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Conserved domains on  [gi|384551685|ref|NP_001245149|]
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protein MIS12 homolog [Homo sapiens]

Protein Classification

Mis12 domain-containing protein( domain architecture ID 10530821)

Mis12 domain-containing protein similar to human protein MIS12 homolog that is part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mis12 pfam05859
Mis12 protein; Kinetochores are the chromosomal sites for spindle interaction and play a vital ...
 8-140 3.04e-41

Mis12 protein; Kinetochores are the chromosomal sites for spindle interaction and play a vital role in chromosome segregation. Fission yeast kinetochore protein Mis12, is required for correct spindle morphogenesis, determining metaphase spindle length. Thirty-five to sixty percent extension of metaphase spindle length takes place in Mis12 mutants. It has been shown that Mis12 genetically interacts with Mal2, another inner centromere core complex protein in S. pombe.


:

Pssm-ID: 461761  Cd Length: 140  Bit Score: 136.58  E-value: 3.04e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551685    8 YEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLDGIPD----CDISPVQIRKCTEKFLCFMKGHFDNLFSKME 83
Cdd:pfam05859   1 LLTEHLGFTPQSLIDDIINAVNDLLYKAVDAVEQVLLKKLEEGEDaagaDEESTEEIEKGTHKLETLLEARVDKNFDKFE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 384551685   84 QLFLQLILRIPS----NILLPEDKCKETPYSEEDfQHLQKEIEQLQEKYKTELCTKQALLA 140
Cdd:pfam05859  81 LYLLRNIFSIPPdlvdWVRLPHDEGLDLDEDGED-AELDEEIDQLRRKLEAELKLNQALKA 140
 
Name Accession Description Interval E-value
Mis12 pfam05859
Mis12 protein; Kinetochores are the chromosomal sites for spindle interaction and play a vital ...
 8-140 3.04e-41

Mis12 protein; Kinetochores are the chromosomal sites for spindle interaction and play a vital role in chromosome segregation. Fission yeast kinetochore protein Mis12, is required for correct spindle morphogenesis, determining metaphase spindle length. Thirty-five to sixty percent extension of metaphase spindle length takes place in Mis12 mutants. It has been shown that Mis12 genetically interacts with Mal2, another inner centromere core complex protein in S. pombe.


Pssm-ID: 461761  Cd Length: 140  Bit Score: 136.58  E-value: 3.04e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551685    8 YEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLDGIPD----CDISPVQIRKCTEKFLCFMKGHFDNLFSKME 83
Cdd:pfam05859   1 LLTEHLGFTPQSLIDDIINAVNDLLYKAVDAVEQVLLKKLEEGEDaagaDEESTEEIEKGTHKLETLLEARVDKNFDKFE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 384551685   84 QLFLQLILRIPS----NILLPEDKCKETPYSEEDfQHLQKEIEQLQEKYKTELCTKQALLA 140
Cdd:pfam05859  81 LYLLRNIFSIPPdlvdWVRLPHDEGLDLDEDGED-AELDEEIDQLRRKLEAELKLNQALKA 140
 
Name Accession Description Interval E-value
Mis12 pfam05859
Mis12 protein; Kinetochores are the chromosomal sites for spindle interaction and play a vital ...
 8-140 3.04e-41

Mis12 protein; Kinetochores are the chromosomal sites for spindle interaction and play a vital role in chromosome segregation. Fission yeast kinetochore protein Mis12, is required for correct spindle morphogenesis, determining metaphase spindle length. Thirty-five to sixty percent extension of metaphase spindle length takes place in Mis12 mutants. It has been shown that Mis12 genetically interacts with Mal2, another inner centromere core complex protein in S. pombe.


Pssm-ID: 461761  Cd Length: 140  Bit Score: 136.58  E-value: 3.04e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551685    8 YEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLDGIPD----CDISPVQIRKCTEKFLCFMKGHFDNLFSKME 83
Cdd:pfam05859   1 LLTEHLGFTPQSLIDDIINAVNDLLYKAVDAVEQVLLKKLEEGEDaagaDEESTEEIEKGTHKLETLLEARVDKNFDKFE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 384551685   84 QLFLQLILRIPS----NILLPEDKCKETPYSEEDfQHLQKEIEQLQEKYKTELCTKQALLA 140
Cdd:pfam05859  81 LYLLRNIFSIPPdlvdWVRLPHDEGLDLDEDGED-AELDEEIDQLRRKLEAELKLNQALKA 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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