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Conserved domains on  [gi|386907447|gb|EIJ72158|]
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TonB-dependent receptor plug domain protein [Pasteurella bettyae CCUG 2042]

Protein Classification

porin family protein( domain architecture ID 229388)

porin family protein is a member of a large superfamily consisting of classical (gram-negative ) porins which are non-specific channels for small hydrophillic molecules, maltoporin-like channels which have specificities for various sugars, and ligand-gated protein channels which cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OM_channels super family cl21487
Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in ...
 74-1005 6.11e-43

Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20), which associate as trimers. Maltoporin-like channels have specificities for various sugars and form 18 beta-stranded barrels (18,22), which associate as trimers. Ligand-gated protein channels cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force and they form monomeric, (22,24) barrels. The 150-200 N-terminal residues form a plug that blocks the channel from the periplasmic end.


The actual alignment was detected with superfamily member TIGR01786:

Pssm-ID: 473880 [Multi-domain]  Cd Length: 715  Bit Score: 167.97  E-value: 6.11e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447    74 ADLFQGFNGVYSGDARNSGAVDPNIRGIQGQgRIPVTIDGTEQAITTWRGYNGANNRNYLDPNLISGITVEKGPDLASGN 153
Cdd:TIGR01786   42 RDLLRYEPGVSVVEGGRGGSQGINIRGLDKN-RVAVLVDGIRQNTSYGGQGSTFYAINSIDPELIKSIEIVKGASSSLYG 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   154 QSGIGGAVKMRTIDADDIVKPGQKIGVELKLETSnnsvkeripdfkwgqdyrvvgdgtpgdfspitlitpkTKGKYFKDN 233
Cdd:TIGR01786  121 SGALGGVVAFRTKDAADLLKPGKDLGGLSKLGYS-------------------------------------SANNRFTQS 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   234 amrLAVGVKEDKFDLLAAYSYRNKGNYLAGKGGahkykgvldqESGREIKQIEPNlpfaasiyrphkeipNTSSTMESYL 313
Cdd:TIGR01786  164 ---VAAAGRNDDVDALVQATYRRGHELKNGNKA----------NIGNESKRSKPN---------------PSDYKSQSFL 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   314 LKNTIRLTDKQTLKMGYRDTKITYGE-IMPSRLDFKAFHG---FVPQWPLA--TVKQNAFNLDYEYNPDNRWINFKAGvW 387
Cdd:TIGR01786  216 AKLGWQLNDAHRLGLSLEYTQTDYDEpEMTNTSYLTKPLGaplLSSTVVLGdsKTRDRRTGLDYELNPDNSWLDTVKL-A 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   388 YTRTKSDTNTSGGNPREANSmdvdwtlatsecvsvnpspttphdyliidhaclarlgdPLVKKNPNTNGKYSYVNAaQVN 467
Cdd:TIGR01786  295 LDKQYIQLYNYLNATSASDY--------------------------------------PGVDKNGRYKDKYDYYTL-GFD 335

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   468 AYNTRRGIHLSNTMNLtdkldltisGALQKELLTSSHFNAKPNPSSTYESPPRAG-RRKEWDITFNF----NYRPTDWLM 542
Cdd:TIGR01786  336 TNNKIEFSVHSLSLTY---------GLDRFKDKVSTGDSRRNLPTAAYNLYGYEGeNRPVKGSNFGLflqdNIKLGDWLS 406

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   543 LTAGARYneywsfddyldylvksgelykpyiiddkaykpkidvgqsiyytevmsekdwnryqqiekrineindcvsdddp 622
Cdd:TIGR01786  407 LSAGLRY------------------------------------------------------------------------- 413

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   623 vciaekkrldaeylkimgnanniedgkrygqsikwyyrddgrlhreDNPFYNGKLKNEKVKDPITgelvnkyelsssvgp 702
Cdd:TIGR01786  414 ----------------------------------------------DHYKTDPKADESKDYGAIS--------------- 432

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   703 fseemkesdkltkverKRGHAFSPAFSATAFLTDHSRMYLRYTQYARMPSIFETTVGFSASADTSARFK-NARLKPEKAR 781
Cdd:TIGR01786  433 ----------------KTYSRWSPSLGLTYKPTPWLTLYYSYSQGFRAPSFDELYGTGAHPGGGPYTFLpNPNLKPETSK 496

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   782 NIEIGYVHDLGhyfstptKADIKLSYYHNETKNVIDRD---------------TEFRFVQLDKRTLEGIELQARYDNGDF 846
Cdd:TIGR01786  497 NWEIGINLHFD-------QLDFKVSYFRNDYKDFIDLGigvtakgnmaqvgsnTITNYVNIDNARIRGIELSGRYDLGSF 569

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   847 FGDL-GVEYHLK---NKVCDANTAVELDPIQMRvptcitggfawgylrtqlqpkySISANLGARFFERKLEIGTRWlYHS 922
Cdd:TIGR01786  570 FSGPdGWTTTLKygyTKGKDSDTNPWLNAITPL----------------------KVVLGLGYDHPDEKWGVGLTL-TFS 626

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   923 KAKNKDEERLWKLKVLDEGVWNRPMsWQPVLTLDAYIKYQISPNLSMELTGTNLTDRYYL-------DPMTRSMIPAPGR 995
Cdd:TIGR01786  627 GAKDAVDAYATYYENGEAAKAGPLR-TPSYTVVDLYGYYKPNKNLTLRFGVYNLLDRKYTtwesarqAGPLATGYTAPGR 705

                          970
                   ....*....|
gi 386907447   996 TVKLGLTAKF 1005
Cdd:TIGR01786  706 NYKASVEYKF 715
 
Name Accession Description Interval E-value
TonB-hemlactrns TIGR01786
TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; This model ...
 74-1005 6.11e-43

TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; This model represents a family of TonB-dependent outer membrane receptor/transporters acting on iron-containing proteins such as hemoglobin, transferrin and lactoferrin. Two subfamily models with a narrower scope are contained within this model, the heme/hemoglobin receptor family protein model (TIGR01785) and the transferrin/lactoferrin receptor family model (TIGR01776). Accessions which score above trusted to this model while not scoring above trusted to the more specific models are most likely to be hemoglobin transporters. Nearly all of the species containing trusted hits to this model have access to hemoglobin, transferrin or lactoferrin or related proteins in their biological niche. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273808 [Multi-domain]  Cd Length: 715  Bit Score: 167.97  E-value: 6.11e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447    74 ADLFQGFNGVYSGDARNSGAVDPNIRGIQGQgRIPVTIDGTEQAITTWRGYNGANNRNYLDPNLISGITVEKGPDLASGN 153
Cdd:TIGR01786   42 RDLLRYEPGVSVVEGGRGGSQGINIRGLDKN-RVAVLVDGIRQNTSYGGQGSTFYAINSIDPELIKSIEIVKGASSSLYG 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   154 QSGIGGAVKMRTIDADDIVKPGQKIGVELKLETSnnsvkeripdfkwgqdyrvvgdgtpgdfspitlitpkTKGKYFKDN 233
Cdd:TIGR01786  121 SGALGGVVAFRTKDAADLLKPGKDLGGLSKLGYS-------------------------------------SANNRFTQS 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   234 amrLAVGVKEDKFDLLAAYSYRNKGNYLAGKGGahkykgvldqESGREIKQIEPNlpfaasiyrphkeipNTSSTMESYL 313
Cdd:TIGR01786  164 ---VAAAGRNDDVDALVQATYRRGHELKNGNKA----------NIGNESKRSKPN---------------PSDYKSQSFL 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   314 LKNTIRLTDKQTLKMGYRDTKITYGE-IMPSRLDFKAFHG---FVPQWPLA--TVKQNAFNLDYEYNPDNRWINFKAGvW 387
Cdd:TIGR01786  216 AKLGWQLNDAHRLGLSLEYTQTDYDEpEMTNTSYLTKPLGaplLSSTVVLGdsKTRDRRTGLDYELNPDNSWLDTVKL-A 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   388 YTRTKSDTNTSGGNPREANSmdvdwtlatsecvsvnpspttphdyliidhaclarlgdPLVKKNPNTNGKYSYVNAaQVN 467
Cdd:TIGR01786  295 LDKQYIQLYNYLNATSASDY--------------------------------------PGVDKNGRYKDKYDYYTL-GFD 335

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   468 AYNTRRGIHLSNTMNLtdkldltisGALQKELLTSSHFNAKPNPSSTYESPPRAG-RRKEWDITFNF----NYRPTDWLM 542
Cdd:TIGR01786  336 TNNKIEFSVHSLSLTY---------GLDRFKDKVSTGDSRRNLPTAAYNLYGYEGeNRPVKGSNFGLflqdNIKLGDWLS 406

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   543 LTAGARYneywsfddyldylvksgelykpyiiddkaykpkidvgqsiyytevmsekdwnryqqiekrineindcvsdddp 622
Cdd:TIGR01786  407 LSAGLRY------------------------------------------------------------------------- 413

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   623 vciaekkrldaeylkimgnanniedgkrygqsikwyyrddgrlhreDNPFYNGKLKNEKVKDPITgelvnkyelsssvgp 702
Cdd:TIGR01786  414 ----------------------------------------------DHYKTDPKADESKDYGAIS--------------- 432

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   703 fseemkesdkltkverKRGHAFSPAFSATAFLTDHSRMYLRYTQYARMPSIFETTVGFSASADTSARFK-NARLKPEKAR 781
Cdd:TIGR01786  433 ----------------KTYSRWSPSLGLTYKPTPWLTLYYSYSQGFRAPSFDELYGTGAHPGGGPYTFLpNPNLKPETSK 496

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   782 NIEIGYVHDLGhyfstptKADIKLSYYHNETKNVIDRD---------------TEFRFVQLDKRTLEGIELQARYDNGDF 846
Cdd:TIGR01786  497 NWEIGINLHFD-------QLDFKVSYFRNDYKDFIDLGigvtakgnmaqvgsnTITNYVNIDNARIRGIELSGRYDLGSF 569

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   847 FGDL-GVEYHLK---NKVCDANTAVELDPIQMRvptcitggfawgylrtqlqpkySISANLGARFFERKLEIGTRWlYHS 922
Cdd:TIGR01786  570 FSGPdGWTTTLKygyTKGKDSDTNPWLNAITPL----------------------KVVLGLGYDHPDEKWGVGLTL-TFS 626

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   923 KAKNKDEERLWKLKVLDEGVWNRPMsWQPVLTLDAYIKYQISPNLSMELTGTNLTDRYYL-------DPMTRSMIPAPGR 995
Cdd:TIGR01786  627 GAKDAVDAYATYYENGEAAKAGPLR-TPSYTVVDLYGYYKPNKNLTLRFGVYNLLDRKYTtwesarqAGPLATGYTAPGR 705

                          970
                   ....*....|
gi 386907447   996 TVKLGLTAKF 1005
Cdd:TIGR01786  706 NYKASVEYKF 715
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
30-996 4.05e-27

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 118.01  E-value: 4.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   30 LSTIVVHATSERKDEQgkddEYQRNITNMyaGKETVERYKGAAPADLFQGFNGVYSgDARNSGAVDPNIRGIQG-QGRIP 108
Cdd:COG1629     1 LEEVVVTATRTDESLQ----DVPGSVSVI--SREQLEDQPATDLGDLLRRVPGVSV-TSAGGGAGQISIRGFGGgGNRVL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  109 VTIDGteqaITTWRGYNGANNRNYLDPNLISGITVEKGPDLASGNQSGIGGAVKMRTIdaddivKPGQKIGVELKLETSN 188
Cdd:COG1629    74 VLVDG----VPLNDPSGGDGGLSYIDPEDIERVEVLRGPSSALYGSGALGGVINIVTK------KPKDGKGGEVSASYGS 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  189 NSvkeripdfkwgqDYRVvgdgtpgdfspitlitpktkgkyfkdnamRLAVGVKEDKFDLLAAYSYRNKGNYlagkggah 268
Cdd:COG1629   144 YG------------TYRA-----------------------------SLSLSGGNGKLAYRLSASYRDSDGY-------- 174

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  269 kykgvldqesgreikqiepnlpfaasiyrphkeIPNTSSTMESYLLKNTIRLTDKQTLK---MGYRDTKITYGEIMPSRL 345
Cdd:COG1629   175 ---------------------------------RDNSDSDRYNLRAKLGYQLGDDTRLTlsaSYSDSDQDSPGYLTLAAL 221

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  346 DFKAFH--GFVP-QWPLATVKQNAFNLDYEYNPDNRWINFKAGVWYTRTKSDTNTSGGNPREANSmdvdwtlatsecvsv 422
Cdd:COG1629   222 RPRGAMddGTNPySNDTDDNTRDRYSLSLEYEHLGDGLKLSASAYYRYDDTDLDSDFTPTPADGG--------------- 286

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  423 npspttphdyliidhaclarlgdplvkknpntngkysyvNAAQVNAYNTRRGIHLSNT--MNLTDKLDLTISGALQKELL 500
Cdd:COG1629   287 ---------------------------------------TLEQTDFDNRTYGLELRLTydLGFGGKHTLLVGLDYQRQDL 327

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  501 TSSHFN---AKPNPSSTYESPPRAGRRKEWDITFNFNYRPTDWLMLTAGARYnEYWSFDdyldylvksgelykpyiiddk 577
Cdd:COG1629   328 DGSGYPldlGSGSLPTLTSGADDDGTTTSLALYAQDTYKLTDKLTLTAGLRY-DYVSYD--------------------- 385

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  578 aykpkidvgqsiyytevmsekdwnryqqiekrineindcvsdddpvciaekkrldaeylkimgnanniedgkrygqsikw 657
Cdd:COG1629       --------------------------------------------------------------------------------

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  658 yyrddgrlhrednpfyngklknekVKDPITGelvnkyelsssvgpfseemkesdKLTKVERKRGHAFSPAFSATAFLTDH 737
Cdd:COG1629   386 ------------------------VDDTVTG-----------------------TDSASGSRSYSAFSPSLGLTYQLSPN 418

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  738 SRMYLRYTQYARMPSIFEttvgFSASADTSARFKNARLKPEKARNIEIGYvhdlgHYFSTPTKADIKLSYYHNETKNVID 817
Cdd:COG1629   419 LSLYASYSRGFRAPTFGE----LYANGTDPYSVGNPDLKPETSTNYELGL-----RYRLLDGRLSLSLALFYSDVDNEIL 489

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  818 RDT-------EFRFVQLDKRTLEGIELQARYDNGD-FFGDLGVEYhLKNKVCDANTAveldpiqmrvpTCITGGFAWGYl 889
Cdd:COG1629   490 SVPlpndsgfSTYYTNAGKARSYGVELELSYQLTPgLSLNASYSY-TDAKFDDDTDG-----------SADLDGNRLPG- 556

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  890 rtqlQPKYSISANLGARFFErKLEIGTRWLYHSKAKNKDEerlwklkvldegvwNRPMSWQPVLTLDAYIKYQISPNLSM 969
Cdd:COG1629   557 ----VPPLTANLGLTYEFPG-GWSLGLGVRYVGDRYLDDA--------------NTQGAPGGYTLVDLGAGYRFGDNLTL 617

                         970       980
                  ....*....|....*....|....*..
gi 386907447  970 ELTGTNLTDRYYLDPMTRSMIPAPGRT 996
Cdd:COG1629   618 SLGVDNLFDKKYATSLSVRASNVRGFL 644
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 718-1004 3.66e-22

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 101.00  E-value: 3.66e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   718 RKRGHAFSPAFSATAFLTDHSRMYLRYTQYARMPSIFETTVGFSASADTSARFKNARLKPEKARNIEIGYVHDlghyfst 797
Cdd:pfam00593  215 SRSYSAFSPRLGLVYKPTDNLSLYASYSRGFRAPSLGELYGSGSGGGGGAVAGGNPDLKPETSDNYELGLKYD------- 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   798 PTKADIKLSYYHNETKNVIDRDT--------EFRFVQLDKRTLEGIELQARYDNGDFFGDLGVeYHLKNKVCDANTAVEL 869
Cdd:pfam00593  288 DGRLSLSLALFYIDIKNLITSDPdgpglggtVYTYTNVGKARIRGVELELSGRLWGLGLSGGG-YTYTDADDDADADDTG 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   870 DPIQMRvptcitggfawgylrtqlqPKYsiSANLGARFFERK----LEIGTRWLYHSKAKNKDEERLWKLKvldegvwnr 945
Cdd:pfam00593  367 NPLPNV-------------------PRH--TANLGLTYDFPLggwgARLGARYVGSGERRYGDAANTFKTP--------- 416

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 386907447   946 pmswqPVLTLDAYIKYQISPNLSMELTGTNLTDRYY-----LDPMTRSMIPAPGRTVKLGLTAK 1004
Cdd:pfam00593  417 -----GYTLVDLSAGYRLNKNLTLRLGVNNLFDKYYkryysSGGGNLGGYPGPGRTFYLGLSYK 475
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 719-1005 3.31e-19

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 92.90  E-value: 3.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  719 KRGHAFSPAFSATAFLTDHSRMYLRYTQYARMPSIFETTVGFSASADTSARFKNarLKPEKARNIEIGYVHDLGHYFSTp 798
Cdd:cd01347   376 KSYSHWSPSLGLVYKLTDGLSLYASYSQGFRAPSLGELYGGGSHGGTAAVGNPN--LKPEKSKQYELGLKYDPGDGLTL- 452

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  799 tkadiKLSYYHNETKNVIDRD-------TEFRFVQLDKRTLEGIELQARYD-NGDFFGDLGVEY-HLKNKVCDANTAVEL 869
Cdd:cd01347   453 -----SAALFRIDIKNEIVSTptntglgLVTVYVNGGKARIRGVELEASYDlTDGLGLTGSYTYtDTEVKRTDGATTGNR 527

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  870 DPIQmrvptcitggfawgylrtqlqPKYSISANLGARFFERKLEIGTRWLYHSKAKNKDEERLWKLKVLDEGVWnrpmsw 949
Cdd:cd01347   528 LPGI---------------------PKHTANLGLDYELPDEGLTAGGGVRYRGKQYADTANGNNTVKVPGYTLV------ 580

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386907447  950 qpvltlDAYIKYQISPNLSMELTGTNLTDRYY-----LDPMTRSMIPAPGRTVKLGLTAKF 1005
Cdd:cd01347   581 ------DLSASYQFTKNLTLRLGVNNLFDKDYytslsVRGSGLYGYYGPGRTYYLSVSYKF 635
 
Name Accession Description Interval E-value
TonB-hemlactrns TIGR01786
TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; This model ...
 74-1005 6.11e-43

TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; This model represents a family of TonB-dependent outer membrane receptor/transporters acting on iron-containing proteins such as hemoglobin, transferrin and lactoferrin. Two subfamily models with a narrower scope are contained within this model, the heme/hemoglobin receptor family protein model (TIGR01785) and the transferrin/lactoferrin receptor family model (TIGR01776). Accessions which score above trusted to this model while not scoring above trusted to the more specific models are most likely to be hemoglobin transporters. Nearly all of the species containing trusted hits to this model have access to hemoglobin, transferrin or lactoferrin or related proteins in their biological niche. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273808 [Multi-domain]  Cd Length: 715  Bit Score: 167.97  E-value: 6.11e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447    74 ADLFQGFNGVYSGDARNSGAVDPNIRGIQGQgRIPVTIDGTEQAITTWRGYNGANNRNYLDPNLISGITVEKGPDLASGN 153
Cdd:TIGR01786   42 RDLLRYEPGVSVVEGGRGGSQGINIRGLDKN-RVAVLVDGIRQNTSYGGQGSTFYAINSIDPELIKSIEIVKGASSSLYG 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   154 QSGIGGAVKMRTIDADDIVKPGQKIGVELKLETSnnsvkeripdfkwgqdyrvvgdgtpgdfspitlitpkTKGKYFKDN 233
Cdd:TIGR01786  121 SGALGGVVAFRTKDAADLLKPGKDLGGLSKLGYS-------------------------------------SANNRFTQS 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   234 amrLAVGVKEDKFDLLAAYSYRNKGNYLAGKGGahkykgvldqESGREIKQIEPNlpfaasiyrphkeipNTSSTMESYL 313
Cdd:TIGR01786  164 ---VAAAGRNDDVDALVQATYRRGHELKNGNKA----------NIGNESKRSKPN---------------PSDYKSQSFL 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   314 LKNTIRLTDKQTLKMGYRDTKITYGE-IMPSRLDFKAFHG---FVPQWPLA--TVKQNAFNLDYEYNPDNRWINFKAGvW 387
Cdd:TIGR01786  216 AKLGWQLNDAHRLGLSLEYTQTDYDEpEMTNTSYLTKPLGaplLSSTVVLGdsKTRDRRTGLDYELNPDNSWLDTVKL-A 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   388 YTRTKSDTNTSGGNPREANSmdvdwtlatsecvsvnpspttphdyliidhaclarlgdPLVKKNPNTNGKYSYVNAaQVN 467
Cdd:TIGR01786  295 LDKQYIQLYNYLNATSASDY--------------------------------------PGVDKNGRYKDKYDYYTL-GFD 335

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   468 AYNTRRGIHLSNTMNLtdkldltisGALQKELLTSSHFNAKPNPSSTYESPPRAG-RRKEWDITFNF----NYRPTDWLM 542
Cdd:TIGR01786  336 TNNKIEFSVHSLSLTY---------GLDRFKDKVSTGDSRRNLPTAAYNLYGYEGeNRPVKGSNFGLflqdNIKLGDWLS 406

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   543 LTAGARYneywsfddyldylvksgelykpyiiddkaykpkidvgqsiyytevmsekdwnryqqiekrineindcvsdddp 622
Cdd:TIGR01786  407 LSAGLRY------------------------------------------------------------------------- 413

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   623 vciaekkrldaeylkimgnanniedgkrygqsikwyyrddgrlhreDNPFYNGKLKNEKVKDPITgelvnkyelsssvgp 702
Cdd:TIGR01786  414 ----------------------------------------------DHYKTDPKADESKDYGAIS--------------- 432

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   703 fseemkesdkltkverKRGHAFSPAFSATAFLTDHSRMYLRYTQYARMPSIFETTVGFSASADTSARFK-NARLKPEKAR 781
Cdd:TIGR01786  433 ----------------KTYSRWSPSLGLTYKPTPWLTLYYSYSQGFRAPSFDELYGTGAHPGGGPYTFLpNPNLKPETSK 496

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   782 NIEIGYVHDLGhyfstptKADIKLSYYHNETKNVIDRD---------------TEFRFVQLDKRTLEGIELQARYDNGDF 846
Cdd:TIGR01786  497 NWEIGINLHFD-------QLDFKVSYFRNDYKDFIDLGigvtakgnmaqvgsnTITNYVNIDNARIRGIELSGRYDLGSF 569

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   847 FGDL-GVEYHLK---NKVCDANTAVELDPIQMRvptcitggfawgylrtqlqpkySISANLGARFFERKLEIGTRWlYHS 922
Cdd:TIGR01786  570 FSGPdGWTTTLKygyTKGKDSDTNPWLNAITPL----------------------KVVLGLGYDHPDEKWGVGLTL-TFS 626

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   923 KAKNKDEERLWKLKVLDEGVWNRPMsWQPVLTLDAYIKYQISPNLSMELTGTNLTDRYYL-------DPMTRSMIPAPGR 995
Cdd:TIGR01786  627 GAKDAVDAYATYYENGEAAKAGPLR-TPSYTVVDLYGYYKPNKNLTLRFGVYNLLDRKYTtwesarqAGPLATGYTAPGR 705

                          970
                   ....*....|
gi 386907447   996 TVKLGLTAKF 1005
Cdd:TIGR01786  706 NYKASVEYKF 715
TonB-hemin TIGR01785
TonB-dependent heme/hemoglobin receptor family protein; This model represents the ...
 30-1005 6.05e-42

TonB-dependent heme/hemoglobin receptor family protein; This model represents the TonB-dependent outer membrane heme/hemoglobin receptor/transporter found in bacteria which live in contact with animals (which contain hemoglobin or other heme-bearing globins) or legumes (which contain leghemoglobin). Some species having hits to this model such as Nostoc, Caulobacter and Chlorobium do not have an obvious source of hemoglobin-like proteins in their biological niche and so the possibility exists that they act on some other substance. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273807 [Multi-domain]  Cd Length: 665  Bit Score: 164.10  E-value: 6.05e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447    30 LSTIVVHATSERkdEQGKDDEYQRNITnmyaGKETVERYKGAAPADLFQGFNGVYSGDARNSGAVDPNIRGIQGQgRIPV 109
Cdd:TIGR01785    1 LDTVTVTATRTR--QVLSEAPASVSVI----SGEQIESKQANNLADALNTVPGVDVTGGGRPPGQSINIRGLQDN-RVLV 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   110 TIDGTEQAITTwrgYNGANNRNYLDPNLISGITVEKGPDLASGNQSGIGGAVKMRTIDADDIVKPGQKIGVELKLetsnn 189
Cdd:TIGR01785   74 VVDGARQNYQR---GGAHNGSLFVDPELLKRIEIVKGPSSSLYGSGALGGVVAFRTKDAADLLRPGQLFGGLAKL----- 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   190 svkeripdfkwgqDYRVVGDGTPGDFSpitlitpktkgkyfkdNAMRLAvgvkeDKFDLLAAYSYRNKGNYLAGKGGahk 269
Cdd:TIGR01785  146 -------------SYGSNNNSFGGSVA----------------VAGRLD-----DNLDALVAATYRDGGNYRNGNKE--- 188

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   270 ykgvldqesgreikqiepnlpfaasiyrphkEIPNTSSTMESYLLKNTIRLTDKQTLKMGYRDTKITYGEIMPSRLDFKA 349
Cdd:TIGR01785  189 -------------------------------EATNSAYVQKNLLAKLGWQLDDAQRLEFSYFTTEGSLDEAQNSGPGTEY 237

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   350 FHGFVPQWPLATVKQNAFNLDYEYNP-DNRWINFKAGVWYTRTKSDTNTSGGNPREANSMDVDWTLATSEcvsvNPSptt 428
Cdd:TIGR01785  238 VLGSSSTLLASSTRDRSATLTYNWTPeDNPWLDATASLYYNRTENDNDRSARGVGREEGYQYTTYGATLQ----NTS--- 310

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   429 phDYLIIDHACLARLGDPLVKKNPNTNGKYSYVNAAQVNAYNTRRgihlsntmnltdkldLTISGALQKELltsshfnak 508
Cdd:TIGR01785  311 --RFDVASWSTLTYGVDWMKDKRRTESFDPNSVTTIVPNPPSAKE---------------YFFGLFLQDNI--------- 364

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   509 pnpsstyesppragrrKEWDitfnfnyrptDWLMLTAGARYneywsfddyldylvksgelykpyiiddkaykpkidvgqs 588
Cdd:TIGR01785  365 ----------------PLLD----------DRLTLSAGLRY--------------------------------------- 379

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   589 iyytevmsekDWnryqqiekrineindcvsdddpvciaekkrldaeylkimgnanniedgkrygqsikwyyrddgrlhre 668
Cdd:TIGR01785  380 ----------DH-------------------------------------------------------------------- 381

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   669 dnpfyngklknekvkdpitgelvnkYELSSsvgpfseemKESDKLTKVERKRGHaFSPAFSATAFLTDHSRMYLRYTQYA 748
Cdd:TIGR01785  382 -------------------------YKLSP---------KTTADTEAVDRSYSR-WSPSLGLSYKPVDWLTLYASYSQGF 426

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   749 RMPSIFETTVGFSASAD--TSARFKNARLKPEKARNIEIGYVHDLGHYFSTPTKADIKLSYYHNETKNVIDR-------- 818
Cdd:TIGR01785  427 RAPSIDELYGTGDHPGTpgGYTFAPNPNLKPETSKTWELGANLSFDNLLLDNDQLQFKVAYFYNDVKDFIDLtigvtdnv 506

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   819 ----DTEFRFVQLDKRTLEGIELQARYDNGDFFGDLGVEyHLKNKVCDANTaveldpiqmrvptcitggfawgYLRTqlQ 894
Cdd:TIGR01785  507 tagmNNITQYVNIDGARIRGIEASASYDAGLWATGLSYG-YTIGKDQNTNQ----------------------WLSN--I 561

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   895 PKYSISANLGARFFERKLEIGTRWLY-HSKAKNKDEERL--WKLKVLDE-GVWNRPMSWQPvltldayikyQISPNLSME 970
Cdd:TIGR01785  562 PPLKLVVTVGYRFPDRRLDLGAKAAYyERQSESPTTEDVaaNGLLTTPGyTVVDLYATYQP----------NAVKGLTVR 631

                          970       980       990
                   ....*....|....*....|....*....|....*
gi 386907447   971 LTGTNLTDRYYLDPMTrSMIPAPGRTVKLGLTAKF 1005
Cdd:TIGR01785  632 FGVNNLTDRKYTPAQS-VPGAGPGRNFKGSVKYQF 665
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
30-996 4.05e-27

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 118.01  E-value: 4.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   30 LSTIVVHATSERKDEQgkddEYQRNITNMyaGKETVERYKGAAPADLFQGFNGVYSgDARNSGAVDPNIRGIQG-QGRIP 108
Cdd:COG1629     1 LEEVVVTATRTDESLQ----DVPGSVSVI--SREQLEDQPATDLGDLLRRVPGVSV-TSAGGGAGQISIRGFGGgGNRVL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  109 VTIDGteqaITTWRGYNGANNRNYLDPNLISGITVEKGPDLASGNQSGIGGAVKMRTIdaddivKPGQKIGVELKLETSN 188
Cdd:COG1629    74 VLVDG----VPLNDPSGGDGGLSYIDPEDIERVEVLRGPSSALYGSGALGGVINIVTK------KPKDGKGGEVSASYGS 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  189 NSvkeripdfkwgqDYRVvgdgtpgdfspitlitpktkgkyfkdnamRLAVGVKEDKFDLLAAYSYRNKGNYlagkggah 268
Cdd:COG1629   144 YG------------TYRA-----------------------------SLSLSGGNGKLAYRLSASYRDSDGY-------- 174

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  269 kykgvldqesgreikqiepnlpfaasiyrphkeIPNTSSTMESYLLKNTIRLTDKQTLK---MGYRDTKITYGEIMPSRL 345
Cdd:COG1629   175 ---------------------------------RDNSDSDRYNLRAKLGYQLGDDTRLTlsaSYSDSDQDSPGYLTLAAL 221

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  346 DFKAFH--GFVP-QWPLATVKQNAFNLDYEYNPDNRWINFKAGVWYTRTKSDTNTSGGNPREANSmdvdwtlatsecvsv 422
Cdd:COG1629   222 RPRGAMddGTNPySNDTDDNTRDRYSLSLEYEHLGDGLKLSASAYYRYDDTDLDSDFTPTPADGG--------------- 286

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  423 npspttphdyliidhaclarlgdplvkknpntngkysyvNAAQVNAYNTRRGIHLSNT--MNLTDKLDLTISGALQKELL 500
Cdd:COG1629   287 ---------------------------------------TLEQTDFDNRTYGLELRLTydLGFGGKHTLLVGLDYQRQDL 327

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  501 TSSHFN---AKPNPSSTYESPPRAGRRKEWDITFNFNYRPTDWLMLTAGARYnEYWSFDdyldylvksgelykpyiiddk 577
Cdd:COG1629   328 DGSGYPldlGSGSLPTLTSGADDDGTTTSLALYAQDTYKLTDKLTLTAGLRY-DYVSYD--------------------- 385

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  578 aykpkidvgqsiyytevmsekdwnryqqiekrineindcvsdddpvciaekkrldaeylkimgnanniedgkrygqsikw 657
Cdd:COG1629       --------------------------------------------------------------------------------

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  658 yyrddgrlhrednpfyngklknekVKDPITGelvnkyelsssvgpfseemkesdKLTKVERKRGHAFSPAFSATAFLTDH 737
Cdd:COG1629   386 ------------------------VDDTVTG-----------------------TDSASGSRSYSAFSPSLGLTYQLSPN 418

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  738 SRMYLRYTQYARMPSIFEttvgFSASADTSARFKNARLKPEKARNIEIGYvhdlgHYFSTPTKADIKLSYYHNETKNVID 817
Cdd:COG1629   419 LSLYASYSRGFRAPTFGE----LYANGTDPYSVGNPDLKPETSTNYELGL-----RYRLLDGRLSLSLALFYSDVDNEIL 489

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  818 RDT-------EFRFVQLDKRTLEGIELQARYDNGD-FFGDLGVEYhLKNKVCDANTAveldpiqmrvpTCITGGFAWGYl 889
Cdd:COG1629   490 SVPlpndsgfSTYYTNAGKARSYGVELELSYQLTPgLSLNASYSY-TDAKFDDDTDG-----------SADLDGNRLPG- 556

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  890 rtqlQPKYSISANLGARFFErKLEIGTRWLYHSKAKNKDEerlwklkvldegvwNRPMSWQPVLTLDAYIKYQISPNLSM 969
Cdd:COG1629   557 ----VPPLTANLGLTYEFPG-GWSLGLGVRYVGDRYLDDA--------------NTQGAPGGYTLVDLGAGYRFGDNLTL 617

                         970       980
                  ....*....|....*....|....*..
gi 386907447  970 ELTGTNLTDRYYLDPMTRSMIPAPGRT 996
Cdd:COG1629   618 SLGVDNLFDKKYATSLSVRASNVRGFL 644
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 718-1004 3.66e-22

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 101.00  E-value: 3.66e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   718 RKRGHAFSPAFSATAFLTDHSRMYLRYTQYARMPSIFETTVGFSASADTSARFKNARLKPEKARNIEIGYVHDlghyfst 797
Cdd:pfam00593  215 SRSYSAFSPRLGLVYKPTDNLSLYASYSRGFRAPSLGELYGSGSGGGGGAVAGGNPDLKPETSDNYELGLKYD------- 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   798 PTKADIKLSYYHNETKNVIDRDT--------EFRFVQLDKRTLEGIELQARYDNGDFFGDLGVeYHLKNKVCDANTAVEL 869
Cdd:pfam00593  288 DGRLSLSLALFYIDIKNLITSDPdgpglggtVYTYTNVGKARIRGVELELSGRLWGLGLSGGG-YTYTDADDDADADDTG 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   870 DPIQMRvptcitggfawgylrtqlqPKYsiSANLGARFFERK----LEIGTRWLYHSKAKNKDEERLWKLKvldegvwnr 945
Cdd:pfam00593  367 NPLPNV-------------------PRH--TANLGLTYDFPLggwgARLGARYVGSGERRYGDAANTFKTP--------- 416

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 386907447   946 pmswqPVLTLDAYIKYQISPNLSMELTGTNLTDRYY-----LDPMTRSMIPAPGRTVKLGLTAK 1004
Cdd:pfam00593  417 -----GYTLVDLSAGYRLNKNLTLRLGVNNLFDKYYkryysSGGGNLGGYPGPGRTFYLGLSYK 475
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 719-1005 3.31e-19

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 92.90  E-value: 3.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  719 KRGHAFSPAFSATAFLTDHSRMYLRYTQYARMPSIFETTVGFSASADTSARFKNarLKPEKARNIEIGYVHDLGHYFSTp 798
Cdd:cd01347   376 KSYSHWSPSLGLVYKLTDGLSLYASYSQGFRAPSLGELYGGGSHGGTAAVGNPN--LKPEKSKQYELGLKYDPGDGLTL- 452

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  799 tkadiKLSYYHNETKNVIDRD-------TEFRFVQLDKRTLEGIELQARYD-NGDFFGDLGVEY-HLKNKVCDANTAVEL 869
Cdd:cd01347   453 -----SAALFRIDIKNEIVSTptntglgLVTVYVNGGKARIRGVELEASYDlTDGLGLTGSYTYtDTEVKRTDGATTGNR 527

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  870 DPIQmrvptcitggfawgylrtqlqPKYSISANLGARFFERKLEIGTRWLYHSKAKNKDEERLWKLKVLDEGVWnrpmsw 949
Cdd:cd01347   528 LPGI---------------------PKHTANLGLDYELPDEGLTAGGGVRYRGKQYADTANGNNTVKVPGYTLV------ 580

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386907447  950 qpvltlDAYIKYQISPNLSMELTGTNLTDRYY-----LDPMTRSMIPAPGRTVKLGLTAKF 1005
Cdd:cd01347   581 ------DLSASYQFTKNLTLRLGVNNLFDKDYytslsVRGSGLYGYYGPGRTYYLSVSYKF 635
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 449-968 4.44e-15

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 79.52  E-value: 4.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  449 KKNPNTNGKYSYVNAAQVNAYNTRRGIHLSNTmnlTDKLDLTISGalqkelltsSHFNAKPNPSSTYESPPRAGRRKEWD 528
Cdd:COG4771   154 KKPTDELEGSVSLGYGSNGNGTYSGSLSLGGP---GDKLSFLLSG---------SYRDRDGYLDYRNGGFVGNSGYERYN 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  529 ITFNFNYRPTDWLMLTAGARY----NEYWSFDDYLDYLVKSGELYKPYIID--------DKAYKPKIDVgqSIYYTEVMS 596
Cdd:COG4771   222 LNAKLGYRLSDNHRLSLSGGYsrqdRDGGPPTLGDTEISSDNAGDRDTTTDrgnyslryNGDLGDNLDL--SLYYSRTDR 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  597 EKDWNRYQQIEKRINEINDcvsdddpvciaEKKRLDAEYLKIMGNANNIedgkRYGQSIKWYYRDDGRLHREDNPFYNgk 676
Cdd:COG4771   300 DSTNGSLGGSTGSFSDSDD-----------TTYGLELDLTYPLGGNHTL----TLGAEYRYDDLDSSSFLGGADASRD-- 362

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  677 lknekvkdpitgelvnkyelssSVGPFSE-EMKESDKLT-----------KVERKRGHAFSPAFSATAFLTDHSRMYLRY 744
Cdd:COG4771   363 ----------------------TYGLFAQdEWKLTDKLTltaglrydyysTFGASNYTAFSPRLGLRYDLSDNLTLRASY 420

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  745 TQYARMPSIFETTVGFSASADTSARFkNARLKPEKARNIEIGYVHDLGHyfstpTKADIKLSYYHNETKNVIDRDTE--- 821
Cdd:COG4771   421 GRGFRAPSLAELYGSGTGTPGRYVLG-NPDLKPETSDNYELGLEYRLGN-----GGLSLSLTGFYTDIKDLIVLVPVgpg 494

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  822 ----FRFVQLDKRTLEGIELQARYD-NGDFFGDLGVEYhLKNKVCDANTAVELDpiqmrvptcitggfawgylrtqLQPK 896
Cdd:COG4771   495 pgdvLQYENVGKARTYGLELELKYRlGKGLTLTASYTY-LDSKIDDGDTGEPLP----------------------NVPP 551

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386907447  897 YSISANLGARFFERKLEIGTRWLYHSKAKNKDEERlwklkvldegvwnRPMSWQPVLTLDAYIKYQISPNLS 968
Cdd:COG4771   552 HKANLGLDYRLPKWWLLLLLTRYYGGRYVTPPSGR-------------LEGYTPGYTLLDLRASYKLTKNLT 610
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 74-575 5.02e-12

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 69.79  E-value: 5.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   74 ADLFQ---GFNGVYSGDARNSGavdPNIRGIqGQGRIPVTIDGTEQAIttwRGYNGANNRNYLDPNLISGITVEKGPDLA 150
Cdd:cd01347    19 ADLLRripGVSVTRGGGGGGST---ISIRGF-GPDRTLVLVDGLPLAS---SNYGRGVDLNTIPPELIERVEVLKGPSSA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  151 SGNQSGIGGAVKMRTidaddiVKPGQKIGVELKLETSNNSVKeripdFKWGQDYRVVGDGTpgdfspitlitpktkgkyf 230
Cdd:cd01347    92 LYGSGAIGGVVNIIT------KRPTDEFGGSVTAGYGSDNSG-----SSGGGGFDVSGALA------------------- 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  231 kdnamrlavgvKEDKFDLLAAYSYRNKGNYLAGKGGA----HKYKGVLdqesgreikqiepnlpfAASIYRPHkeiPNTS 306
Cdd:cd01347   142 -----------DDGAFGARLYGAYRDGDGTIDGDGQAddsdEERYNVA-----------------GKLDWRPD---DDTR 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  307 STMESYLLKNTIrltdkqtlkMGYRDTKITYGEIMPSRLDFKAFHGFVPQWPLATVKQNAFNLDYEYNPDNRWINFKAGV 386
Cdd:cd01347   191 LTLDAGYQDQDA---------DGPGGTLPANGTGSSLGGGPSSNTNGDRDWDYRDRYRKRASLGLEHDLNDTGWTLRANL 261

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  387 WYTRTKSDTNTsggnpreANSMDVDWTLATSECVSVNPSPTTpHDYLIIDHACLARLGDPLVKKNPNTNGKYSYvnaAQV 466
Cdd:cd01347   262 SYSYTDNDGDP-------LILNGGNNAAGGDLGRSGYSSERD-TTQLGFDAGLNAPFGTGPVAHTLTLGVEYRR---EEL 330

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  467 NAYNTrrGIHLSNTMNLTDKLDLTISGALQKELLTSSHFNAKPNPSSTYESP--PRAGrrkewditfnFNYRPTDWLMLT 544
Cdd:cd01347   331 DEKQT--ALYAQDTIELTDDLTLTLGLRYDHYDQDSKDTIAGGTTAKKSYSHwsPSLG----------LVYKLTDGLSLY 398

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 386907447  545 AGA-------RYNEYWSFDDYLDYLVKSGELYKPYIID 575
Cdd:cd01347   399 ASYsqgfrapSLGELYGGGSHGGTAAVGNPNLKPEKSK 436
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
718-1005 7.26e-12

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 69.52  E-value: 7.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  718 RKRGHAFSPAFSATAFLTDHSRMYLRYTQyarmpsifettvGFSASADT-SARFKNARLKPEKARNIEIGYVHDLGHyfs 796
Cdd:COG4774   397 SYDDSAFSPRAGLVYKPTPNLSLYASYST------------SFNPGGGApSLSNAGQALDPEKSRQYEVGVKWDLLD--- 461

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  797 tpTKADIKLSYYHNETKNVI--DRDTEFRFVQLDKRTLEGIELQArydNGDFFGDLGVeyhlknkvcDANTAVeLDPIQM 874
Cdd:COG4774   462 --GRLSLTAALFRIEKTNVRttDPANPGVYVQTGEQRSRGVELEA---TGELTPGWSV---------LAGYTY-LDAEIT 526

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  875 RVPTCITGGfawgyLRTQLQPKYSisANLGA--RFFERKLEIGTRWLYHSKAKNkDEERLWKLkvldEGVWnrpmswqpv 952
Cdd:COG4774   527 KSANAANVG-----NRLPNVPRHS--ASLWTtyDLPLPGLTLGGGVRYVGSRYA-DAANTVKL----PSYT--------- 585

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 386907447  953 lTLDAYIKYQISPNLSMELTGTNLTDRYYLDPMTRS--MIPAPGRTVKLGLTAKF 1005
Cdd:COG4774   586 -RFDAGASYRLNKNLTLRLNVNNLTDKRYYASAYGSgyVTPGAPRTVLLSASYRF 639
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 62-160 5.74e-11

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 60.36  E-value: 5.74e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447    62 KETVERYKGAAPADLFQGFNGVYSGDARNSGAVDPNIRGIQGQgRIPVTIDGTEQAittwRGYNGANNRNYLDPNLISGI 141
Cdd:pfam07715   14 AEDIEDQGATNLADALRGVPGVSVSSGGGGGGSSISIRGFGSN-RVLVLVDGVPLN----SGGGGSVDLNSIDPEDIERV 88

                           90
                   ....*....|....*....
gi 386907447   142 TVEKGPDLASGNQSGIGGA 160
Cdd:pfam07715   89 EVLKGPASALYGSGAIGGV 107
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 24-547 4.69e-09

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 60.26  E-value: 4.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   24 AETTDQLSTIVVhaTSERKDEQGKDDEYQRNITNmyagKETVERYKGAAPADLFQGFNGVYSGDARN-SGAVDPNIRGIQ 102
Cdd:COG4771    21 AEDATELEEVVV--TATRTEQSLSDAPASVSVIT----AEEIEKLGATDLADALRLLPGVSVTRSGGrGGSSGISIRGLG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  103 GQgRIPVTIDGTEQaitTWRGYNGANNRNYLDPNLISGITVEKGPDLASGNQSGIGGAVKMRTidaddiVKPGQKIGVEL 182
Cdd:COG4771    95 GD-RVLVLIDGVPV---NNPALGGGGDLSYIPPDDIERIEVIRGPASALYGSDAIGGVINIIT------KKPTDELEGSV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  183 KLETSNNSvkeripdfkwGQDYRVvgdgtpgdfspitlitpktkgkyfkdnamRLAVGVKEDKFDLLAAYSYRNKGNYLA 262
Cdd:COG4771   165 SLGYGSNG----------NGTYSG-----------------------------SLSLGGPGDKLSFLLSGSYRDRDGYLD 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  263 gkggahkykgvldqesgreikqiepnlpfaasiYRPHKEIPNTSSTMESYLLKNTIRLTDKQTLKMGYRDTKITYGEIMP 342
Cdd:COG4771   206 ---------------------------------YRNGGFVGNSGYERYNLNAKLGYRLSDNHRLSLSGGYSRQDRDGGPP 252

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  343 SRLDFKAFHGFVPQWPLATVKQNaFNLDYEYNPDNRWiNFKAGVWYTRTKSDTNTSGGNPREANSMDVDWTLATSEcvsV 422
Cdd:COG4771   253 TLGDTEISSDNAGDRDTTTDRGN-YSLRYNGDLGDNL-DLSLYYSRTDRDSTNGSLGGSTGSFSDSDDTTYGLELD---L 327

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  423 NPSPTTPHDYliidhaclaRLGdplvkknpnTNGKYSYVNAAQVNAYNTRR----GIHLSNTMNLTDKLDLTISGALQKE 498
Cdd:COG4771   328 TYPLGGNHTL---------TLG---------AEYRYDDLDSSSFLGGADASrdtyGLFAQDEWKLTDKLTLTAGLRYDYY 389

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 386907447  499 LLTSSHFNAKPNPSstyesppragrrkewditFNFNYRPTDWLMLTAGA 547
Cdd:COG4771   390 STFGASNYTAFSPR------------------LGLRYDLSDNLTLRASY 420
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
722-1005 1.34e-07

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 55.70  E-value: 1.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  722 HAFSPAFSATAFLTDHSRMYLRYTQYARMPSIFETTVGFSASADtsarfknarLKPEKARNIEIGYVHDLGHYFStptkA 801
Cdd:COG4772   429 SEFLPGLGLLYQLTDNLQLYANVSRGFEPPTFGDLAYGNGGNPD---------LKPEKSWNYELGTRGRIGNGLS----A 495

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  802 DIklSYYHNETKNVIDRDT-----EFRFVQLDKRTLEGIELQARYdngDFFGDLGVEYHLknkvcDANTAVeLDPIQMRV 876
Cdd:COG4772   496 EV--ALFYIDYDNELGSCSaaggdRSTFTNAGETRHQGLELALDY---DLLKGGGLGLPL-----FAAYTY-TDAEFTSD 564

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  877 PTCITGGFAWGYLrtqlqPKYSISANLGARFfeRKLEIGTRWLYHSKAKNKDEERlwklkvLDEGVWNRPMSWQpvlTLD 956
Cdd:COG4772   565 FGPVFAGNRLPYV-----PRHQLTAGLGYEH--GGWTANLNGRYVSEQFTDAANT------VADGSFGKIPSYT---VLD 628

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 386907447  957 AYIKYQISPNLSMELTGTNLTDRYY----LDPMTRSMIPAPGRTVKLGLTAKF 1005
Cdd:COG4772   629 LSASYDFGKNLSLFAGVNNLFDKRYiasrAPNYAAGIRPGPPRTVYAGLRLKF 681
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 714-1005 5.95e-07

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 53.36  E-value: 5.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  714 TKVERKRGHAFSPAFSATAFLTDHSRMYLRYTQyarmpsIFETTVGFSASadtsarfkNARLKPEKARNIEIGYVHDLgh 793
Cdd:COG4773   447 GSTTSYDDSAFTPRAGLVYDLTPGLSLYASYSE------SFEPQSGADNN--------GNPLDPETGKQYEAGVKGEL-- 510

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  794 yfsTPTKADIKLSYYHNETKNVI--DRDTEFRFVQLDKRTLEGIELQArydNGDFFGDLGVE--Y-HLKNKVCDANTAVE 868
Cdd:COG4773   511 ---FDGRLNATLAVFDITQKNVAttDPDNPNFYVQVGEVRSRGVELEL---SGELTPGLNLIagYtYTDAKITKDADALE 584

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447  869 LDpiqmrvptcitggfawgylRTQLQPKYSISANLGARF---FERKLEIGTRWLYHSKAKNKDEERLWklkvldegvwnr 945
Cdd:COG4773   585 GK-------------------RLTNVPRHTASLWTTYRFpsgALKGLGLGGGVRYVGERYGDAANTFT------------ 633

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386907447  946 pmswQP-VLTLDAYIKYQISPNLSMELTGTNLTD-RYYLDPMTRSMI-PAPGRTVKLGLTAKF 1005
Cdd:COG4773   634 ----LPsYTLVDAGARYDLGKNWTLQLNVNNLFDkKYYASSGSRGYVyYGAPRNVRLSLSYKF 692
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 704-1005 1.15e-06

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 52.41  E-value: 1.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   704 SEEMKESDKLTKVERKR-GHAFSPAFSATAFLTDHSRMYLRYTQYARMPSIFETTVGFSASAdtsarfknarLKPEKARN 782
Cdd:TIGR01783  387 SVDVKSNNGVAGSTGKRdDSQFTPSLGVAYKPTDDWSLYASYAESFKPGGYYPKGAGNSGDI----------LEPEKGKN 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   783 IEIGYVHDLGHYFSTptkadiKLSYYHNETKNVI--DRDTEFRFVQLDKRTLEGIELQARY---DNGDFFGdlGVEYhlk 857
Cdd:TIGR01783  457 YELGVRYDLGDSLLA------TAALFRITKDNQLvqDPVNGTFSVNAGKTRNRGVELEARGyltPGLSLSA--GYTY--- 525

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   858 NKVcDANTAVELDPIQMRVPTCitggfawgylrtqlqPKY--SISANLGARFFERKLEIGTRWLYHSKAKNKDEERLwKL 935
Cdd:TIGR01783  526 TDA-EFTEDTNGDTQGNTVPFV---------------PKHtaSLWASYAPPVGDNGLTLGGGVQYTGKAYVDGGNTG-KV 588

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386907447   936 KvldegvwnrpmswqPVLTLDAYIKYQISPNLSMELTG--TNLTDRYY------LDPmTRSMIPAPGRTVKLGLTAKF 1005
Cdd:TIGR01783  589 P--------------SYTVVDLSVRYDLTKKKNLTLALnvNNLFDRDYytsgyrWGP-SAYIYPGAPRTVGLSVSYDF 651
TonB-Xanth-Caul TIGR01782
TonB-dependent receptor; This model represents a family of TonB-dependent outer-membrane ...
 937-1005 6.24e-06

TonB-dependent receptor; This model represents a family of TonB-dependent outer-membrane receptors which are found mainly in Xanthomonas and Caulobacter. These appear to represent the expansion of a paralogous family in that the 22 X. axonopodis (21 in X. campestris) and 18 C. crescentus sequences are more closely related to each other than any of the many TonB-dependent receptors found in other species. In fact, the Crescentus and Xanthomonas sequences are inseparable on a phylogenetic tree using a PAM-weighted neighbor-joining method, indicating that one of the two genuses may have acquired this set of receptors from the other. The mechanism by which this family is shared between Xanthomonas, a gamma proteobacterial plant pathogen and Caulobacter, an alpha proteobacterial aquatic organism is unclear. [Transport and binding proteins, Porins]


Pssm-ID: 273804 [Multi-domain]  Cd Length: 845  Bit Score: 50.41  E-value: 6.24e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386907447   937 VLDEGVWN---RPMSWQPVLTLDAYIKYQISPNLSMELTGTNLTD----RYYLDPMTRSMIPAPGRTVKLGLTAKF 1005
Cdd:TIGR01782  770 LLDVGGSNinrLDRYVDPRGQLDLSASYQVSDHLSLGLQASNLTNepsrWYTGGKQRPREYVETGRTYMLGLRYKF 845
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
63-165 1.26e-04

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 44.86  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386907447   63 ETVERYKGAAPADLFQGFNGVYSGDARNSGAV-DPNIRGIqGQGRIPVTIDGteqaITTWRGYNGANNRNYLDPNLISGI 141
Cdd:COG4206    25 EELERSGATSLADALRRVPGVQVSSSGGPGSAaSISIRGL-GSNQTLVLIDG----VPLNDPSLGGVDLSLIPPDDIERI 99

                          90       100
                  ....*....|....*....|....*..
gi 386907447  142 TVEKGPdlAS---GNQsGIGGAVKMRT 165
Cdd:COG4206   100 EVLKGA--ASalyGSD-AIGGVINITT 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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