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Conserved domains on  [gi|385288037|gb|AFI58965|]
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isocitrate dehydrogenase, partial [Exiguobacterium sp. 16a07]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 296)

isocitrate/isopropylmalate dehydrogenase family protein such as isocitrate dehydrogenase that in the Krebs cycle catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2, and isopropylmalate dehydrogenase that in leucine biosynthesis catalyzes the oxidation and decarboxylation of 3-isopropyl-l-malate to 4-methyl-2-oxovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
2-221 1.40e-161

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member PRK07006:

Pssm-ID: 444908  Cd Length: 409  Bit Score: 452.21  E-value: 1.40e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037   2 FLKEEMNVNKIRFPETSGIGIKPISSEGTKRLVRAALEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYELAEEEYGDKV 81
Cdd:PRK07006 171 FLQEEMGVKKIRFPETSGIGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEEEFGDEL 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  82 FTWAQYDRIKEesgeaaaneaqskAEAEGKIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGIAP 161
Cdd:PRK07006 251 IDGGPWDKIKN-------------PETGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAP 317

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037 162 GANINyvTGHAIFEATHGTAPKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLIINSMEK 221
Cdd:PRK07006 318 GANIN--DGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEK 375
 
Name Accession Description Interval E-value
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 2-221 1.40e-161

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 452.21  E-value: 1.40e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037   2 FLKEEMNVNKIRFPETSGIGIKPISSEGTKRLVRAALEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYELAEEEYGDKV 81
Cdd:PRK07006 171 FLQEEMGVKKIRFPETSGIGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEEEFGDEL 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  82 FTWAQYDRIKEesgeaaaneaqskAEAEGKIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGIAP 161
Cdd:PRK07006 251 IDGGPWDKIKN-------------PETGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAP 317

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037 162 GANINyvTGHAIFEATHGTAPKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLIINSMEK 221
Cdd:PRK07006 318 GANIN--DGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEK 375
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 2-221 1.23e-138

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 394.09  E-value: 1.23e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037   2 FLKEEMNVNKIRFPETSGIGIKPISSEGTKRLVRAALEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYELAEEEYGDKV 81
Cdd:COG0538  168 FLEDEMGVTVIRFPEDSGIGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEEEFGDKF 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  82 FTWAQYDRIKEEsgeaaaneaqskaEAEGKIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGIAP 161
Cdd:COG0538  248 ITEGPWEKYKGP-------------KPAGKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAP 314

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037 162 GANINYVTGhAIFEATHGTAPKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLIINSMEK 221
Cdd:COG0538  315 GANIGDDGG-AEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEK 373
prok_nadp_idh TIGR00183
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent ...
 1-221 4.82e-131

isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; Prokaryotic NADP-dependent isocitrate dehydrogenases resemble their NAD-dependent counterparts and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent isocitrate dehydrogenases. [Energy metabolism, TCA cycle]


Pssm-ID: 272948  Cd Length: 416  Bit Score: 375.32  E-value: 4.82e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037    1 SFLKEEMNVNKIRFPETSGIGIKPISSEGTKRLVRAALEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYELAEEEYGDK 80
Cdd:TIGR00183 177 RFLQNELGVKKIRFPEDSGIGIKPISEEGTKRLVRAAIEYAIENDRKSVTLVHKGNIMKFTEGAFRDWGYELAKKEFGAE 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037   81 VFTWAQYDRIKEESgeaaaneaqskaeaEGK-IIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGI 159
Cdd:TIGR00183 257 CITWGLWDKYKNPN--------------PGKeIVIKDRIADAFLQQILTRPDEYDVIATMNLNGDYISDALAAQVGGIGI 322

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 385288037  160 APGANINYVTGhaIFEATHGTAPKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLIINSMEK 221
Cdd:TIGR00183 323 APGANIGDEIG--IFEATHGTAPKYAGQDKVNPGSIILSGEMMLEHMGWKEAADLIKKAMEK 382
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
16-221 4.24e-62

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 197.13  E-value: 4.24e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037   16 ETSGIGIKPISSEGTKRLVRAALEYAIANNRKSLTLVHKGNIMKFTEGafknWGY---ELAEEEYGDkvftwaqydrike 92
Cdd:pfam00180 147 NEVAVDTKLYSRDEIERIARVAFELARKRGRKKVTSVDKANVLKSSDL----WRKivtEVAKAEYPD------------- 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037   93 esgeaaaneaqskaeaegkIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGIAPGANINYvTGHA 172
Cdd:pfam00180 210 -------------------VELEHQLVDNAAMQLVKNPSQFDVIVTPNLFGDILSDEASMLTGSLGLLPSASLGA-NGFG 269

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 385288037  173 IFEATHGTAPKYAGLDKVNPSSVILSGEMMLRH-MNWNEAADLIINSMEK 221
Cdd:pfam00180 270 IFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLK 319
 
Name Accession Description Interval E-value
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 2-221 1.40e-161

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 452.21  E-value: 1.40e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037   2 FLKEEMNVNKIRFPETSGIGIKPISSEGTKRLVRAALEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYELAEEEYGDKV 81
Cdd:PRK07006 171 FLQEEMGVKKIRFPETSGIGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEEEFGDEL 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  82 FTWAQYDRIKEesgeaaaneaqskAEAEGKIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGIAP 161
Cdd:PRK07006 251 IDGGPWDKIKN-------------PETGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAP 317

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037 162 GANINyvTGHAIFEATHGTAPKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLIINSMEK 221
Cdd:PRK07006 318 GANIN--DGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEK 375
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 2-221 1.23e-138

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 394.09  E-value: 1.23e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037   2 FLKEEMNVNKIRFPETSGIGIKPISSEGTKRLVRAALEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYELAEEEYGDKV 81
Cdd:COG0538  168 FLEDEMGVTVIRFPEDSGIGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEEEFGDKF 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  82 FTWAQYDRIKEEsgeaaaneaqskaEAEGKIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGIAP 161
Cdd:COG0538  248 ITEGPWEKYKGP-------------KPAGKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAP 314

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037 162 GANINYVTGhAIFEATHGTAPKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLIINSMEK 221
Cdd:COG0538  315 GANIGDDGG-AEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEK 373
prok_nadp_idh TIGR00183
isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent ...
 1-221 4.82e-131

isocitrate dehydrogenase, NADP-dependent, prokaryotic type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; Prokaryotic NADP-dependent isocitrate dehydrogenases resemble their NAD-dependent counterparts and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent isocitrate dehydrogenases. [Energy metabolism, TCA cycle]


Pssm-ID: 272948  Cd Length: 416  Bit Score: 375.32  E-value: 4.82e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037    1 SFLKEEMNVNKIRFPETSGIGIKPISSEGTKRLVRAALEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYELAEEEYGDK 80
Cdd:TIGR00183 177 RFLQNELGVKKIRFPEDSGIGIKPISEEGTKRLVRAAIEYAIENDRKSVTLVHKGNIMKFTEGAFRDWGYELAKKEFGAE 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037   81 VFTWAQYDRIKEESgeaaaneaqskaeaEGK-IIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGI 159
Cdd:TIGR00183 257 CITWGLWDKYKNPN--------------PGKeIVIKDRIADAFLQQILTRPDEYDVIATMNLNGDYISDALAAQVGGIGI 322

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 385288037  160 APGANINYVTGhaIFEATHGTAPKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLIINSMEK 221
Cdd:TIGR00183 323 APGANIGDEIG--IFEATHGTAPKYAGQDKVNPGSIILSGEMMLEHMGWKEAADLIKKAMEK 382
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
8-221 2.47e-84

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 258.10  E-value: 2.47e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037   8 NVNKIRFPETSGIGIKPISSEGTKRLVRAALEYA--IANNRKSLTLVHKGNIMKFTEGAFKNWGYELAEEEYGDKVFT-- 83
Cdd:PRK07362 191 ELGKRQIPLGSGIGIKPVSKTGSQRHIRRAIEHAlrLPGDKRHVTLVHKGNIMKYTEGAFRDWGYELATTEFRDECVTer 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  84 --W---------------------AQYDRIKEESGEAAANEAQSKAEAEG----------KIIVKDSIADIFLQQILTRP 130
Cdd:PRK07362 271 esWilsnkeknpnisiednarmiePGYDSLTPEKKAAICAEVKEVLDSIWsshgngkwkeKVLVDDRIADSIFQQIQTRP 350

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037 131 REFDVVATMNLNGDYISDALAAQVGGIGIAPGANINyvTGHAIFEATHGTAPKYAGLDKVNPSSVILSGEMMLRHMNWNE 210
Cdd:PRK07362 351 QEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIG--DNAAIFEATHGTAPKHAGLDRINPGSVILSGVMMLEYLGWQE 428

                        250
                 ....*....|.
gi 385288037 211 AADLIINSMEK 221
Cdd:PRK07362 429 AADLITKGLSA 439
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
1-215 9.95e-74

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 228.95  E-value: 9.95e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037   1 SFLKEEMNVNkirFPETSGIGIKPISSEGTKRLVRAALEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYELAEEEYGDK 80
Cdd:PRK06451 172 DFLRKELGVE---VEDDTGIGIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAYEVALKEFRDY 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  81 VFTwaqydrikeesgEAAANEAQSKAEAEGKIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGIA 160
Cdd:PRK06451 249 VVT------------EEEVTKNYNGVPPSGKVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGML 316

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 385288037 161 PGANINYVTGhaIFEATHGTAPKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLI 215
Cdd:PRK06451 317 GGANIGDTGG--MFEAIHGTAPKYAGKNVANPTGIIKGGELMLRFMGWDKAADLI 369
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
16-221 4.24e-62

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 197.13  E-value: 4.24e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037   16 ETSGIGIKPISSEGTKRLVRAALEYAIANNRKSLTLVHKGNIMKFTEGafknWGY---ELAEEEYGDkvftwaqydrike 92
Cdd:pfam00180 147 NEVAVDTKLYSRDEIERIARVAFELARKRGRKKVTSVDKANVLKSSDL----WRKivtEVAKAEYPD------------- 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037   93 esgeaaaneaqskaeaegkIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGIAPGANINYvTGHA 172
Cdd:pfam00180 210 -------------------VELEHQLVDNAAMQLVKNPSQFDVIVTPNLFGDILSDEASMLTGSLGLLPSASLGA-NGFG 269

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 385288037  173 IFEATHGTAPKYAGLDKVNPSSVILSGEMMLRH-MNWNEAADLIINSMEK 221
Cdd:pfam00180 270 IFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLK 319
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 15-221 6.29e-50

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 165.57  E-value: 6.29e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  15 PETSGIGIKPISSEGTKRLVRAALEYAIANnRKSLTLVHKGNIMKFTEGAFKNWGYELAEEeYGDkvftwaqydrikees 94
Cdd:COG0473  147 GEEVAIDTRVYTRKGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKE-YPD--------------- 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  95 geaaaneaqskaeaegkIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGIAPGANINyVTGHAIF 174
Cdd:COG0473  210 -----------------VELDHMYVDAAAMQLVRNPEQFDVIVTENLFGDILSDLAAGLTGSLGLAPSANIG-DEGKALF 271

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 385288037 175 EATHGTAPKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLIINSMEK 221
Cdd:COG0473  272 EPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAAVEK 318
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
22-217 1.59e-43

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 151.97  E-value: 1.59e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  22 IKPISSEGTKRLVRAALEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYELAEEeygdkvftwaqYDRIkeesgeaaane 101
Cdd:PRK09222 143 LKLISRPGSEKIIRYAFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKE-----------YPDI----------- 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037 102 aqskaEAEGKIIvkdsiaDIFLQQILTRPREFDVVATMNLNGDYISDaLAAQV-GGIGIAPGANInyvtGH--AIFEATH 178
Cdd:PRK09222 201 -----EAEHYIV------DIGAARLATNPENFDVIVTPNLYGDILSD-IAAEIsGSVGLAGSANI----GEeyAMFEAVH 264

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 385288037 179 GTAPKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLIIN 217
Cdd:PRK09222 265 GSAPDIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIEN 303
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 25-215 1.76e-38

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 135.62  E-value: 1.76e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  25 ISSEGTKRLVRAALEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYELAEeeygdkvftwaQYDRIKEEsgeaaaneaqs 104
Cdd:PRK08997 144 ITRKGAERIVRFAYELARKEGRKKVTAVHKANIMKSTSGLFLKVAREVAL-----------RYPDIEFE----------- 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037 105 kaeaegkiivkDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGIAPGANINyvTGHAIFEATHGTAPKY 184
Cdd:PRK08997 202 -----------EMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLVGGLGMAPGANIG--RDAAIFEAVHGSAPDI 268

                        170       180       190
                 ....*....|....*....|....*....|.
gi 385288037 185 AGLDKVNPSSVILSGEMMLRHMNWNEAADLI 215
Cdd:PRK08997 269 AGKNLANPTSVILAAIQMLEYLGMPDKAERI 299
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 22-215 3.29e-38

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 134.82  E-value: 3.29e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037   22 IKPISSEGTKRLVRAALEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYELAEEeygdkvftwaqYDRIKEESgeaaane 101
Cdd:TIGR00175 139 LKVITRDKSERIARYAFEYARKNGRKKVTAVHKANIMKLADGLFLNVCREVAKE-----------YPDITFES------- 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  102 aqskaeaegkIIVKDSIadiflQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGIAPGANINYVtgHAIFE-ATHGT 180
Cdd:TIGR00175 201 ----------MIVDNTC-----MQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGGPGLVPGANIGRD--YAVFEpGVRHT 263

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 385288037  181 APKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLI 215
Cdd:TIGR00175 264 GPDIAGQNIANPTALILSSVMMLNHLGLKEHADRI 298
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 14-221 1.34e-36

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 130.64  E-value: 1.34e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  14 FPETSGIGIKPISSEGTKRLVRAALEYA----IANNRKSLTLVHKGNIMKFTEGAFKNWGYELAEEeygdkvftwaqYDR 89
Cdd:PRK14025 126 IADGVTVATRVITRKASERIFRFAFEMAkrrkKMGKEGKVTCAHKANVLKKTDGLFKKTFYEVAKE-----------YPD 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  90 IKEEsgeaaaneaqskaeaegkiivkDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGIAPGANINyvT 169
Cdd:PRK14025 195 IKAE----------------------DYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIG--D 250

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 385288037 170 GHAIFEATHGTAPKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLIINSMEK 221
Cdd:PRK14025 251 KYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEE 302
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 29-215 5.21e-33

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 121.57  E-value: 5.21e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  29 GTKRLVRAALEYAIANNRKSLTLVHKGNIMKFtegAFKNWgyelaeeeygdkvftWAQYDRIKEESGEAAANEAQSKAea 108
Cdd:PRK03437 161 GVERVVRDAFERAQKRPRKHLTLVHKTNVLTF---AGDLW---------------QRTVDEVAAEYPDVTVDYQHVDA-- 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037 109 egkiivkdsiADIFLqqiLTRPREFDVVATMNLNGDYISDALAAQVGGIGIAPGANINYV-TGHAIFEATHGTAPKYAGL 187
Cdd:PRK03437 221 ----------ATIFM---VTDPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTgTNPSMFEPVHGSAPDIAGQ 287

                        170       180
                 ....*....|....*....|....*...
gi 385288037 188 DKVNPSSVILSGEMMLRHMNWNEAADLI 215
Cdd:PRK03437 288 GIADPTAAILSVALLLDHLGEEDAAARI 315
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 22-219 6.70e-31

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 116.52  E-value: 6.70e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  22 IKPISSEGTKRLVRAALEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYELAEEeYGDkvftwaqydrikeesgeaaane 101
Cdd:PLN00118 178 LKIITRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEK-YPE---------------------- 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037 102 aqskaeaegkIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGIAPGANINyVTGHAIFEATHGTA 181
Cdd:PLN00118 235 ----------IVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIG-ENGLALAEAVHGSA 303

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 385288037 182 PKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLIINSM 219
Cdd:PLN00118 304 PDIAGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAI 341
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 22-213 2.58e-27

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 106.49  E-value: 2.58e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  22 IKPISSEGTKRLVRAALEYAIANNRKSLTLVHKGNIMKFTEGAFKNWGYELAEeeygdkvftwaQYDRIKEEsgeaaane 101
Cdd:PLN00123 162 LKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAK-----------KYPGIKYN-------- 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037 102 aqskaeaegKIIVkdsiaDIFLQQILTRPREFDVVATMNLNGDYISDALAAQVGGIGIAPGANINyvTGHAIFE--ATHG 179
Cdd:PLN00123 223 ---------EIIV-----DNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVG--ADHAVFEqgASAG 286

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 385288037 180 TA--PKYAGLDKVNPSSVILSGEMMLRHMNWNEAAD 213
Cdd:PLN00123 287 NVgnEKLVEQKKANPVALLLSSAMMLRHLQFPSFAD 322
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 125-221 5.27e-23

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 94.78  E-value: 5.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037 125 QILTRPREFDVVATMNLNGDYISDALAAQVGGIGIAPGANINyVTGHAIFEATHGTAPKYAGLDKVNPSSVILSGEMMLR 204
Cdd:PRK00772 228 QLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLG-ESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLR 306

                         90
                 ....*....|....*...
gi 385288037 205 H-MNWNEAADLIINSMEK 221
Cdd:PRK00772 307 YsLGLEEAADAIEAAVEK 324
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 26-220 1.39e-22

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 93.63  E-value: 1.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037  26 SSEGTKRLVRAALEYAiANNRKSLTLVHKGN----IMKFTEGAFKNWGyelaeEEYGDkVFTWAQYdrikeesgeaaane 101
Cdd:PRK08194 159 TRKGTERAMRYAFELA-AKRRKHVTSATKSNgivhSMPFWDEVFQEVG-----KDYPE-IETDSQH-------------- 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037 102 aqskaeaegkiivKDSIADIFLqqilTRPREFDVVATMNLNGDYISDALAAQVGGIGIAPGANINyVTGH--AIFEATHG 179
Cdd:PRK08194 218 -------------IDALAAFFV----TRPEEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANIN-VNGKypSMFEPVHG 279

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 385288037 180 TAPKYAGLDKVNPSSVILSGEMMLRHMNWNEAADLIINSME 220
Cdd:PRK08194 280 SAPDIAGKGIANPIGQIWTAKLMLDHFGEEELGSHLLDVIE 320
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 125-221 7.54e-14

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 69.72  E-value: 7.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385288037 125 QILTRPREFDVVATMNLNGDYISDALAAQVGGIGIAPGANINyVTGHAIFEATHGTAPKYAGLDKVNPSSVILSGEMMLR 204
Cdd:PLN02329 273 QLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLG-ESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLK 351

                         90       100
                 ....*....|....*....|..
gi 385288037 205 HMNWNEAA-----DLIINSMEK 221
Cdd:PLN02329 352 YGLGEEKAakrieDAVVDALNK 373
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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