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Conserved domains on  [gi|38454274|ref|NP_942064|]
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toll-like receptor 2 precursor [Rattus norvegicus]

Protein Classification

toll-like receptor( domain architecture ID 17988233)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
640-784 3.75e-39

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 141.69  E-value: 3.75e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274    640 CYDAFVSYSEQDsyWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDF 719
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38454274    720 SHFRLFDENNDAAILVLLEPIeKKAIPQRFCKLRKIMnTKTYLEWPLDEGQRevFWANLRTAIKS 784
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVI-PSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPS 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
335-551 4.77e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 4.77e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 335 LEKVKRITVENSKVFLVPCSFSQhLKSLEFLDLSENLM--VEEYLKNsaceggWPSLQSLVLSQNHLRSIRKTaeiLLTL 412
Cdd:COG4886 112 LTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLtdLPEPLGN------LTNLKSLDLSNNQLTDLPEE---LGNL 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 413 KNLTALDISKNSFQPMPDSCQWPGKMRFLNLSSTGIQAVKTCIPQ--TLEVLDVSNNNLDSFSLF--LPRLQELYISRNK 488
Cdd:COG4886 182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPELgnLTNLEELDLSNNQ 261

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38454274 489 LKTLPEASLFPVLQVMKIRENAISTFSKDQLGSFPKLETLEAGDNHFICSCELLSFILERPAL 551
Cdd:COG4886 262 LTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
39-290 1.06e-08

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 1.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  39 SSRSFTSIPSGLTANT--KKLDLSFNKITYIGHgDLRACVNLRVLTLESSGINTIeGDAFYSLGSLEHLDLSNNhLSSLS 116
Cdd:COG4886 144 SNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN-QLTDL 220

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 117 SSWFRPLSSLKYLNLMGNPYRTLGEtslFSNLTNLQTLRVGNvdtfSEIRRIDF-AGLTSLNELEIQVLSLGNYESRSLQ 195
Cdd:COG4886 221 PEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSN----NQLTDLPPlANLTNLKTLDLSNNQLTDLKLKELE 293

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 196 SIRDIYHLTLHLSESAFLLGIFADILSSVRYLELRDTNLARFQFSELSVDEINSPMKKLAFRNADLTDKSFNELLKLLRY 275
Cdd:COG4886 294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373

                       250
                ....*....|....*
gi 38454274 276 ILELMEVEFDHCTLN 290
Cdd:COG4886 374 LLEATLLTLALLLLT 388
LRRCT smart00082
Leucine rich repeat C-terminal domain;
533-586 1.34e-05

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.80  E-value: 1.34e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 38454274    533 NHFICSCELLSFILERPALVHVLvdWPDSYLCDSPPRLHGqRLQDARPSVLECH 586
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG-PLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
640-784 3.75e-39

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 141.69  E-value: 3.75e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274    640 CYDAFVSYSEQDsyWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDF 719
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38454274    720 SHFRLFDENNDAAILVLLEPIeKKAIPQRFCKLRKIMnTKTYLEWPLDEGQRevFWANLRTAIKS 784
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVI-PSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPS 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
335-551 4.77e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 4.77e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 335 LEKVKRITVENSKVFLVPCSFSQhLKSLEFLDLSENLM--VEEYLKNsaceggWPSLQSLVLSQNHLRSIRKTaeiLLTL 412
Cdd:COG4886 112 LTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLtdLPEPLGN------LTNLKSLDLSNNQLTDLPEE---LGNL 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 413 KNLTALDISKNSFQPMPDSCQWPGKMRFLNLSSTGIQAVKTCIPQ--TLEVLDVSNNNLDSFSLF--LPRLQELYISRNK 488
Cdd:COG4886 182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPELgnLTNLEELDLSNNQ 261

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38454274 489 LKTLPEASLFPVLQVMKIRENAISTFSKDQLGSFPKLETLEAGDNHFICSCELLSFILERPAL 551
Cdd:COG4886 262 LTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 641-784 7.29e-18

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 81.64  E-value: 7.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274   641 YDAFVSYSEQDSY-WVENLMVQQLenSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDF 719
Cdd:pfam01582   1 YDVFLSFRGSDTReWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274   720 S-HFRLfdENNDAAILVLLEPIE------KKAIPQRFCKLRKIMNTKTYLEWP---------------LDEGQrevFWAN 777
Cdd:pfam01582  79 IlECAL--DLGQKVIPIFYEVDPsdvrkqTGSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsksvSDESK---FWKK 153


                  ....*..
gi 38454274   778 LRTAIKS 784
Cdd:pfam01582 154 IAYDISN 160
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
340-558 2.36e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.87  E-value: 2.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  340 RITVENSKVFLVPCSFSQHLKSLeFLDLSENLMVEEYLKNSaceggwpsLQSLVLSQNHLRSIRKT-----AEILLTLKN 414
Cdd:PRK15370 182 ELRLKILGLTTIPACIPEQITTL-ILDNNELKSLPENLQGN--------IKTLYANSNQLTSIPATlpdtiQEMELSINR 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  415 LT-----------ALDISKNSFQPMPDSCqwPGKMRFLNLSSTGIQAVKTCIPQTLEVLDVSNNNLDSFSLFLP-RLQEL 482
Cdd:PRK15370 253 ITelperlpsalqSLDLFHNKISCLPENL--PEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPpGLKTL 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  483 YISRNKLKTLPEaSLFPVLQVMKIRENAISTF-------------SKDQLGSFPK-----LETLEAGDNHFICSCELL-S 543
Cdd:PRK15370 331 EAGENALTSLPA-SLPPELQVLDVSKNQITVLpetlpptittldvSRNALTNLPEnlpaaLQIMQASRNNLVRLPESLpH 409

                        250
                 ....*....|....*
gi 38454274  544 FILERPALVHVLVDW 558
Cdd:PRK15370 410 FRGEGPQPTRIIVEY 424
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-290 1.06e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 1.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  39 SSRSFTSIPSGLTANT--KKLDLSFNKITYIGHgDLRACVNLRVLTLESSGINTIeGDAFYSLGSLEHLDLSNNhLSSLS 116
Cdd:COG4886 144 SNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN-QLTDL 220

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 117 SSWFRPLSSLKYLNLMGNPYRTLGEtslFSNLTNLQTLRVGNvdtfSEIRRIDF-AGLTSLNELEIQVLSLGNYESRSLQ 195
Cdd:COG4886 221 PEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSN----NQLTDLPPlANLTNLKTLDLSNNQLTDLKLKELE 293

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 196 SIRDIYHLTLHLSESAFLLGIFADILSSVRYLELRDTNLARFQFSELSVDEINSPMKKLAFRNADLTDKSFNELLKLLRY 275
Cdd:COG4886 294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373

                       250
                ....*....|....*
gi 38454274 276 ILELMEVEFDHCTLN 290
Cdd:COG4886 374 LLEATLLTLALLLLT 388
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 324-535 2.66e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 2.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 324 LFYDLSTVYSLLE-KVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLmveeyLKNSACEG------GWPSLQSLVLSQ 396
Cdd:cd00116 100 VLESLLRSSSLQElKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNR-----LEGASCEAlakalrANRDLKELNLAN 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 397 NHLRS--IRKTAEILLTLKNLTALDISKNSFQPmpdscqwpgkmrflnlssTGIQAVKTCIPQ--TLEVLDVSNNNLDS- 471
Cdd:cd00116 175 NGIGDagIRALAEGLKANCNLEVLDLNNNGLTD------------------EGASALAETLASlkSLEVLNLGDNNLTDa 236

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 472 --------FSLFLPRLQELYISRNKL-----KTLPEA-SLFPVLQVMKIRENAISTFSKDQLGS-----FPKLETLEAGD 532
Cdd:cd00116 237 gaaalasaLLSPNISLLTLSLSCNDItddgaKDLAEVlAEKESLLELDLRGNKFGEEGAQLLAEsllepGNELESLWVKD 316


                ...
gi 38454274 533 NHF 535
Cdd:cd00116 317 DSF 319
LRR_8 pfam13855
Leucine rich repeat;
77-135 6.38e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 6.38e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 38454274    77 NLRVLTLESSGINTIEGDAFYSLGSLEHLDLSNNHLSSLSSSWFRPLSSLKYLNLMGNP 135
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRRCT smart00082
Leucine rich repeat C-terminal domain;
533-586 1.34e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.80  E-value: 1.34e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 38454274    533 NHFICSCELLSFILERPALVHVLvdWPDSYLCDSPPRLHGqRLQDARPSVLECH 586
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
477-535 3.42e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.42e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38454274   477 PRLQELYISRNKLKTLPEASLF--PVLQVMKIRENAISTFSKDQLGSFPKLETLEAGDNHF 535
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-535 6.08e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 6.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274   39 SSRSFT-SIPSGLTANTKKLDLSFNKITYIGHGDLRACVNLRVLTLessGINTIEGDAFYSLGSlehldlsnnhlsslss 117
Cdd:PLN00113 126 SNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDL---GGNVLVGKIPNSLTN---------------- 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  118 swfrpLSSLKYLNLMGNPY-----RTLGEtslfsnLTNLQTLRVGNVDTFSEIrRIDFAGLTSLNELEIQVLSLGNYESR 192
Cdd:PLN00113 187 -----LTSLEFLTLASNQLvgqipRELGQ------MKSLKWIYLGYNNLSGEI-PYEIGGLTSLNHLDLVYNNLTGPIPS 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  193 SLQSIRDIYHLTLHLSESAFLL--GIFAdiLSSVRYLELRDTNLARfQFSELSVDEINSPMKKLaFRNaDLTDKSFNELL 270
Cdd:PLN00113 255 SLGNLKNLQYLFLYQNKLSGPIppSIFS--LQKLISLDLSDNSLSG-EIPELVIQLQNLEILHL-FSN-NFTGKIPVALT 329

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  271 KLLRY-ILELMEVEFdhctlngvgnfnpsESDVVRELGKVETVTIrslhipqfylfYDLSTvysllekvkritveNSKVF 349
Cdd:PLN00113 330 SLPRLqVLQLWSNKF--------------SGEIPKNLGKHNNLTV-----------LDLST--------------NNLTG 370

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  350 LVP---CSfSQHLKSLEFLDLSENLMVEEYLknSACEggwpSLQSLVLSQNHLRSIRKTAEILLTLKNLtaLDISKNSFQ 426
Cdd:PLN00113 371 EIPeglCS-SGNLFKLILFSNSLEGEIPKSL--GACR----SLRRVRLQDNSFSGELPSEFTKLPLVYF--LDISNNNLQ 441

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  427 PMPDSCQWPgkmrflnlsstgiqavktcIPQtLEVLDVSNNNldsFSLFLP------RLQELYISRNKLKTLPEASL--F 498
Cdd:PLN00113 442 GRINSRKWD-------------------MPS-LQMLSLARNK---FFGGLPdsfgskRLENLDLSRNQFSGAVPRKLgsL 498

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 38454274  499 PVLQVMKIRENAISTFSKDQLGSFPKLETLEAGDNHF 535
Cdd:PLN00113 499 SELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
640-784 3.75e-39

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 141.69  E-value: 3.75e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274    640 CYDAFVSYSEQDsyWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDF 719
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38454274    720 SHFRLFDENNDAAILVLLEPIeKKAIPQRFCKLRKIMnTKTYLEWPLDEGQRevFWANLRTAIKS 784
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVI-PSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPS 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
335-551 4.77e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 4.77e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 335 LEKVKRITVENSKVFLVPCSFSQhLKSLEFLDLSENLM--VEEYLKNsaceggWPSLQSLVLSQNHLRSIRKTaeiLLTL 412
Cdd:COG4886 112 LTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLtdLPEPLGN------LTNLKSLDLSNNQLTDLPEE---LGNL 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 413 KNLTALDISKNSFQPMPDSCQWPGKMRFLNLSSTGIQAVKTCIPQ--TLEVLDVSNNNLDSFSLF--LPRLQELYISRNK 488
Cdd:COG4886 182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPELgnLTNLEELDLSNNQ 261

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38454274 489 LKTLPEASLFPVLQVMKIRENAISTFSKDQLGSFPKLETLEAGDNHFICSCELLSFILERPAL 551
Cdd:COG4886 262 LTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 641-784 7.29e-18

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 81.64  E-value: 7.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274   641 YDAFVSYSEQDSY-WVENLMVQQLenSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDF 719
Cdd:pfam01582   1 YDVFLSFRGSDTReWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274   720 S-HFRLfdENNDAAILVLLEPIE------KKAIPQRFCKLRKIMNTKTYLEWP---------------LDEGQrevFWAN 777
Cdd:pfam01582  79 IlECAL--DLGQKVIPIFYEVDPsdvrkqTGSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsksvSDESK---FWKK 153


                  ....*..
gi 38454274   778 LRTAIKS 784
Cdd:pfam01582 154 IAYDISN 160
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
350-535 2.33e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 2.33e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 350 LVPCSFSQHLKSLEFLDLSENLMVE--EYLKNsaceggWPSLQSLVLSQNHLRSIRKTaeiLLTLKNLTALDISKNSFQP 427
Cdd:COG4886 103 LSGNEELSNLTNLESLDLSGNQLTDlpEELAN------LTNLKELDLSNNQLTDLPEP---LGNLTNLKSLDLSNNQLTD 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 428 MPDSCQWPGKMRFLNLSSTGIQAVKTCIPQ--TLEVLDVSNNNLDSFSLF---LPRLQELYISRNKLKTLPEASLFPVLQ 502
Cdd:COG4886 174 LPEELGNLTNLKELDLSNNQITDLPEPLGNltNLEELDLSGNQLTDLPEPlanLTNLETLDLSNNQLTDLPELGNLTNLE 253

                       170       180       190
                ....*....|....*....|....*....|...
gi 38454274 503 VMKIRENAISTFSKdqLGSFPKLETLEAGDNHF 535
Cdd:COG4886 254 ELDLSNNQLTDLPP--LANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
334-535 2.11e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 2.11e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 334 LLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEyLKNsaceggwpsLQSLVLSQNHLRSIrktAEILLTLK 413
Cdd:COG4886  70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSN-LTN---------LESLDLSGNQLTDL---PEELANLT 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 414 NLTALDISKNSFQPMPDSCQWPGKMRFLNLSSTGIQAVKTCIPQ--TLEVLDVSNNNLDSFSLF---LPRLQELYISRNK 488
Cdd:COG4886 137 NLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPEPlgnLTNLEELDLSGNQ 216

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 38454274 489 LKTLPEA-SLFPVLQVMKIRENAISTFSkdQLGSFPKLETLEAGDNHF 535
Cdd:COG4886 217 LTDLPEPlANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 644-718 2.86e-14

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 69.65  E-value: 2.86e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38454274   644 FVSYSEQDSYWVENLmVQQLENSDppFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELD 718
Cdd:pfam13676   2 FISYAGEDRAWAEWL-ADALEAAG--YRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWE 73
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
359-535 8.30e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 8.30e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 359 LKSLEFLDLSENLMVEEYLKNSACEGGWPSLQSLVLSQNhlrsirktaEILLTLKNLTALDISKNSFQPMPDSCQWPGKM 438
Cdd:COG4886  68 LLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLTDLPEELANLTNL 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 439 RFLNLSSTGIQAVKTCIPQ--TLEVLDVSNNNLDSFSLF---LPRLQELYISRNKLKTLPEA-SLFPVLQVMKIRENAIS 512
Cdd:COG4886 139 KELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPEElgnLTNLKELDLSNNQITDLPEPlGNLTNLEELDLSGNQLT 218

                       170       180
                ....*....|....*....|...
gi 38454274 513 TFSkDQLGSFPKLETLEAGDNHF 535
Cdd:COG4886 219 DLP-EPLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
194-551 1.11e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.11e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 194 LQSIRDIYHLTLHLSESAFLLGIFADILSSVRYLELRDTNLARFQFSELSVDEINSPMKKLAFRNADLTDKSFNELLKLL 273
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 274 RYILELMEVEFDHctLNGVGNFNPSESDVVRELGKVETVTIRSLHIpqfylfYDLSTVYSLLEKVKRITVENSKVFLVPC 353
Cdd:COG4886  82 LSLLLLGLTDLGD--LTNLTELDLSGNEELSNLTNLESLDLSGNQL------TDLPEELANLTNLKELDLSNNQLTDLPE 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 354 SFSQhLKSLEFLDLSENLMVEeyLKNSAceGGWPSLQSLVLSQNHLRSIrktAEILLTLKNLTALDISKNSFQPMPDSCQ 433
Cdd:COG4886 154 PLGN-LTNLKSLDLSNNQLTD--LPEEL--GNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPLA 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 434 WPGKMRFLNLSSTGIqavkTCIPQ-----TLEVLDVSNNNLDSF--SLFLPRLQELYISRNKLKTLPEASLFPVLQVMKI 506
Cdd:COG4886 226 NLTNLETLDLSNNQL----TDLPElgnltNLEELDLSNNQLTDLppLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSL 301

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 38454274 507 RENAISTFSKDQLGSFPKLETLEAGDNHFICSCELLSFILERPAL 551
Cdd:COG4886 302 LLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
340-558 2.36e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.87  E-value: 2.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  340 RITVENSKVFLVPCSFSQHLKSLeFLDLSENLMVEEYLKNSaceggwpsLQSLVLSQNHLRSIRKT-----AEILLTLKN 414
Cdd:PRK15370 182 ELRLKILGLTTIPACIPEQITTL-ILDNNELKSLPENLQGN--------IKTLYANSNQLTSIPATlpdtiQEMELSINR 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  415 LT-----------ALDISKNSFQPMPDSCqwPGKMRFLNLSSTGIQAVKTCIPQTLEVLDVSNNNLDSFSLFLP-RLQEL 482
Cdd:PRK15370 253 ITelperlpsalqSLDLFHNKISCLPENL--PEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPpGLKTL 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  483 YISRNKLKTLPEaSLFPVLQVMKIRENAISTF-------------SKDQLGSFPK-----LETLEAGDNHFICSCELL-S 543
Cdd:PRK15370 331 EAGENALTSLPA-SLPPELQVLDVSKNQITVLpetlpptittldvSRNALTNLPEnlpaaLQIMQASRNNLVRLPESLpH 409

                        250
                 ....*....|....*
gi 38454274  544 FILERPALVHVLVDW 558
Cdd:PRK15370 410 FRGEGPQPTRIIVEY 424
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-290 1.06e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 1.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  39 SSRSFTSIPSGLTANT--KKLDLSFNKITYIGHgDLRACVNLRVLTLESSGINTIeGDAFYSLGSLEHLDLSNNhLSSLS 116
Cdd:COG4886 144 SNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN-QLTDL 220

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 117 SSWFRPLSSLKYLNLMGNPYRTLGEtslFSNLTNLQTLRVGNvdtfSEIRRIDF-AGLTSLNELEIQVLSLGNYESRSLQ 195
Cdd:COG4886 221 PEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSN----NQLTDLPPlANLTNLKTLDLSNNQLTDLKLKELE 293

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 196 SIRDIYHLTLHLSESAFLLGIFADILSSVRYLELRDTNLARFQFSELSVDEINSPMKKLAFRNADLTDKSFNELLKLLRY 275
Cdd:COG4886 294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373

                       250
                ....*....|....*
gi 38454274 276 ILELMEVEFDHCTLN 290
Cdd:COG4886 374 LLEATLLTLALLLLT 388
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 324-535 2.66e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 2.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 324 LFYDLSTVYSLLE-KVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLmveeyLKNSACEG------GWPSLQSLVLSQ 396
Cdd:cd00116 100 VLESLLRSSSLQElKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNR-----LEGASCEAlakalrANRDLKELNLAN 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 397 NHLRS--IRKTAEILLTLKNLTALDISKNSFQPmpdscqwpgkmrflnlssTGIQAVKTCIPQ--TLEVLDVSNNNLDS- 471
Cdd:cd00116 175 NGIGDagIRALAEGLKANCNLEVLDLNNNGLTD------------------EGASALAETLASlkSLEVLNLGDNNLTDa 236

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 472 --------FSLFLPRLQELYISRNKL-----KTLPEA-SLFPVLQVMKIRENAISTFSKDQLGS-----FPKLETLEAGD 532
Cdd:cd00116 237 gaaalasaLLSPNISLLTLSLSCNDItddgaKDLAEVlAEKESLLELDLRGNKFGEEGAQLLAEsllepGNELESLWVKD 316


                ...
gi 38454274 533 NHF 535
Cdd:cd00116 317 DSF 319
LRR_8 pfam13855
Leucine rich repeat;
77-135 6.38e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 6.38e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 38454274    77 NLRVLTLESSGINTIEGDAFYSLGSLEHLDLSNNHLSSLSSSWFRPLSSLKYLNLMGNP 135
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 358-528 7.29e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 7.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 358 HLKSLEFLDLSENLmVEEYLKNSACE-----GGWPSLQSLVLSQNHLRSIrktaEILLTLKNLTALDISKnsfQPMPDSC 432
Cdd:cd21340  35 KITKIENLEFLTNL-THLYLQNNQIEkienlENLVNLKKLYLGGNRISVV----EGLENLTNLEELHIEN---QRLPPGE 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 433 qwpgKMRFLNLSSTGIQavktcipQTLEVLDVSNNNLDSFSLF--LPRLQELYISRNKLKTLPEA----SLFPVLQVMKI 506
Cdd:cd21340 107 ----KLTFDPRSLAALS-------NSLRVLNISGNNIDSLEPLapLRNLEQLDASNNQISDLEELldllSSWPSLRELDL 175

                       170       180
                ....*....|....*....|....*
gi 38454274 507 RENAISTFSK--DQL-GSFPKLETL 528
Cdd:cd21340 176 TGNPVCKKPKyrDKIiLASKSLEVL 200
LRRCT smart00082
Leucine rich repeat C-terminal domain;
533-586 1.34e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.80  E-value: 1.34e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 38454274    533 NHFICSCELLSFILERPALVHVLvdWPDSYLCDSPPRLHGqRLQDARPSVLECH 586
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
477-535 3.42e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.42e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38454274   477 PRLQELYISRNKLKTLPEASLF--PVLQVMKIRENAISTFSKDQLGSFPKLETLEAGDNHF 535
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
362-533 5.53e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.47  E-value: 5.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 362 LEFLDLSENLMVEEYLKNSACEGGWPSLQSLVLSQNHLRSIRKTAEILLTLKNLTALDISKNSFQPMPDSCQWPGKMRFL 441
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 442 NLSSTGIQAVKTCIPQTLEVLDVSNNNLDSfslFLPRLQELYISRNKLKTLPEA-SLFPVLQVMKIRENAISTFSKDqLG 520
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEELS---NLTNLESLDLSGNQLTDLPEElANLTNLKELDLSNNQLTDLPEP-LG 156

                       170
                ....*....|...
gi 38454274 521 SFPKLETLEAGDN 533
Cdd:COG4886 157 NLTNLKSLDLSNN 169
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-535 6.08e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 6.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274   39 SSRSFT-SIPSGLTANTKKLDLSFNKITYIGHGDLRACVNLRVLTLessGINTIEGDAFYSLGSlehldlsnnhlsslss 117
Cdd:PLN00113 126 SNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDL---GGNVLVGKIPNSLTN---------------- 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  118 swfrpLSSLKYLNLMGNPY-----RTLGEtslfsnLTNLQTLRVGNVDTFSEIrRIDFAGLTSLNELEIQVLSLGNYESR 192
Cdd:PLN00113 187 -----LTSLEFLTLASNQLvgqipRELGQ------MKSLKWIYLGYNNLSGEI-PYEIGGLTSLNHLDLVYNNLTGPIPS 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  193 SLQSIRDIYHLTLHLSESAFLL--GIFAdiLSSVRYLELRDTNLARfQFSELSVDEINSPMKKLaFRNaDLTDKSFNELL 270
Cdd:PLN00113 255 SLGNLKNLQYLFLYQNKLSGPIppSIFS--LQKLISLDLSDNSLSG-EIPELVIQLQNLEILHL-FSN-NFTGKIPVALT 329

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  271 KLLRY-ILELMEVEFdhctlngvgnfnpsESDVVRELGKVETVTIrslhipqfylfYDLSTvysllekvkritveNSKVF 349
Cdd:PLN00113 330 SLPRLqVLQLWSNKF--------------SGEIPKNLGKHNNLTV-----------LDLST--------------NNLTG 370

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  350 LVP---CSfSQHLKSLEFLDLSENLMVEEYLknSACEggwpSLQSLVLSQNHLRSIRKTAEILLTLKNLtaLDISKNSFQ 426
Cdd:PLN00113 371 EIPeglCS-SGNLFKLILFSNSLEGEIPKSL--GACR----SLRRVRLQDNSFSGELPSEFTKLPLVYF--LDISNNNLQ 441

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  427 PMPDSCQWPgkmrflnlsstgiqavktcIPQtLEVLDVSNNNldsFSLFLP------RLQELYISRNKLKTLPEASL--F 498
Cdd:PLN00113 442 GRINSRKWD-------------------MPS-LQMLSLARNK---FFGGLPdsfgskRLENLDLSRNQFSGAVPRKLgsL 498

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 38454274  499 PVLQVMKIRENAISTFSKDQLGSFPKLETLEAGDNHF 535
Cdd:PLN00113 499 SELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR_8 pfam13855
Leucine rich repeat;
53-107 1.26e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 1.26e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 38454274    53 NTKKLDLSFNKITYIGHGDLRACVNLRVLTLESSGINTIEGDAFYSLGSLEHLDL 107
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-273 4.21e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 4.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  52 ANTKKLDLSFNKityighgDLRACVNLRVLTLESSGINTIeGDAFYSLGSLEHLDLsNNHLSSLSSSWFRPLSSLKYLNL 131
Cdd:COG4886  96 TNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDL-SNNQLTDLPEPLGNLTNLKSLDL 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 132 MGNPYRTLGETslFSNLTNLQTLRVGN--VDTFSEirriDFAGLTSLNELEI---QVLSLgnyeSRSLQSIRDIYHLTLH 206
Cdd:COG4886 167 SNNQLTDLPEE--LGNLTNLKELDLSNnqITDLPE----PLGNLTNLEELDLsgnQLTDL----PEPLANLTNLETLDLS 236

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 207 ---LSESAFLLGifadiLSSVRYLELRDTnlarfQFSELSVDEINSPMKKLAFRNADLTDKSFNELLKLL 273
Cdd:COG4886 237 nnqLTDLPELGN-----LTNLEELDLSNN-----QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLL 296
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
441-535 5.65e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 43.61  E-value: 5.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274  441 LNLSSTGIQAVKTCIPQTLEVLDVSNNNLDSFSLFLPRLQELYISRNKLKTLPeaSLFPVLQVMKIRENAISTFSK---- 516
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLP--VLPPGLLELSIFSNPLTHLPAlpsg 283

                         90       100       110
                 ....*....|....*....|....*....|.
gi 38454274  517 --------DQLGSF----PKLETLEAGDNHF 535
Cdd:PRK15387 284 lcklwifgNQLTSLpvlpPGLQELSVSDNQL 314
LRR_8 pfam13855
Leucine rich repeat;
387-448 1.42e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38454274   387 PSLQSLVLSQNHLRSIRKTAeiLLTLKNLTALDISKNSFQPM-PDSCQWPGKMRFLNLSSTGI 448
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGA--FKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
414-489 2.32e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274   414 NLTALDISKNSFQPMPDSCqwpgkmrFLNLSStgiqavktcipqtLEVLDVSNNNLDSFSL----FLPRLQELYISRNKL 489
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGA-------FKGLSN-------------LKVLDLSNNLLTTLSPgafsGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 356-555 4.84e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 4.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 356 SQHLKSL---EFLDLSENLMVEEYLKNSACE-GGWPSLQSLVLSQNHLRSI----RKTAEILLTLKNLTALDISKNSFQp 427
Cdd:cd00116  16 TELLPKLlclQVLRLEGNTLGEEAAKALASAlRPQPSLKELCLSLNETGRIprglQSLLQGLTKGCGLQELDLSDNALG- 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38454274 428 mPDSCQwpgkmRFLNLSSTgiqavktcipQTLEVLDVSNNNLDSFSLFL---------PRLQELYISRNKLK---TLPEA 495
Cdd:cd00116  95 -PDGCG-----VLESLLRS----------SSLQELKLNNNGLGDRGLRLlakglkdlpPALEKLVLGRNRLEgasCEALA 158

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 38454274 496 SLFPV---LQVMKIRENAISTFS----KDQLGSFPKLETLEAGDNHFICS-CELLSFILERPALVHVL 555
Cdd:cd00116 159 KALRAnrdLKELNLANNGIGDAGiralAEGLKANCNLEVLDLNNNGLTDEgASALAETLASLKSLEVL 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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