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Conserved domains on  [gi|387537419|gb|ACN43198|]
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DNA gyrase subunit A, partial [Bacillus mojavensis]

Protein Classification

DNA gyrase subunit A family protein( domain architecture ID 1000081)

DNA gyrase subunit A (GyrA) forms a 2:2 heterotetrameric complex with GyrB to form gyrase, a type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state; may be partial

CATH:  1.10.268.10|3.90.199.10
PubMed:  11395412|9519293|17397985

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05560 super family cl35335
DNA gyrase subunit A; Validated
 1-402 0e+00

DNA gyrase subunit A; Validated


The actual alignment was detected with superfamily member PRK05560:

Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 883.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIAMEILRDITKDT 80
Cdd:PRK05560  60 YKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKET 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQELMEFIPGPDFPTAGQ 160
Cdd:PRK05560 140 VDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGI 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 161 ILGRSGIRKAYESGRGSITIRAKAEIEETSsGKERILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDESDRNGMRI 240
Cdd:PRK05560 220 ILGRSGIREAYRTGRGSIVMRAKAEIEEIK-GREAIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRI 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 241 VIEIRRDANAHVILNNLYKQTALQTSFGINMLALVDGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:PRK05560 299 VIELKRDAVPEVVLNNLYKHTQLQTSFGINMLALVDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGL 378

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 321 RIALDHLDAVISLIRSSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEILANEEK 400
Cdd:PRK05560 379 LIALDNIDEVIALIRASPTPAEAKEGLMERFGLSEIQAQAILDMRLQRLTGLERDKIEDEYKELLALIADLKDILASPER 458


                 ..
gi 387537419 401 VL 402
Cdd:PRK05560 459 LL 460
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-402 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 883.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIAMEILRDITKDT 80
Cdd:PRK05560  60 YKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKET 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQELMEFIPGPDFPTAGQ 160
Cdd:PRK05560 140 VDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGI 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 161 ILGRSGIRKAYESGRGSITIRAKAEIEETSsGKERILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDESDRNGMRI 240
Cdd:PRK05560 220 ILGRSGIREAYRTGRGSIVMRAKAEIEEIK-GREAIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRI 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 241 VIEIRRDANAHVILNNLYKQTALQTSFGINMLALVDGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:PRK05560 299 VIELKRDAVPEVVLNNLYKHTQLQTSFGINMLALVDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGL 378

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 321 RIALDHLDAVISLIRSSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEILANEEK 400
Cdd:PRK05560 379 LIALDNIDEVIALIRASPTPAEAKEGLMERFGLSEIQAQAILDMRLQRLTGLERDKIEDEYKELLALIADLKDILASPER 458


                 ..
gi 387537419 401 VL 402
Cdd:PRK05560 459 LL 460
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-402 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 857.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIAMEILRDITKDT 80
Cdd:COG0188   65 YKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDT 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQELMEFIPGPDFPTAGQ 160
Cdd:COG0188  145 VDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGI 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 161 ILGRSGIRKAYESGRGSITIRAKAEIEETSSGKERILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDESDRNGMRI 240
Cdd:COG0188  225 IVGREGIREAYETGRGSIRVRAKAEIEELKRGREQIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESDRDGMRI 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 241 VIEIRRDANAHVILNNLYKQTALQTSFGINMLALVDGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:COG0188  305 VIELKRDANPEVVLNQLYKHTQLQTSFGINMLALVDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGL 384

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 321 RIALDHLDAVISLIRSSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEILANEEK 400
Cdd:COG0188  385 LIALDNIDEVIAIIRASKDPDEAKEALMERFGLSEIQAEAILDMRLRRLTGLEREKIEDEYAELLKEIAELEDILASEER 464


                 ..
gi 387537419 401 VL 402
Cdd:COG0188  465 LL 466
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-402 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 763.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419    1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIAMEILRDITKDT 80
Cdd:TIGR01063  56 YKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKET 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQELMEFIPGPDFPTAGQ 160
Cdd:TIGR01063 136 VDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGI 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  161 ILGRSGIRKAYESGRGSITIRAKAEIEETSSGKERILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDESDRNGMRI 240
Cdd:TIGR01063 216 ILGRSGIRSAYETGRGSIVIRARAEIEEDSKGREAIIVTEIPYQVNKARLIEKIAELVREKKIEGISDIRDESDREGIRI 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  241 VIEIRRDANAHVILNNLYKQTALQTSFGINMLALVDGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:TIGR01063 296 VIELKRDAVAEVVLNNLYKQTQLQVSFGINMLALVKGLPKVLNLKELLEAFVEHRKDVITRRTIFELRKAEERAHILEGL 375

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  321 RIALDHLDAVISLIRSSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEILANEEK 400
Cdd:TIGR01063 376 LIALDNIDEVIALIRASQNTEEAKTRLVERFSLSEIQAQAILDMRLQRLTGLEREKLQEEYKELLELIADLEDILASEER 455


                  ..
gi 387537419  401 VL 402
Cdd:TIGR01063 456 VL 457
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-402 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 638.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIAMEILRDITKDT 80
Cdd:cd00187   34 EKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNFGSRDGDDAAAMRYTETRLSPIARLLLPDIDDPT 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQELMEFIPGPDFPTAGQ 160
Cdd:cd00187  114 VDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLREVIDALRALIDNPEASIDELMEIIKGPDFPTGGI 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 161 ILGRSGIRKAYESGRGSITIRAKAEIEETsSGKERILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDESDRNGMRI 240
Cdd:cd00187  194 IEGRAGIREAYETGRGRYIIRGKYEIEDD-EGRNTIEITELPYQVNKAKLKEKIAELVKDKKIEGISDVRDESDREGIRF 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 241 VIEIRRDANAHVILNNLYKQTALQTSFGINMLALV-DGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARAHILEG 319
Cdd:cd00187  273 VIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFDpNGRPKKLNLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEG 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 320 LRIALDHLDAVISLIRSSqtaEIARTGLIEQF---SLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEILA 396
Cdd:cd00187  353 LLKAILNIDEVINLIRSS---DEAKKALIEELeklGFSEIQADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILA 429


                 ....*.
gi 387537419 397 NEEKVL 402
Cdd:cd00187  430 SEERPK 435
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-402 0e+00

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 582.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419    1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKIAMEILRDITKD 79
Cdd:pfam00521  31 YKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGSRiDGDKDAAMRYTETRLSKIARELFPDIDDD 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   80 TIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIqeLMEFIPGPDFPTAG 159
Cdd:pfam00521 111 TVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREIIDALIALLDGPEATL--LMKYIMGPDFPTGG 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  160 QILGRSGIRKAYESGRGSITIRAKAEIEEtssgKERILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDESDRnGMR 239
Cdd:pfam00521 189 GIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTSDLIEKIEELVKNGKIKGISDIRDESDR-GVR 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  240 IVIEIRRDANAHVILNNLYKQTALQTSFGINMLALVDGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARAHILEG 319
Cdd:pfam00521 264 IVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGGPKYLGLKEILKEFLDHRLEVYERRKEYLLEKLEERLHILEG 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  320 LRIALDHLDAVISLIRSSQTAEIARTGLIEQfsLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEILANEE 399
Cdd:pfam00521 344 LLIALNNIDFVIEIIRGSIDRKKAKKNLIEE--LSEIQADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASEK 421


                  ...
gi 387537419  400 KVL 402
Cdd:pfam00521 422 KLN 424
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-402 0e+00

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 570.66  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419     1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKIAMEILRDITKD 79
Cdd:smart00434  53 KVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKD 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419    80 TIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQELMEFIPGPDFPTAG 159
Cdd:smart00434 133 TVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGG 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   160 QILGRSgirkayesgrgSITIRAKAEIEETssgkERILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDES-DRNGM 238
Cdd:smart00434 213 EIVGPG-----------KYVVRGKIEIEDD----NTIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGV 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   239 RIVIEIRRDANAHVILNNLYKQTALQTSFGINMLALVD-GEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAE-ARAHI 316
Cdd:smart00434 278 RIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALFDnGRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLEaERLHI 357

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   317 LEGLRIALDHLDAVISLIRSSQ-TAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEIL 395
Cdd:smart00434 358 LEGLFIALSIIDEIIVLIRSSKdLAKEAKEKLMERFELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKIL 437


                   ....*..
gi 387537419   396 ANEEKVL 402
Cdd:smart00434 438 ASEEWLN 444
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-402 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 883.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIAMEILRDITKDT 80
Cdd:PRK05560  60 YKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKET 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQELMEFIPGPDFPTAGQ 160
Cdd:PRK05560 140 VDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGI 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 161 ILGRSGIRKAYESGRGSITIRAKAEIEETSsGKERILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDESDRNGMRI 240
Cdd:PRK05560 220 ILGRSGIREAYRTGRGSIVMRAKAEIEEIK-GREAIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRI 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 241 VIEIRRDANAHVILNNLYKQTALQTSFGINMLALVDGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:PRK05560 299 VIELKRDAVPEVVLNNLYKHTQLQTSFGINMLALVDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGL 378

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 321 RIALDHLDAVISLIRSSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEILANEEK 400
Cdd:PRK05560 379 LIALDNIDEVIALIRASPTPAEAKEGLMERFGLSEIQAQAILDMRLQRLTGLERDKIEDEYKELLALIADLKDILASPER 458


                 ..
gi 387537419 401 VL 402
Cdd:PRK05560 459 LL 460
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-402 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 857.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIAMEILRDITKDT 80
Cdd:COG0188   65 YKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDT 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQELMEFIPGPDFPTAGQ 160
Cdd:COG0188  145 VDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGI 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 161 ILGRSGIRKAYESGRGSITIRAKAEIEETSSGKERILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDESDRNGMRI 240
Cdd:COG0188  225 IVGREGIREAYETGRGSIRVRAKAEIEELKRGREQIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESDRDGMRI 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 241 VIEIRRDANAHVILNNLYKQTALQTSFGINMLALVDGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:COG0188  305 VIELKRDANPEVVLNQLYKHTQLQTSFGINMLALVDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGL 384

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 321 RIALDHLDAVISLIRSSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEILANEEK 400
Cdd:COG0188  385 LIALDNIDEVIAIIRASKDPDEAKEALMERFGLSEIQAEAILDMRLRRLTGLEREKIEDEYAELLKEIAELEDILASEER 464


                 ..
gi 387537419 401 VL 402
Cdd:COG0188  465 LL 466
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-402 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 763.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419    1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIAMEILRDITKDT 80
Cdd:TIGR01063  56 YKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKET 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQELMEFIPGPDFPTAGQ 160
Cdd:TIGR01063 136 VDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGI 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  161 ILGRSGIRKAYESGRGSITIRAKAEIEETSSGKERILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDESDRNGMRI 240
Cdd:TIGR01063 216 ILGRSGIRSAYETGRGSIVIRARAEIEEDSKGREAIIVTEIPYQVNKARLIEKIAELVREKKIEGISDIRDESDREGIRI 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  241 VIEIRRDANAHVILNNLYKQTALQTSFGINMLALVDGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:TIGR01063 296 VIELKRDAVAEVVLNNLYKQTQLQVSFGINMLALVKGLPKVLNLKELLEAFVEHRKDVITRRTIFELRKAEERAHILEGL 375

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  321 RIALDHLDAVISLIRSSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEILANEEK 400
Cdd:TIGR01063 376 LIALDNIDEVIALIRASQNTEEAKTRLVERFSLSEIQAQAILDMRLQRLTGLEREKLQEEYKELLELIADLEDILASEER 455


                  ..
gi 387537419  401 VL 402
Cdd:TIGR01063 456 VL 457
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-400 0e+00

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 661.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIAMEILRDITKDT 80
Cdd:PRK05561  65 FKKSARVVGDVLGKYHPHGDSSIYDAMVRMAQDFSYRYPLVDGQGNFGSIDGDPAAAMRYTEARLSPIAELLLEEIDEGT 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQELMEFIPGPDFPTAGQ 160
Cdd:PRK05561 145 VDFVPNFDGTLKEPTVLPARFPNLLLNGATGIAVGMATDIPPHNLREVIDAAIHLIDNPDATLEELMEFVPGPDFPTGGE 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 161 IL-GRSGIRKAYESGRGSITIRAKAEIEETSSGKERILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDESDR-NGM 238
Cdd:PRK05561 225 IItGRDGIRKAYETGRGSIRVRARWEIEDLAGGRWQIVITELPYQVSKAKLIEQIAELMNAKKLPGIADVRDESDReNPV 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 239 RIVIEIR-RDANAHVILNNLYKQTALQTSFGINMLAL-VDGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARAHI 316
Cdd:PRK05561 305 RIVIEPKsNRVDPEALMNHLFATTDLESSYRVNMNAIgLDGRPRVKGLKEILSEWLDHRREVVTRRSQFRLDKVEKRLHI 384

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 317 LEGLRIALDHLDAVISLIRSSqtaEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEILA 396
Cdd:PRK05561 385 LEGLLIAFLNIDEVIRIIRES---DEPKANLMARFDLSEIQAEAILELRLRRLAKLEEIEIRKEQDELRKEIAELEAILA 461


                 ....
gi 387537419 397 NEEK 400
Cdd:PRK05561 462 SERK 465
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-402 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 638.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIAMEILRDITKDT 80
Cdd:cd00187   34 EKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNFGSRDGDDAAAMRYTETRLSPIARLLLPDIDDPT 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQELMEFIPGPDFPTAGQ 160
Cdd:cd00187  114 VDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLREVIDALRALIDNPEASIDELMEIIKGPDFPTGGI 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 161 ILGRSGIRKAYESGRGSITIRAKAEIEETsSGKERILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDESDRNGMRI 240
Cdd:cd00187  194 IEGRAGIREAYETGRGRYIIRGKYEIEDD-EGRNTIEITELPYQVNKAKLKEKIAELVKDKKIEGISDVRDESDREGIRF 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 241 VIEIRRDANAHVILNNLYKQTALQTSFGINMLALV-DGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARAHILEG 319
Cdd:cd00187  273 VIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFDpNGRPKKLNLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEG 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 320 LRIALDHLDAVISLIRSSqtaEIARTGLIEQF---SLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEILA 396
Cdd:cd00187  353 LLKAILNIDEVINLIRSS---DEAKKALIEELeklGFSEIQADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILA 429


                 ....*.
gi 387537419 397 NEEKVL 402
Cdd:cd00187  430 SEERPK 435
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-402 0e+00

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 582.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419    1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKIAMEILRDITKD 79
Cdd:pfam00521  31 YKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGSRiDGDKDAAMRYTETRLSKIARELFPDIDDD 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   80 TIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIqeLMEFIPGPDFPTAG 159
Cdd:pfam00521 111 TVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREIIDALIALLDGPEATL--LMKYIMGPDFPTGG 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  160 QILGRSGIRKAYESGRGSITIRAKAEIEEtssgKERILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDESDRnGMR 239
Cdd:pfam00521 189 GIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTSDLIEKIEELVKNGKIKGISDIRDESDR-GVR 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  240 IVIEIRRDANAHVILNNLYKQTALQTSFGINMLALVDGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARAHILEG 319
Cdd:pfam00521 264 IVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGGPKYLGLKEILKEFLDHRLEVYERRKEYLLEKLEERLHILEG 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  320 LRIALDHLDAVISLIRSSQTAEIARTGLIEQfsLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEILANEE 399
Cdd:pfam00521 344 LLIALNNIDFVIEIIRGSIDRKKAKKNLIEE--LSEIQADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASEK 421


                  ...
gi 387537419  400 KVL 402
Cdd:pfam00521 422 KLN 424
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-402 0e+00

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 570.66  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419     1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKIAMEILRDITKD 79
Cdd:smart00434  53 KVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKD 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419    80 TIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQELMEFIPGPDFPTAG 159
Cdd:smart00434 133 TVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGG 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   160 QILGRSgirkayesgrgSITIRAKAEIEETssgkERILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDES-DRNGM 238
Cdd:smart00434 213 EIVGPG-----------KYVVRGKIEIEDD----NTIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGV 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   239 RIVIEIRRDANAHVILNNLYKQTALQTSFGINMLALVD-GEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAE-ARAHI 316
Cdd:smart00434 278 RIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALFDnGRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLEaERLHI 357

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   317 LEGLRIALDHLDAVISLIRSSQ-TAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEIL 395
Cdd:smart00434 358 LEGLFIALSIIDEIIVLIRSSKdLAKEAKEKLMERFELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKIL 437


                   ....*..
gi 387537419   396 ANEEKVL 402
Cdd:smart00434 438 ASEEWLN 444
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 1-402 0e+00

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 534.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIAMEILRDITKDT 80
Cdd:PRK13979  68 YYKSARIVGDILGKYHPHGDSSVYDAMVILAQDFTTRMPLIDGHGNWGSIDGDSAAAMRYTEARLTPIAMEMLRDIDKDV 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQELMEFIPGPDFPTAGQ 160
Cdd:PRK13979 148 VNMVDNYSDSEKEPEVLPARYPNLLVNGAFGIAVGLATNIPPHNLKEVIDGTLAYIDNNEITTKELMNYIKGPDLPTGGI 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 161 ILGRSGIRKAYESGRGSITIRAKAEIEETSSGKERILVTELPYQVNKARLIEKIADLVRDKK----IEGITDLRDESDRN 236
Cdd:PRK13979 228 LIGKKSLLSAYETGEGKVTLRAKTKIEKLENGRLGIVITEFPYRRNKAKLLQTISEMTADKKhskaLENISDIRDESDRN 307

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 237 GMRIVIEIRRDAN---AHVILNNLYKQTALQTSFGINMLALVDGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEAR 313
Cdd:PRK13979 308 GIRAVIEFKKSADedvAEKVLKYLYKKTDLQCNISFNMVALADGKPETMGLKTMLKHYVEHQKEVVTRRTKKELEIAEKR 387

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 314 AHILEGLRIALDHLDAVISLIRSSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKE 393
Cdd:PRK13979 388 FHIVEGFIKAIGIMDEIIKTIRSSKSKKDASENLIEKFGFTDEQAEAILELMLYRLTGLEIVAFEKEYKELEKLIKKLTK 467


                 ....*....
gi 387537419 394 ILANEEKVL 402
Cdd:PRK13979 468 ILSSEKELL 476
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
 1-402 1.37e-159

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 466.59  E-value: 1.37e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419    1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIAMEILRDITKDT 80
Cdd:TIGR01061  56 YKKSARTVGEIMGKYHPHGDSSIYDAMVRMSQDWKNNWTLVEMHGNNGSIDGDNAAAMRYTEARLSLIASELLKDIDKKT 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQELMEFIPGPDFPTAGQ 160
Cdd:TIGR01061 136 VSFIPNFDDSEKEPTVLPALFPNLLINGATGIAAGYATNIPPHNLNEVIDALIYRIDHPNCSVDKLMEIVKGPDFPTGGI 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  161 ILGRSGIRKAYESGRGSITIRAKAEIEETSSGKERILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDESDRNGMRI 240
Cdd:TIGR01061 216 IQGEDGISKAYETGKGKFIIRAKIEIEVNKNGLNQIVITEIPYETNKANIVKKIEEIIFDNKVAGIEEVRDESDRNGIRI 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  241 VIEIRRDANAHVILNNLYKQTALQTSFGINMLALVDGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:TIGR01061 296 IIELKKDANAEKILNFLFKHTDLQINYNFNMVAIANRTPIQVGLLSYLDAYIKHCHEVIINRSKYELEKASKRLEIVEGL 375

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  321 RIALDHLDAVISLIRSSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEILANEEK 400
Cdd:TIGR01061 376 IKAISIIDEIIKLIRSSEDKSDAKENLIDNFKFTENQAEAIVSLRLYRLTNTDIFELKEEQNELEKKIISLEQIIASEKA 455


                  ..
gi 387537419  401 VL 402
Cdd:TIGR01061 456 RN 457
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 1-401 6.65e-145

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 428.94  E-value: 6.65e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419    1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDG-DSAAAMRYTEARMSKIAMEILRDITKD 79
Cdd:TIGR01062  56 YKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDpKSFAAMRYTESRLSKISELLLEELGQG 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   80 TIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQELMEFIPGPDFPTAG 159
Cdd:TIGR01062 136 TVDFRPNFDGTLLEPVILPARLPNILLNGTTGIAVGMATDIPPHNLHELADAALYLIDNPKAGLDDILNIVQGPDFPTEA 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  160 QILG-RSGIRKAYESGRGSITIRAKAEIEETSsgkerILVTELPYQVNKARLIEKIADLVRDKKIEGITDLRDESDR-NG 237
Cdd:TIGR01062 216 EIIDkAEEIRKIYETGRGSFRMRARWKKEDGQ-----IVISALPHQISKSKVIEQIAIQMKDKKLPMISDIRDESDHeNP 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  238 MRIVIEIR-RDANAHVILNNLYKQTALQTSFGINMLAL-VDGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARAH 315
Cdd:TIGR01062 291 IRVVIVPRsNRVDPDIVMEHLFATTDLEKSYRLNMNMIgLDNVPAVKNLLEILQEWLVFRRNTVIRRLTYRLNKVLQRLH 370

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  316 ILEGLRIALDHLDAVISLIRSSQTaeiARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAELKEIL 395
Cdd:TIGR01062 371 ILEGLRIAFLNIDEVIEIIREEDE---PKTILMERFKLSAIQAEAILNLRLRHLAKLEEHAIIDEQSELEKERAILEKIL 447


                  ....*.
gi 387537419  396 ANEEKV 401
Cdd:TIGR01062 448 KSEREL 453
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 3-397 2.82e-53

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 187.22  E-value: 2.82e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   3 KSARIVGEVIgKYHPHGDSAVYESMVRMAQdfnyRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKIAMEIL--RDITkd 79
Cdd:PRK09631  53 KVANVVGNTM-KYHPHGDASIYEALVNLAN----KDLFIDKQGNFGNLfTGDPASAARYIECRLTPLAKEVLynKEIT-- 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  80 tiDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQelmefipgPDFPTAG 159
Cdd:PRK09631 126 --EYEPSYDGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHNFNEILQAVKSELLGESFALY--------PDFPTGG 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 160 qILGRSGirkaYESGRGSITIRAKaeIEETSSgkERILVTELPYQVNKARLIEKIADLVRDKKIEgITDLRDESDRNgMR 239
Cdd:PRK09631 196 -IVDVSE----YADGNGKVLVRAK--IETKDE--KTIVIREIPFGTTTESLIASIEKAARKGKIK-ISSINDYTAEN-VE 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 240 IVIEIRRDANAHVILNNLYKQTALQTSFGINMLALVDGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEAR--AHIL 317
Cdd:PRK09631 265 IEIKLPRGVYASEVIEALYAYTDCEVSISVNLLVIKDRYPVIYTVTDIIKFHAEHLQKVLKMELELERAKLLEKifAKTL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 318 EglRIALDH-LDAVISLIRSSQTA-EIARTGLI---EQFS--LTEKQAQAILDMRLQRLTGLEREKIEEEYQSLIKLIAE 390
Cdd:PRK09631 345 E--QIFIEErIYKRIETISSEEDViSIVLSELKpfkEELSrdVTEEDIENLLKIPIRRISLFDIDKNQKEIRILNKELKS 422


                 ....*..
gi 387537419 391 LKEILAN 397
Cdd:PRK09631 423 VEKNLKS 429
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
1-397 1.28e-48

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 176.73  E-value: 1.28e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   1 YKKSARIVGEVIgKYHPHGDSAVYESMVRMAQdfnyRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKIAMEILrdITKD 79
Cdd:PRK12758  70 YNKVANVVGHTM-QYHPHGDASIGDALVQLGQ----KDLLIDTQGNWGNIlTGDGAAAPRYIEARLSKFALEVV--FNPK 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  80 TIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQelmefipgPDFPTAG 159
Cdd:PRK12758 143 TTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEGIAVGLSTKILPHNFNELIDASIAYLKGKEFKLY--------PDFPTGG 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 160 qILGRSgirkAYESGR--GSITIRAKAEIEEtssgKERILVTELPYQVNKARLIEKIADLVrDK---KIEGITDLRDEsd 234
Cdd:PRK12758 215 -IIDVS----NYNDGErgGRVRVRAKIEKLD----KKTLVITEIPYGTTTSSLIDSILKAN-DKgkiKIKKVEDNTAA-- 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 235 rnGMRIVIEIRRDANAHVILNNLYKQTALQTSFGINMLALVDGEPKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARA 314
Cdd:PRK12758 283 --DVEILVHLAPGVSPDKTIDALYAFTDCEVSISPNACVIIDNKPHFLGVSDILRRSTDHTVSLLKQELEIRLSELEEQW 360

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 315 HI--LEGL----RIALD-----HLDAVISLIRSSQTAEIARtgLIEQfsLTEKQAQAILDMRLQRLTGLEREKIEEEYQS 383
Cdd:PRK12758 361 HFasLEKIfieeRIYKEieeaeTWEAVIEAIDKGLEPFKKQ--FIRE--VTEDDIVRLTEIKIKRISKFDSDKADELIAR 436

                        410
                 ....*....|....
gi 387537419 384 LIKLIAELKEILAN 397
Cdd:PRK12758 437 LEAEIAEVKHHLAH 450
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 3-279 3.92e-36

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 137.72  E-value: 3.92e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   3 KSARIVGEVIGkYHPHGDSAVYESMVRMAqdfNYRYmLVDGHGNFGS-VDGDSAAAMRYTEARMSKIAMEILrdITKDTI 81
Cdd:PRK09630  53 KVANIAGRTMA-LHPHGDAPIVEALVVLA---NKGY-LIDTQGNFGNpLTGDPHAAARYIEARLSPLAKEVL--FNTDLM 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  82 DYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITIQelmefipgPDFPTAGQI 161
Cdd:PRK09630 126 TFHDSYDGREKEPDILPAKLPLLLLHGVDGIAVGMTTKIFPHNFCELLEAQIAILNDQPFTLL--------PDFPSGGTM 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 162 LGRSgirkaYESGRGSITIRAKAEIEETSSgkerILVTELPYQVNKARLIEKIADLVRDK--KIEGITDLRDESDrngmR 239
Cdd:PRK09630 198 DASE-----YQDGLGSITLRASIDIINDKT----LLIKEICPSTTTETLIRSIENAAKRGiiKIDSIQDFSTDLP----H 264

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 387537419 240 IVIEIRRDANAHVILNNLYKQTALQTSFGINMLALVDGEP 279
Cdd:PRK09630 265 IEIKLPKGIYAKDLLRPLFTHTECQVILTSRPTAIYQNKP 304
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 1-393 6.30e-33

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 128.25  E-value: 6.30e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   1 YKKSARIVGEV-IGKYHpHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSkiamEILRDITKD 79
Cdd:PHA02592  58 FDKVAAIAGGVaDLGYH-HGETSAQDAGALMANTWNNNIPLLDGQGNFGSRLVQKAAAARYIFARVH----DNFRKIYKD 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  80 tIDYQDNYDGSERepvvMPSRF-----PNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDITiqelmefIPGPD 154
Cdd:PHA02592 133 -EDLAPVHEDPEH----IPPAFylpiiPMVLLNGVSGIATGYATNILPHSPKSVIKAVLAALNGKDIT-------EPKVQ 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 155 FPtagqilGRSGirKAYESGRGSITIRAKAEIeetsSGKERILVTELPYQVNKARLIEKIADLVRDKKIEGItdlrDESD 234
Cdd:PHA02592 201 FP------EFKG--EVVEIEPGSYEIRGTYEL----NGKTKLHITEIPVKYDRETYVAVLDPLEEKGKIVSY----DDCT 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 235 RNGMRIVIEIRRDANAHVILNNLYKQTALQTSFGINMLALV-DGEPKVL-NLKQCLVHYLDHQKVVIRRR-------TAY 305
Cdd:PHA02592 265 EDGFRFKVTLKREENEEATHEKIMKDFGLIERVSQNITVINeNGKLKVYeNAEDLIRDFVEIRKTYVQKRiqyeikeTEE 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419 306 ELRKAEARAHILEglrialDHLDAVISL---IRSSQTAEIArtglieQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQ 382
Cdd:PHA02592 345 AFDLALAKAEFIK------RVIAGEIVLqgkTRSELTEELS------DNKDFGEYADKLVAMNIYSMTSDEREKLQKEAE 412

                        410
                 ....*....|.
gi 387537419 383 SLIKLIAELKE 393
Cdd:PHA02592 413 ELEKEHEYWKK 423
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 15-318 7.93e-17

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 82.79  E-value: 7.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   15 YHpHGDSAVYESMVRMAQDF----NYRYMLVDGHgnFGS--VDGDSAAAMRYTEARMSKIAMEILRDITKDTIDYQDNyD 88
Cdd:PTZ00108  724 YH-HGEQSLQQTIVGMAQNFvgsnNINLLYPCGQ--FGSrlQGGKDHAAARYIFTKLSKITRYIFPEEDDPILDYLED-D 799

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   89 GSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVlavseNKDITIQELMEFIPgpdfptagqilgrsgir 168
Cdd:PTZ00108  800 GQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNL-----RRRLNGEEVRPLVP----------------- 857

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  169 kAYESGRGSITIRAKAEIEetSSGK------ERILVTELPYQVNKARLIEKIADLVRDKKiEGITDLRDESDRNGMRIVI 242
Cdd:PTZ00108  858 -WYRGFKGTIERNPKGKFI--SKGIyekvpdGTVEITELPIGKWTEDYKEFLESETLKEK-DVIVDYRDYSTANTVHFTV 933

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 387537419  243 EIRRDANAHVILNNLYKQTALQTSFGINMLALVDGE---PKVLNLKQCLVHYLDHQKVVIRRRTAYELRKAEARAHILE 318
Cdd:PTZ00108  934 KLNDGVLEQWEEEGIEKVFKLKSTISTTNMVLFDENgkiKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLS 1012
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 15-394 2.30e-16

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 81.29  E-value: 2.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   15 YHpHGDSAVYESMVRMAQDF---NYRYMLVDgHGNFGS--VDGDSAAAMRYTEARMSKIAMEILRDITKDTIDYQDNyDG 89
Cdd:PLN03128  717 YH-HGEASLASTIIGMAQDFvgsNNINLLTP-SGQFGTrlQGGKDAASARYIFTRLSPITRALFPKDDDVLLNYLNE-DG 793

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   90 SEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENKDitiQELMEfipgpdfPTAGQILGRsgIRK 169
Cdd:PLN03128  794 QSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEE---LEPMH-------PWYRGFKGT--ITE 861

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  170 AYESGRGSITIRAKAE-IEETSsgkerILVTELPYQV---NKARLIEKIADLVRDKKIEgITDLRDESDRNGMRIVIEIR 245
Cdd:PLN03128  862 VSTSRSGSYTVTGIIEqIGDTT-----IRITELPVRKwtqDYKEFLEALLTGTKKKEPE-IKDFKENHTDTTVHFTVTLS 935

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  246 RDANAHVILNNLYKQTALQTSFGINMLALVDGEPKV------LNLKQCLVH----YLDHQKVVIRRRTAYELRKAEARAH 315
Cdd:PLN03128  936 EEKMARALAEGLEKKFKLSTTISTSNMHLFDKDGKIkkydspEDILEEFFHlrldLYVKRKEVLLENLEYELKKLDNKAR 1015

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  316 ILEGL-----------RIALDHLDAVISLIRSSQTAEIARTGLI----EQFSLTEKQAQAILDMRLQRLTG-----LERE 375
Cdd:PLN03128 1016 FILAVvkgeivvnnrkRAELLAELEEKGFDKFPKTAKISETNVVgdrdGEASEEEEASDNELAKSYDYLLGmpissLTLE 1095

                         410
                  ....*....|....*....
gi 387537419  376 KIEEEYQSLIKLIAELKEI 394
Cdd:PLN03128 1096 KVDELRAERAKKETEVEEL 1114
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 3-342 1.44e-09

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 60.26  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419    3 KSARIVGEV--IGKYHpHGDSAVYESMVRMAQDF---NYRYMLVDGhGNFG--SVDGDSAAAMRYTEARMSKIAMEILRD 75
Cdd:PLN03237  728 KVAQLSGYVseHSAYH-HGEQSLASTIIGMAQDFvgsNNINLLLPN-GQFGtrLQGGKDHASARYIFTRLSPITRFLFPK 805

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419   76 ITKDTIDYQDNyDGSEREPV-VMPSrFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVlavsenKDITIQELMEfipgPD 154
Cdd:PLN03237  806 DDDILLDYLNE-DGQSIEPTwYMPI-IPTVLVNGAEGIGTGWSTFIPNYNPRDIVANI------RRLLNGESME----PM 873

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  155 FPTagqilgrsgirkaYESGRGSI--TIRAKAEIEETSSGK------ERILVTELP---YQVNKARLIEKIADLVRDKKI 223
Cdd:PLN03237  874 HPW-------------YRGFKGTIekTASKEGGCTYTITGLyeevdeTTLRITELPirrWTDDYKEFLESLKTDNNKNKD 940

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537419  224 EGITDLRDESDRNGMRIVIEIRRDANAHVILNNLYKQTALQTSFGINMLALVD---GEPKVLNLKQCLVHYLDhqkvviR 300
Cdd:PLN03237  941 PFIKDVKAYNDDTTVHFEVILSEENMLAAKQEGLLKKFKLTTTISTSNMHLFDskgVIKKYDTPEQILEEFFH------L 1014

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 387537419  301 RRTAYELRKAEarahILEGLRIALDHLDAVISLIRSSQTAEI 342
Cdd:PLN03237 1015 RLEYYEKRKEV----LLKNLEFELLKLENKVRFILAVVDGEI 1052
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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