cdd:PRK09599  13 GNMARRLLRGGHEVVGYDRNPEAVEALAEEGA--------TGADSLEELVAKLPAPRVVWLMVPAGEITDATIDELAPLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    94 EKGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKADDGRpcVT 173
Cdd:PRK09599  85 SPGDIVIDGGNSYYKDDIRRAELLAEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALAPRAEDGY--LH 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   174 MnGSGGAGSCVKMYHNSGEYAILQIWGEVFDILRAMGLNNDeVAAVLEDWKSKNFLKSYMLDISiAAARAKDKDGSYLTE 253
Cdd:PRK09599 163 A-GPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEASRFDLD-LAAVAEVWRRGSVIRSWLLDLT-ADALAEDPKLDEISG 239

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 3891387   254 HVMDrigsKGTGLWSAQEALEIGVPAPSLNMAVVSR 289
Cdd:PRK09599 240 YVED----SGEGRWTVEEAIDLAVPAPVIAAALFMR 271
YqeC COG1023
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
14-293 1.72e-58

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 194.92  E-value: 1.72e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   14 ANLALNIAEKGFKVAVFNRTYSKSEEFMKANAsapfagnlKAFETMEAFAASLKKPRKALILVQAGAATDSTIEQLKKVF 93
Cdd:COG1023  13 GNMARRLLRHGHEVVGYDRNPEAVAALAAEGA--------TGADSLEELVAKLPAPRVVWLMVPAGEITDQVIEELAPLL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   94 EKGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKADDGrpCVT 173
Cdd:COG1023  85 EPGDIVIDGGNSNYKDDIRRAEELAEKGIHFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALAPGAENG--YLH 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387  174 MnGSGGAGSCVKMYHNSGEYAILQIWGEVFDILRAMGLNNDeVAAVLEDWKSKNFLKSYMLDIsIAAARAKDKDGSYLTE 253
Cdd:COG1023 163 C-GPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEASEFDLD-LAEVAEVWRRGSVIRSWLLDL-TADALAEDPKLEGISG 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 3891387  254 HVMDrigSkGTGLWSAQEALEIGVPAP----SLNMAVVSRQ---FTM 293
Cdd:COG1023 240 YVED---S-GEGRWTVEEAIELGVPAPvitaALFARFRSRQedsFAD 282
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 14-176 2.33e-46

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 158.02  E-value: 2.33e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387     14 ANLALNIAEKGFKVAVFNRTYSKSEEFMKANAsapfagnlKAFETMEAFAASLkkpRKALILVQAGAATDSTIEQ--LKK 91
Cdd:pfam03446  12 SPMALNLLKAGYTVTVYNRTPEKVEELVAAGA--------IAAASPAEFVAGL---DVVITMVPAGAAVDAVIFGegLLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387     92 VFEKGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGP-AFFPGGTLSVWEEIRPIVEAAAAkaddgrp 170
Cdd:pfam03446  81 GLKPGDIIIDGSTSSPEDARRRAKELKEKGLHFLDAPVSGGEAGAENGTlSIMVGGDEEAFERVKPILEAMGA------- 153


                  ....*.
gi 3891387    171 CVTMNG 176
Cdd:pfam03446 154 CVTYIG 159
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 10-285 3.34e-11

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 63.98  E-value: 3.34e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   10 GVMGANLALNIAEKGFKVAVFNRTYSKSEEFMKANASApfAGNLKafetmEAFAASlkkprKALIL-VQAGAATDSTIEQ 88
Cdd:COG2084  10 GAMGAPMARNLLKAGHEVTVWNRTPAKAEALVAAGARV--AASPA-----EAAAAA-----DVVITmLPDDAAVEEVLLG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387   89 LKKVFE---KGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGP-AFFPGGTLSVWEEIRPIVEAAAAK 164
Cdd:COG2084  78 EDGLLAalrPGAVVVDMSTISPETARELAAAAAARGVRYLDAPVSGGPAGAEAGTlTIMVGGDEAAFERARPVLEAMGKR 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387  165 addgrpcVTMNGSGGAGSCVKMYHNSGEYAILQIWGEVFDILRAMGLNNDEVAAVLEDWksknFLKSYMLDISIAAARAK 244
Cdd:COG2084 158 -------IVHVGDAGAGQAAKLANNLLLAGTMAALAEALALAEKAGLDPETLLEVLSGG----AAGSWVLENRGPRMLAG 226

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 3891387  245 DKDGSYLTEHVMdrigsKGTGLwSAQEALEIGVPAPSLNMA 285
Cdd:COG2084 227 DFDPGFALDLML-----KDLGL-ALEAARAAGVPLPLAAAA 261
PRK15059 PRK15059
2-hydroxy-3-oxopropionate reductase;
95-186 3.81e-04

2-hydroxy-3-oxopropionate reductase;


Pssm-ID: 185019 [Multi-domain]  Cd Length: 292  Bit Score: 42.32  E-value: 3.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3891387    95 KGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGP-AFFPGGTLSVWEEIRPIVEAAAAKaddgrpcVT 173
Cdd:PRK15059  85 KGKTIVDMSSISPIETKRFARQVNELGGDYLDAPVSGGEIGAREGTlSIMVGGDEAVFERVKPLFELLGKN-------IT 157

                         90
                 ....*....|...
gi 3891387   174 MNGSGGAGSCVKM 186
Cdd:PRK15059 158 LVGGNGDGQTCKV 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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