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Conserved domains on  [gi|38372925|ref|NP_940991|]
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basigin isoform 2 precursor [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12208729)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

CATH:  2.60.40.10
PubMed:  7932691|10436082

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 112-202 3.82e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 57.90  E-value: 3.82e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372925    112 SSEHINEGETAMLVCKSESVPPVTDWaWYKitdseDKALMNGSESRFFVSSSQGRSELHIENLNMEaDPGQYRCNGTSSK 191
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVT-WYK-----QGGKLLAESGRFSVSRSGSTSTLTISNVTPE-DSGTYTCAATNSS 74

                           90
                   ....*....|.
gi 38372925    192 GSDQAIITLRV 202
Cdd:smart00410  75 GSASSGTTLTV 85
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 112-202 3.82e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 57.90  E-value: 3.82e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372925    112 SSEHINEGETAMLVCKSESVPPVTDWaWYKitdseDKALMNGSESRFFVSSSQGRSELHIENLNMEaDPGQYRCNGTSSK 191
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVT-WYK-----QGGKLLAESGRFSVSRSGSTSTLTISNVTPE-DSGTYTCAATNSS 74

                           90
                   ....*....|.
gi 38372925    192 GSDQAIITLRV 202
Cdd:smart00410  75 GSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 104-185 4.30e-09

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 52.18  E-value: 4.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372925   104 PPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWaWYKitdsEDKALMNGSESRFFVSSSQGRseLHIENLNMEaDPGQY 183
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEATGSPPPTIT-WYK----NGEPISSGSTRSRSLSGSNST--LTISNVTRS-DAGTY 72


                  ..
gi 38372925   184 RC 185
Cdd:pfam13927  73 TC 74
IgI_5_KIRREL3-like cd05758
Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar ...
 103-201 4.89e-06

Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (also known as Neph1), Kirrel2 (also known as Neph3), and Drosophila RST (also known as irregular chiasm C-roughest) protein. These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development.


Pssm-ID: 319310  Cd Length: 98  Bit Score: 44.06  E-value: 4.89e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372925 103 GPPRVKAVKSSEHInEGETAMLVCKSESVPPVTD--WAWykitdsEDKALMNGSESRFFV---SSSQGR-SELHIENLNM 176
Cdd:cd05758   1 GPPIITAEATQPAI-LGEKARLECLVFSSPPPDRivWSW------DEGFLESGSSGRFSVetfPTEPGViSVLHISGTQR 73

                        90       100
                ....*....|....*....|....*
gi 38372925 177 EADPGQYRCNGTSSKGSDQAIITLR 201
Cdd:cd05758  74 SDFQTSFNCSAWNRFGEGTAIVSLG 98
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 112-202 3.82e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 57.90  E-value: 3.82e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372925    112 SSEHINEGETAMLVCKSESVPPVTDWaWYKitdseDKALMNGSESRFFVSSSQGRSELHIENLNMEaDPGQYRCNGTSSK 191
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVT-WYK-----QGGKLLAESGRFSVSRSGSTSTLTISNVTPE-DSGTYTCAATNSS 74

                           90
                   ....*....|.
gi 38372925    192 GSDQAIITLRV 202
Cdd:smart00410  75 GSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 104-185 4.30e-09

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 52.18  E-value: 4.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372925   104 PPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWaWYKitdsEDKALMNGSESRFFVSSSQGRseLHIENLNMEaDPGQY 183
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEATGSPPPTIT-WYK----NGEPISSGSTRSRSLSGSNST--LTISNVTRS-DAGTY 72


                  ..
gi 38372925   184 RC 185
Cdd:pfam13927  73 TC 74
I-set pfam07679
Immunoglobulin I-set domain;
116-202 8.99e-08

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 48.79  E-value: 8.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372925   116 INEGETAMLVCKSESVPP--VTdwaWYKitdsEDKALmnGSESRFFVSSSQGRSELHIENLNMEaDPGQYRCNGTSSKGS 193
Cdd:pfam07679  12 VQEGESARFTCTVTGTPDpeVS---WFK----DGQPL--RSSDRFKVTYEGGTYTLTISNVQPD-DSGKYTCVATNSAGE 81


                  ....*....
gi 38372925   194 DQAIITLRV 202
Cdd:pfam07679  82 AEASAELTV 90
IgI_5_KIRREL3-like cd05758
Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar ...
 103-201 4.89e-06

Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (also known as Neph1), Kirrel2 (also known as Neph3), and Drosophila RST (also known as irregular chiasm C-roughest) protein. These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development.


Pssm-ID: 319310  Cd Length: 98  Bit Score: 44.06  E-value: 4.89e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372925 103 GPPRVKAVKSSEHInEGETAMLVCKSESVPPVTD--WAWykitdsEDKALMNGSESRFFV---SSSQGR-SELHIENLNM 176
Cdd:cd05758   1 GPPIITAEATQPAI-LGEKARLECLVFSSPPPDRivWSW------DEGFLESGSSGRFSVetfPTEPGViSVLHISGTQR 73

                        90       100
                ....*....|....*....|....*
gi 38372925 177 EADPGQYRCNGTSSKGSDQAIITLR 201
Cdd:cd05758  74 SDFQTSFNCSAWNRFGEGTAIVSLG 98
Ig_Pro_neuregulin-1 cd05895
Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1; The members here are composed of ...
 105-196 2.98e-05

Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1; The members here are composed of the immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1. There are many NRG-1 isoforms which arise from the alternative splicing of mRNA. NRG-1 belongs to the neuregulin gene family which is comprised of four genes. This group represents NRG-1. NRGs are signaling molecules which participate in cell-cell interactions in the nervous system, breast, and heart, and other organ systems, and are implicated in the pathology of diseases including schizophrenia, multiple sclerosis, and breast cancer. The NRG-1 protein binds to and activates the tyrosine kinases receptors ErbB3 and ErbB4, initiating signaling cascades. NRG-1 has multiple functions, for example, in the brain it regulates various processes such as radial glia formation and neuronal migration, dendritic development, and expression of neurotransmitters receptors in the peripheral nervous system NRG-1 regulates processes such as target cell differentiation, and Schwann cell survival.


Pssm-ID: 409476  Cd Length: 93  Bit Score: 41.90  E-value: 2.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372925 105 PRVKAVKSSEhINEGETAMLVCKSESVPPVTDWAWYKitdSEDKALMNGSESRFFVSSSQGRSELHIENLNMeADPGQYR 184
Cdd:cd05895   1 PKLKEMKSQE-VAAGSKLVLRCETSSEYPSLRFKWFK---NGKEINRKNKPENIKIQKKKKKSELRINKASL-ADSGEYM 75

                        90
                ....*....|..
gi 38372925 185 CNGTSSKGSDQA 196
Cdd:cd05895  76 CKVSSKLGNDSA 87
Ig_Pro_neuregulin cd05750
Immunoglobulin (Ig)-like domain in neuregulins; The members here are composed of the ...
 105-202 3.11e-05

Immunoglobulin (Ig)-like domain in neuregulins; The members here are composed of the immunoglobulin (Ig)-like domain in neuregulins (NRGs). NRGs are signaling molecules which participate in cell-cell interactions in the nervous system, breast, heart, and other organ systems, and are implicated in the pathology of diseases including schizophrenia, multiple sclerosis, and breast cancer. There are four members of the neuregulin gene family (NRG-1, NRG-2, NRG-3, and NRG-4). The NRG-1 protein, binds to and activates the tyrosine kinases receptors ErbB3 and ErbB4, initiating signaling cascades. The other NRGs proteins bind one or the other or both of these ErbBs. NRG-1 has multiple functions: in the brain it regulates various processes such as radial glia formation and neuronal migration, dendritic development, and expression of neurotransmitters receptors, while in the peripheral nervous system NRG-1 regulates processes such as target cell differentiation, and Schwann cell survival. There are many NRG-1 isoforms which arise from the alternative splicing of mRNA. Less is known of the functions of the other NRGs. NRG-2 and NRG-3 are expressed predominantly in the nervous system. NRG-2 is expressed by motor neurons and terminal Schwann cells, and is concentrated near synaptic sites and may be a signal that regulates synaptic differentiation. NRG-4 has been shown to direct pancreatic islet cell development towards the delta-cell lineage.


Pssm-ID: 409408 [Multi-domain]  Cd Length: 92  Bit Score: 41.73  E-value: 3.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372925 105 PRVKAVKSSEhINEGETAMLVCKSESVPPVTDWAWYKitdsEDKALMNGSESRFFVSSSQGRSELHIENLNMEaDPGQYR 184
Cdd:cd05750   1 PKLKEMKSQT-VQEGSKLVLKCEATSENPSPRYRWFK----DGKELNRKRPKNIKIRNKKKNSELQINKAKLE-DSGEYT 74

                        90
                ....*....|....*...
gi 38372925 185 CNGTSSKGSDQAIITLRV 202
Cdd:cd05750  75 CVVENILGKDTVTGNVTV 92
IgI_5_KIRREL3 cd05898
Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; ...
 103-201 9.44e-05

Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (Neph1). These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development. Neph1 and 2 may mediate axonal guidance and synapse formation in certain areas of the CNS. In the kidney they participate in the formation of the slit diaphragm.


Pssm-ID: 409479  Cd Length: 98  Bit Score: 40.70  E-value: 9.44e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372925 103 GPPRVKAvKSSEHINEGETAMLVCKSESVPPVTD--WAWykitdsEDKALMNGSESRFFV----SSSQGRSELHIENLnM 176
Cdd:cd05898   1 GPPIISS-EQVQYAVRGERGKVKCFIGSTPPPDRiaWAW------KENVLESGTLERYTVertsTGSGVLSTLTINNI-M 72

                        90       100
                ....*....|....*....|....*.
gi 38372925 177 EAD-PGQYRCNGTSSKGSDQAIITLR 201
Cdd:cd05898  73 EADfQTHYNCTAWNSFGSGTAIIQLE 98
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 112-197 1.23e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 40.40  E-value: 1.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372925 112 SSEHINEGETAMLVCKSESVPPVTDWAWYK-----------ITDSEDKALMNGSESRFFVSSSQG-RSELHIENLNMEaD 179
Cdd:cd00099   6 RSLSVQEGESVTLSCEVSSSFSSTYIYWYRqkpgqgpefliYLSSSKGKTKGGVPGRFSGSRDGTsSFSLTISNLQPE-D 84

                        90
                ....*....|....*...
gi 38372925 180 PGQYRCNGTSSKGSDQAI 197
Cdd:cd00099  85 SGTYYCAVSESGGTDKLT 102
Ig3_L1-CAM_like cd05731
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar ...
 112-203 2.38e-04

Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; The members here are composed of the third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, and spastic paraplegia type 1, that involves abnormalities of axonal growth. This group also contains the chicken neuron-glia cell adhesion molecule, Ng-CAM and human neurofascin.


Pssm-ID: 409394 [Multi-domain]  Cd Length: 83  Bit Score: 38.93  E-value: 2.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372925 112 SSEHINEGETAMLVCKSESVPpvTDW-AWYKITDSedkaLMNGsesRFFVSSSQgrSELHIENLNmEADPGQYRCNGTSS 190
Cdd:cd05731   3 SSTMVLRGGVLLLECIAEGLP--TPDiRWIKLGGE----LPKG---RTKFENFN--KTLKIENVS-EADSGEYQCTASNT 70

                        90
                ....*....|...
gi 38372925 191 KGSDQAIITLRVR 203
Cdd:cd05731  71 MGSARHTISVTVE 83
IgI_1_NCAM-1_like cd04977
First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1, and similar ...
 106-202 1.74e-03

First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1. NCAM-1 plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM) and heterophilic (NCAM-nonNCAM) interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves the Ig1, Ig2, and Ig3 domains. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions), through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain. Also included in this group is NCAM-2 (also known as OCAM/mamFas II and RNCAM). NCAM-2 is differentially expressed in the developing and mature olfactory epithelium (OE). This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409366  Cd Length: 95  Bit Score: 36.85  E-value: 1.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38372925 106 RVKAVKSSEHINEGETAMLVCKSESVPPVTDWawykiTDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEaDPGQYRC 185
Cdd:cd04977   2 QVKIIPSYAEISVGESKFFLCKVSGDAKNINW-----VSPNGEKVLTKHGNLKVVNHGSVLSSLTIYNANIN-DAGIYKC 75

                        90
                ....*....|....*...
gi 38372925 186 NGTSSKGSD-QAIITLRV 202
Cdd:cd04977  76 VATNGKGTEsEATVKLDI 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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