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Conserved domains on  [gi|384479390|gb|AFH93185|]
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ankyrin repeat-containing protein [Providencia stuartii MRSN 2154]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-228 5.50e-39

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 136.24  E-value: 5.50e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  11 LAYMLGILSMSLILMAKSFAQVDSSSLVTLAEKGDLSGVTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQGA 90
Cdd:COG0666   32 LLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  91 NVNARDAIQDSPYLYAGARGLQEILEMTLENGADLASTNRYGGTALIPAAERGHVKTVQTLIDAGVNVNHVNRLGWTALI 170
Cdd:COG0666  112 DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 384479390 171 EAIILGdgsekYATIVTQLIKGGADVNLADASGNSPLTLAKQKGYSNLVEILERSGAK 228
Cdd:COG0666  192 LAAENG-----HLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-228 5.50e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 136.24  E-value: 5.50e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  11 LAYMLGILSMSLILMAKSFAQVDSSSLVTLAEKGDLSGVTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQGA 90
Cdd:COG0666   32 LLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  91 NVNARDAIQDSPYLYAGARGLQEILEMTLENGADLASTNRYGGTALIPAAERGHVKTVQTLIDAGVNVNHVNRLGWTALI 170
Cdd:COG0666  112 DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 384479390 171 EAIILGdgsekYATIVTQLIKGGADVNLADASGNSPLTLAKQKGYSNLVEILERSGAK 228
Cdd:COG0666  192 LAAENG-----HLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 53-227 1.78e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 80.09  E-value: 1.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  53 LKQGANIEQRDLRLRTPLMAATHANQI-----EVARFLIEQGANVNARDAIQDSPYLYAGARGLQ--EILEMTLENGADL 125
Cdd:PHA03100  55 LDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNsySIVEYLLDNGANV 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 126 ASTNRYGGTALIPAAERGHVKT--VQTLIDAGVNVNHVNRL----------------GWTALIEAIilgdgSEKYATIVT 187
Cdd:PHA03100 135 NIKNSDGENLLHLYLESNKIDLkiLKLLIDKGVDINAKNRVnyllsygvpinikdvyGFTPLHYAV-----YNNNPEFVK 209

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 384479390 188 QLIKGGADVNLADASGNSPLTLAKQKGYSNLVEILERSGA 227
Cdd:PHA03100 210 YLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
Ank_2 pfam12796
Ankyrin repeats (3 copies);
105-200 1.33e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.97  E-value: 1.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  105 YAGARGLQEILEMTLENGADLASTNRYGGTALIPAAERGHVKTVQTLIDaGVNVNHVNRlGWTALIEAIILGdgsekYAT 184
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSG-----HLE 75

                          90
                  ....*....|....*.
gi 384479390  185 IVTQLIKGGADVNLAD 200
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 88-227 4.61e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.77  E-value: 4.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  88 QGANVNARDAIQDSPYLYAGARG-LQEILEMTLENGADLASTNRYGGTALIPAAERGHVKTVQTLIDAG---VNVNHVNR 163
Cdd:cd22192    6 DELHLLQQKRISESPLLLAAKENdVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 164 L--GWTALIEAIILGDgsekyATIVTQLIKGGADVNLADAS--------------GNSPLTLAKQKGYSNLVEILERSGA 227
Cdd:cd22192   86 LyqGETALHIAVVNQN-----LNLVRELIARGADVVSPRATgtffrpgpknliyyGEHPLSFAACVGNEEIVRLLIEHGA 160
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 41-211 2.19e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 38.91  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390   41 AEKGDLSGVTQALKQGA--NIEQRDLRLRTPLM-AATHANQIEVARFLIEQGANVNARDAIqdspyLYAGARGLQEILEM 117
Cdd:TIGR00870  25 AERGDLASVYRDLEEPKklNINCPDRLGRSALFvAAIENENLELTELLLNLSCRGAVGDTL-----LHAISLEYVDAVEA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  118 TL---------ENGADLA---STNRY--GGTALIPAAERGHVKTVQTLIDAGVNVN------------HVNRLGWTALIE 171
Cdd:TIGR00870 100 ILlhllaafrkSGPLELAndqYTSEFtpGITALHLAAHRQNYEIVKLLLERGASVParacgdffvksqGVDSFYHGESPL 179

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 384479390  172 AIILGDGSEkyaTIVTQLIKGGADVNLADASGNSPLTLAK 211
Cdd:TIGR00870 180 NAAACLGSP---SIVALLSEDPADILTADSLGNTLLHLLV 216
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 67-94 2.46e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 2.46e-03
                           10        20
                   ....*....|....*....|....*...
gi 384479390    67 RTPLMAATHANQIEVARFLIEQGANVNA 94
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-228 5.50e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 136.24  E-value: 5.50e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  11 LAYMLGILSMSLILMAKSFAQVDSSSLVTLAEKGDLSGVTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQGA 90
Cdd:COG0666   32 LLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  91 NVNARDAIQDSPYLYAGARGLQEILEMTLENGADLASTNRYGGTALIPAAERGHVKTVQTLIDAGVNVNHVNRLGWTALI 170
Cdd:COG0666  112 DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 384479390 171 EAIILGdgsekYATIVTQLIKGGADVNLADASGNSPLTLAKQKGYSNLVEILERSGAK 228
Cdd:COG0666  192 LAAENG-----HLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-228 2.58e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 134.31  E-value: 2.58e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  33 DSSSLVTLAEKGDLSGVTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQGANVNARDAIQDSPYLYAGARGLQ 112
Cdd:COG0666   87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 113 EILEMTLENGADLASTNRYGGTALIPAAERGHVKTVQTLIDAGVNVNHVNRLGWTALIEAIILGdgsekYATIVTQLIKG 192
Cdd:COG0666  167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG-----NLEIVKLLLEA 241

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 384479390 193 GADVNLADASGNSPLTLAKQKGYSNLVEILERSGAK 228
Cdd:COG0666  242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLL 277
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
14-228 2.95e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.21  E-value: 2.95e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  14 MLGILSMSLILMAKSFAQVDSSSLVTLAEKGDLSGVTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQGANVN 93
Cdd:COG0666    2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  94 ARDAIQDSPYLYAGARGLQEILEMTLENGADLASTNRYGGTALIPAAERGHVKTVQTLIDAGVNVNHVNRLGWTALIEAI 173
Cdd:COG0666   82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAA 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 384479390 174 ILGDgsekyATIVTQLIKGGADVNLADASGNSPLTLAKQKGYSNLVEILERSGAK 228
Cdd:COG0666  162 ANGN-----LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
37-201 6.11e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.56  E-value: 6.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  37 LVTLAEKGDLSGVTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQGANVNARDAIQDSPYLYAGARGLQEILE 116
Cdd:COG0666  124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVK 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 117 MTLENGADLASTNRYGGTALIPAAERGHVKTVQTLIDAGVNVNHVNRLGWTALIEAIILGDGSEKYATIVTQLIKGGADV 196
Cdd:COG0666  204 LLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283


                 ....*
gi 384479390 197 NLADA 201
Cdd:COG0666  284 DLLTL 288
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 53-227 1.78e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 80.09  E-value: 1.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  53 LKQGANIEQRDLRLRTPLMAATHANQI-----EVARFLIEQGANVNARDAIQDSPYLYAGARGLQ--EILEMTLENGADL 125
Cdd:PHA03100  55 LDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNsySIVEYLLDNGANV 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 126 ASTNRYGGTALIPAAERGHVKT--VQTLIDAGVNVNHVNRL----------------GWTALIEAIilgdgSEKYATIVT 187
Cdd:PHA03100 135 NIKNSDGENLLHLYLESNKIDLkiLKLLIDKGVDINAKNRVnyllsygvpinikdvyGFTPLHYAV-----YNNNPEFVK 209

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 384479390 188 QLIKGGADVNLADASGNSPLTLAKQKGYSNLVEILERSGA 227
Cdd:PHA03100 210 YLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
41-169 3.35e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.46  E-value: 3.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  41 AEKGDLSGVTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQGANVNARDAIQDSPYLYAGARGLQEILEMTLE 120
Cdd:COG0666  161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 384479390 121 NGADLASTNRYGGTALIPAAERGHVKTVQTLIDAGVNVNHVNRLGWTAL 169
Cdd:COG0666  241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03095 PHA03095
ankyrin-like protein; Provisional
 53-210 4.82e-17

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 79.30  E-value: 4.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  53 LKQGANIEQRDLRLRTPL---MAATHANqIEVARFLIEQGANVNARDAIQDSPY----LYAGARglQEILEMTLENGADL 125
Cdd:PHA03095 139 LRKGADVNALDLYGMTPLavlLKSRNAN-VELLRLLIDAGADVYAVDDRFRSLLhhhlQSFKPR--ARIVRELIRAGCDP 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 126 ASTNRYGGTALIPAAERGHVKT--VQTLIDAGVNVNHVNRLGWTALIeaiilgdgsekYATIVTQ------LIKGGADVN 197
Cdd:PHA03095 216 AATDMLGNTPLHSMATGSSCKRslVLPLLIAGISINARNRYGQTPLH-----------YAAVFNNpracrrLIALGADIN 284

                        170
                 ....*....|...
gi 384479390 198 LADASGNSPLTLA 210
Cdd:PHA03095 285 AVSSDGNTPLSLM 297
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 49-212 1.13e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 75.00  E-value: 1.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  49 VTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQGANVNARDAIQDSPYLYAGARGLQEILEMTLENGADLAST 128
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 129 NRYGGTALIPAAERGHVKTVQTLIDAGVNVNHVNRLGWTALIEAIIlgdgsekYATIVTQLIKGGADVNLADASGNSPLT 208
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII-------HNRSAIELLINNASINDQDIDGSTPLH 259


                 ....
gi 384479390 209 LAKQ 212
Cdd:PHA02874 260 HAIN 263
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 35-228 1.55e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 75.10  E-value: 1.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  35 SSLVTLAEKG-DLSGVTQALKQGANIEQRDLRLRTPL-MAATHANQIEVARFLIEQGANVNARDAIQDSPYLYAGARGLQ 112
Cdd:PHA02876 309 TPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLhQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNV 388

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 113 EILEMTLENGADLASTNRYGGTAL-IPAAERGHVKTVQTLIDAGVNVNHVNRLGWTALIEAIilgdGSEKYATIVTQLIK 191
Cdd:PHA02876 389 VIINTLLDYGADIEALSQKIGTALhFALCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYAC----KKNCKLDVIEMLLD 464

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 384479390 192 GGADVNLADASGNSPLTLAkqKGYSNLVEILERSGAK 228
Cdd:PHA02876 465 NGADVNAINIQNQYPLLIA--LEYHGIVNILLHYGAE 499
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 44-227 7.15e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 72.69  E-value: 7.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  44 GDLSGVTQALKQGANIEQRDL-RLRTPLMAATHANQIEVARFLIEQGANVNARDAIQDSPYLYAGARGLQEILEMTLENG 122
Cdd:PHA02874  12 GDIEAIEKIIKNKGNCINISVdETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 123 ADlastnryggTALIPAAERGHvKTVQTLIDAGVNVNHVNRLGWTALIEAIILGDgsekyATIVTQLIKGGADVNLADAS 202
Cdd:PHA02874  92 VD---------TSILPIPCIEK-DMIKTILDCGIDVNIKDAELKTFLHYAIKKGD-----LESIKMLFEYGADVNIEDDN 156

                        170       180
                 ....*....|....*....|....*
gi 384479390 203 GNSPLTLAKQKGYSNLVEILERSGA 227
Cdd:PHA02874 157 GCYPIHIAIKHNFFDIIKLLLEKGA 181
PHA03095 PHA03095
ankyrin-like protein; Provisional
 53-207 1.15e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 72.36  E-value: 1.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  53 LKQGANIEQRDLRLRTPL---MAATHANQIEVARFLIEQGANVNARDAIQDSP---YLYAGARglQEILEMTLENGADLA 126
Cdd:PHA03095  34 LAAGADVNFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPlhlYLYNATT--LDVIKLLIKAGADVN 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 127 STNRYGGTAL--IPAAERGHVKTVQTLIDAGVNVNHVNRLGWTALIEAIILGDGSekyATIVTQLIKGGADVNLADASGN 204
Cdd:PHA03095 112 AKDKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNAN---VELLRLLIDAGADVYAVDDRFR 188


                 ...
gi 384479390 205 SPL 207
Cdd:PHA03095 189 SLL 191
PHA03095 PHA03095
ankyrin-like protein; Provisional
 53-207 1.35e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 71.98  E-value: 1.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  53 LKQGANIEQRDLRLRTPLMA-ATHANQIEVARFLIEQGANVNARDAIQDSPyLYAGARGLQ---EILEMTLENGADLAST 128
Cdd:PHA03095  70 LEAGADVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTP-LHVYLSGFNinpKVIRLLLRKGADVNAL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 129 NRYGGTALipAA----ERGHVKTVQTLIDAGVNVNHVNRLGWTALieaIILGDGSEKYATIVTQLIKGGADVNLADASGN 204
Cdd:PHA03095 149 DLYGMTPL--AVllksRNANVELLRLLIDAGADVYAVDDRFRSLL---HHHLQSFKPRARIVRELIRAGCDPAATDMLGN 223


                 ...
gi 384479390 205 SPL 207
Cdd:PHA03095 224 TPL 226
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 52-227 5.56e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 67.38  E-value: 5.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  52 ALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQGANVNARDAIQDSPYLYAG-----ARGLQEILEMTLENGADLA 126
Cdd:PHA03100  21 IIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnikynLTDVKEIVKLLLEYGANVN 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 127 STNRYGGTALIPAA--ERGHVKTVQTLIDAGVNVNHVNRLGWTALIEAIILGDGSEKyatIVTQLIKGGADVN------- 197
Cdd:PHA03100 101 APDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLK---ILKLLIDKGVDINaknrvny 177

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 384479390 198 ---------LADASGNSPLTLAKQKGYSNLVEILERSGA 227
Cdd:PHA03100 178 llsygvpinIKDVYGFTPLHYAVYNNNPEFVKYLLDLGA 216
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 53-197 5.42e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 64.30  E-value: 5.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  53 LKQGANIEQRDLRLRTPLMAA--THANQIEVARFLIEQGANVNARDAIQDSP---YLYAGARGLqEILEMTLENGADLAS 127
Cdd:PHA03100  93 LEYGANVNAPDNNGITPLLYAisKKSNSYSIVEYLLDNGANVNIKNSDGENLlhlYLESNKIDL-KILKLLIDKGVDINA 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 128 TNR----------------YGGTALIPAAERGHVKTVQTLIDAGVNVNHVNRLGWTALIEAIilgDGSEKYatIVTQLIK 191
Cdd:PHA03100 172 KNRvnyllsygvpinikdvYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAI---LNNNKE--IFKLLLN 246


                 ....*.
gi 384479390 192 GGADVN 197
Cdd:PHA03100 247 NGPSIK 252
PHA03095 PHA03095
ankyrin-like protein; Provisional
 79-207 1.29e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.12  E-value: 1.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  79 IEVARFLIEQGANVNARDAIQDSP---YLYAGARGLQEILEMTLENGADLASTNRYGGTALIPAAERGHV-KTVQTLIDA 154
Cdd:PHA03095  27 VEEVRRLLAAGADVNFRGEYGKTPlhlYLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIKA 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 384479390 155 GVNVNHVNRLGWTALieAIILGdGSEKYATIVTQLIKGGADVNLADASGNSPL 207
Cdd:PHA03095 107 GADVNAKDKVGRTPL--HVYLS-GFNINPKVIRLLLRKGADVNALDLYGMTPL 156
Ank_2 pfam12796
Ankyrin repeats (3 copies);
105-200 1.33e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.97  E-value: 1.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  105 YAGARGLQEILEMTLENGADLASTNRYGGTALIPAAERGHVKTVQTLIDaGVNVNHVNRlGWTALIEAIILGdgsekYAT 184
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSG-----HLE 75

                          90
                  ....*....|....*.
gi 384479390  185 IVTQLIKGGADVNLAD 200
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 53-215 1.35e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 63.36  E-value: 1.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  53 LKQGANIEQRDL-RLRTPLMAATHANQIEVARFLIEQGANVNARDAIQDSPYLYAGARGLQEILEMTLENGADLASTNRY 131
Cdd:PHA02878 154 LSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKC 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 132 GGTAL-IPAAERGHVKTVQTLIDAGVNVNHVNR-LGWTALIEAIilgdgseKYATIVTQLIKGGADVNLADASGNSPLTL 209
Cdd:PHA02878 234 GNTPLhISVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI-------KSERKLKLLLEYGADINSLNSYKLTPLSS 306


                 ....*.
gi 384479390 210 AKQKGY 215
Cdd:PHA02878 307 AVKQYL 312
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 32-209 7.73e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 61.04  E-value: 7.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  32 VDSSSLVTLAEKGDLSGVTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQGANVNARDAIQDSPYLYAGARGL 111
Cdd:PLN03192 524 NMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKH 603

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 112 QEILEMTLENGAdlASTNRYGGTALIPAAERGHVKTVQTLIDAGVNVNHVNRLGWTALIEAIilgdgSEKYATIVTQLIK 191
Cdd:PLN03192 604 HKIFRILYHFAS--ISDPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAM-----AEDHVDMVRLLIM 676

                        170
                 ....*....|....*....
gi 384479390 192 GGADVNLADASGN-SPLTL 209
Cdd:PLN03192 677 NGADVDKANTDDDfSPTEL 695
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 77-215 1.08e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 60.85  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  77 NQIEVARFLIEQGANVNARDAIQDSPYLYAGARGLQEILEMTLENGADLASTNRYGGTALIPAAERGHVKTVQTLIDAGV 156
Cdd:PHA02876 156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 157 NVNH-----VNRLGWTALIEAIILGDG--------------------SEKYATIVTQLIKGGADVNLADASGNSPLTLAK 211
Cdd:PHA02876 236 NINKndlslLKAIRNEDLETSLLLYDAgfsvnsiddckntplhhasqAPSLSRLVPKLLERGADVNAKNIKGETPLYLMA 315


                 ....
gi 384479390 212 QKGY 215
Cdd:PHA02876 316 KNGY 319
Ank_2 pfam12796
Ankyrin repeats (3 copies);
41-162 1.25e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.28  E-value: 1.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390   41 AEKGDLSGVTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQgANVNARDaiqdspylyagarglqeilemtle 120
Cdd:pfam12796   5 AKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD------------------------ 59

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 384479390  121 ngadlastnrYGGTALIPAAERGHVKTVQTLIDAGVNVNHVN 162
Cdd:pfam12796  60 ----------NGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
139-222 4.07e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 4.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  139 AAERGHVKTVQTLIDAGVNVNHVNRLGWTALIEAIILGdgsekYATIVTQLIKgGADVNLADaSGNSPLTLAKQKGYSNL 218
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNG-----HLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEI 76


                  ....
gi 384479390  219 VEIL 222
Cdd:pfam12796  77 VKLL 80
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 42-210 1.27e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 57.28  E-value: 1.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  42 EKGDLSGVTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQGANVNARDAIQDSPYLYAGARGLQEILEMTLEN 121
Cdd:PHA02874 133 KKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 122 GADLASTNRYGGTALIPAAErgHVKTVQTLI--DAGVNVNHVNrlGWTALIEAIilgdgseKYAT---IVTQLIKGGADV 196
Cdd:PHA02874 213 GNHIMNKCKNGFTPLHNAII--HNRSAIELLinNASINDQDID--GSTPLHHAI-------NPPCdidIIDILLYHKADI 281

                        170
                 ....*....|....
gi 384479390 197 NLADASGNSPLTLA 210
Cdd:PHA02874 282 SIKDNKGENPIDTA 295
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 35-198 1.43e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 1.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  35 SSLVTLAEKGDLSGVTQALKQGANIEqrDLRLR---TPLMAATHANQIEVARFLIEQGANVNARDAIQDSPYLYAGARGL 111
Cdd:PHA02875  70 SELHDAVEEGDVKAVEELLDLGKFAD--DVFYKdgmTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGD 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 112 QEILEMTLENGADLASTNRYGGTALIPAAERGHVKTVQTLIDAGVNVNHVNRLGWTALIEAIILGDGSEkyatIVTQLIK 191
Cdd:PHA02875 148 IKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKID----IVRLFIK 223


                 ....*..
gi 384479390 192 GGADVNL 198
Cdd:PHA02875 224 RGADCNI 230
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 41-228 3.41e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 56.23  E-value: 3.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  41 AEKGDLSGVTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQGAN----------------------------- 91
Cdd:PHA02876 186 AERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNinkndlsllkairnedletslllydagfs 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  92 VNARDAIQDSPYLYAG-ARGLQEILEMTLENGADLASTNRYGGTALIPAAERGH-VKTVQTLIDAGVNVNHVNRLGWTAL 169
Cdd:PHA02876 266 VNSIDDCKNTPLHHASqAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPL 345

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 384479390 170 IEAIILgdgsEKYATIVTQLIKGGADVNLADASGNSPLTLAKQKGYSNLVEILERSGAK 228
Cdd:PHA02876 346 HQASTL----DRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
PHA02798 PHA02798
ankyrin-like protein; Provisional
 49-169 4.03e-08

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 52.91  E-value: 4.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  49 VTQALKQGANIEQRDLRLRTPLMA-----ATHANQIEVARFLIEQGANVNARDAIQDSP---YLYAGARGLQEILEMTLE 120
Cdd:PHA02798  54 VKLFINLGANVNGLDNEYSTPLCTilsniKDYKHMLDIVKILIENGADINKKNSDGETPlycLLSNGYINNLEILLFMIE 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 384479390 121 NGADLASTNRYGGTALIPAAERGH---VKTVQTLIDAGVNVN-HVNRLGWTAL 169
Cdd:PHA02798 134 NGADTTLLDKDGFTMLQVYLQSNHhidIEIIKLLLEKGVDINtHNNKEKYDTL 186
Ank_4 pfam13637
Ankyrin repeats (many copies);
132-177 8.77e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.57  E-value: 8.77e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 384479390  132 GGTALIPAAERGHVKTVQTLIDAGVNVNHVNRLGWTALIEAIILGD 177
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGN 46
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 50-227 1.00e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.10  E-value: 1.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  50 TQALKQGANIEQRD--LRLRTPLMAATHANQIEVARFLIEQGANVNarDAIQDSPYLYAGARGLQEILEMTLENGADLAS 127
Cdd:PLN03192 476 TSTLIEAMQTRQEDnvVILKNFLQHHKELHDLNVGDLLGDNGGEHD--DPNMASNLLTVASTGNAALLEELLKAKLDPDI 553

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 128 TNRYGGTALIPAAERGHVKTVQTLIDAGVNVNHVNRLGWTALIEAIILG------------DGSEKYA------------ 183
Cdd:PLN03192 554 GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKhhkifrilyhfaSISDPHAagdllctaakrn 633

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 384479390 184 --TIVTQLIKGGADVNLADASGNSPLTLAKQKGYSNLVEILERSGA 227
Cdd:PLN03192 634 dlTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 37-119 1.25e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 48.74  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  37 LVTLAEKGDLSGVTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQGANVNARDAIQDSPYLYAGARGLQEILE 116
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165


                 ...
gi 384479390 117 MTL 119
Cdd:PTZ00322 166 LLS 168
Ank_4 pfam13637
Ankyrin repeats (many copies);
101-152 7.22e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 7.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 384479390  101 SPYLYAGARGLQEILEMTLENGADLASTNRYGGTALIPAAERGHVKTVQTLI 152
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 140-227 1.05e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.79  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 140 AERGHVKTVQTLIDAGVNVNHVNRLGWTALieAIILGDGSEKYATIVTQLIKGGADVNLADASGNSPLTLAKQKGYS-NL 218
Cdd:PHA03095  22 ASNVTVEEVRRLLAAGADVNFRGEYGKTPL--HLYLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDV 99


                 ....*....
gi 384479390 219 VEILERSGA 227
Cdd:PHA03095 100 IKLLIKAGA 108
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 67-96 1.17e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.12  E-value: 1.17e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 384479390   67 RTPLM-AATHANQIEVARFLIEQGANVNARD 96
Cdd:pfam00023   3 NTPLHlAAGRRGNLEIVKLLLSKGADVNARD 33
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 33-189 4.08e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 43.72  E-value: 4.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  33 DSSSLVTLAEKGDLSGVTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQGANVNARDAIQDSPYLYAGARGLQ 112
Cdd:PHA02878 168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKD 247

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 384479390 113 -EILEMTLENGADLASTNRYGGTALIPAAERGHVKTvQTLIDAGVNVNHVNRLGWTALIEAIILGDGSEKYATIVTQL 189
Cdd:PHA02878 248 yDILKLLLEHGVDVNAKSYILGLTALHSSIKSERKL-KLLLEYGADINSLNSYKLTPLSSAVKQYLCINIGRILISNI 324
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 112-207 4.15e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 43.96  E-value: 4.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 112 QEILEMTLENGADLASTNRyGGTALIPAAERGHVKT--VQTLIDAGVNVNHvnrlgwTALIE----AIILGD--GSEKYA 183
Cdd:PHA02989  16 KNALEFLLRTGFDVNEEYR-GNSILLLYLKRKDVKIkiVKLLIDNGADVNY------KGYIEtplcAVLRNReiTSNKIK 88

                         90       100
                 ....*....|....*....|....
gi 384479390 184 TIVTQLIKGGADVNLADASGNSPL 207
Cdd:PHA02989  89 KIVKLLLKFGADINLKTFNGVSPI 112
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 140-224 5.02e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.73  E-value: 5.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 140 AERGHVKTVQTLIDAGVNVNHVNRLGWTALIEAIILGdgsekYATIVTQLIKGGADVNLADASGNSPLTLAKQKGYSNLV 219
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANG-----HVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV 164


                 ....*
gi 384479390 220 EILER 224
Cdd:PTZ00322 165 QLLSR 169
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 42-214 7.87e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 42.11  E-value: 7.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  42 EKGDLSGVTQALKQgANiEQRDLRlRTPLMAATHANQI--EVARFLIEQGANVNARdaIQD------SPYLYAGARGLQE 113
Cdd:PHA02859  30 EKDDIEGVKKWIKF-VN-DCNDLY-ETPIFSCLEKDKVnvEILKFLIENGADVNFK--TRDnnlsalHHYLSFNKNVEPE 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 114 ILEMTLENGADLASTNRYGGTALIPAAERGHVK--TVQTLIDAGVNVNHVNRLGWTALIEAIILGDGSEkyatIVTQLIK 191
Cdd:PHA02859 105 ILKILIDSGSSITEEDEDGKNLLHMYMCNFNVRinVIKLLIDSGVSFLNKDFDNNNILYSYILFHSDKK----IFDFLTS 180

                        170       180
                 ....*....|....*....|...
gi 384479390 192 GGADVNLADASGNSPLTLAKQKG 214
Cdd:PHA02859 181 LGIDINETNKSGYNCYDLIKFRN 203
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 88-227 4.61e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.77  E-value: 4.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  88 QGANVNARDAIQDSPYLYAGARG-LQEILEMTLENGADLASTNRYGGTALIPAAERGHVKTVQTLIDAG---VNVNHVNR 163
Cdd:cd22192    6 DELHLLQQKRISESPLLLAAKENdVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 164 L--GWTALIEAIILGDgsekyATIVTQLIKGGADVNLADAS--------------GNSPLTLAKQKGYSNLVEILERSGA 227
Cdd:cd22192   86 LyqGETALHIAVVNQN-----LNLVRELIARGADVVSPRATgtffrpgpknliyyGEHPLSFAACVGNEEIVRLLIEHGA 160
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 82-151 5.11e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 5.11e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  82 ARFLIEQGANVNARDAIQDSPYLYAGARGLQEILEMTLENGADLASTNRYGGTALIPAAERGHVKTVQTL 151
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 68-227 9.22e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.59  E-value: 9.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  68 TPLMAATHANQIEVARFLIEQGANVNARDAIQDSPYLYAGARGLQEILEMTLENGADLAST-NRYGGTALIPAAERGHVK 146
Cdd:PHA02875  37 SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVfYKDGMTPLHLATILKKLD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 147 TVQTLIDAGVNVNHVNRLGWTALIEAIILGDgsekyATIVTQLIKGGADVNLADASGNSPLTLAKQKGYSNLVEILERSG 226
Cdd:PHA02875 117 IMKLLIARGADPDIPNTDKFSPLHLAVMMGD-----IKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSG 191


                 .
gi 384479390 227 A 227
Cdd:PHA02875 192 A 192
Ank_5 pfam13857
Ankyrin repeats (many copies);
57-106 1.31e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 1.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 384479390   57 ANIEQRDLRLRTPLMAATHANQIEVARFLIEQGANVNARDAIQDSPYLYA 106
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
67-117 1.53e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 1.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 384479390   67 RTPLMAATHANQIEVARFLIEQGANVNARDAIQDSPYLYAGARGLQEILEM 117
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKL 52
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 41-211 2.19e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 38.91  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390   41 AEKGDLSGVTQALKQGA--NIEQRDLRLRTPLM-AATHANQIEVARFLIEQGANVNARDAIqdspyLYAGARGLQEILEM 117
Cdd:TIGR00870  25 AERGDLASVYRDLEEPKklNINCPDRLGRSALFvAAIENENLELTELLLNLSCRGAVGDTL-----LHAISLEYVDAVEA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  118 TL---------ENGADLA---STNRY--GGTALIPAAERGHVKTVQTLIDAGVNVN------------HVNRLGWTALIE 171
Cdd:TIGR00870 100 ILlhllaafrkSGPLELAndqYTSEFtpGITALHLAAHRQNYEIVKLLLERGASVParacgdffvksqGVDSFYHGESPL 179

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 384479390  172 AIILGDGSEkyaTIVTQLIKGGADVNLADASGNSPLTLAK 211
Cdd:TIGR00870 180 NAAACLGSP---SIVALLSEDPADILTADSLGNTLLHLLV 216
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 67-94 2.46e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 2.46e-03
                           10        20
                   ....*....|....*....|....*...
gi 384479390    67 RTPLMAATHANQIEVARFLIEQGANVNA 94
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
119-172 4.29e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.63  E-value: 4.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 384479390  119 LENG-ADLASTNRYGGTALIPAAERGHVKTVQTLIDAGVNVNHVNRLGWTALIEA 172
Cdd:pfam13857   2 LEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02798 PHA02798
ankyrin-like protein; Provisional
 79-197 4.68e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 37.51  E-value: 4.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  79 IEVARFLIEQGANVNARDAIQDSPY--LYAGARGLQEILEMTL---ENGADLASTNRYGGTALIPAAERGHVKTVQTL-- 151
Cdd:PHA02798  51 TDIVKLFINLGANVNGLDNEYSTPLctILSNIKDYKHMLDIVKiliENGADINKKNSDGETPLYCLLSNGYINNLEILlf 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 384479390 152 -IDAGVNVNHVNRLGWTALieAIILGDGSEKYATIVTQLIKGGADVN 197
Cdd:PHA02798 131 mIENGADTTLLDKDGFTML--QVYLQSNHHIDIEIIKLLLEKGVDIN 175
Ank_5 pfam13857
Ankyrin repeats (many copies);
151-210 5.13e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.24  E-value: 5.13e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 384479390  151 LIDAG-VNVNHVNRLGWTALIEAIILGdgsekYATIVTQLIKGGADVNLADASGNSPLTLA 210
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYG-----ALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 42-227 6.12e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 37.17  E-value: 6.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  42 EKGDLSGVTQALKQGANIEQRDLRLRTPL-MAATHANQIEVARFL--IEQGANVNARDAIQDSPYlyagARGLqEILEMT 118
Cdd:PHA02878  46 EARNLDVVKSLLTRGHNVNQPDHRDLTPLhIICKEPNKLGMKEMIrsINKCSVFYTLVAIKDAFN----NRNV-EIFKII 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 119 LENGADLASTNRYGGTALIPAAERGHVKTVQTLIDAGVNVNHVNR-LGWTALIEAiilgdGSEKYATIVTQLIKGGADVN 197
Cdd:PHA02878 121 LTNRYKNIQTIDLVYIDKKSKDDIIEAEITKLLLSYGADINMKDRhKGNTALHYA-----TENKDQRLTELLLSYGANVN 195

                        170       180       190
                 ....*....|....*....|....*....|
gi 384479390 198 LADASGNSPLTLAKQKGYSNLVEILERSGA 227
Cdd:PHA02878 196 IPDKTNNSPLHHAVKHYNKPIVHILLENGA 225
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 67-94 6.36e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 33.38  E-value: 6.36e-03
                          10        20
                  ....*....|....*....|....*...
gi 384479390   67 RTPLMAATHANQIEVARFLIEQGANVNA 94
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02946 PHA02946
ankyin-like protein; Provisional
 49-223 7.91e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 36.96  E-value: 7.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390  49 VTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLIEQGANVNARDAIQDSP--YLYAGARGLQEILEMTLENGADLA 126
Cdd:PHA02946  55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPlyYLSGTDDEVIERINLLVQYGAKIN 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384479390 127 STNRYGGTALIPAAERGHVKTVQTLIDAGVNVNHVNRLGWTAlIEAIILGDGSEkyATIVTQLIKGGADVNLADASGNSP 206
Cdd:PHA02946 135 NSVDEEGCGPLLACTDPSERVFKKIMSIGFEARIVDKFGKNH-IHRHLMSDNPK--ASTISWMMKLGISPSKPDHDGNTP 211

                        170
                 ....*....|....*..
gi 384479390 207 LTLAKQKGYSNlVEILE 223
Cdd:PHA02946 212 LHIVCSKTVKN-VDIIN 227
Ank_4 pfam13637
Ankyrin repeats (many copies);
34-86 9.62e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 33.40  E-value: 9.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 384479390   34 SSSLVTLAEKGDLSGVTQALKQGANIEQRDLRLRTPLMAATHANQIEVARFLI 86
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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