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Conserved domains on  [gi|386783237]
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Chain H, Fab EP6b_B01, heavy chain

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
3-131 1.46e-53

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd04981:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 118  Bit Score: 168.64  E-value: 1.46e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237   3 QLQESGPGLVKPSETLSLTCTVSGASISanSYYGVWVRQSPGKGLEWVGSIayrgNSNSGSTYYNPSLKSRATVSVDSSK 82
Cdd:cd04981    1 QLQESGPGLVKPGQSLKLSCKASGFTFT--SYGMGWVRQAPGKGLEWIGLI----YPGGGDTYYADSFKGRFTITRDTSK 74
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 386783237  83 NQVSLRLTSVTAADTALYYCARrqlldDGTGYQWAAFDVWGQGTMVTVS 131
Cdd:cd04981   75 STAYLQLNSLTSEDTAVYYCAR-----GLGGYGYSYFDYWGQGTTVTVS 118
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
137-230 1.05e-41

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd21817:

Pssm-ID: 472250  Cd Length: 94  Bit Score: 137.58  E-value: 1.05e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237 137 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN 216
Cdd:cd21817    1 APSVFPLAPCCKSTNGSSVTLGCLVTGYFPEPVTVTWNSGSLTSGVKTFPAVLQSSGLYTTSSQVTVPSSSWGSQTFTCN 80
                         90
                 ....*....|....
gi 386783237 217 VNHKPSNTKVDKKV 230
Cdd:cd21817   81 VEHKPSSTKVDKKI 94
 
Name Accession Description Interval E-value
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
3-131 1.46e-53

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 168.64  E-value: 1.46e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237   3 QLQESGPGLVKPSETLSLTCTVSGASISanSYYGVWVRQSPGKGLEWVGSIayrgNSNSGSTYYNPSLKSRATVSVDSSK 82
Cdd:cd04981    1 QLQESGPGLVKPGQSLKLSCKASGFTFT--SYGMGWVRQAPGKGLEWIGLI----YPGGGDTYYADSFKGRFTITRDTSK 74
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 386783237  83 NQVSLRLTSVTAADTALYYCARrqlldDGTGYQWAAFDVWGQGTMVTVS 131
Cdd:cd04981   75 STAYLQLNSLTSEDTAVYYCAR-----GLGGYGYSYFDYWGQGTTVTVS 118
IgC1_CH1_IgEG cd21817
CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy epsilon and ...
137-230 1.05e-41

CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy epsilon and gamma chain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin constant-1 set domain of epsilon and gamma chains. It belongs to a family composed of the first immunoglobulin constant-1 set domain of alpha, delta, epsilon, gamma, and mu heavy chains. This domain is found on the Fab antigen-binding fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.


Pssm-ID: 409622  Cd Length: 94  Bit Score: 137.58  E-value: 1.05e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237 137 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN 216
Cdd:cd21817    1 APSVFPLAPCCKSTNGSSVTLGCLVTGYFPEPVTVTWNSGSLTSGVKTFPAVLQSSGLYTTSSQVTVPSSSWGSQTFTCN 80
                         90
                 ....*....|....
gi 386783237 217 VNHKPSNTKVDKKV 230
Cdd:cd21817   81 VEHKPSSTKVDKKI 94
IGv smart00406
Immunoglobulin V-Type;
17-104 8.88e-27

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 98.61  E-value: 8.88e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237    17 TLSLTCTVSGasiSANSYYGV-WVRQSPGKGLEWVGSIayrgnSNSGSTYYNPSLKSRATVSVDSSKNQVSLRLTSVTAA 95
Cdd:smart00406   1 SVTLSCKFSG---STFSSYYVsWVRQPPGKGLEWLGYI-----GSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVE 72

                   ....*....
gi 386783237    96 DTALYYCAR 104
Cdd:smart00406  73 DTGTYYCAV 81
C1-set pfam07654
Immunoglobulin C1-set domain;
140-220 1.00e-13

Immunoglobulin C1-set domain;


Pssm-ID: 462221  Cd Length: 85  Bit Score: 64.58  E-value: 1.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237  140 VFPLAPSSKSTsGGTAALGCLVKDYFPEPVTVSW--NSGALTSGVHTFPAVLQSSGLYSLSSV-VTVPSSSLGTQTYICN 216
Cdd:pfam07654   1 VYVFPPSPEEL-GKPNTLTCLVTGFYPPDITVTWlkNGQEVTEGVKTTPPSPNSDWTYQLSSYlTVTPSDWESGDEYTCR 79

                  ....
gi 386783237  217 VNHK 220
Cdd:pfam07654  80 VEHE 83
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
5-103 3.64e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 50.15  E-value: 3.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237    5 QESGPGLVKPSETLSLTCTVSGASISANSYYGvWVRQSPGKGLEWVgsIAYRGNSNSgstyyNPSLKSRATVSVDSSKNQ 84
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEASTSVY-WYRQPPGKGPTFL--IAYYSNGSE-----EGVKKGRFSGRGDPSNGD 72
                          90
                  ....*....|....*....
gi 386783237   85 VSLRLTSVTAADTALYYCA 103
Cdd:pfam07686  73 GSLTIQNLTLSDSGTYTCA 91
IGc1 smart00407
Immunoglobulin C-Type;
154-219 1.98e-06

Immunoglobulin C-Type;


Pssm-ID: 214651  Cd Length: 75  Bit Score: 44.61  E-value: 1.98e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386783237   154 TAALGCLVKDYFPEPVTVSW--NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGT-QTYICNVNH 219
Cdd:smart00407   1 KATLVCLVSGFYPPDITVTWlrNGQEVTEGVSTTDPLKNSDGTYFLSSYLTVPASTWESgDVYTCQVTH 69
 
Name Accession Description Interval E-value
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
3-131 1.46e-53

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 168.64  E-value: 1.46e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237   3 QLQESGPGLVKPSETLSLTCTVSGASISanSYYGVWVRQSPGKGLEWVGSIayrgNSNSGSTYYNPSLKSRATVSVDSSK 82
Cdd:cd04981    1 QLQESGPGLVKPGQSLKLSCKASGFTFT--SYGMGWVRQAPGKGLEWIGLI----YPGGGDTYYADSFKGRFTITRDTSK 74
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 386783237  83 NQVSLRLTSVTAADTALYYCARrqlldDGTGYQWAAFDVWGQGTMVTVS 131
Cdd:cd04981   75 STAYLQLNSLTSEDTAVYYCAR-----GLGGYGYSYFDYWGQGTTVTVS 118
IgC1_CH1_IgEG cd21817
CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy epsilon and ...
137-230 1.05e-41

CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy epsilon and gamma chain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin constant-1 set domain of epsilon and gamma chains. It belongs to a family composed of the first immunoglobulin constant-1 set domain of alpha, delta, epsilon, gamma, and mu heavy chains. This domain is found on the Fab antigen-binding fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.


Pssm-ID: 409622  Cd Length: 94  Bit Score: 137.58  E-value: 1.05e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237 137 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN 216
Cdd:cd21817    1 APSVFPLAPCCKSTNGSSVTLGCLVTGYFPEPVTVTWNSGSLTSGVKTFPAVLQSSGLYTTSSQVTVPSSSWGSQTFTCN 80
                         90
                 ....*....|....
gi 386783237 217 VNHKPSNTKVDKKV 230
Cdd:cd21817   81 VEHKPSSTKVDKKI 94
IgC1_CH1_IgADEGM cd04985
CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy alpha, delta, ...
137-230 3.66e-28

CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy alpha, delta, epsilon, gamma, and mu chains; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin constant-1 set domain of alpha, delta, epsilon, gamma, and mu heavy chains. This domain is found on the Fab antigen-binding fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.


Pssm-ID: 409374  Cd Length: 98  Bit Score: 103.05  E-value: 3.66e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237 137 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW---NSGALTSGVHTFPAVLQSSGLYSLSSVVTV-PSSSLGTQT 212
Cdd:cd04985    1 APTVFPLQSATKSQSNGPVALGCLISDYFPESITVSWqknTNSITSGFTRTFPVVLRSGGDYSCSSQLTVpLQEWNSGEV 80
                         90
                 ....*....|....*...
gi 386783237 213 YICNVNHKPSNTKVDKKV 230
Cdd:cd04985   81 YKCQVQHSASNSKQEKDV 98
IGv smart00406
Immunoglobulin V-Type;
17-104 8.88e-27

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 98.61  E-value: 8.88e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237    17 TLSLTCTVSGasiSANSYYGV-WVRQSPGKGLEWVGSIayrgnSNSGSTYYNPSLKSRATVSVDSSKNQVSLRLTSVTAA 95
Cdd:smart00406   1 SVTLSCKFSG---STFSSYYVsWVRQPPGKGLEWLGYI-----GSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVE 72

                   ....*....
gi 386783237    96 DTALYYCAR 104
Cdd:smart00406  73 DTGTYYCAV 81
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
5-130 9.05e-17

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 73.52  E-value: 9.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237   5 QESGPGLVKPSETLSLTCTVSGasiSANSYYGVWVRQSPGKGLEWVGSIayrgnsNSGSTYYNPSLKSRATVSVDSSKnQ 84
Cdd:cd00099    3 QSPRSLSVQEGESVTLSCEVSS---SFSSTYIYWYRQKPGQGPEFLIYL------SSSKGKTKGGVPGRFSGSRDGTS-S 72
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 386783237  85 VSLRLTSVTAADTALYYCARRqllDDGTGYQWaafdVWGQGTMVTV 130
Cdd:cd00099   73 FSLTISNLQPEDSGTYYCAVS---ESGGTDKL----TFGSGTRLTV 111
C1-set pfam07654
Immunoglobulin C1-set domain;
140-220 1.00e-13

Immunoglobulin C1-set domain;


Pssm-ID: 462221  Cd Length: 85  Bit Score: 64.58  E-value: 1.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237  140 VFPLAPSSKSTsGGTAALGCLVKDYFPEPVTVSW--NSGALTSGVHTFPAVLQSSGLYSLSSV-VTVPSSSLGTQTYICN 216
Cdd:pfam07654   1 VYVFPPSPEEL-GKPNTLTCLVTGFYPPDITVTWlkNGQEVTEGVKTTPPSPNSDWTYQLSSYlTVTPSDWESGDEYTCR 79

                  ....
gi 386783237  217 VNHK 220
Cdd:pfam07654  80 VEHE 83
IgC1_CH1_IgA cd21818
CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy alpha chain; ...
138-219 4.91e-13

CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy alpha chain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin constant-1 set domain of alpha chains. It belongs to a family composed of the first immunoglobulin constant-1 set domain of alpha, epsilon, gamma, and mu heavy chains. This domain is found on the Fab antigen-binding fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.


Pssm-ID: 409623  Cd Length: 94  Bit Score: 62.91  E-value: 4.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237 138 PSVFPLApSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSS-LGTQTYICN 216
Cdd:cd21818    2 PTVFPLS-LCPSLSSDPVVIGCLVQGFFPEPVNVTWNYSGKGGTARNFPAMLASGGRYTQSSQLTLPADQcPEGEAYKCS 80

                 ...
gi 386783237 217 VNH 219
Cdd:cd21818   81 VQH 83
IgC1_CH1_IgM cd21819
CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy mu chain; ...
138-232 5.74e-13

CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy mu chain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin constant-1 set domain of mu chains. It belongs to a family composed of the first immunoglobulin constant-1 set domain of alpha, delta, epsilon, gamma, and mu heavy chains. This domain is found on the Fab antigen-binding fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.


Pssm-ID: 409624  Cd Length: 95  Bit Score: 62.73  E-value: 5.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237 138 PSVFPLAPSSkSTSGGTAALGCLVKDYFPEPVTVSWNSG--ALTSGVHTFPAVLqSSGLYSLSSVVTVPSSSLGTQTYI- 214
Cdd:cd21819    2 PTLFPLVSCG-SSTSDPVTVGCLATDFLPDSITFSWTDDnnSLTTGVKTYPSVL-TGGTYTASSQLQVPESEWKSKENFy 79
                         90
                 ....*....|....*...
gi 386783237 215 CNVNHkpSNTKVDKKVEP 232
Cdd:cd21819   80 CKVEH--PGGNKEVPVPK 95
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
16-130 4.35e-10

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 55.35  E-value: 4.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237  16 ETLSLTCTVSgasiSANSYYGVWVRQSPGKGLEWVGSIAYRGNSNSgstyynpslKSRATVSVDSSKNQVSLRLTSVTAA 95
Cdd:cd04983   14 ENVTLNCNYS----TSTFYYLFWYRQYPGQGPQFLIYISSDSGNKK---------KGRFSATLDKSRKSSSLHISAAQLS 80
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 386783237  96 DTALYYCArrqlLDDGTGYQWAAFdvwGQGTMVTV 130
Cdd:cd04983   81 DSAVYFCA----LSESGGTGKLTF---GKGTRLTV 108
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
139-230 6.59e-10

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 54.77  E-value: 6.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237 139 SVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW--NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQ-TYIC 215
Cdd:cd00098    1 TVTLLPPSPEEKGGGKVTLVCLVSGFYPKDITVTWlkNGVPLTSGVSTSSPVEPNDGTYSVTSSLTVPPSDWDEGaTYTC 80
                         90
                 ....*....|....*
gi 386783237 216 NVNHKPSNTKVDKKV 230
Cdd:cd00098   81 VVTHESLKSPLSKTW 95
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
14-131 7.30e-10

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 55.06  E-value: 7.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237  14 PSETLSLTCTVSGASISANSYYgvWVRQSPGKGLEWVGSIAYRGNSNSGSTYYnpslKSRATVSVDSSKNQVSLRLTSVT 93
Cdd:cd04982   12 ESKSVTISCKVSGIDFSTTYIH--WYRQKPGQALERLLYVSSTSAVRKDSGKT----KNKFEARKDVGKSTSTLTITNLE 85
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 386783237  94 AADTALYYCARrqlLDDGTGYQWAAFdvwGQGTMVTVS 131
Cdd:cd04982   86 KEDSATYYCAY---WESGSGYYIKVF---GSGTKLIVT 117
IgV_H_TCR_mu cd16095
T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the ...
3-130 3.28e-09

T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain of the T-cell receptor Mu. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409514  Cd Length: 115  Bit Score: 53.33  E-value: 3.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237   3 QLQESGPGLVKPSETLSLTCTVSG--ASISANSYYgVWVrqsPGKGLEWVGSIAYRGNSNSGstyynpslkSRATVSVDS 80
Cdd:cd16095    3 QLEESGGGSHPAGKTLSLKCQTSGfqFNTSQLSWY-LWV---PGHAPLWLTSLDHISTKVSE---------DRITSSRED 69
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 386783237  81 SKNQVSLRLTSVTAADTALYYCARRQLLDDGTGYQwaafdVWGQGTMVTV 130
Cdd:cd16095   70 TNSQIFLQIKGLGLRDSGQYHCARRVGYGDDTDKL-----IFGPGTDVIV 114
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
5-103 3.64e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 50.15  E-value: 3.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237    5 QESGPGLVKPSETLSLTCTVSGASISANSYYGvWVRQSPGKGLEWVgsIAYRGNSNSgstyyNPSLKSRATVSVDSSKNQ 84
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEASTSVY-WYRQPPGKGPTFL--IAYYSNGSE-----EGVKKGRFSGRGDPSNGD 72
                          90
                  ....*....|....*....
gi 386783237   85 VSLRLTSVTAADTALYYCA 103
Cdd:pfam07686  73 GSLTIQNLTLSDSGTYTCA 91
IgV_TCR_gammadelta cd20988
Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the ...
12-130 1.44e-07

Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409580  Cd Length: 114  Bit Score: 48.71  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237  12 VKPSETLSLTCTVSGASISanSYYGVWVRQSPGKGLEWVgsiaYRgnsnSGSTYyNPSLKSRATVSVDSSKNQVSLRLTS 91
Cdd:cd20988   10 VSVGKPVTLKCSMKGEAIS--NYYINWYRKTQGNTMTFI----YR----EGGIY-GPGFKDNFRGDIDSSNNLAVLKILE 78
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 386783237  92 VTAADTALYYCARRQLLdDGTGYQWAAFdvwGQGTMVTV 130
Cdd:cd20988   79 ASERDEGSYYCASDTPG-GGREYDPLIF---GKGTYLTV 113
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
7-105 4.90e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.34  E-value: 4.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237     7 SGPGLVKPSETLSLTCTVSGASisanSYYGVWVRQspgkGLEWvgsiayrgnsnsgstyynpsLKSRATVSVDSSKNQVS 86
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSP----PPEVTWYKQ----GGKL--------------------LAESGRFSVSRSGSTST 52
                           90
                   ....*....|....*....
gi 386783237    87 LRLTSVTAADTALYYCARR 105
Cdd:smart00410  53 LTISNVTPEDSGTYTCAAT 71
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
12-130 1.80e-06

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 45.53  E-value: 1.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237  12 VKPSETLSLTCTVSGASISanSYYGVWVRQSPGKGLEWVgsiaYRGNSNSGStyynpSLKSRATVSvdSSKNQVSLRLTS 91
Cdd:cd04984   10 VSPGETVTITCTGSSGNIS--GNYVNWYQQKPGSAPRYL----IYEDKHRPS-----GIPDRFSGS--KSGNTASLTISG 76
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 386783237  92 VTAADTALYYCArrqlLDDGTGYqwaafdVWGQGTMVTV 130
Cdd:cd04984   77 AQTEDEADYYCQ----VWDSNSY------VFGGGTKLTV 105
IGc1 smart00407
Immunoglobulin C-Type;
154-219 1.98e-06

Immunoglobulin C-Type;


Pssm-ID: 214651  Cd Length: 75  Bit Score: 44.61  E-value: 1.98e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386783237   154 TAALGCLVKDYFPEPVTVSW--NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGT-QTYICNVNH 219
Cdd:smart00407   1 KATLVCLVSGFYPPDITVTWlrNGQEVTEGVSTTDPLKNSDGTYFLSSYLTVPASTWESgDVYTCQVTH 69
IgC1_CH3_IgAGD_CH4_IgAEM cd05768
CH3 domain (third constant Ig domain of the heavy chain) in immunoglobulin heavy alpha, gamma, ...
138-176 4.78e-06

CH3 domain (third constant Ig domain of the heavy chain) in immunoglobulin heavy alpha, gamma, and delta chains, and CH4 domain (fourth constant Ig domain of the heavy chain) in immunoglobulin heavy alpha, epsilon, and mu chains; member of the C1-set of I; The members here are composed of the third and fourth immunoglobulin constant domain (IgC) of alpha, delta, gamma and alpha, epsilon, and mu heavy chains, respectively. This domain is found on the Fc fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns.


Pssm-ID: 409425  Cd Length: 105  Bit Score: 44.25  E-value: 4.78e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 386783237 138 PSVFPLAPSSKS-TSGGTAALGCLVKDYFPEPVTVSWNSG 176
Cdd:cd05768    1 PSVYLLPPPEEElSLNETVTLTCLVKGFYPEDIFVSWLQN 40
IgC1_CH1_IgD cd16092
CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin delta chain; member ...
137-225 8.94e-06

CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin delta chain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin constant-1 set domain of delta chains. It belongs to a family composed of the first immunoglobulin constant-1 set domain of alpha, delta, epsilon, gamma, and mu heavy chains. This domain is found on the Fab antigen-binding fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.


Pssm-ID: 319341  Cd Length: 96  Bit Score: 43.29  E-value: 8.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237 137 GPSVFPLAPSSKSTSGGT-AALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC 215
Cdd:cd16092    1 APDVFPIISGCRHPKDNSpVVLACLITGYHPTSVTVTWYMGTQSQPQRTFPEIQRRDSYYMTSSQLSTPLQQWRQGEYKC 80
                         90
                 ....*....|
gi 386783237 216 NVNHKPSNTK 225
Cdd:cd16092   81 VVQHTASKSK 90
IgC1_L cd07699
Immunoglobulin light chain Constant domain; member of the C1-set of Ig superfamily (IgSF) ...
138-232 3.21e-05

Immunoglobulin light chain Constant domain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig) light chain constant (C) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determine the type of immunoglobulin: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409496  Cd Length: 99  Bit Score: 41.67  E-value: 3.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237 138 PSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW--NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGT-QTYI 214
Cdd:cd07699    2 PSVTIFPPSSEELSSGKATLVCLINKFYPGFATVTWkvDGSTVSSGVTTSKTEQQSDNTYSMSSYLTLSSSDWNKhKVYT 81
                         90
                 ....*....|....*...
gi 386783237 215 CNVNHKPSNTKVDKKVEP 232
Cdd:cd07699   82 CEVTHEGLSSTITKSFNR 99
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
11-130 4.37e-05

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 41.50  E-value: 4.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237  11 LVKPSETLSLTCTVSgasISANSYYgvWVRQSPGKGLEWVGsiayrgNSNSGSTYYNPSLK-SRATVSVDSSKNQvSLRL 89
Cdd:cd05899    9 IKRRGQSVTLRCSQK---SGHDNMY--WYRQDPGKGLQLLF------YSYGGGLNEEGDLPgDRFSASRPSLTRS-SLTI 76
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 386783237  90 TSVTAADTALYYCArrqLLDDGTGYQwAAFdvwGQGTMVTV 130
Cdd:cd05899   77 KSAEPEDSAVYLCA---SSLGGGADE-AYF---GPGTRLTV 110
IgC1_TCR_beta cd05769
T cell receptor (TCR) beta chain constant immunoglobulin domain; member of the C1-set of Ig ...
136-193 2.29e-04

T cell receptor (TCR) beta chain constant immunoglobulin domain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the T cell receptor (TCR) beta chain constant immunoglobulin domain. TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the beta chain. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The antigen binding site is formed by the variable domains of the alpha and beta chains, located at the N-terminus of each chain. Alpha/beta TCRs recognize antigens differently from gamma/delta TCRs.


Pssm-ID: 409426 [Multi-domain]  Cd Length: 116  Bit Score: 39.67  E-value: 2.29e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386783237 136 KGPSVFPLAPSSKSTSG-GTAALGCLVKDYFPEPVTVSW--NSGALTSGVHTFPAVLQSSG 193
Cdd:cd05769    1 TPPTVALFPPSEAEIRNkRKATLVCLATGFYPDHVSLSWkvNGKEVKDGVATDPQALRENT 61
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
16-130 2.10e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 36.73  E-value: 2.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237  16 ETLSLTCTVSgasISANSYYGVWVRQSPGKGLEWVgsiaYRGNSNSGSTyynpsLKSRATVSVDSSKNQVSLRLTSVTAA 95
Cdd:cd07706   15 EEVTLNCRYE---TSWTNYYLFWYKQLPSGEMTFL----IRQDSSEQNA-----KSGRYSVNFQKAQKSISLTISALQLE 82
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 386783237  96 DTALYYCARRQLLDDGTgyqwaafDVWGQGTMVTV 130
Cdd:cd07706   83 DSAKYFCALSLPYDTDK-------LIFGKGTRLTV 110
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
4-103 2.14e-03

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 37.04  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386783237   4 LQESGPGLVKPSETLSLTCTVSGASISANSYygvWVRQ----SPGKGLEWVGSiayrGNSNSGSTYYNPSLKSRATVSVD 79
Cdd:cd07700    2 LQTPGSLLVQTNQTVKMSCEAKTSPKNTRIY---WLRQrqapSKDSHFEFLAS----WDPSKGIVYGEGVDQEKLIILSD 74
                         90       100
                 ....*....|....*....|....
gi 386783237  80 SSKNQVSLRLTSVTAADTALYYCA 103
Cdd:cd07700   75 SDSSRYILSLMSVKPEDSGTYFCM 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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