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Conserved domains on  [gi|384871699|ref|NP_001245209|]
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zinc finger protein 501 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
20-256 1.78e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699  20 KPSKCSECGKFFTQRSSLTQHQRIHRGEKPYVCSECGSCFRKQSNLTQHLRIHTGEKPYKCNECEKAFQTKAILVQHLRI 99
Cdd:COG5048  197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPN 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699 100 HTGE-------KPYKCNECGKAFCQSPSLIKHQR--IHTGE--KPYKCTE--CGKAFSQSICLTRHQRSHSGDKPFKC-- 164
Cdd:COG5048  277 ESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEkl 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699 165 NECGKAFNQ-----SACLMQHQRIHSGEKPYTCT--ECGKAFTQNSSLVEHERTHT--GEKLYKCSECEKTFRKQAHLSE 235
Cdd:COG5048  357 LNSSSKFSPllnnePPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIP 436

                        250       260
                 ....*....|....*....|.
gi 384871699 236 HYRIHTGEKPYECVGCGKSFR 256
Cdd:COG5048  437 HKKIHTNHAPLLCSILKSFRR 457
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
20-256 1.78e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699  20 KPSKCSECGKFFTQRSSLTQHQRIHRGEKPYVCSECGSCFRKQSNLTQHLRIHTGEKPYKCNECEKAFQTKAILVQHLRI 99
Cdd:COG5048  197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPN 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699 100 HTGE-------KPYKCNECGKAFCQSPSLIKHQR--IHTGE--KPYKCTE--CGKAFSQSICLTRHQRSHSGDKPFKC-- 164
Cdd:COG5048  277 ESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEkl 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699 165 NECGKAFNQ-----SACLMQHQRIHSGEKPYTCT--ECGKAFTQNSSLVEHERTHT--GEKLYKCSECEKTFRKQAHLSE 235
Cdd:COG5048  357 LNSSSKFSPllnnePPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIP 436

                        250       260
                 ....*....|....*....|.
gi 384871699 236 HYRIHTGEKPYECVGCGKSFR 256
Cdd:COG5048  437 HKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
120-145 6.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 6.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 384871699  120 SLIKHQRIHTGEKPYKCTECGKAFSQ 145
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 76-128 2.89e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 2.89e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 384871699  76 KPYkCNECEKAFQTKAILVQHLRIHTgekpYKCNECGKAFCQSPSLIKH-QRIH 128
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
20-256 1.78e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699  20 KPSKCSECGKFFTQRSSLTQHQRIHRGEKPYVCSECGSCFRKQSNLTQHLRIHTGEKPYKCNECEKAFQTKAILVQHLRI 99
Cdd:COG5048  197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPN 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699 100 HTGE-------KPYKCNECGKAFCQSPSLIKHQR--IHTGE--KPYKCTE--CGKAFSQSICLTRHQRSHSGDKPFKC-- 164
Cdd:COG5048  277 ESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEkl 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699 165 NECGKAFNQ-----SACLMQHQRIHSGEKPYTCT--ECGKAFTQNSSLVEHERTHT--GEKLYKCSECEKTFRKQAHLSE 235
Cdd:COG5048  357 LNSSSKFSPllnnePPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIP 436

                        250       260
                 ....*....|....*....|.
gi 384871699 236 HYRIHTGEKPYECVGCGKSFR 256
Cdd:COG5048  437 HKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
104-176 2.20e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 2.20e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 384871699 104 KPYKCNECGKAFCQSPSLIKHQRIHTGEKPYKCT--ECGKAFSQSICLTRHQRSHSGDKPFKCNECGKAFNQSAC 176
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 74-159 4.79e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 4.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699  74 GEKPYKCN--ECEKAFQTKAILVQHlRIHtgekpykcNECGKAFCQSPSLIKHQRIHTGEKPYKCTECGKAFSQSICLTR 151
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*...
gi 384871699 152 HqRSHSGD 159
Cdd:COG5189  417 H-RKHSHD 423
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
16-270 2.54e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699  16 NMQKKPSKCSECGKFFTQRSSLTQHQRIHRGEKPYVCS--ECGSCFRKQSNLTQHLRIHTGEKPYKCN------------ 81
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskass 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699  82 --------------------ECEKAFQTKAILVQHLRIHTGEKPYKCNECGKAFCQSPSL-------------------- 121
Cdd:COG5048  108 sslsssssnsndnnllsshsLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLhpplpanslskdpssnlsll 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699 122 IKHQRIHTGEKPYKCTECGKAFSQSICLTRHQRSHSgDKPFKCNECGKAFNQSACLMQHQRIHSGEKPYTCTECGKAFTQ 201
Cdd:COG5048  188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699 202 NSSLVEHERTHTGE-------KLYKCSECEKTFRKQAHLSEHYR--IHTGE--KPYECV--GCGKSFRHSSALLRHQRLH 268
Cdd:COG5048  267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLH 346


                 ..
gi 384871699 269 AG 270
Cdd:COG5048  347 TS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
120-145 6.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 6.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 384871699  120 SLIKHQRIHTGEKPYKCTECGKAFSQ 145
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
64-87 6.76e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 6.76e-04
                          10        20
                  ....*....|....*....|....
gi 384871699   64 NLTQHLRIHTGEKPYKCNECEKAF 87
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
177-201 8.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 8.64e-04
                          10        20
                  ....*....|....*....|....*
gi 384871699  177 LMQHQRIHSGEKPYTCTECGKAFTQ 201
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
93-115 1.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.05e-03
                          10        20
                  ....*....|....*....|...
gi 384871699   93 LVQHLRIHTGEKPYKCNECGKAF 115
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
149-173 1.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.36e-03
                          10        20
                  ....*....|....*....|....*
gi 384871699  149 LTRHQRSHSGDKPFKCNECGKAFNQ 173
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
96-268 1.75e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699  96 HLRIHTGEKPYKCNECGKAFCQSPSLIKHQRIHTGEKPYKCTECGKAFSQSICLTRHQRSHSGDKPFKCNECGKAFNQSA 175
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699 176 --CLMQHQRIHSGE-----KPYTCTECGKAFTQNSSLVEHERT--HTGEKLYKCSE----CEKTFRKQAHLSEHYRIHTG 242
Cdd:COG5048  269 ssQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTS 348

                        170       180
                 ....*....|....*....|....*...
gi 384871699 243 EKPYECV--GCGKSFRHSSALLRHQRLH 268
Cdd:COG5048  349 ISPAKEKllNSSSKFSPLLNNEPPQSLQ 376
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 76-128 2.89e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 2.89e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 384871699  76 KPYkCNECEKAFQTKAILVQHLRIHTgekpYKCNECGKAFCQSPSLIKH-QRIH 128
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 130-213 4.05e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.16  E-value: 4.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699 130 GEKPYKC--TECGKAFSQSICLTRHQrshsgdkpfKCNECGKAFNQSACLMQHQRIHSGEKPYTCTECGKAFTQNSSLVE 207
Cdd:COG5189  346 DGKPYKCpvEGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 384871699 208 HeRTHT 213
Cdd:COG5189  417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
18-176 4.38e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 4.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699  18 QKKPSKCSECGKFFTQRSSLTQHQR--IHRGE--KPYVCSE--CGSCFRKQSNLTQHLRIHTGEKPYKC--NECEKAFQT 89
Cdd:COG5048  286 FSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSP 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871699  90 KAI--LVQHLRIHTGEKPYKCNECGKAFCQSPS-----LIKHQRIHTGEKPY--KCTECGKAFSQSICLTRHQRSHSGDK 160
Cdd:COG5048  366 LLNnePPQSLQQYKDLKNDKKSETLSNSCIRNFkrdsnLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHA 445

                        170
                 ....*....|....*.
gi 384871699 161 PFKCNECGKAFNQSAC 176
Cdd:COG5048  446 PLLCSILKSFRRDLDL 461
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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