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Conserved domains on  [gi|384490437|gb|EIE81659|]
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hypothetical protein RO3G_06364 [Rhizopus delemar RA 99-880]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 2-252 1.37e-53

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17323:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 376  Bit Score: 177.38  E-value: 1.37e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   2 GAGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETsrsfptqepr 81
Cdd:cd17323  108 GAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLPIV---------- 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  82 ekqgaqyierkakirtinplraLRLLLYPNIALVVAYvGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRI 161
Cdd:cd17323  178 ----------------------LLLGLYVGLVYAILY-LFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRL 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437 162 SDKVYNKRVAKAKEKEEdiyPEMRLSGLVLGCasIIQLLSLVAYGWCVQKEVHFAYGLVCQFLYGSAFMLPNVTATAYMV 241
Cdd:cd17323  235 SDYYYRRLKKKNGGKPE---PEARLPPAFIGA--FLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLV 309

                        250
                 ....*....|.
gi 384490437 242 DSFRKDGASAT 252
Cdd:cd17323  310 DSYPKYAASAL 320
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 2-252 1.37e-53

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 177.38  E-value: 1.37e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   2 GAGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETsrsfptqepr 81
Cdd:cd17323  108 GAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLPIV---------- 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  82 ekqgaqyierkakirtinplraLRLLLYPNIALVVAYvGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRI 161
Cdd:cd17323  178 ----------------------LLLGLYVGLVYAILY-LFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRL 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437 162 SDKVYNKRVAKAKEKEEdiyPEMRLSGLVLGCasIIQLLSLVAYGWCVQKEVHFAYGLVCQFLYGSAFMLPNVTATAYMV 241
Cdd:cd17323  235 SDYYYRRLKKKNGGKPE---PEARLPPAFIGA--FLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLV 309

                        250
                 ....*....|.
gi 384490437 242 DSFRKDGASAT 252
Cdd:cd17323  310 DSYPKYAASAL 320
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-251 9.61e-27

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 106.21  E-value: 9.61e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   1 MGAGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSRSFPTQEP 80
Cdd:COG2814  118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLR 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  81 REkqgaqyierkakIRTINPLRALRLLLYPNIALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGR 160
Cdd:COG2814  198 GS------------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGR 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437 161 ISDKVYNKRVAkakekeediypemrLSGLVLGCASIIqLLSLVAYGWCVqkevhfaygLVCQFLYGSAFMLPNVTATAYM 240
Cdd:COG2814  266 LADRFGRRRLL--------------LIGLLLLALGLL-LLALAGSLWLL---------LLALFLLGFGFGLLFPLLQALV 321

                        250
                 ....*....|.
gi 384490437 241 VDSFRKDGASA 251
Cdd:COG2814  322 AELAPPEARGR 332
MFS_1 pfam07690
Major Facilitator Superfamily;
1-247 3.00e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 85.55  E-value: 3.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437    1 MGAGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSRsfPTQEP 80
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPES--KRPKP 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   81 REKQGAQYIERKAKIRTINPLRALRLLLYpniaLVVAYVGVFAVFTrVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGR 160
Cdd:pfam07690 183 AEEARLSLIVAWKALLRDPVLWLLLALLL----FGFAFFGLLTYLP-LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGR 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  161 ISDKVYNKRVAKakekeediypeMRLSGLVLGCASIIQLLSLVAYGWcvqkevhfayGLVCQFLYGSAFMLPNVTATAYM 240
Cdd:pfam07690 258 LSDRLGRRRRLL-----------LALLLLILAALGLLLLSLTLSSLW----------LLLALLLLGFGFGLVFPALNALV 316


                  ....*..
gi 384490437  241 VDSFRKD 247
Cdd:pfam07690 317 SDLAPKE 323
2_A_01_02 TIGR00880
Multidrug resistance protein;
1-71 1.87e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 73.84  E-value: 1.87e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 384490437    1 MGAGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPET 71
Cdd:TIGR00880  71 AGAALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
emrD PRK11652
multidrug transporter EmrD;
8-88 2.34e-10

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 59.92  E-value: 2.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   8 DIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETsrsFPTQEPREKQGAQ 87
Cdd:PRK11652 123 DLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPET---RPADARRTRVLAS 199


                 .
gi 384490437  88 Y 88
Cdd:PRK11652 200 Y 200
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 2-252 1.37e-53

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 177.38  E-value: 1.37e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   2 GAGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETsrsfptqepr 81
Cdd:cd17323  108 GAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLPIV---------- 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  82 ekqgaqyierkakirtinplraLRLLLYPNIALVVAYvGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRI 161
Cdd:cd17323  178 ----------------------LLLGLYVGLVYAILY-LFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRL 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437 162 SDKVYNKRVAKAKEKEEdiyPEMRLSGLVLGCasIIQLLSLVAYGWCVQKEVHFAYGLVCQFLYGSAFMLPNVTATAYMV 241
Cdd:cd17323  235 SDYYYRRLKKKNGGKPE---PEARLPPAFIGA--FLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLV 309

                        250
                 ....*....|.
gi 384490437 242 DSFRKDGASAT 252
Cdd:cd17323  310 DSYPKYAASAL 320
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-251 9.61e-27

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 106.21  E-value: 9.61e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   1 MGAGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSRSFPTQEP 80
Cdd:COG2814  118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLR 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  81 REkqgaqyierkakIRTINPLRALRLLLYPNIALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGR 160
Cdd:COG2814  198 GS------------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGR 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437 161 ISDKVYNKRVAkakekeediypemrLSGLVLGCASIIqLLSLVAYGWCVqkevhfaygLVCQFLYGSAFMLPNVTATAYM 240
Cdd:COG2814  266 LADRFGRRRLL--------------LIGLLLLALGLL-LLALAGSLWLL---------LLALFLLGFGFGLLFPLLQALV 321

                        250
                 ....*....|.
gi 384490437 241 VDSFRKDGASA 251
Cdd:COG2814  322 AELAPPEARGR 332
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 1-253 3.93e-21

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 91.10  E-value: 3.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   1 MGAGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSRSFPTQEP 80
Cdd:cd17320  107 VARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPL 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  81 REKQGAQYierkakirtINPLRALRLLLYpNIALVVAYVGVFAVFTR---VYTNQYGLDSGIVGVCYLPYAVGAMIGGNI 157
Cdd:cd17320  187 LSSLLRAY---------KRVLKNRRFLGY-ALALGLSFAGLFAYLAAapfIYIEQLGLSPAQFGLLFALNAIALILGSLL 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437 158 GGRISDKvynkrvakakekeediYPEMRLSGLVLGCAsIIQLLSLVAYGWCVQKEVHFAYGLVCQFLYGSAFMLPNVTAT 237
Cdd:cd17320  257 NGRLVRR----------------FGPRRLLRLGLLLL-LAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSL 319

                        250
                 ....*....|....*.
gi 384490437 238 AymVDSFRKDGASATG 253
Cdd:cd17320  320 A--LEPFPHVAGTASA 333
MFS_1 pfam07690
Major Facilitator Superfamily;
1-247 3.00e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 85.55  E-value: 3.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437    1 MGAGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSRsfPTQEP 80
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPES--KRPKP 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   81 REKQGAQYIERKAKIRTINPLRALRLLLYpniaLVVAYVGVFAVFTrVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGR 160
Cdd:pfam07690 183 AEEARLSLIVAWKALLRDPVLWLLLALLL----FGFAFFGLLTYLP-LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGR 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  161 ISDKVYNKRVAKakekeediypeMRLSGLVLGCASIIQLLSLVAYGWcvqkevhfayGLVCQFLYGSAFMLPNVTATAYM 240
Cdd:pfam07690 258 LSDRLGRRRRLL-----------LALLLLILAALGLLLLSLTLSSLW----------LLLALLLLGFGFGLVFPALNALV 316


                  ....*..
gi 384490437  241 VDSFRKD 247
Cdd:pfam07690 317 SDLAPKE 323
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 6-248 9.57e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 78.77  E-value: 9.57e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   6 IADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSRsfptqePREKQG 85
Cdd:cd17325  109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRP------PPNKRA 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  86 AQYIERKAKIRTINPLRALRLLLYPNIALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRISDKV 165
Cdd:cd17325  183 VSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437 166 YNKRVAkakekeediypemrLSGLVLgCASIIQLLSLVAYGWCVqkevhfaygLVCQFLYGSAFMLPNVTATAYMVDSFR 245
Cdd:cd17325  263 GRKPLI--------------LIGLLL-SAVALLLLPLATSFWLL---------LLLLALLGLGLGLVFPATLALLADIVP 318


                 ...
gi 384490437 246 KDG 248
Cdd:cd17325  319 PEG 321
2_A_01_02 TIGR00880
Multidrug resistance protein;
1-71 1.87e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 73.84  E-value: 1.87e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 384490437    1 MGAGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPET 71
Cdd:TIGR00880  71 AGAALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 1-171 4.14e-15

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 74.12  E-value: 4.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   1 MGAGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSRSFPTQEP 80
Cdd:cd17324  107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLG 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  81 REKqgaqyierkakirtiNPLRALR----LLLYPNIALVVAyvGVFAVFTRV---YTNQYGLDSGIVGVCYLPYAVGAMI 153
Cdd:cd17324  187 LLS---------------SLLLLLRnprlRLAYLITFLLFG--GFFALYTYLapfLTDVPGFSSSAIIGLLLLFGVAGVV 249

                        170
                 ....*....|....*...
gi 384490437 154 GGNIGGRISDKVYNKRVA 171
Cdd:cd17324  250 GSPLAGRLADRGGRRALL 267
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 2-238 6.95e-13

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 67.58  E-value: 6.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   2 GAGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALciwIAIFFllpetsrsfptqepr 81
Cdd:cd17321  105 SLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL---VALLL--------------- 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  82 ekqgaqyierkakirtinpLRALRLLLYPNIALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRI 161
Cdd:cd17321  167 -------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRL 227

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 384490437 162 SDKVYNKRVAkakekeediypemrLSGLVLGCASIIQLLSLVAYGWCVQkevhFAYGLVCQFLyGSAFMLPNVTATA 238
Cdd:cd17321  228 ADRFGPRLVL--------------VAGLLLTAVGLLLLALLGADSSVWL----LLPGLVLLGL-GLGLFATPLTNAA 285
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 5-165 2.25e-12

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 65.87  E-value: 2.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437    5 TIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSrsfpTQEPREKQ 84
Cdd:TIGR00710 117 LVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETL----PYEARIQI 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   85 GAQyierkakIRTIN-PLRALRLLLYpniALVVAYV--GVFAVFTR---VYTNQYGLDSGIVGVCYLPYAVGAMIGGNIG 158
Cdd:TIGR00710 193 STY-------FETFLlLLKSKMFWGY---ALIYGASfgGFFAFFSGapfVYIDIMGVSPSVFGLLFALNIIAMIFGGFLN 262


                  ....*..
gi 384490437  159 GRISDKV 165
Cdd:TIGR00710 263 GRFIKKW 269
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 6-169 2.29e-12

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 66.05  E-value: 2.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   6 IADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNqGLGWRSNFWFLAIFALCIWIAIFFLLPETsrsfptqePREKQG 85
Cdd:cd17474  112 IGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLPEP--------KEKAKS 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  86 AQYIERKAKIRTINPlRALRLLLYPNIALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRISDKV 165
Cdd:cd17474  183 SSATKLRDLKKALRG-RGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKR 261


                 ....
gi 384490437 166 YNKR 169
Cdd:cd17474  262 FGAR 265
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 6-161 4.76e-12

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 64.45  E-value: 4.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   6 IADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALcIWIAIFFLLPEtSRSFPTQEPREKQG 85
Cdd:COG0477  127 IAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGL-LALVLRLRLPE-SRGLLLALLALALA 204

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 384490437  86 AQYIERKAKIRTINPLRALRLLLYPNIALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRI 161
Cdd:COG0477  205 ALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLL 280
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 5-256 7.28e-11

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 61.44  E-value: 7.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   5 TIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIffllpetsrsfptqeprekq 84
Cdd:cd17503  108 ILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLA-------------------- 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  85 gaqyierkakirtinPLRALRLLLYPN--------IALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGN 156
Cdd:cd17503  168 ---------------PLLDLRLFKDRNftlglllsFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSP 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437 157 IGGRISDKVYNKRVAkakekeediypemrLSGLVLGCASIIQLLSLVAYGWcvqkEVHFAYGLVCQFLYGSAFMLP-NVT 235
Cdd:cd17503  233 LVGRLLDKFGPRLLL--------------LAGLLLLALGTLLLAFLTPDTS----LWLIILPLFIRGLGMGLVFMPlNTL 294

                        250       260
                 ....*....|....*....|.
gi 384490437 236 ATAYMVDSFRKDGASATGKLR 256
Cdd:cd17503  295 ALNSLPPEQIGDATALFNTIR 315
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 5-165 1.01e-10

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 61.24  E-value: 1.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437    5 TIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSRsfPTQEPREKQ 84
Cdd:TIGR00711 114 TLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKP--AASENFDFL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   85 GA----------QYIERKAK----------------------------IRTINPLRALRLLLYPNIA--------LVVAY 118
Cdd:TIGR00711 192 GLlllsvglgslLYGLSEGPergwfdsneililsitglvaiiafvvweLTDDNPLVDLRLFKYRNFTigcvymslLGLGL 271

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 384490437  119 VGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRISDKV 165
Cdd:TIGR00711 272 YGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKI 318
emrD PRK11652
multidrug transporter EmrD;
8-88 2.34e-10

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 59.92  E-value: 2.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   8 DIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETsrsFPTQEPREKQGAQ 87
Cdd:PRK11652 123 DLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPET---RPADARRTRVLAS 199


                 .
gi 384490437  88 Y 88
Cdd:PRK11652 200 Y 200
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
5-240 3.76e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 59.50  E-value: 3.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   5 TIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALcIWIAIFFLlpetsrsfptqeprekq 84
Cdd:COG2271  122 LIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGL-LLALLRFW----------------- 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  85 gaqyierkakirtinplralrLLLYPNIALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRISDK 164
Cdd:COG2271  184 ---------------------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR 242

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 384490437 165 VYNKRVakakekeediypemrlsgLVLGCASIIQLLSLVAYGWCVQKEVHFAYGLVCQFLYGSAFMLPNVTATAYM 240
Cdd:COG2271  243 LGRRRK------------------LVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 6-251 4.34e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 59.36  E-value: 4.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   6 IADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQ--GLGWRSNFWFLAIFALCIWIAIFFLLPETsrsfPTQEPREK 83
Cdd:cd06174  109 IADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILLLLVVPDP----PESARAKN 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  84 QGAQYIERKAKIRTINPLRALRLLLYPNIALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRISD 163
Cdd:cd06174  185 EEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437 164 KVYNKRVakakekeediypemrlsglVLGCASIIQLLSLVAYGWCvqkeVHFAYGLVCQFLYGSAFMLPNVTATAYMVDS 243
Cdd:cd06174  265 RLIGRKP-------------------LLLIGLLLMALGLALLLLA----PSLLLLLLLLLLLGFGLGGLLPLSFALIAEL 321


                 ....*...
gi 384490437 244 FRKDGASA 251
Cdd:cd06174  322 FPPEIRGT 329
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
2-170 1.10e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 57.97  E-value: 1.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   2 GAGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETsrsfptqepr 81
Cdd:COG2223  114 GIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDP---------- 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  82 ekqgAQYIERKAKIRTINPLRALRL-------LLYpnIALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIG 154
Cdd:COG2223  184 ----PAGAAAAAKASLRDQLEALRDprfwllsLLY--FGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALG 257

                        170
                 ....*....|....*.
gi 384490437 155 GNIGGRISDKVYNKRV 170
Cdd:COG2223  258 RPLGGWLSDRIGGRRV 273
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
11-257 1.58e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 57.60  E-value: 1.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  11 ESHERGRVFAY----YTLGPLLGPAFGPIIGGYL--NQGLGWRSNFWFLAIFALCIWIAIFFLLPEtsrsfPTQEPREKQ 84
Cdd:COG2211  141 DYEERTRLSSWrfafAGLGGLLASVLPPPLVAAFggDAALGYRLTALIFAVLGLLAFLLTFFGTKE-----RPVPEEEKV 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  85 GAqyierKAKIRTINPLRALRLLLYPNIALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRISDK 164
Cdd:COG2211  216 SL-----KESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437 165 VYNKRVakakekeediypeMRLSGLVLGCASIiqLLSLVAYGwcvqkevHFAYGLVCQFLYGSAFMLPNVTATAYMVDSF 244
Cdd:COG2211  291 FGKKKA-------------FIIGLLLAALGLL--LLFFLGPG-------NLWLLLVLAALAGIGLGAILVLPWAMLADVV 348

                        250
                 ....*....|...
gi 384490437 245 RKDgASATGKLRE 257
Cdd:COG2211  349 DYD-EWKTGRRRE 360
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 1-252 5.32e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 56.06  E-value: 5.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   1 MGAGTI-ADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSRSFPTQE 79
Cdd:cd17489  103 TAAATLvADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAE 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  80 PREKQGAQYIERKAkirtinplralrllLYPNIALVVAYVGVFAV--FTRVYTNQYGLDSGivGVCYLPYAVGAMIGGNI 157
Cdd:cd17489  183 AGTRAFRRLVEKKV--------------LPPALILFLASIAYGAIstFLPLYAAERGISNA--GLFFTVYAIALLLSRPF 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437 158 GGRISDKVYNKRVakakekeedIYPemrlsGLVLGCASIIqLLSLVAYGWcvqkevhfaYGLVCQFLYGSAFMLPNVTAT 237
Cdd:cd17489  247 SGKLSDRKGPKTV---------IIP-----GLLLLALGLL-LLSFAGSPW---------MLLLAAVLYGLGFGLLFPALQ 302

                        250
                 ....*....|....*
gi 384490437 238 AYMVDSFRKDGASAT 252
Cdd:cd17489  303 ALAVDLVPPHRRGAA 317
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
8-71 1.58e-08

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 54.54  E-value: 1.58e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 384490437   8 DIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPET 71
Cdd:PRK11102 106 DMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPET 169
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 28-171 6.78e-08

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 52.58  E-value: 6.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  28 LGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIffllpetsrsfptqeprekqgaqyierkakirtinPLRALRLL 107
Cdd:cd17504  130 IGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV-----------------------------------PLIDLRLL 174

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 384490437 108 LYPNIAL--VVAYVGVFAVFTRVYTNQ----------YGLDSGIVGVCYLPYAVGAMIGGNIGGRISDKVYNKRVA 171
Cdd:cd17504  175 RRRNVLLanITALLAGFGMFMVFQLLPqllqlptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 32-240 2.03e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 51.08  E-value: 2.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  32 FGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLlpetsRSFPTQEPREKQGAQYIERKAKIRTINPLRALRLLLYPN 111
Cdd:cd06173  143 IGPALGGLLVALLGPGGAFAINALSFLLSALLLLFI-----RRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLAL 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437 112 IALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRISDKVYNKRVakakekeediypeMRLSGLVL 191
Cdd:cd06173  218 ALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRL-------------LLIGALLL 284

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 384490437 192 GCASIIqlLSLVAYGWcvqkevhfaYGLVCQFLYGSAFMLPNVTATAYM 240
Cdd:cd06173  285 GLALLV--LGLSPSLW---------LLLAALFLLGLAGGLFNVPLNTLL 322
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
5-73 5.41e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.87  E-value: 5.41e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 384490437   5 TIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSR 73
Cdd:COG2271  295 LAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 5-69 2.97e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 47.57  E-value: 2.97e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 384490437   5 TIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLP 69
Cdd:cd17319  115 ALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR 179
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
28-170 4.63e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.16  E-value: 4.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  28 LGPAFGPIIGGYL---NQGLGWRSNFWFLAIFALCIWIAIFFllpetsRSFPTQEPREKQGAqyiERKAKIRTINPLRAL 104
Cdd:COG0738  142 LGALLGPLLGGLLillGLSLSWHLPYLILAVLLLLLALLFLR------SKLPEIEEEEEEAA---GSAASLKSLLKNPRL 212

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 384490437 105 RLLLYPNIALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRISDKVYNKRV 170
Cdd:COG0738  213 LLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRL 278
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 3-170 5.34e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 46.78  E-value: 5.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   3 AGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALcIWIAIFFLLPETSRSFPTQEPRE 82
Cdd:cd17478  105 GARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGL-AVALLLLRLRPLKKPEAKKAAAK 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  83 KQGAQYieRKAKIRTINPLRALRLLlypnIALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLpyaVGAMIGGNIGGRIS 162
Cdd:cd17478  184 SSARST--LKGVWRALLLLLIIVFL----RSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFL---FAGAIGTLIGGPLS 254


                 ....*...
gi 384490437 163 DKVYNKRV 170
Cdd:cd17478  255 DRFGRRRV 262
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 6-164 7.86e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 46.41  E-value: 7.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   6 IADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQgLGWRSNFWFLAiFALCIWIAIFFLLPetsrsfptqEPREKQG 85
Cdd:cd17473  113 IGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL-LALPVLILVLLFLP---------EPARKSK 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  86 AQYIERKAKIRTINPLRALRLLlypnIALVVAYVGVFAVFT---RVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRIS 162
Cdd:cd17473  182 SAASPGAATAAALPWKRVLPIY----FLAFLAMLLFYVIPIqlpFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLK 257


                 ..
gi 384490437 163 DK 164
Cdd:cd17473  258 RR 259
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 6-244 1.03e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 46.06  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   6 IADIFESHERGRVFAY----YTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIaiffllpetsrsfptqepr 81
Cdd:cd17316  114 VAEFAPSKRRGFALGLlqsgWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALL------------------- 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  82 ekqgaqyierkakIRtinplRALRLLLYPNIALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRI 161
Cdd:cd17316  175 -------------LR-----RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLL 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437 162 SDKVYNKRvakakekeediypemrlsglVLGCASIIQLLSLVAYGWCVQKevHFAYGLVCQFLYGSAFMLPNVTATAYMV 241
Cdd:cd17316  237 SDRIGRKK--------------------TLVIGLILSGILALPLFYLLSG--SPTLLLLLLFILSFFVGGVWGALYAYLA 294


                 ...
gi 384490437 242 DSF 244
Cdd:cd17316  295 ELF 297
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 5-169 2.64e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 44.67  E-value: 2.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437    5 TIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGY-LNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSRS--------F 75
Cdd:TIGR00881 107 TVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQScglppaeeM 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   76 PTQEPREKQGAQYIERKAK---IRTINPLRALRLLLYPNIALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCYLPYAVGAM 152
Cdd:TIGR00881 187 PNEEPDGDAEKKEEELTKKqifLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGL 266

                         170
                  ....*....|....*..
gi 384490437  153 IGGNIGGRISDKVYNKR 169
Cdd:TIGR00881 267 VGTLLAGWLSDKLFNGR 283
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 3-126 2.88e-05

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 44.55  E-value: 2.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   3 AGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNqGLGWRSNFWFLAIFALCIWIAIFFLLPETsrsfptqEPRE 82
Cdd:cd17388  112 AAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLG-EISPRAPFLVAAGLNGLNFLLGLFVLPES-------LPPE 183

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 384490437  83 KQgaqyieRKAKIRTINPLRALRLLLypNIALVVAYVGVFAVFT 126
Cdd:cd17388  184 RR------RAFRWRRANPFGSLRWLT--GFPGLLGLLAVFFLIQ 219
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 6-60 3.32e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 44.48  E-value: 3.32e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 384490437   6 IADIFESHERGRVFAYytLGPLLGPA--FGPIIGGYLNQGLGWRSNFWF-LAIFALCI 60
Cdd:cd17502  108 IADLVPPRERGKYQGY--IGAVFGIAsvAGPLIGGAFTDHLSWRWCFYInLPIGGLAL 163
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 15-67 5.89e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 43.77  E-value: 5.89e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 384490437  15 RGRVFAYYTLGPLLGPAFGPIIGGYL--NQGLGWRSNFWFLAIFALCIWIAIFFL 67
Cdd:cd06179  118 RGLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYINAIFNALALILLFFF 172
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 6-173 1.84e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 42.22  E-value: 1.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   6 IADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQ-GLGWRSNFWFLAIFALCIWIAIFFLLPETSRSFPTQEPREKQ 84
Cdd:cd17328  112 IADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKS 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  85 GAQYIERKAKIRTINPlralrlllyPNIALVVAYVGV-FAV----------FTRVYTNQyGLDSGIVGVCY-LPYAVGAM 152
Cdd:cd17328  192 TATSFLADLKALAKNP---------SFILSTLGFTAVsFVTgalafwaptfFLRAFGVG-DLSSADVGLIFgAITCIAGV 261

                        170       180
                 ....*....|....*....|.
gi 384490437 153 IGGNIGGRISDKvYNKRVAKA 173
Cdd:cd17328  262 LGVLLGGILADR-LRRKTPRA 281
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 6-67 3.03e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.41  E-value: 3.03e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 384490437   6 IADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIF-ALCIWIAIFFL 67
Cdd:cd17325  313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALlLLAAVLFLLLR 375
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 6-137 3.34e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 41.44  E-value: 3.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   6 IADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSRSFPTQEPREKqg 85
Cdd:cd17331  111 VTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEAKES-- 188

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  86 aqyierKAKIRTINPLRALRLLLYPNIALVVAY-------VGVF-AVFTRVYTNQYGLDS 137
Cdd:cd17331  189 ------ASPPSVFNLKEILRLLRLPGVAFLLLVkllsglpIGMFqSMFSLVAMDFFGLTP 242
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 6-67 5.17e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 40.63  E-value: 5.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 384490437   6 IADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFL 67
Cdd:cd17474  313 VTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 6-75 7.30e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 40.25  E-value: 7.30e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   6 IADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSRSF 75
Cdd:cd17330  111 IADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLRRLL 180
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 6-144 1.34e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.52  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   6 IADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQgLGWRSNFWFLAIFALCIWIAIFFLLPETsrsFPTQEPREKQg 85
Cdd:cd17329  113 IADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPET---RPKRRAAEKT- 187

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 384490437  86 aqyiERKAKIRTINPLRALRLLLYPNIALVVAYVGVFAVFTRVYTNQYGLDSGIVGVCY 144
Cdd:cd17329  188 ----EILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLL 242
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 14-68 1.60e-03

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 39.14  E-value: 1.60e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 384490437  14 ERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFAlCIWIAIFFLL 68
Cdd:cd17318  144 ERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLG-LLWCLLWFFL 197
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
17-80 1.66e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 39.11  E-value: 1.66e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 384490437  17 RVFAyyTLGPL--LGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSRSFPTQEP 80
Cdd:PRK11043 130 RVFA--TIMPLvaLSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKKARKQSQDA 193
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 1-173 1.81e-03

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 39.15  E-value: 1.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   1 MGAG----TIADIFESHERGRVFAYYTL-----GPLLGPAFGPIIGGYLNQGlgWRSNFWFLAIFALCIWIAIFFLLPET 71
Cdd:cd17345  111 MGWPpsgrTMVHWFSKKERGTWTSIWNIshnvgGGLVGPLAGLGLAIFGDGW--WRGAFIFPAIIAIIVAVIVLFLGKDT 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  72 SRSF---PTQEPREKQGAQYIERKAKiRTINPLRALRLLLYPN-IALVVAYVGVFavftrVYTNQYGLDSGI-------- 139
Cdd:cd17345  189 PESEglpPIEEYKGDYPEEADGEEEE-QELSAWEIFVKYVLKNkLLWYIAIANVF-----VYLVRYGILDWAptylsevk 262

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 384490437 140 ------VGVCYLPYAVGAMIGGNIGGRISDKVYNKRVAKA 173
Cdd:cd17345  263 gfskaqAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPT 302
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
1-74 2.39e-03

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 38.65  E-value: 2.39e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 384490437   1 MGAGTIADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSRS 74
Cdd:PRK15403 124 VGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKR 197
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 8-170 2.42e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 38.98  E-value: 2.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   8 DIFESHERGRVFAY-----YtLGPLLGPAF------GPIIGGYLNQGLGWRSNFWFLAI-FALCIWIaIFFLLPETSRSf 75
Cdd:COG2270  135 DIATPEEIGRVSGLgwalgY-LGGVLLLLInlalflKPEAFGLPDAGEAVRISFLLTALwWLLFALP-LFLFLPERPRP- 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  76 PTQEPREKQGAQYIERKAKIRTINPLRALRLLLypnIALVVAYVGVFAVFT--RVY-TNQYGLDSGIVGVCYLPYAVGAM 152
Cdd:COG2270  212 GPAPPRGAVRAGFRELRRTLRELRRYRDLLRFL---LAYFFYRDGVQTVIAfaGIYaAGVLGFSTTELIVFGLLVQIVAA 288

                        170
                 ....*....|....*...
gi 384490437 153 IGGNIGGRISDKVYNKRV 170
Cdd:COG2270  289 LGALLFGRLDDRIGPKRV 306
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 13-68 3.11e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 38.30  E-value: 3.11e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 384490437  13 HERGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALcIWIAIFFLL 68
Cdd:cd17380  121 SERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGL-LWALVWLIY 175
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
27-71 3.31e-03

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 38.38  E-value: 3.31e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 384490437  27 LLGPAFGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPET 71
Cdd:PRK15402 147 LLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPET 191
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 15-170 3.81e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 38.11  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   15 RGRVFAYYTLGPLLGPAFGPIIGGYLNQGLGWRSNFWFLAIF-ALCIWIAIFFL----------LPETSRSFPTQEPREK 83
Cdd:TIGR00895 139 RGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIApLLLLLLLMRFLpesidflvskRPETVRRIVNAIAPQM 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   84 QGAQYIERKAKIRTINPLRALRLLLYPNI------ALVVAY----VGVFAV--FTRVYTNQYGLDSGIVGVCYLPYAVGA 151
Cdd:TIGR00895 219 QAEAQSALPEQKSTQGTKRSVFKALFQGKtaritvLLWLLYfmllVGVYFLtnWLPKLMVELGFSLSLAATGGALFNFGG 298

                         170
                  ....*....|....*....
gi 384490437  152 MIGGNIGGRISDKvYNKRV 170
Cdd:TIGR00895 299 VIGSIIFGWLADR-LGPRV 316
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 6-255 3.88e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 37.92  E-value: 3.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   6 IADIFESHERGRVFAYYTLGPLLGPAFGPIIGGYLNQGlgwrSNFWFLAIFALCIWIAIFFLLpeTSRSFPTQEPREKqg 85
Cdd:cd17477  109 LNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA----GALPFLIAAVLLLLALVPLLL--TRRAAPEIEEAES-- 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  86 aqyierkakirtINPLRALRLLLYPNIALVVAYVGVFAVFT--RVYTNQYGLDSGIVGVCYLPYAVGAMIGGNIGGRISD 163
Cdd:cd17477  181 ------------ISLRRLLRIAPLALLGAFVAGFLEGAFYSllPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLAD 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437 164 KvYNKRVAkakekeediypeMRLSGLvLGCASIIQLLSLVAYGWCVqkevhfaygLVCQFLYGSAFMLPNVTATAYMVDS 243
Cdd:cd17477  249 R-FDRRRV------------LLGCAL-LGALAALLLPLVPGLPLAL---------LVLLFLWGGAAGPLYTLALALAGDR 305

                        250
                 ....*....|...
gi 384490437 244 FRKDG-ASATGKL 255
Cdd:cd17477  306 LPGDElVAANAAL 318
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 32-92 5.24e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 37.53  E-value: 5.24e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 384490437  32 FGPIIGGYLNQGLGWRSNFWFLAIFALCIWIAIFFLLPETSRSFPTQEPREKQGAQYIERK 92
Cdd:cd17471  140 IGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRR 200
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 28-155 8.17e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 37.20  E-value: 8.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437  28 LGPAFGPIIGGYLNQGLGWRSNFWFLAIFALciwiaIFFLLpetsrSFPTQEPREKQGAQYIERKAKIRTInplrALRLL 107
Cdd:cd17490  131 LGQLIAFLIGGLIAEHFGMRAPFLLAALAGV-----LGFIL-----SLFIKEERREKKPVLTELKELLSVL----KDKKL 196

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 384490437 108 LYPNI-ALVVAYVGvFAV---FTRVYTNQYGLDSGIVGVCY----LPYAVGAMIGG 155
Cdd:cd17490  197 LFFSLlAILQQMIT-FSTtfgFTPLIAKQLGASSFQLGLLSiiylLPNALASLLSG 251
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 8-164 8.34e-03

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 37.40  E-value: 8.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437    8 DIFESHER-GRVFAYYTLGPLLGPAFGPIIGGYLNQGLG--WRSN----------------FW--FLAIFALCIWIAI-F 65
Cdd:TIGR00805 197 DDFAKSKNsPLYIGILESGSVFGPAFGFLLGSFCLQIYVdtGSVNtedliitptdprwigaWWigFLVCGFVALLTSIpL 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384490437   66 FLLPETSRSFPTQEP-REKQGAQYIERKAKIRTIN-------PLRALRLLLYPNIALVV--------AYVGVFAVFTRVY 129
Cdd:TIGR00805 277 FFFPKTLPKEGKRVNvDVHEAEKLEKSRGEDRKKNsgitkdfPKFIKRLLCNKIYMLVIlaqvidvlAFNGYITFLPKYL 356

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 384490437  130 TNQYGLDSG----IVGVCYLPyavGAMIGGNIGGRISDK 164
Cdd:TIGR00805 357 ENQYGISSAeanlLIGVVNVP---PIGLGYLIGGFIMKK 392
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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