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Conserved domains on  [gi|383397573|gb|AFH22356|]
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hypothetical protein OSG_eHP23_00135 [environmental Halophage eHP-23]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR super family cl43541
DNA-binding transcriptional regulator, MarR family [Transcription];
39-113 8.89e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


The actual alignment was detected with superfamily member COG1846:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.87  E-value: 8.89e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 383397573  39 VLKALNGMGlaSCTINELAKETlaGWEKSTISGRLNDLRDHDLVVKAGKRDDkysGRKSQTnMITEKGKNYLDEL 113
Cdd:COG1846   43 VLAALAEAG--GLTQSELAERL--GLTKSTVSRLLDRLEEKGLVEREPDPED---RRAVLV-RLTEKGRALLEEA 109
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
39-113 8.89e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.87  E-value: 8.89e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 383397573  39 VLKALNGMGlaSCTINELAKETlaGWEKSTISGRLNDLRDHDLVVKAGKRDDkysGRKSQTnMITEKGKNYLDEL 113
Cdd:COG1846   43 VLAALAEAG--GLTQSELAERL--GLTKSTVSRLLDRLEEKGLVEREPDPED---RRAVLV-RLTEKGRALLEEA 109
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-91 9.89e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 35.26  E-value: 9.89e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 383397573   38 AVLKALNGMGlaSCTINELAKETlaGWEKSTISGRLNDLRDHDLVVKAGKRDDK 91
Cdd:pfam12802   9 RVLLALARNP--GLTVAELARRL--GISKQTVSRLVKRLEAKGLVEREPSPADR 58
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
39-113 8.89e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.87  E-value: 8.89e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 383397573  39 VLKALNGMGlaSCTINELAKETlaGWEKSTISGRLNDLRDHDLVVKAGKRDDkysGRKSQTnMITEKGKNYLDEL 113
Cdd:COG1846   43 VLAALAEAG--GLTQSELAERL--GLTKSTVSRLLDRLEEKGLVEREPDPED---RRAVLV-RLTEKGRALLEEA 109
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-91 9.89e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 35.26  E-value: 9.89e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 383397573   38 AVLKALNGMGlaSCTINELAKETlaGWEKSTISGRLNDLRDHDLVVKAGKRDDK 91
Cdd:pfam12802   9 RVLLALARNP--GLTVAELARRL--GISKQTVSRLVKRLEAKGLVEREPSPADR 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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