DNA primase large subunit, partial [Homo sapiens]
List of domain hits
Name | Accession | Description | Interval | E-value | ||
PriL super family | cl11970 | Archaeal/eukaryotic core primase: Large subunit, PriL; Primases synthesize the RNA primers ... |
1-62 | 4.53e-27 | ||
Archaeal/eukaryotic core primase: Large subunit, PriL; Primases synthesize the RNA primers required for DNA replication. Primases are grouped into two classes, bacteria/bacteriophage and archaeal/eukaryotic. The proteins in the two classes differ in structure and the replication apparatus components. The DNA replication machinery of archaeal organisms contains only the core primase, a simpler arrangement compared to eukaryotes. Archaeal/eukaryotic core primase is a heterodimeric enzyme consisting of a small catalytic subunit (PriS) and a large subunit (PriL). Although the catalytic activity resides within PriS, the PriL subunit is essential for primase function as disruption of the PriL gene in yeast is lethal. PriL is composed of two structural domains. Several functions have been proposed for PriL, such as the stabilization of PriS, involvement in the initiation of synthesis, the improvement of primase processivity, and the determination of product size. The actual alignment was detected with superfamily member cd07322: Pssm-ID: 416393 [Multi-domain] Cd Length: 390 Bit Score: 100.03 E-value: 4.53e-27
|
||||||
Name | Accession | Description | Interval | E-value | ||
PriL_PriS_Eukaryotic | cd07322 | Eukaryotic core primase: Large subunit, PriL; Primases synthesize the RNA primers required for ... |
1-62 | 4.53e-27 | ||
Eukaryotic core primase: Large subunit, PriL; Primases synthesize the RNA primers required for DNA replication. Primases are grouped into two classes, bacteria/bacteriophage and archaeal/eukaryotic. The proteins in the two classes differ in structure and the replication apparatus components. Archaeal/eukaryotic core primase is a heterodimeric enzyme consisting of a small catalytic subunit (PriS) and a large subunit (PriL). In eukaryotic organisms, a heterotetrameric enzyme formed by DNA polymerase alpha, the B subunit and two primase subunits has primase activity. Although the catalytic activity resides within PriS, the PriL subunit is essential for primase function as disruption of the PriL gene in yeast is lethal. PriL is composed of two structural domains. Several functions have been proposed for PriL such as stabilization of the PriS, involvement in synthesis initiation, improvement of primase processivity, determination of product size and transfer of the products to DNA polymerase alpha. Pssm-ID: 143474 [Multi-domain] Cd Length: 390 Bit Score: 100.03 E-value: 4.53e-27
|
||||||
DNA_primase_lrg | pfam04104 | Eukaryotic and archaeal DNA primase, large subunit; DNA primase is the polymerase that ... |
1-62 | 1.09e-21 | ||
Eukaryotic and archaeal DNA primase, large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. DNA primase is a heterodimer of two subunits, the small subunit Pri1 (48 kDa in yeast), and the large subunit Pri2 (58 kDa in the yeast S. cerevisiae). The large subunit of DNA primase forms interactions with the small subunit and the structure implicates that it is not directly involved in catalysis, but plays roles in correctly positioning the primase/DNA complex, and in the transfer of RNA to DNA polymerase. Pssm-ID: 397980 Cd Length: 222 Bit Score: 82.87 E-value: 1.09e-21
|
||||||
Name | Accession | Description | Interval | E-value | ||
PriL_PriS_Eukaryotic | cd07322 | Eukaryotic core primase: Large subunit, PriL; Primases synthesize the RNA primers required for ... |
1-62 | 4.53e-27 | ||
Eukaryotic core primase: Large subunit, PriL; Primases synthesize the RNA primers required for DNA replication. Primases are grouped into two classes, bacteria/bacteriophage and archaeal/eukaryotic. The proteins in the two classes differ in structure and the replication apparatus components. Archaeal/eukaryotic core primase is a heterodimeric enzyme consisting of a small catalytic subunit (PriS) and a large subunit (PriL). In eukaryotic organisms, a heterotetrameric enzyme formed by DNA polymerase alpha, the B subunit and two primase subunits has primase activity. Although the catalytic activity resides within PriS, the PriL subunit is essential for primase function as disruption of the PriL gene in yeast is lethal. PriL is composed of two structural domains. Several functions have been proposed for PriL such as stabilization of the PriS, involvement in synthesis initiation, improvement of primase processivity, determination of product size and transfer of the products to DNA polymerase alpha. Pssm-ID: 143474 [Multi-domain] Cd Length: 390 Bit Score: 100.03 E-value: 4.53e-27
|
||||||
DNA_primase_lrg | pfam04104 | Eukaryotic and archaeal DNA primase, large subunit; DNA primase is the polymerase that ... |
1-62 | 1.09e-21 | ||
Eukaryotic and archaeal DNA primase, large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. DNA primase is a heterodimer of two subunits, the small subunit Pri1 (48 kDa in yeast), and the large subunit Pri2 (58 kDa in the yeast S. cerevisiae). The large subunit of DNA primase forms interactions with the small subunit and the structure implicates that it is not directly involved in catalysis, but plays roles in correctly positioning the primase/DNA complex, and in the transfer of RNA to DNA polymerase. Pssm-ID: 397980 Cd Length: 222 Bit Score: 82.87 E-value: 1.09e-21
|
||||||
Blast search parameters | ||||
|