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Conserved domains on  [gi|386768468|ref|NP_726245|]
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cyclin B, isoform E [Drosophila melanogaster]

Protein Classification

G2/mitotic-specific cyclin-B( domain architecture ID 15334103)

G2/mitotic-specific cyclin-B is essential for the control of the cell cycle at the G2/M (mitosis) transition

Gene Ontology:  GO:0051301|GO:0007049

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 252-382 2.27e-73

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 228.95  E-value: 2.27e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 252 VSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKdTKRTYL 331
Cdd:cd20507    1 VSEYVKDIYKYLRQLEKKYAIDPDYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQ-VPRKKL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 386768468 332 QLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDC 382
Cdd:cd20507   80 QLVGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 387-507 3.92e-53

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410213  Cd Length: 111  Bit Score: 175.49  E-value: 3.92e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 387 PLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLngnhragtgfNDRHWTPTLTFYS 466
Cdd:cd20509    1 PLPLHFLRRFSKAGGADAQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKIL----------DEPEWTPTLEHYS 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 386768468 467 RYSAAHLRPITRLIAKLARDAPQAKLKAIYNKYQGSKFQKI 507
Cdd:cd20509   71 TYSEEDLLPIVQKMAKLVVKSQTSKYQAVKNKYSSSKFMRI 111
 
Name Accession Description Interval E-value
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 252-382 2.27e-73

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 228.95  E-value: 2.27e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 252 VSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKdTKRTYL 331
Cdd:cd20507    1 VSEYVKDIYKYLRQLEKKYAIDPDYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQ-VPRKKL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 386768468 332 QLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDC 382
Cdd:cd20507   80 QLVGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
230-513 7.38e-54

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 188.06  E-value: 7.38e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 230 LSSKRLAGIEDIDANDKENLVLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETF 309
Cdd:COG5024  155 ESKRESQSWQDLDATDQEDPLMVPEYASDIFEYLLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETL 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 310 QLAVAIIDRYL--QVVKDTKrtyLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDCNLSRP 387
Cdd:COG5024  235 FLAINIIDRFLssRVVSLEK---YQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWP 311

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 388 LPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNhragtgfndrHWTPTLTFYS- 466
Cdd:COG5024  312 SPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQN----------QWDRTLIHYSg 381

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 386768468 467 RYSAAHLRPITRLIAKLaRDAPQAKLKAIYNKYQGSKFQKIALRTEL 513
Cdd:COG5024  382 NYTNPDLKPLNESNKEN-LQNPSVHHDAIFPKYPSPTFGKASSPTGE 427
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 387-507 3.92e-53

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 175.49  E-value: 3.92e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 387 PLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLngnhragtgfNDRHWTPTLTFYS 466
Cdd:cd20509    1 PLPLHFLRRFSKAGGADAQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKIL----------DEPEWTPTLEHYS 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 386768468 467 RYSAAHLRPITRLIAKLARDAPQAKLKAIYNKYQGSKFQKI 507
Cdd:cd20509   71 TYSEEDLLPIVQKMAKLVVKSQTSKYQAVKNKYSSSKFMRI 111
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 258-385 2.66e-51

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 171.16  E-value: 2.66e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468  258 DIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVvKDTKRTYLQLVGVT 337
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSK-KSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 386768468  338 ALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDCNLS 385
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 387-513 4.33e-40

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 141.22  E-value: 4.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468  387 PLPIHFLRRYSKAAGAED--EHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNHragtgfndrhWTPTLTF 464
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHdlELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPE----------WTETLEH 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 386768468  465 YSRYSAAHLRPITRLIAKLARDAPQAKLKAIYNKYQGSKFQKIALRTEL 513
Cdd:pfam02984  71 YTGYSEEDLKPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 293-378 2.48e-17

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 76.86  E-value: 2.48e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468   293 DWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRtYLQLVGVTALFIATKYEELFPPAIGDFVFITDdtYTARQIRQM 372
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKY-SPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRM 77


                   ....*.
gi 386768468   373 ELQIFK 378
Cdd:smart00385  78 ERLLLE 83
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 391-482 4.74e-14

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 67.23  E-value: 4.74e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468   391 HFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNhragtgfndrHWTPTLTFYSRY-S 469
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETP----------PWTKELVHYTGYfT 70

                           90
                   ....*....|...
gi 386768468   470 AAHLRPITRLIAK 482
Cdd:smart00385  71 EEEILRMERLLLE 83
 
Name Accession Description Interval E-value
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 252-382 2.27e-73

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 228.95  E-value: 2.27e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 252 VSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKdTKRTYL 331
Cdd:cd20507    1 VSEYVKDIYKYLRQLEKKYAIDPDYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQ-VPRKKL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 386768468 332 QLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDC 382
Cdd:cd20507   80 QLVGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
230-513 7.38e-54

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 188.06  E-value: 7.38e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 230 LSSKRLAGIEDIDANDKENLVLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETF 309
Cdd:COG5024  155 ESKRESQSWQDLDATDQEDPLMVPEYASDIFEYLLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETL 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 310 QLAVAIIDRYL--QVVKDTKrtyLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDCNLSRP 387
Cdd:COG5024  235 FLAINIIDRFLssRVVSLEK---YQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWP 311

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 388 LPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNhragtgfndrHWTPTLTFYS- 466
Cdd:COG5024  312 SPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQN----------QWDRTLIHYSg 381

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 386768468 467 RYSAAHLRPITRLIAKLaRDAPQAKLKAIYNKYQGSKFQKIALRTEL 513
Cdd:COG5024  382 NYTNPDLKPLNESNKEN-LQNPSVHHDAIFPKYPSPTFGKASSPTGE 427
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 387-507 3.92e-53

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 175.49  E-value: 3.92e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 387 PLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLngnhragtgfNDRHWTPTLTFYS 466
Cdd:cd20509    1 PLPLHFLRRFSKAGGADAQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKIL----------DEPEWTPTLEHYS 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 386768468 467 RYSAAHLRPITRLIAKLARDAPQAKLKAIYNKYQGSKFQKI 507
Cdd:cd20509   71 TYSEEDLLPIVQKMAKLVVKSQTSKYQAVKNKYSSSKFMRI 111
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 258-385 2.66e-51

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 171.16  E-value: 2.66e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468  258 DIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVvKDTKRTYLQLVGVT 337
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSK-KSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 386768468  338 ALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDCNLS 385
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 253-381 3.53e-50

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 168.52  E-value: 3.53e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 253 SEYVNDIYDYLYQVELEQPIHKDHLAGQkEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRTyLQ 332
Cdd:cd20565    2 SEYVKDIYAYLRQLEEEQAVRPKYLEGQ-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKM-LQ 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 386768468 333 LVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAID 381
Cdd:cd20565   80 LVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALD 128
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 238-376 4.72e-49

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 165.98  E-value: 4.72e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 238 IEDIDANDKENLVLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIID 317
Cdd:cd20567    4 LPDIDEVDKNNPLAAVEYVEDIYSFYRKVEPESCVPPYYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLID 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 386768468 318 RYLQvVKDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQI 376
Cdd:cd20567   84 RFLS-VKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTM 141
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 251-381 1.20e-47

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 161.95  E-value: 1.20e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 251 LVSEYVNDIYDYLYQVELEQPIHKDHLAGQkEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVvKDTKRTY 330
Cdd:cd20566    4 LCSDYVKDIYQYLRQLEVQQSIRPHYLDGK-EINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQV-QPVSRKK 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 386768468 331 LQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAID 381
Cdd:cd20566   82 LQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELN 132
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 240-382 4.73e-45

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 155.10  E-value: 4.73e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 240 DIDANDKENLVLVSEYVNDIYDYLYQVELEQPIhKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRY 319
Cdd:cd20508    1 DIDEENSDDPFQVSEYAKDIFDYMKEREEKFVV-PDYLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLY 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386768468 320 LqVVKDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDC 382
Cdd:cd20508   80 L-SKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDF 141
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 254-378 6.81e-44

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 151.63  E-value: 6.81e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 254 EYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVkDTKRTYLQL 333
Cdd:cd20504    1 EYADDIYEYLRESELKHRPKPDYMRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQM-SVLRSKLQL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 386768468 334 VGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFK 378
Cdd:cd20504   80 VGTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLK 124
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 250-381 9.18e-44

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 151.29  E-value: 9.18e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 250 VLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYL--QVVKDTK 327
Cdd:cd20568    3 LMVAEYVPEIFEYLRELELKTLPNPNYMDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLskRVVSLNK 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 386768468 328 rtyLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAID 381
Cdd:cd20568   83 ---LQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLE 133
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 387-513 4.33e-40

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 141.22  E-value: 4.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468  387 PLPIHFLRRYSKAAGAED--EHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNHragtgfndrhWTPTLTF 464
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHdlELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPE----------WTETLEH 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 386768468  465 YSRYSAAHLRPITRLIAKLARDAPQAKLKAIYNKYQGSKFQKIALRTEL 513
Cdd:pfam02984  71 YTGYSEEDLKPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 251-380 4.06e-35

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 128.30  E-value: 4.06e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 251 LVSEYVNDIYDYLYQVELEQ-PIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVvKDTKRT 329
Cdd:cd20562    4 MCSLYATDIYLNLRVAELKRrPLPDYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSG-NYVNRQ 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 386768468 330 YLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAI 380
Cdd:cd20562   83 RLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNAL 133
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 252-380 2.48e-34

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 125.94  E-value: 2.48e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 252 VSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKdTKRTYL 331
Cdd:cd20561    1 VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMS-VLRGKL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 386768468 332 QLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAI 380
Cdd:cd20561   80 QLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVL 128
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 286-381 6.90e-33

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 122.04  E-value: 6.90e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 286 KMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYT 365
Cdd:cd20519   35 RMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKTQLQLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACT 114

                         90
                 ....*....|....*.
gi 386768468 366 ARQIRQMELQIFKAID 381
Cdd:cd20519  115 EDEILTMELIILKALN 130
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 239-380 7.50e-32

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 120.33  E-value: 7.50e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 239 EDIDANDKENLVLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDR 318
Cdd:cd20560   20 SEDDSAADVDVLAVPEYAEDIHQYLREAELKHRPKPGYMRKQPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDR 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386768468 319 YLQVVKdTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAI 380
Cdd:cd20560  100 FLSCMS-VLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVL 160
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 287-380 6.40e-29

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 109.72  E-value: 6.40e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 287 MRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDtKRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTA 366
Cdd:cd20536    1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPV-ARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTR 79

                         90
                 ....*....|....
gi 386768468 367 RQIRQMELQIFKAI 380
Cdd:cd20536   80 EQICNLECIILTKL 93
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 387-509 5.56e-28

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 107.75  E-value: 5.56e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 387 PLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLlngnhragtgFNDRHWTPTLTFYS 466
Cdd:cd20510    1 PLSYRFLRRYAKCARASMETLTLARYILELSLMEYQFVQERASKLAAAALLLALKM----------KNLGEWTPTLEYYS 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 386768468 467 RYSAAHLRPITRLIAKLARDAPQAKLKAIYNKYQGSKFQKIAL 509
Cdd:cd20510   71 GYSAEDLLPLVRKLNAMLTKPPNKKLKTVRSKYSHKVFFEVAK 113
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 387-513 1.37e-27

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 106.89  E-value: 1.37e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 387 PLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNhragtgfndrHWTPTLTFYS 466
Cdd:cd20570    1 PLPLHFLRRASKAGSADVEKHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLDGG----------KWSLTQQYYT 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 386768468 467 RYSAAHLRPITRLIAKLARDAPQAKLK--AIYNKYQGSKFQKIALRTEL 513
Cdd:cd20570   71 GYTEDDLKPIMQHMAKNVVKVNEGLTKhvAVKNKYASSKLMKISTIPQL 119
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 387-509 1.94e-27

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 106.62  E-value: 1.94e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 387 PLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNHRagtgfndrhWTPTLTFYS 466
Cdd:cd20511    1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLNKTPE---------WTSTLEFHT 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 386768468 467 RYSAAHLRPITRLIAKLARDAPQAKLKAIYNKYQGSKFQKIAL 509
Cdd:cd20511   72 GYSESQLMECARLMVRLHSKAGTGKLTAVYKKYSSSKFGAVAL 114
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 288-384 2.49e-26

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 102.78  E-value: 2.49e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 288 RAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRTYlQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTAR 367
Cdd:cd20542    1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLL-QLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKK 79

                         90
                 ....*....|....*..
gi 386768468 368 QIRQMELQIFKAIDCNL 384
Cdd:cd20542   80 QVLRMERRVLRRLRFDL 96
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 387-513 6.93e-26

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 102.28  E-value: 6.93e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 387 PLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNhragtgfndrHWTPTLTFYS 466
Cdd:cd20569    1 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILDNG----------EWTPTLQHYM 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 386768468 467 RYSAAHLRPITRLIAKLARDAPQAKLK--AIYNKYQGSKFQKIALRTEL 513
Cdd:cd20569   71 SYTEESLLPVMQHMAKNVVKVNQGLTKhmTVKNKYASSKQMKISTLPQL 119
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 392-504 1.25e-24

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 98.47  E-value: 1.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 392 FLRRYSKAAGAEDEHHTM---SKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNgnhragtgfndRH-WTPTLTFYSR 467
Cdd:cd20506    6 FLRRFLRAAQASVPDLKLeflANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLN-----------PHpWNPTLEHYTG 74

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 386768468 468 YSAAHLRPITRLIAKLARDAPQAKLKAIYNKYQGSKF 504
Cdd:cd20506   75 YKAADLKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 286-381 2.06e-24

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 98.80  E-value: 2.06e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 286 KMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYT 365
Cdd:cd20579   41 KMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQENVVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACT 120

                         90
                 ....*....|....*.
gi 386768468 366 ARQIRQMELQIFKAID 381
Cdd:cd20579  121 EDEILSMELIIMKALK 136
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 286-380 1.07e-23

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 96.84  E-value: 1.07e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 286 KMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYT 365
Cdd:cd20580   41 KMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKNINKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACS 120

                         90
                 ....*....|....*
gi 386768468 366 ARQIRQMELQIFKAI 380
Cdd:cd20580  121 EDDILDMELIILKAL 135
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 387-485 1.47e-22

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 91.99  E-value: 1.47e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 387 PLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNgnhragtgfNDRHWTPTLTFYS 466
Cdd:cd20537    1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILG---------EPPPSPQLLQLVT 71

                         90
                 ....*....|....*....
gi 386768468 467 RYSAAHLRPITRLIAKLAR 485
Cdd:cd20537   72 GYSENDLQECAKELLELLA 90
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 389-509 8.55e-22

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 90.37  E-value: 8.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 389 PIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNhragtgfndrHWTPTLTFYSRY 468
Cdd:cd20512    2 PMNFLRRISKADDYDIQTRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKMLGRG----------DWNDNLVHYSGY 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 386768468 469 SAAHLRPITRLIAKLARDAPQAkLKAIYNKYQGSKFQKIAL 509
Cdd:cd20512   72 TESQLIPCADIMLEYLVKPIKH-HDAFFKKYSSKKFLKASI 111
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 293-378 2.48e-17

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 76.86  E-value: 2.48e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468   293 DWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRtYLQLVGVTALFIATKYEELFPPAIGDFVFITDdtYTARQIRQM 372
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKY-SPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRM 77


                   ....*.
gi 386768468   373 ELQIFK 378
Cdd:smart00385  78 ERLLLE 83
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 280-376 5.64e-16

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 75.03  E-value: 5.64e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 280 QKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVkDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFI 359
Cdd:cd20515   48 QTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLV-PIRKSQLQLLGAVCLFLASKLKETIPLTAEKLCIY 126

                         90
                 ....*....|....*..
gi 386768468 360 TDDTYTARQIRQMELQI 376
Cdd:cd20515  127 TDNSITLQELLDWELLV 143
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 285-380 1.09e-15

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 72.35  E-value: 1.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 285 HKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKdTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTY 364
Cdd:cd20521    1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRK-VPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTY 79

                         90
                 ....*....|....*.
gi 386768468 365 TARQIRQMELQIFKAI 380
Cdd:cd20521   80 KYEDVVRMMGEIVAAL 95
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 392-505 2.49e-14

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 69.24  E-value: 2.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 392 FLRRYSKAAGAEDEHHTMSKYFIELASVDYE-MATYRPSEIAAASLFLSLHLLNGnhragtgfndRHWTPTLTFYSRYSA 470
Cdd:cd20505    6 FLERFLKHSNADEKTKSLAMYLCELSLIDADpYLKYLPSVIAAAAVCLANHTLGN----------EVWPQKLARSTGYSL 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 386768468 471 AHLRPITRLIAKLARDAPQAKLKAIYNKYQGSKFQ 505
Cdd:cd20505   76 EDLLPCLRDLHRTFLNAPSSPQQAIREKYKSSKYH 110
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 391-482 4.74e-14

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 67.23  E-value: 4.74e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468   391 HFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNhragtgfndrHWTPTLTFYSRY-S 469
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETP----------PWTKELVHYTGYfT 70

                           90
                   ....*....|...
gi 386768468   470 AAHLRPITRLIAK 482
Cdd:smart00385  71 EEEILRMERLLLE 83
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 280-374 2.25e-13

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 67.70  E-value: 2.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 280 QKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVvKDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFI 359
Cdd:cd20573   47 QKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSV-EPTKKSRLQLLGATCMFLASKMKETIPLTAEKLCIY 125

                         90
                 ....*....|....*
gi 386768468 360 TDDTYTARQIRQMEL 374
Cdd:cd20573  126 TDNSIRPEELLQMEL 140
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 291-381 1.05e-12

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 63.94  E-value: 1.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 291 LIDWINEVHLQFHLAAETFQLAVAIIDRYLQvVKDTKRTYLQLVGVTALFIATKYEELFP--PAIGDFVFITDDTYTARQ 368
Cdd:cd20559    2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCS-KRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEEL 80

                         90
                 ....*....|...
gi 386768468 369 IRQMELQIFKAID 381
Cdd:cd20559   81 FIQMEMHILNTLN 93
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 280-377 2.40e-12

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 64.63  E-value: 2.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 280 QKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKdTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFI 359
Cdd:cd20575   48 QREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVP-TRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIY 126

                         90
                 ....*....|....*...
gi 386768468 360 TDDTYTARQIRQMELQIF 377
Cdd:cd20575  127 TDNSISPRQLLDWEILVL 144
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 292-373 9.61e-12

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 61.56  E-value: 9.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 292 IDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKdTKRTYLQLVGVTALFIA--TKYEELFPPAIGDFVFITDDTYTARQI 369
Cdd:cd20526    6 VRWLAELNSQFKFYPETFALAVSILDRFLASVK-ARPKYLRCIAISCLFLAakTNEEDEVIPSTKDLVRVSKCGCSVAEV 84


                 ....
gi 386768468 370 RQME 373
Cdd:cd20526   85 LRME 88
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 291-375 5.80e-11

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 58.58  E-value: 5.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 291 LIDWINEVHLQFHLAAETFQLAVAIIDRYLQvVKDTKRTYLQLVGVTALFIATKYEElFPPAIGDFVFITDdtYTARQIR 370
Cdd:cd00043    2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLS-KGLLLGRSPELIAAACLYLACKLEE-LPRTLKEIAKVSG--VSEKELR 77


                 ....*
gi 386768468 371 QMELQ 375
Cdd:cd00043   78 KAEKE 82
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 286-381 1.51e-10

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 58.00  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 286 KMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRTyLQLVGVTALFIATKYEELFP--PAIGDFVFITD-D 362
Cdd:cd20528    5 HLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQ-LHLVALTCLLLAAKFEELDDniPKISDLNRYLCnS 83

                         90
                 ....*....|....*....
gi 386768468 363 TYTARQIRQMELQIFKAID 381
Cdd:cd20528   84 VYSKQEYLQMELLILEFFQ 102
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 280-383 2.42e-10

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 58.85  E-value: 2.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 280 QKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKdTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFI 359
Cdd:cd20574   48 QKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVP-TRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIY 126

                         90       100
                 ....*....|....*....|....
gi 386768468 360 TDDTYTARQIRQMELQIFKAIDCN 383
Cdd:cd20574  127 TDNSIKPQELLEWELVVLGKLKWN 150
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 283-380 8.28e-08

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 50.25  E-value: 8.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 283 VSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRTYlQLVGVTALFIATKYEELFPPAIGDFVFITDD 362
Cdd:cd20517    1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETL-QKTGAACLLIASKIRTVKPITVSKLTYLSCD 79

                         90
                 ....*....|....*...
gi 386768468 363 TYTARQIRQMELQIFKAI 380
Cdd:cd20517   80 CFTNLELINQEKDILEAL 97
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 292-381 1.94e-07

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 49.24  E-value: 1.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 292 IDWINEVHLQFHLAAETFQLAVAIIDRYLQVV--KDTKRTYLQLVGVTALFIATKYEELFPPAIGDF-VFITDDTYTARQ 368
Cdd:cd20543    6 IDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYdlPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLqVEEPKYVFEAKT 85

                         90
                 ....*....|...
gi 386768468 369 IRQMELQIFKAID 381
Cdd:cd20543   86 IQRMELLVLSTLE 98
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 392-509 3.11e-07

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 49.42  E-value: 3.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 392 FLRRYSKAAGAEDEHHTMSKYFIELASVDYE-MATYRPSEIAAASLFLSLHLLNGNHragtgfndrhWTPTLTFYSRYSA 470
Cdd:cd20563    6 FLLQYLKRHEVCEKTENLAMYVAELSLLEVDpFLKYLPSLTAAAAYCLANYTVNKVF----------WPETLAAFTGYSL 75

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 386768468 471 AHLRPITRLIAKLARDAPQAKLKAIYNKYQGSKFQKIAL 509
Cdd:cd20563   76 SEIVPCLSDLHKACLGAPHRPQQAIREKYKGSKYMQVSL 114
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 412-508 5.03e-07

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 48.39  E-value: 5.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 412 YFIELASVDYEMATYRPSEIAAASLFLSLHLLNgnhragtgfNDRHWTPTLTFYSRYSAAHLRPITRLIAK--LARDAP- 488
Cdd:cd20522    5 YICELSLLHTELGRYSPAVIAASCLLLARVLLN---------QALPWPSQLEEFTGFSLEDLLSCVLHLHKkcFHEDSPk 75

                         90       100
                 ....*....|....*....|...
gi 386768468 489 ---QAKLKAIYNKYQGSKFQKIA 508
Cdd:cd20522   76 dyrNVSLTAVKQRYEDERFLSIS 98
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 389-480 1.36e-06

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 46.97  E-value: 1.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 389 PIHFLRRY-SKAAGAEDEHHTMSK---------------YFIELASVDYEMATYRPSEIAAASLFLSLHLLNgnhragtg 452
Cdd:cd20529    3 PAHFLEYYlSQGVLFVDDHDGLPSellekvkeyvrkyadFFLDLSLQDYAFLNYKPSLLAAACIAAARKALG-------- 74

                         90       100
                 ....*....|....*....|....*...
gi 386768468 453 fNDRHWTPTLTFYSRYSAAHLRPITRLI 480
Cdd:cd20529   75 -LSPTWPEELEKLTGYSEDELEPCVELL 101
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 302-373 1.71e-06

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 46.19  E-value: 1.71e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 386768468 302 FHLAAETFQLAVAIIDRYLQVVKdTKRTYLQLVGVTALFIATKY--EELFPPAIGDFVFITDDTYTARQIRQME 373
Cdd:cd20523   15 YGFSPETFALAVNLLDRFLSKVK-VKPKHLACITVSCFHIAIKSveEDQNIPSAEDLIRISQCGCTAADLMRME 87
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 387-504 1.60e-05

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 44.05  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 387 PLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYE-MATYRPSEIAAASLFLSLHLLNGnhragtgfndRHWTPTLTFY 465
Cdd:cd20564    1 PTINQFLTQYFLHQQANCKVESLSMFLGELSLIDADpYLKYLPSVIAAAAFHLALYTVTG----------QSWPESLVQK 70

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 386768468 466 SRYSAAHLRPITRLIAKLARDAPQAKLKAIYNKYQGSKF 504
Cdd:cd20564   71 TGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKY 109
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 302-373 5.59e-05

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 42.14  E-value: 5.59e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 386768468 302 FHLAAETFQLAVAIIDRYLQVVKdTKRTYLQLVGVTALFIATKY--EELFPPAIGDFVFITDDTYTARQIRQME 373
Cdd:cd20584   16 FGFSTETFVLAVNILDRFLALMK-VKPKHLSCIGICCFHLAARVveEECNIPSSHDLIRISQCKCTVSDLKRME 88
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 302-373 1.12e-04

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 41.35  E-value: 1.12e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 386768468 302 FHLAAETFQLAVAIIDRYLQVVKDTKRtYLQLVGVTALFIATKY--EELFPPAIGDFVFITDDTYTARQIRQME 373
Cdd:cd20583   16 FGFSTETFSLAVNLLDRFLAKMKVQPK-HLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFTVSDMMRME 88
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 389-444 1.18e-03

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 37.78  E-value: 1.18e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 386768468 389 PIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLN 444
Cdd:cd00043    2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEE 57
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 294-444 1.65e-03

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 40.49  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 294 WINEVHLQFHLAAETFQLAVAIIDRYlqVVKDTKRTY-LQLVGVTALFIATKYEElfppaigDFVFITDDTYTARQ---- 368
Cdd:COG5333   51 LIMDLCTRLNLPQTVLATAILFFSRF--YLKNSVEEIsLYSVVTTCVYLACKVED-------TPRDISIESFEARDlwse 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768468 369 --------IRQMELQIFKAIDCNLSRPLPIHFLRRYSKAAGAED--EHHTMSKYFIELASVDYEMATYRPSEIAAASLFL 438
Cdd:COG5333  122 epkssrerILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEKDkyKLLQIAWKIINDALRTDLCLLYPPHIIALAALLI 201


                 ....*.
gi 386768468 439 SLHLLN 444
Cdd:COG5333  202 ACEVLG 207
CYCLIN_CCND_rpt2 cd20516
second cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 391-450 4.03e-03

second cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410220  Cd Length: 98  Bit Score: 36.82  E-value: 4.03e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386768468 391 HFLRRYSKAagaEDEHHTMSK---YFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNHRAG 450
Cdd:cd20516    8 HILHRLPLD---SEDVDKVRKhaeTFIALCATDYKFSSYPPSMIAAASILAALRGLLLHSGNS 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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