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Conserved domains on  [gi|38327599|ref|NP_937870|]
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regulator of G-protein signaling 12 isoform 3 [Homo sapiens]

Protein Classification

regulator of G-protein signaling 12( domain architecture ID 12961912)

regulator of G-protein signaling 12 is an RGS protein (regulator of G-protein signaling) which increases the GTPase activity of Gi class G-protein alpha subunits; it is a multifunctional protein mediating interactions with its PTB domain, among others, and may be part of signal termination mechanisms in G-protein-coupled pathways

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGS_RGS12 cd08742
Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of ...
 68-182 8.21e-82

Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS12 protein. RGS12 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS12 belong to the R12 RGS subfamily, which includes RGS10 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS12 exist in multiple splice variants: RGS12s (short) contains the core RGS/RBD/GoLoco domains, while RGS12L (long) has additional N-terminal PDZ and PTB domains. RGS12 splice variants show distinct expression patterns, suggesting that they have discrete functions during mouse embryogenesis. RGS12 also may play a critical role in coordinating Ras-dependent signals that are required for promoting and maintaining neuronal differentiation.


:

Pssm-ID: 188696  Cd Length: 115  Bit Score: 256.91  E-value: 8.21e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  68 FERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVL 147
Cdd:cd08742   1 FERLLQDPVGVRYFSEFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDIL 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 38327599 148 RAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08742  81 NAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 115
RGS12_usC pfam16612
C-terminal unstructured region of RGS12; RGS12_usC is a region of Regulator of G-protein ...
 591-728 5.24e-64

C-terminal unstructured region of RGS12; RGS12_usC is a region of Regulator of G-protein signalling 12 proteins that is natively unstructured and lies at the very C-terminus. It has a highly conserved central section. The function is not known.


:

Pssm-ID: 465198  Cd Length: 146  Bit Score: 210.48  E-value: 5.24e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599   591 KGFSKRSATGNGRESASQPGEQWEPVQESSDSPSTSPGSASSPPGPPGTTPPGQKSPSGPFCTPQSPVSLAQEGTAQIWK 670
Cdd:pfam16612   1 KGLSKRSGKGNGKDKAAQPGGRQEPAQSYNESSAKSPGSAESRPRPPGTTLPGQKSPSVPFSAPLSPIPHAQEGSAQIWK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38327599   671 RQSQEVEAGGIQTVEDEHVAELTLMGEGDISSPNSTLLPPPSTP--------QEVPGPSRPGSGTH 728
Cdd:pfam16612  81 RQSRELEAEGIQTVEDENVADLTLVGEGDISSPNSTLLPPPPTPpsdaskltQDNPGPPRPGTGAR 146
RGS12_us1 pfam16613
Unstructured region of RGS12; RGS12_us1 is a region of Regulator of G-protein signalling 12 ...
 188-303 4.41e-55

Unstructured region of RGS12; RGS12_us1 is a region of Regulator of G-protein signalling 12 proteins that is natively unstructured and lies N-terminal to other such regions in UniProt:E1BPP4. It is very glycine-rich, and the function is not known.


:

Pssm-ID: 465199  Cd Length: 118  Bit Score: 185.12  E-value: 4.41e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599   188 VEGRALPDSQQVPSSPASKHSLGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREH 267
Cdd:pfam16613   1 VEGRPLPDPQQVPSSPTSKHSVGSDRSNISTPKKLSKKSKSGRSLNEESGEEDSERKKKGAFFSWSRNKSFGKSQKKREN 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 38327599   268 GDHADDALHANGGLCRRESQGSVSSAGSLDLSEACR 303
Cdd:pfam16613  81 GEINNDSSHINGGSYRRESQGSLSSGASLELGDSSR 116
Ubl1_cv_Nsp3_N-like super family cl28922
first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV ...
 384-456 2.04e-44

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.


The actual alignment was detected with superfamily member cd17138:

Pssm-ID: 475130  Cd Length: 73  Bit Score: 153.92  E-value: 2.04e-44
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38327599 384 RTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLGAPISSLDGQRVVLEEK 456
Cdd:cd17138   1 RTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLNLNELVARISGEKEPLDLGLPISNLDGQRVVLEEK 73
RBD1_RGS12 cd17136
Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12); RGS12 (regulator of ...
 314-383 1.25e-39

Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12); RGS12 (regulator of G protein signaling 12) is a multidomain RGS protein with numerous signaling regulatory elements. In addition to a central RGS domain which is responsible for GAP activity, the long RGS12 splice variant contains a PDZ (PSD-95/Discs-large/ZO-1 homology) domain capable of binding the interleukin-8 receptor B (CXCR2) or its own C-terminal, a phosphotyrosine-binding (PTB) domain that associates with tyrosine-phosphorylated N-type calcium channel, two tandem Ras-binding domains (RBDs) that may integrate signaling pathways involving both heterotrimeric and monomeric G-proteins, and a GoLoco (G-alpha-i/o-Loco) interaction motif which has guanine nucleotide dissociation inhibitor (GDI) activity toward G-alpha-i subunits. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS proteins belong to a large family of GTpase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes.


:

Pssm-ID: 340656  Cd Length: 70  Bit Score: 140.27  E-value: 1.25e-39
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599 314 KHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLEK 383
Cdd:cd17136   1 KHCCVNLPDGSSCAVAIKPGVSIREMLSGLCEKLGINLAAVDLFLVGGDKPLVLDQDSSTLESRDLRLEK 70
RGS12_us2 pfam16611
Unstructured region between RBD and GoLoco; RGs12_us2 is a region of Regulator of G-protein ...
 458-532 1.59e-30

Unstructured region between RBD and GoLoco; RGs12_us2 is a region of Regulator of G-protein signalling 12 proteins that is natively unstructured and lies between an RBD domain and a GoLoco motif, pfam02196 and pfam02188. The function is not known.


:

Pssm-ID: 435461  Cd Length: 72  Bit Score: 114.55  E-value: 1.59e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38327599   458 PSRGKasaDKQKGVPVKQNTAVNSSSRNHSATGEERTLGKSNSIKIKGENGKNARDPRLSKREESIAKIGKKKYQ 532
Cdd:pfam16611   1 PARGK---DKQKGVSLKQSPAVASNTRNQSTTGEERPLGKSNSIKIKGENGKNSRDARLLKREESVAKTGKRKYQ 72
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 540-561 6.44e-06

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


:

Pssm-ID: 214645  Cd Length: 23  Bit Score: 43.26  E-value: 6.44e-06
                           10        20
                   ....*....|....*....|..
gi 38327599    540 EEFFELISKAQSNRADDQRGLL 561
Cdd:smart00390   2 EDLFDLLLRMQSSRMDDQRCEL 23
 
Name Accession Description Interval E-value
RGS_RGS12 cd08742
Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of ...
 68-182 8.21e-82

Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS12 protein. RGS12 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS12 belong to the R12 RGS subfamily, which includes RGS10 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS12 exist in multiple splice variants: RGS12s (short) contains the core RGS/RBD/GoLoco domains, while RGS12L (long) has additional N-terminal PDZ and PTB domains. RGS12 splice variants show distinct expression patterns, suggesting that they have discrete functions during mouse embryogenesis. RGS12 also may play a critical role in coordinating Ras-dependent signals that are required for promoting and maintaining neuronal differentiation.


Pssm-ID: 188696  Cd Length: 115  Bit Score: 256.91  E-value: 8.21e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  68 FERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVL 147
Cdd:cd08742   1 FERLLQDPVGVRYFSEFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDIL 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 38327599 148 RAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08742  81 NAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 115
RGS12_usC pfam16612
C-terminal unstructured region of RGS12; RGS12_usC is a region of Regulator of G-protein ...
 591-728 5.24e-64

C-terminal unstructured region of RGS12; RGS12_usC is a region of Regulator of G-protein signalling 12 proteins that is natively unstructured and lies at the very C-terminus. It has a highly conserved central section. The function is not known.


Pssm-ID: 465198  Cd Length: 146  Bit Score: 210.48  E-value: 5.24e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599   591 KGFSKRSATGNGRESASQPGEQWEPVQESSDSPSTSPGSASSPPGPPGTTPPGQKSPSGPFCTPQSPVSLAQEGTAQIWK 670
Cdd:pfam16612   1 KGLSKRSGKGNGKDKAAQPGGRQEPAQSYNESSAKSPGSAESRPRPPGTTLPGQKSPSVPFSAPLSPIPHAQEGSAQIWK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38327599   671 RQSQEVEAGGIQTVEDEHVAELTLMGEGDISSPNSTLLPPPSTP--------QEVPGPSRPGSGTH 728
Cdd:pfam16612  81 RQSRELEAEGIQTVEDENVADLTLVGEGDISSPNSTLLPPPPTPpsdaskltQDNPGPPRPGTGAR 146
RGS12_us1 pfam16613
Unstructured region of RGS12; RGS12_us1 is a region of Regulator of G-protein signalling 12 ...
 188-303 4.41e-55

Unstructured region of RGS12; RGS12_us1 is a region of Regulator of G-protein signalling 12 proteins that is natively unstructured and lies N-terminal to other such regions in UniProt:E1BPP4. It is very glycine-rich, and the function is not known.


Pssm-ID: 465199  Cd Length: 118  Bit Score: 185.12  E-value: 4.41e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599   188 VEGRALPDSQQVPSSPASKHSLGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREH 267
Cdd:pfam16613   1 VEGRPLPDPQQVPSSPTSKHSVGSDRSNISTPKKLSKKSKSGRSLNEESGEEDSERKKKGAFFSWSRNKSFGKSQKKREN 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 38327599   268 GDHADDALHANGGLCRRESQGSVSSAGSLDLSEACR 303
Cdd:pfam16613  81 GEINNDSSHINGGSYRRESQGSLSSGASLELGDSSR 116
RBD2_RGS12 cd17138
Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12); RGS12 (regulator of ...
 384-456 2.04e-44

Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12); RGS12 (regulator of G-protein signaling 12) is a multidomain RGS protein with numerous signaling regulatory elements. In addition to a central RGS domain which is responsible for GAP activity, the long RGS12 splice variant contains a PDZ (PSD-95/Discs-large/ZO-1 homology) domain capable of binding the interleukin-8 receptor B (CXCR2) or its own C-terminal, a phosphotyrosine-binding (PTB) domain that associates with tyrosine-phosphorylated N-type calcium channel, two tandem Ras-binding domains (RBDs) that may integrate signaling pathways involving both heterotrimeric and monomeric G-proteins, and a GoLoco (G-alpha-i/o-Loco) interaction motif which has guanine nucleotide dissociation inhibitor (GDI) activity toward G-alpha-i subunits. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS proteins belong to a large family of GTpase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes.


Pssm-ID: 340658  Cd Length: 73  Bit Score: 153.92  E-value: 2.04e-44
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38327599 384 RTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLGAPISSLDGQRVVLEEK 456
Cdd:cd17138   1 RTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLNLNELVARISGEKEPLDLGLPISNLDGQRVVLEEK 73
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 67-183 2.78e-40

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 143.91  E-value: 2.78e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599    67 SFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHvpAHDKKELSYRAREIFSKFLCSKATTPVNIDSQ--AQLAD 144
Cdd:pfam00615   1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKK--ADPDEERLKKAKEIYNEFLAPGSPKEINLDSDlrEEIRE 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 38327599   145 DVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQEC 183
Cdd:pfam00615  79 NLEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117
RBD1_RGS12 cd17136
Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12); RGS12 (regulator of ...
 314-383 1.25e-39

Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12); RGS12 (regulator of G protein signaling 12) is a multidomain RGS protein with numerous signaling regulatory elements. In addition to a central RGS domain which is responsible for GAP activity, the long RGS12 splice variant contains a PDZ (PSD-95/Discs-large/ZO-1 homology) domain capable of binding the interleukin-8 receptor B (CXCR2) or its own C-terminal, a phosphotyrosine-binding (PTB) domain that associates with tyrosine-phosphorylated N-type calcium channel, two tandem Ras-binding domains (RBDs) that may integrate signaling pathways involving both heterotrimeric and monomeric G-proteins, and a GoLoco (G-alpha-i/o-Loco) interaction motif which has guanine nucleotide dissociation inhibitor (GDI) activity toward G-alpha-i subunits. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS proteins belong to a large family of GTpase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes.


Pssm-ID: 340656  Cd Length: 70  Bit Score: 140.27  E-value: 1.25e-39
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599 314 KHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLEK 383
Cdd:cd17136   1 KHCCVNLPDGSSCAVAIKPGVSIREMLSGLCEKLGINLAAVDLFLVGGDKPLVLDQDSSTLESRDLRLEK 70
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 67-183 5.07e-39

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 140.48  E-value: 5.07e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599     67 SFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHvpAHDKKELSYRAREIFSKFLCSKATTPVNIDSQ--AQLAD 144
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKK--AEDDEERIAKAREIYDKFLSPNAPKEVNLDSDlrEKIEE 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 38327599    145 DVLRA-PHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQEC 183
Cdd:smart00315  79 NLESEePPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS12_us2 pfam16611
Unstructured region between RBD and GoLoco; RGs12_us2 is a region of Regulator of G-protein ...
 458-532 1.59e-30

Unstructured region between RBD and GoLoco; RGs12_us2 is a region of Regulator of G-protein signalling 12 proteins that is natively unstructured and lies between an RBD domain and a GoLoco motif, pfam02196 and pfam02188. The function is not known.


Pssm-ID: 435461  Cd Length: 72  Bit Score: 114.55  E-value: 1.59e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38327599   458 PSRGKasaDKQKGVPVKQNTAVNSSSRNHSATGEERTLGKSNSIKIKGENGKNARDPRLSKREESIAKIGKKKYQ 532
Cdd:pfam16611   1 PARGK---DKQKGVSLKQSPAVASNTRNQSTTGEERPLGKSNSIKIKGENGKNSRDARLLKREESVAKTGKRKYQ 72
RBD smart00455
Raf-like Ras-binding domain;
315-384 1.65e-23

Raf-like Ras-binding domain;


Pssm-ID: 128731  Cd Length: 70  Bit Score: 94.27  E-value: 1.65e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599    315 HCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLEKR 384
Cdd:smart00455   1 TCKVHLPDNQRTVVKVRPGKTVRDALAKALKKRGLNPECCVVRLRGEKKPLDLNQPISSLDGQELVVEEL 70
RBD pfam02196
Raf-like Ras-binding domain;
315-382 1.97e-22

Raf-like Ras-binding domain;


Pssm-ID: 460485  Cd Length: 69  Bit Score: 91.43  E-value: 1.97e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38327599   315 HCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDK-PLVLHQDSSILESRDLRLE 382
Cdd:pfam02196   1 LCRVYLPDGQRTVVQVRPGETVRDALSKLCKKRGLNPEACDVYLVGGDKyPLDLDTDSSTLEGEEVRVE 69
RBD smart00455
Raf-like Ras-binding domain;
387-456 1.76e-20

Raf-like Ras-binding domain;


Pssm-ID: 128731  Cd Length: 70  Bit Score: 85.80  E-value: 1.76e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599    387 FRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLGAPISSLDGQRVVLEEK 456
Cdd:smart00455   1 TCKVHLPDNQRTVVKVRPGKTVRDALAKALKKRGLNPECCVVRLRGEKKPLDLNQPISSLDGQELVVEEL 70
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 540-561 6.44e-06

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 43.26  E-value: 6.44e-06
                           10        20
                   ....*....|....*....|..
gi 38327599    540 EEFFELISKAQSNRADDQRGLL 561
Cdd:smart00390   2 EDLFDLLLRMQSSRMDDQRCEL 23
GoLoco pfam02188
GoLoco motif;
540-561 8.65e-06

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 42.79  E-value: 8.65e-06
                          10        20
                  ....*....|....*....|..
gi 38327599   540 EEFFELISKAQSNRADDQRGLL 561
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 568-797 6.42e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 6.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599   568 LPEFLRLPPGSTELTLPTPAAVAKGFSK-RSATGNGRESA--SQPGEQWE--PVQESSDSPSTSPGSASSPPGPPGTTPP 642
Cdd:PHA03307  134 LSEMLRPVGSPGPPPAASPPAAGASPAAvASDAASSRQAAlpLSSPEETAraPSSPPAEPPPSTPPAAASPRPPRRSSPI 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599   643 GQKSPSGPFCTPQSPVSLAQEGTAQIWKRQSQEVEAGGIQTVEDEHVAELTLMG------EGDISSPNSTLLPPPSTPQE 716
Cdd:PHA03307  214 SASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTriweasGWNGPSSRPGPASSSSSPRE 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599   717 ---VPGPSRPGSGTHGSRDLPVNRIIDVDLVTGSAPGRDG-GIAGAQAGPGRSQASGGPPTSDLPGLGPVP------GEP 786
Cdd:PHA03307  294 rspSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSeSSRGAAVSPGPSPSRSPSPSRPPPPADPSSprkrprPSR 373

                         250
                  ....*....|.
gi 38327599   787 AKPKTSAHHAT 797
Cdd:PHA03307  374 APSSPAASAGR 384
 
Name Accession Description Interval E-value
RGS_RGS12 cd08742
Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of ...
 68-182 8.21e-82

Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS12 protein. RGS12 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS12 belong to the R12 RGS subfamily, which includes RGS10 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS12 exist in multiple splice variants: RGS12s (short) contains the core RGS/RBD/GoLoco domains, while RGS12L (long) has additional N-terminal PDZ and PTB domains. RGS12 splice variants show distinct expression patterns, suggesting that they have discrete functions during mouse embryogenesis. RGS12 also may play a critical role in coordinating Ras-dependent signals that are required for promoting and maintaining neuronal differentiation.


Pssm-ID: 188696  Cd Length: 115  Bit Score: 256.91  E-value: 8.21e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  68 FERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVL 147
Cdd:cd08742   1 FERLLQDPVGVRYFSEFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDIL 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 38327599 148 RAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08742  81 NAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 115
RGS_R12-like cd08706
Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS ...
 68-182 1.65e-74

Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R12 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling, controlled by RGS domain, accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP that results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R12 RGS subfamily includes RGS10, RGS12 and RGS14 all of which are highly selective for G-alpha-i1 over G-alpha-q.


Pssm-ID: 188661  Cd Length: 113  Bit Score: 237.22  E-value: 1.65e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  68 FERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPahDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVL 147
Cdd:cd08706   1 FERLLQDPVGVKYFTEFLKKEFSEENILFWQACEKFKKIP--DKKQLVQEAREIYDTFLSSKASSPVNIDSQAQLAEEML 78

                        90       100       110
                ....*....|....*....|....*....|....*
gi 38327599 148 RAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08706  79 EEPHPDMFQKQQLQIFNLMKFDSYSRFLKSPLYQQ 113
RGS_RGS14 cd08743
Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of ...
 58-186 3.20e-66

Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS14 protein. RGS14 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS14 belong to the R12 RGS subfamily, which includes RGS10 and RGS12, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS14 binds and regulates the subcellular localization and activities of H-Ras and Raf kinases in cells and thereby integrates G protein and Ras/Raf signaling pathways.


Pssm-ID: 188697  Cd Length: 129  Bit Score: 216.05  E-value: 3.20e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  58 ERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNID 137
Cdd:cd08743   1 EKSVASWAVSFERLLQDPLGVEYFTEFLKKEFSAENVNFWKACERFQQIPASDTQQLAQEARKIYNEFLSSSSQSPVNID 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 38327599 138 SQAQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILA 186
Cdd:cd08743  81 QQAWIGEDMLATPSPDMFRAQQLQIFNLMKFDSYARFVKSPLYQDCLLA 129
RGS12_usC pfam16612
C-terminal unstructured region of RGS12; RGS12_usC is a region of Regulator of G-protein ...
 591-728 5.24e-64

C-terminal unstructured region of RGS12; RGS12_usC is a region of Regulator of G-protein signalling 12 proteins that is natively unstructured and lies at the very C-terminus. It has a highly conserved central section. The function is not known.


Pssm-ID: 465198  Cd Length: 146  Bit Score: 210.48  E-value: 5.24e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599   591 KGFSKRSATGNGRESASQPGEQWEPVQESSDSPSTSPGSASSPPGPPGTTPPGQKSPSGPFCTPQSPVSLAQEGTAQIWK 670
Cdd:pfam16612   1 KGLSKRSGKGNGKDKAAQPGGRQEPAQSYNESSAKSPGSAESRPRPPGTTLPGQKSPSVPFSAPLSPIPHAQEGSAQIWK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38327599   671 RQSQEVEAGGIQTVEDEHVAELTLMGEGDISSPNSTLLPPPSTP--------QEVPGPSRPGSGTH 728
Cdd:pfam16612  81 RQSRELEAEGIQTVEDENVADLTLVGEGDISSPNSTLLPPPPTPpsdaskltQDNPGPPRPGTGAR 146
RGS12_us1 pfam16613
Unstructured region of RGS12; RGS12_us1 is a region of Regulator of G-protein signalling 12 ...
 188-303 4.41e-55

Unstructured region of RGS12; RGS12_us1 is a region of Regulator of G-protein signalling 12 proteins that is natively unstructured and lies N-terminal to other such regions in UniProt:E1BPP4. It is very glycine-rich, and the function is not known.


Pssm-ID: 465199  Cd Length: 118  Bit Score: 185.12  E-value: 4.41e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599   188 VEGRALPDSQQVPSSPASKHSLGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREH 267
Cdd:pfam16613   1 VEGRPLPDPQQVPSSPTSKHSVGSDRSNISTPKKLSKKSKSGRSLNEESGEEDSERKKKGAFFSWSRNKSFGKSQKKREN 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 38327599   268 GDHADDALHANGGLCRRESQGSVSSAGSLDLSEACR 303
Cdd:pfam16613  81 GEINNDSSHINGGSYRRESQGSLSSGASLELGDSSR 116
RBD2_RGS12 cd17138
Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12); RGS12 (regulator of ...
 384-456 2.04e-44

Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12); RGS12 (regulator of G-protein signaling 12) is a multidomain RGS protein with numerous signaling regulatory elements. In addition to a central RGS domain which is responsible for GAP activity, the long RGS12 splice variant contains a PDZ (PSD-95/Discs-large/ZO-1 homology) domain capable of binding the interleukin-8 receptor B (CXCR2) or its own C-terminal, a phosphotyrosine-binding (PTB) domain that associates with tyrosine-phosphorylated N-type calcium channel, two tandem Ras-binding domains (RBDs) that may integrate signaling pathways involving both heterotrimeric and monomeric G-proteins, and a GoLoco (G-alpha-i/o-Loco) interaction motif which has guanine nucleotide dissociation inhibitor (GDI) activity toward G-alpha-i subunits. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS proteins belong to a large family of GTpase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes.


Pssm-ID: 340658  Cd Length: 73  Bit Score: 153.92  E-value: 2.04e-44
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38327599 384 RTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLGAPISSLDGQRVVLEEK 456
Cdd:cd17138   1 RTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLNLNELVARISGEKEPLDLGLPISNLDGQRVVLEEK 73
RGS_RGS10 cd08741
Regulator of G protein signaling (RGS) domain found in the RGS10 protein; RGS (Regulator of ...
 68-180 9.97e-42

Regulator of G protein signaling (RGS) domain found in the RGS10 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS10 protein. RGS10 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS10 belong to the R12 RGS subfamily, which includes RGS12 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS10 exists in 2 splice isoforms. RGS10A is specifically expressed in osteoclasts and is a key component in the RANKL signaling mechanism for osteoclast differentiation, whereas RGS10B expressed in brain and in immune tissues and has been implicated in diverse processes including: promoting of dopaminergic neuron survival via regulation of the microglial inflammatory response, modulation of presynaptic and postsynaptic G-protein signalling, as well as a possible role in regulation of gene expression.


Pssm-ID: 188695  Cd Length: 113  Bit Score: 147.88  E-value: 9.97e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  68 FERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHvpAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVL 147
Cdd:cd08741   1 LENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKK--MQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKIL 78

                        90       100       110
                ....*....|....*....|....*....|...
gi 38327599 148 RAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLY 180
Cdd:cd08741  79 EEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLF 111
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 67-183 2.78e-40

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 143.91  E-value: 2.78e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599    67 SFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHvpAHDKKELSYRAREIFSKFLCSKATTPVNIDSQ--AQLAD 144
Cdd:pfam00615   1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKK--ADPDEERLKKAKEIYNEFLAPGSPKEINLDSDlrEEIRE 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 38327599   145 DVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQEC 183
Cdd:pfam00615  79 NLEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117
RBD1_RGS12 cd17136
Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12); RGS12 (regulator of ...
 314-383 1.25e-39

Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12); RGS12 (regulator of G protein signaling 12) is a multidomain RGS protein with numerous signaling regulatory elements. In addition to a central RGS domain which is responsible for GAP activity, the long RGS12 splice variant contains a PDZ (PSD-95/Discs-large/ZO-1 homology) domain capable of binding the interleukin-8 receptor B (CXCR2) or its own C-terminal, a phosphotyrosine-binding (PTB) domain that associates with tyrosine-phosphorylated N-type calcium channel, two tandem Ras-binding domains (RBDs) that may integrate signaling pathways involving both heterotrimeric and monomeric G-proteins, and a GoLoco (G-alpha-i/o-Loco) interaction motif which has guanine nucleotide dissociation inhibitor (GDI) activity toward G-alpha-i subunits. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS proteins belong to a large family of GTpase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes.


Pssm-ID: 340656  Cd Length: 70  Bit Score: 140.27  E-value: 1.25e-39
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599 314 KHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLEK 383
Cdd:cd17136   1 KHCCVNLPDGSSCAVAIKPGVSIREMLSGLCEKLGINLAAVDLFLVGGDKPLVLDQDSSTLESRDLRLEK 70
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 67-183 5.07e-39

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 140.48  E-value: 5.07e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599     67 SFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHvpAHDKKELSYRAREIFSKFLCSKATTPVNIDSQ--AQLAD 144
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKK--AEDDEERIAKAREIYDKFLSPNAPKEVNLDSDlrEKIEE 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 38327599    145 DVLRA-PHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQEC 183
Cdd:smart00315  79 NLESEePPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS_R7-like cd08705
Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS ...
 60-182 7.65e-38

Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R7 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R7 subfamily includes RGS6, RGS7, RGS9, and RGS11, all of which, in humans, are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes. In addition, R7 proteins were found to bind many other proteins outside of the G protein signaling pathways including: m-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, guanylyl cyclase, among others.


Pssm-ID: 188660  Cd Length: 121  Bit Score: 136.98  E-value: 7.65e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  60 RVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKElsyRAREIFSKFLCSKATTPVNIDSQ 139
Cdd:cd08705   1 RVKRWGFSFSELLKDPVGREQFLKFLEKEFSGENLRFWEACQDLKYGPQSQVPE---KVQEIYQEFLAPGAPSWINIDSK 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 38327599 140 -AQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08705  78 tMEITLKNLKDPHRYTFDAAQEHIYMLMKKDSYPRFLRSDIYKE 121
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 72-182 5.75e-34

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 125.97  E-value: 5.75e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  72 LQDPVGVRYFSDFLRKEFSEENILFWQACEYFnHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQA-QLADDVLRAP 150
Cdd:cd07440   1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKF-KKTTSSDEELKSKAKEIYDKYISKDAPKEINIPESIrEEIEENLEEP 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 38327599 151 --HPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd07440  80 ypDPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113
RGS12_us2 pfam16611
Unstructured region between RBD and GoLoco; RGs12_us2 is a region of Regulator of G-protein ...
 458-532 1.59e-30

Unstructured region between RBD and GoLoco; RGs12_us2 is a region of Regulator of G-protein signalling 12 proteins that is natively unstructured and lies between an RBD domain and a GoLoco motif, pfam02196 and pfam02188. The function is not known.


Pssm-ID: 435461  Cd Length: 72  Bit Score: 114.55  E-value: 1.59e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38327599   458 PSRGKasaDKQKGVPVKQNTAVNSSSRNHSATGEERTLGKSNSIKIKGENGKNARDPRLSKREESIAKIGKKKYQ 532
Cdd:pfam16611   1 PARGK---DKQKGVSLKQSPAVASNTRNQSTTGEERPLGKSNSIKIKGENGKNSRDARLLKREESVAKTGKRKYQ 72
RBD2_RGS12_like cd17067
Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12) and similar proteins; ...
 384-456 4.82e-29

Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12) and similar proteins; Regulator of G-protein signaling (RGS) proteins belong to a large family of GTPase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes. The RGS12-like subfamily is composed of RGS12 and RGS14, with multidomain architectures including a RGS domain, two tandem Ras-binding domains (RBDs), and a second Galpha interacting domain, the GoLoco motif. The RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. Ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair in eukaryotes.


Pssm-ID: 340587  Cd Length: 72  Bit Score: 110.34  E-value: 4.82e-29
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38327599 384 RTLFRLDLvPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLGAPISSLDGQRVVLEEK 456
Cdd:cd17067   1 RVLFRLDL-PNKKIIGVKAKPTKTLAEVLRPILAKYGYKLDQVVVHLAGTQVPLDLGIPVSSIDNQRLVVETK 72
RGS_RGS11 cd08740
Regulator of G protein signaling (RGS) domain found in the RGS11 protein; The RGS (Regulator ...
 60-187 2.39e-28

Regulator of G protein signaling (RGS) domain found in the RGS11 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS11 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS7, and RGS9, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS11 is expressed exclusively in retinal ON-bipolar neurons in which it forms complexes with G-beta-5 and R7AP (RGS7 anchor protein ) and plays crucial roles in processing the light responses of retinal neurons.


Pssm-ID: 188694  Cd Length: 126  Bit Score: 110.39  E-value: 2.39e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  60 RVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHvpaHDKKELSYRAREIFSKFLCSKATTPVNIDSQ 139
Cdd:cd08740   2 RVERWGFSFRELLNDPVGRKEFLDFLEKEFSAENLSFWEACEELRY---GEQSKIPELVDSVYQQFLAPGATRWVNIDSK 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 38327599 140 A-QLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQEcILAE 187
Cdd:cd08740  79 TmERTLEGLKQPHRYVLDDAQMHIYMLMKKDSYPRFLKSDLYKN-LLAE 126
RBD1_RGS12_like cd01817
Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12) and similar proteins; ...
 314-383 1.58e-27

Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12) and similar proteins; Regulator of G protein signaling (RGS) proteins belong to a large family of GTpase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes. This RGS12-like subfamily is composed of RGS12 and RGS14, with multidomain architectures including a RGS domain, two tandem Ras-binding domains (RBDs), and a second Galpha interacting domain, the GoLoco motif. The RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. Ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair.


Pssm-ID: 340515  Cd Length: 70  Bit Score: 105.70  E-value: 1.58e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599 314 KHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLEK 383
Cdd:cd01817   1 KLCRVILPDGSTTVVQAKPGETIRQLLTRLLEKRGLSYAAFDVFIVGSDKPLDLNEDSSILGGKEVRVEQ 70
RGS_RGS9 cd08739
Regulator of G protein signaling (RGS) domain found in the RGS9 protein; The RGS (Regulator of ...
 60-182 7.83e-27

Regulator of G protein signaling (RGS) domain found in the RGS9 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS9 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS7, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS9 forms constitutive complexes with G-beta-5 subunit and controls such fundamental functions as vision and behavior. RGS9 exists in two splice isoforms: RGS9-1 which regulates phototransduction in rods and cones and RGS9-2 which regulates dopamine and opioid signaling in the basal ganglia. In addition, RGS9 was found to bind many other proteins outside of G protein signaling pathways including: mu-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, and guanylyl cyclase, among others.


Pssm-ID: 188693  Cd Length: 121  Bit Score: 105.88  E-value: 7.83e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  60 RVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKElsyRAREIFSKFLCSKATTPVNIDSQ 139
Cdd:cd08739   1 RVERWAFNFSELIRDPKGRQSFQLFLKKEFSGENLGFWEACEDLKYGDQSKVKE---KAEEIYKLFLAPGARRWINIDGK 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 38327599 140 A-QLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08739  78 TmDITVKGLKHPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYKE 121
RGS_RGS6 cd08737
Regulator of G protein signaling (RGS) domain found in the RGS6 protein; The RGS (Regulator of ...
 59-185 4.89e-26

Regulator of G protein signaling (RGS) domain found in the RGS6 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS6 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). Other members of the R7 subfamily (Neuronal RGS) include: RGS7, RGS9, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS6 exists in multiple splice isoforms with identical RGS domains, but possess complete or incomplete GGL domains and distinct N- and C-terminal domains. RGS6 interacts with SCG10, a neuronal growth-associated protein and therefore regulates neuronal differentiation. Another RGS6-binding protein is DMAP1, a component of the Dnmt1 complex involved in repression of newly replicated genes. Mutations of a critical residue required for interaction of RGS6 protein with G proteins did not affect the ability of RGS6 to interact with both SCG10 and DMAP1. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis.


Pssm-ID: 188691  Cd Length: 125  Bit Score: 103.56  E-value: 4.89e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  59 RRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDkkeLSYRAREIFSKFLCSKATTPVNIDS 138
Cdd:cd08737   1 QRVKRWGFSLDEVLKDPVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQD---VAKRVEEIWQEFLAPGAPSAINLDS 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 38327599 139 QA-QLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECIL 185
Cdd:cd08737  78 HSyEKTSQNVKDPGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLL 125
RBD cd01760
Ras-binding domain (RBD), structurally similar to a beta-grasp ubiquitin-like fold; The RBD of ...
 385-455 6.67e-26

Ras-binding domain (RBD), structurally similar to a beta-grasp ubiquitin-like fold; The RBD of the serine/threonine kinase Raf is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. A Raf-like RBD is also present in Regulator of G protein Signaling (RGS12 and RGS14) members of GTPase activating proteins.


Pssm-ID: 340461  Cd Length: 71  Bit Score: 101.33  E-value: 6.67e-26
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38327599 385 TLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLGAPISSLDGQRVVLEE 455
Cdd:cd01760   1 NTFRLFLPNNETSVVVAVKPGKSLHEVLMPVLERHGLQLECVDVFLLGEKAPLDLNTDASSLIGQELRLDF 71
RGS_RZ-like cd08718
Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of ...
 64-181 6.83e-26

Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS.


Pssm-ID: 188673  Cd Length: 118  Bit Score: 102.93  E-value: 6.83e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  64 WAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHvpAHDKKELSYRAREIFSKFLCSKATTPVNIDSQA-QL 142
Cdd:cd08718   1 WAQSFDKLMKSPAGRNVFREFLRTEYSEENMLFWLACEELKK--EANKHVIEEKARLIYEDYISILSPKEVSLDSRVrEV 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 38327599 143 ADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQ 181
Cdd:cd08718  79 INRNMLEPSPHTFDDAQLQIYTLMHRDSYPRFLNSAIYK 117
RGS_RGS19 cd08745
Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator ...
 64-181 6.87e-26

Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS19 protein (also known as GAIP), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, resulting in a reassociation of the alpha-subunit with the beta-gamma-dimer and an inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS20, and its splice variant Ret-RGS. RGS19 participates in regulation of dopamine receptor D2R and D3R, as well as beta-adrenergic receptors .


Pssm-ID: 188699  Cd Length: 118  Bit Score: 102.83  E-value: 6.87e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  64 WAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNhvPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQA-QL 142
Cdd:cd08745   1 WAQSFDKLMKSPAGRNVFREFLRTEYSEENMLFWLACEELK--AEANKHVIDEKARLIYEDYISILSPKEVSLDSRVrEG 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 38327599 143 ADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQ 181
Cdd:cd08745  79 INRKMQEPSSHTFDDAQLQIYTLMHRDSYPRFLNSPIYK 117
RBD cd01760
Ras-binding domain (RBD), structurally similar to a beta-grasp ubiquitin-like fold; The RBD of ...
 314-383 1.54e-25

Ras-binding domain (RBD), structurally similar to a beta-grasp ubiquitin-like fold; The RBD of the serine/threonine kinase Raf is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. A Raf-like RBD is also present in Regulator of G protein Signaling (RGS12 and RGS14) members of GTPase activating proteins.


Pssm-ID: 340461  Cd Length: 71  Bit Score: 100.17  E-value: 1.54e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38327599 314 KHCCIHLPD-GTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLEK 383
Cdd:cd01760   1 NTFRLFLPNnETSVVVAVKPGKSLHEVLMPVLERHGLQLECVDVFLLGEKAPLDLNTDASSLIGQELRLDF 71
RGS_RGS20 cd08746
Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator ...
 61-182 9.66e-25

Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS20 protein (also known as RGSZ1), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP resulting in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins include RGS17, RGS19 (former GAIP), and the splice variant of RGS20, Ret-RGS. RGS20 is expressed exclusively in brain, with the highest concentrations in the temporal lobe and the caudate nucleus and may play a role in signaling regulation in these brain regions. RGS20 acts as a GAP of both G-alpha-z and G-alpha-I and controls signaling in the mu opioid receptor pathway.


Pssm-ID: 188700 [Multi-domain]  Cd Length: 167  Bit Score: 101.60  E-value: 9.66e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  61 VASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHvpAHDKKELSYRAREIFSKFLCSKATTPVNIDSQA 140
Cdd:cd08746  47 VCAWGQSFDKLMLTPAGRNAFREFLRTEFSEENMLFWMACEELKK--EANKSVIEEKARIIYEDYISILSPKEVSLDSRV 124

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 38327599 141 -QLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08746 125 rEVINRNMLEPSQHTFDDAQLQIYTLMHRDSYPRFMNSAIYKN 167
RGS_RGS16 cd08710
Regulator of G protein signaling (RGS) domain found in the RGS16 protein; The RGS (Regulator ...
 68-182 1.57e-24

Regulator of G protein signaling (RGS) domain found in the RGS16 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS16 protein. RGS16 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS16 is a member of the R4/RGS subfamily and interacts with neuronal G-alpha0. RGS16 expression is upregulated by IL-17 of the NF-kappaB signaling pathway in autoimmune B cells.


Pssm-ID: 188665  Cd Length: 114  Bit Score: 98.99  E-value: 1.57e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  68 FERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVpaHDKKELSYRAREIFSKFLCSKATTPVNIDSQA-QLADDV 146
Cdd:cd08710   1 FDLLLNSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKI--RSATKLASRAHHIFEEFIRSEAPKEVNIDHETrELTRTN 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 38327599 147 LRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08710  79 LQAATTSCFDVAQGKTRTLMEKDSYPRFLKSPAYRD 114
RGS_RGS3 cd08713
Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of ...
 69-182 8.03e-24

Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS3 protein. RGS3 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS3 induces apoptosis when overexpressed and is involved in cell migration through interaction with the Ephrin receptor. RGS3 exits as several splice isoforms and interacts with neuroligin, estrogen receptor-alpha, and 14-3-3 outside of the GPCR pathways.


Pssm-ID: 188668  Cd Length: 114  Bit Score: 96.86  E-value: 8.03e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  69 ERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVpaHDKKELSYRAREIFSKFLCSKATTPVNIDSQA-QLADDVL 147
Cdd:cd08713   2 EKLLLHKYGLAVFRAFLQTEFSEENLEFWLACEEYKKI--KSQSKMASRAKKIFAEYIAIQSCKEVNLDSYTrEHTKENL 79

                        90       100       110
                ....*....|....*....|....*....|....*
gi 38327599 148 RAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08713  80 QNPTRGCFDLAQKRIYGLMEKDSYPRFLRSDLYQD 114
RGS_RGS4 cd08714
Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of ...
 68-182 1.20e-23

Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS4 protein. RGS4 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. RGS4 is expressed widely in brain including prefrontal cortex, striatum, locus coeruleus (LC), and hippocampus and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia. RGS4 also is up-regulated in the failing human heart. RGS4 interacts with many binding partners outside of GPCR pathways, including calmodulin, COP, Kir3, PIP, calcium/CaM, PA, ErbB3, and 14-3-3.


Pssm-ID: 188669  Cd Length: 114  Bit Score: 96.49  E-value: 1.20e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  68 FERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKkeLSYRAREIFSKFLCSKATTPVNIDS--QAQLADD 145
Cdd:cd08714   1 LENLINHECGLAAFKAFLKSEYSEENIDFWVSCEDYKKTKSPSK--LSPKARKIYEEFISVQATKEVNLDSctREETSRN 78

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 38327599 146 VLRaPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08714  79 MLE-PTISCFDEAQKKIFTLMEKDSYRRFLKSRFYLD 114
RBD smart00455
Raf-like Ras-binding domain;
315-384 1.65e-23

Raf-like Ras-binding domain;


Pssm-ID: 128731  Cd Length: 70  Bit Score: 94.27  E-value: 1.65e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599    315 HCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLEKR 384
Cdd:smart00455   1 TCKVHLPDNQRTVVKVRPGKTVRDALAKALKKRGLNPECCVVRLRGEKKPLDLNQPISSLDGQELVVEEL 70
RGS_RGS17 cd08744
Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator ...
 64-181 6.82e-23

Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS17 protein, a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. The RZ subfamily of RGS proteins includes RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS. RGS17 is a relatively non-selective GAP for G-alpha-z and other G-alpha-i/o proteins. RGS17 blocks dopamine receptor-mediated inhibition of cAMP accumulation; it also blocks thyrotropin releasing hormone-stimulated Ca++ mobilization. RGS17, like other members of RZ subfamily, can act either as a GAP or as G-protein effector antogonist.


Pssm-ID: 188698  Cd Length: 118  Bit Score: 94.41  E-value: 6.82e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  64 WAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHvpAHDKKELSYRAREIFSKFLCSKATTPVNIDSQA-QL 142
Cdd:cd08744   1 WSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKK--EQNKKVIEEKARLIYEDYISILSPKEVSLDSRVrEV 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 38327599 143 ADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQ 181
Cdd:cd08744  79 INRNLLDPNPHMYEDAQLQIYTLMHRDSFPRFLNSQIYK 117
RGS_RGS5 cd08717
Regulator of G protein signaling (RGS) domain found in the RGS5 protein; The RGS (Regulator of ...
 68-182 1.90e-22

Regulator of G protein signaling (RGS) domain found in the RGS5 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS5 protein. RGS5 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Two splice isoforms of RGS5 has been found: RGS5L (long) which is expressed in smooth muscle cells (pericytes) and heart and RGS5S (short) which is highly expressed in the ciliary body of the eye, kidney, brain, spleen, skeletal muscle, and small intestine. Outside of the GPCR pathway, RGS5 interacts with the 14-3-3 protein.


Pssm-ID: 188672  Cd Length: 114  Bit Score: 93.13  E-value: 1.90e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  68 FERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKkeLSYRAREIFSKFLCSKATTPVNIDsqaQLADDV- 146
Cdd:cd08717   1 LDKLLQNSYGLASFKSFLKSEFSEENIEFWEACEDYKKTKSPLK--MATKAKKIYEEFIQTEAPKEVNID---HFTKDVt 75

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 38327599 147 ---LRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08717  76 mknLVEPSSSSFDLAQKRIFALMEKDSLPRFVRSEFYQE 114
RBD pfam02196
Raf-like Ras-binding domain;
315-382 1.97e-22

Raf-like Ras-binding domain;


Pssm-ID: 460485  Cd Length: 69  Bit Score: 91.43  E-value: 1.97e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38327599   315 HCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDK-PLVLHQDSSILESRDLRLE 382
Cdd:pfam02196   1 LCRVYLPDGQRTVVQVRPGETVRDALSKLCKKRGLNPEACDVYLVGGDKyPLDLDTDSSTLEGEEVRVE 69
RBD1_RGS14 cd17137
Ras-binding domain (RBD) 1 of regulator of G protein signaling 14 (RGS14); RGS12 (regulator of ...
 314-383 3.52e-22

Ras-binding domain (RBD) 1 of regulator of G protein signaling 14 (RGS14); RGS12 (regulator of G protein signaling 14) is a RGS protein with a multidomain structure that allows it to interact with binding partners from multiple signaling pathways. RGS proteins belong to a large family of GTPase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes. RGS14 contains an N-terminal RGS domain, two tandem Ras-binding domains (RBDs) and a G protein regulatory (GPR, also referred to as a GoLoco) motif. RGS14 binds activated H-Ras-GTP through its first RBD and interacts with Rap2-GTP and RAF kinases by the second tandem RBD. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS14 modulates neuronal physiology and all of its binding partners have roles in synaptic plasticity.


Pssm-ID: 340657  Cd Length: 71  Bit Score: 90.64  E-value: 3.52e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38327599 314 KHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGG-DKPLVLHQDSSILESRDLRLEK 383
Cdd:cd17137   1 KYCCVYLPDGTASLASVRPGLTIRDMLSGICEKRGISLPDVKVYLVGNeKKPLVLDQDCSVLTDQEVRLEN 71
RGS_RGS1 cd08715
Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of ...
 68-180 4.10e-22

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.


Pssm-ID: 188670  Cd Length: 114  Bit Score: 91.94  E-value: 4.10e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  68 FERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNhvpAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQ--LADD 145
Cdd:cd08715   1 LEKLLASQTGQNVFRSFLKSEFSEENIEFWLACEDYK---KTESDLLPCKAEEIYKEFVQSDAAKQINIDFRTResTAKK 77

                        90       100       110
                ....*....|....*....|....*....|....*
gi 38327599 146 vLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLY 180
Cdd:cd08715  78 -IKAPTPTCFDEAQKVIYILMERDSYPRFLKSDIY 111
RGS_RGS2 cd08709
Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of ...
 68-182 5.91e-22

Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS2 protein. RGS2 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G- alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS2 plays important roles in the regulation of blood pressure and the pathogenesis of human hypertension, as well as in bone formation in osteoblasts. Outside of the GPCR pathway RGS2 interacts with calmodulin, beta- COP, tubulin, PKG1-alpha, and TRPV6.


Pssm-ID: 188664  Cd Length: 114  Bit Score: 91.65  E-value: 5.91e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  68 FERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKkeLSYRAREIFSKFLCSKATTPVNIDSQAQ--LADD 145
Cdd:cd08709   1 FDELLASKYGVAAFRAFLKSEFSEENIEFWLACEDFKKTKSPQK--LTSKAKKIYTDFIEKEAPKEINIDFQTKtlIAQN 78

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 38327599 146 VLRAPHpDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08709  79 IQEATS-GCFTAAQKRVYSLMENNSYPRFLESEFYQE 114
RGS_RGS7 cd08738
Regulator of G protein signaling (RGS) domain found in the RGS7 protein; The RGS (Regulator of ...
 60-182 7.26e-22

Regulator of G protein signaling (RGS) domain found in the RGS7 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS7 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS9, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. R7 RGS proteins are key modulators of the pharmacological effects of drugs involved in the development of tolerance and addiction. In addition, RGS7 was found to bind a component of the synaptic fusion complex, snapin, and some other proteins outside of G protein signaling pathways.


Pssm-ID: 188692  Cd Length: 121  Bit Score: 91.70  E-value: 7.26e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  60 RVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAhdkKELSYRAREIFSKFLCSKATTPVNIDSQ 139
Cdd:cd08738   1 RVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPI---REVPSRVQEIWQEFLAPGAPSAINLDSK 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 38327599 140 A-QLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08738  78 SyDKTTQNVKDPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQE 121
RBD smart00455
Raf-like Ras-binding domain;
387-456 1.76e-20

Raf-like Ras-binding domain;


Pssm-ID: 128731  Cd Length: 70  Bit Score: 85.80  E-value: 1.76e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599    387 FRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLGAPISSLDGQRVVLEEK 456
Cdd:smart00455   1 TCKVHLPDNQRTVVKVRPGKTVRDALAKALKKRGLNPECCVVRLRGEKKPLDLNQPISSLDGQELVVEEL 70
RGS_RGS18 cd08712
Regulator of G protein signaling (RGS) domain found in the RGS18 protein; The RGS (Regulator ...
 68-180 1.69e-19

Regulator of G protein signaling (RGS) domain found in the RGS18 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS18 protein. RGS18 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS18 is a member of the R4/RGS subfamily and is expressed predominantly in osteoclasts where it acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT signaling pathway. RANKL (receptor activator of nuclear factor B ligand) stimulates osteoclastogenesis by inhibiting expression of RGS18.


Pssm-ID: 188667  Cd Length: 114  Bit Score: 84.60  E-value: 1.69e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  68 FERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAhdKKELSYRAREIFSKFLCSKATTPVNID-SQAQLADDV 146
Cdd:cd08712   1 FDKLLSHKDGLEAFTRFLKTEFSEENIEFWIACEDYKKSKT--PQQIHLKAKAIYEKFIQTDAPKEVNLDfHTKEVTTNS 78

                        90       100       110
                ....*....|....*....|....*....|....
gi 38327599 147 LRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLY 180
Cdd:cd08712  79 IEQPTLTSFDAAQSRVYQLMEQDSYPRFLKSDIY 112
RGS_RGS8 cd08711
Regulator of G protein signaling (RGS) domain found in the RGS8 protein; The RGS (Regulator of ...
 64-182 1.82e-19

Regulator of G protein signaling (RGS) domain found in the RGS8 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS8 protein. RGS8 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS8 is involved in G-protein-gated potassium channels regulation and predominantly expressed in the brain. RGS8 also is selectively expressed in the hematopoietic system (NK cells).


Pssm-ID: 188666  Cd Length: 125  Bit Score: 84.79  E-value: 1.82e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  64 WAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKkeLSYRAREIFSKFLCSKATTPVNIDSQA-QL 142
Cdd:cd08711   8 WADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAK--LVSKAHRIFEEFVDVQAPREVNIDFQTrEA 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 38327599 143 ADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08711  86 TRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLD 125
RGS_RGS21 cd08723
Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator ...
 71-182 3.56e-19

Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part RGS21 protein, a member of RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, apoptosis, and cell proliferation, as well as modulation of cardiac development. RGS21 is a member of the R4/RGS subfamily and its mRNA was detected only in sensory taste cells that express sweet taste receptors and the taste G-alpha subunit, gustducin, suggesting a potential role in regulating taste transduction.


Pssm-ID: 188678  Cd Length: 111  Bit Score: 83.57  E-value: 3.56e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  71 LLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHvpAHDKKELSYRAREIFSKFLCSKATTPVNID-SQAQLADDVLRA 149
Cdd:cd08723   1 LLANQAGLDAFRTFLKSEFSEENVEFWLACEDFKK--TKSSTEIALKAQMIYSEFIQADAPKEINIDfHTRDLISQNISE 78

                        90       100       110
                ....*....|....*....|....*....|...
gi 38327599 150 PHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08723  79 PTLKCFDEAQSLIYCLMAKDSFPRFLKSEVYKK 111
RBD2_RGS14 cd17139
Ras-binding domain (RBD) 2 of regulator of G protein signaling 14 (RGS14); RGS14 (regulator of ...
 384-454 1.53e-17

Ras-binding domain (RBD) 2 of regulator of G protein signaling 14 (RGS14); RGS14 (regulator of G protein signaling 14) is a RGS protein with a multidomain structure that allows it to interact with binding partners from multiple signaling pathways. RGS proteins belong to a large family of GTPase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes. RGS14 contains an N-terminal RGS domain, two tandem Ras-binding domains (RBDs) and a G protein regulatory (GPR, also referred to as a GoLoco) motif. RGS14 binds activated H-Ras-GTP through its first RBD and interacts with RAP2-GTP and RAF kinases by the second tandem RBD. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS14 modulates neuronal physiology and all of its binding partners have roles in synaptic plasticity.


Pssm-ID: 340659  Cd Length: 73  Bit Score: 77.72  E-value: 1.53e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38327599 384 RTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLGAPISSLDGQRVVLE 454
Cdd:cd17139   1 RITFELEIAFLGKTVRIVAKSSKTLQEALQPILQKYGLRPQEVVLTMSGEKQALDMNTPVSSLANKTLVLD 71
RGS_RGS13 cd08716
Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator ...
 68-182 2.61e-17

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.


Pssm-ID: 188671  Cd Length: 114  Bit Score: 78.43  E-value: 2.61e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  68 FERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKelSYRAREIFSKFLCSKATTPVNIDSQAQLAddVL 147
Cdd:cd08716   1 FENLMATKYGPIIYATYLKTEHSDENIEFWLACETYKKIASQRKR--ISMARKLFASYIQPQAPREINIDSPTRKA--II 76

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 38327599 148 R---APHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08716  77 RniqEPTQSCFDEAQRIVYMHMERDSYPRFLESKFYQK 114
RGS_Axin cd08707
Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of ...
 71-182 3.12e-09

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.


Pssm-ID: 188662  Cd Length: 117  Bit Score: 55.54  E-value: 3.12e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  71 LLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYrAREIFSKFLCSKATTPVNIDSQ--AQLADDVLR 148
Cdd:cd08707   4 LLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMSDSEEKRSKL-AKAIYRRYIKDNGIVSRQLKPAtkSFIKECIKK 82

                        90       100       110
                ....*....|....*....|....*....|....*
gi 38327599 149 AP-HPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08707  83 QQlDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117
RGS_SNX13 cd08719
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; ...
 72-180 3.74e-07

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX13 (Sorting Nexin 13) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. The RGS-domain of SNX13 plays a major role through attenuation of Galphas-mediated signaling and regulates endocytic trafficking and degradation of the epidermal growth factor receptor. Snx13-null mice were embryonic lethal around midgestation which supports an essential role for SNX13 in mouse development and regulation of endocytosis dynamics.


Pssm-ID: 188674  Cd Length: 135  Bit Score: 50.10  E-value: 3.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  72 LQDPVGVRYFSDFLRKEFSEENILFWQACEYF------------------NHVPAHDKKELSYRAREIFSKFLCSKATTP 133
Cdd:cd08719   2 LVNNVALSYFIDFMQSVGGQAYLFFWLTVEGYrvsaeqqlselhlrqrggEHQRSDVYEMLRAAALNIYDQYLSEKASPR 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 38327599 134 VNIDSqaQLADDVLR-----APHPDMFKEQQLQIFNLMKFDS--YTRFLKSPLY 180
Cdd:cd08719  82 VPLDD--SLVKKLLNrlrndTPSDLWFDDIQQKVFDIMQEDErfYPAFKKSPAY 133
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 80-180 4.77e-06

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


Pssm-ID: 188676  Cd Length: 121  Bit Score: 46.19  E-value: 4.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  80 YFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRARE-----IFSKFLCSKATTPVNIDSQAQLA--DDVLRA--P 150
Cdd:cd08721  10 YFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQndamiIYDKYFSLQATEPLGFDDKTRLEveSNICREggP 89

                        90       100       110
                ....*....|....*....|....*....|
gi 38327599 151 HPDMFKEQQLQIFNLMKFDSYTRFLKSPLY 180
Cdd:cd08721  90 LPSCFEAPLLQALTTLEQHYLPGFLSSQLY 119
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 540-561 6.44e-06

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 43.26  E-value: 6.44e-06
                           10        20
                   ....*....|....*....|..
gi 38327599    540 EEFFELISKAQSNRADDQRGLL 561
Cdd:smart00390   2 EDLFDLLLRMQSSRMDDQRCEL 23
GoLoco pfam02188
GoLoco motif;
540-561 8.65e-06

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 42.79  E-value: 8.65e-06
                          10        20
                  ....*....|....*....|..
gi 38327599   540 EEFFELISKAQSNRADDQRGLL 561
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
RGS_FLBA cd08708
Regulator of G protein signaling (RGS) domain found in the FLBA (Fluffy Low BrlA) protein; The ...
 69-180 8.65e-06

Regulator of G protein signaling (RGS) domain found in the FLBA (Fluffy Low BrlA) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the FLBA (Fluffy Low BrlA) protein. FLBA is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain accelerates the GTPase activity of the alpha subunit by hydrolysis of GTP to GDP which results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. The RGS domain of the FLBA protein antagonizes G protein signaling to block proliferation and allow development. It is required for control of mycelial proliferation and activation of asexual sporulation in yeast.


Pssm-ID: 188663  Cd Length: 148  Bit Score: 46.22  E-value: 8.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  69 ERLLQDPvGVRY-FSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYR----------------AREIFSKFLCSKAT 131
Cdd:cd08708   3 DKILKDP-GLRYlFREHLEKEFCEENLSFYLEVKEFLKKMTILSKLLDFKssqaadedldreslaqAYHIYNTYLAPGSP 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38327599 132 TPVNIDSQ--AQLADDVLRAP-------------HPDMFKEQQLQIF-NLMKFDSYTRFLKSPLY 180
Cdd:cd08708  82 CELNIDHNlrNRITTIMTEKIvgeddsmaeslqgVEALFEEAQNAVFkPLMAGDSVPKFLKQPEY 146
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 72-166 1.81e-05

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 44.69  E-value: 1.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  72 LQDPVGVRYFSDF--LRKEFSEENILFWQACEYFNHVpAHDKKELSYR---AREIFSKFLCSKATTPVNIDSQAQLADDV 146
Cdd:cd08725   1 LLNPVTSEQFQRFvsLKGEELENDLLFWLEVQKYKDL-CHSHSDEHIIqnkITAIISCFIDSSVPPALQIDIPPEIANRI 79

                        90       100
                ....*....|....*....|...
gi 38327599 147 L---RAPHPDMFKEQQLQIFNLM 166
Cdd:cd08725  80 LehrRELGPYIFREAQLTVFRVL 102
RGS_SNX25 cd08720
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; ...
 71-182 8.11e-05

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX25 (Sorting Nexin 25) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX25 is a member of the Dopamine receptors (DAR) signalplex and regulates the trafficking of D1 and D2 DARs.


Pssm-ID: 188675  Cd Length: 110  Bit Score: 42.40  E-value: 8.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  71 LLQDPVGVRYFSDFLRKEFSEENILFWQACEyfnHVPAHDKKELSYRAREIFSKFLC-SKATTPVNIDSQAQLADDVLRA 149
Cdd:cd08720   1 ILANVFGRKYLSQFLERMDSQALIGFWEAVE---ELRSANKSEWHQLGAEIFYTFIVePTAEIKVDKSLRKRIEQFLLGD 77

                        90       100       110
                ....*....|....*....|....*....|...
gi 38327599 150 PHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 182
Cdd:cd08720  78 KGPEVFYEVQENVVETLEEKYYPSFVVSDQYKQ 110
RGS_GRK-like cd08724
Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase (GRK); ...
 73-180 1.55e-04

Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase (GRK); The RGS domain is found in G protein-coupled receptor kinases (GRKs). These proteins play a key role in phosphorylation-dependent desensitization/resensitization of GPCRs (G protein-coupled receptors), intracellular trafficking, endocytosis, as well as in the modulation of important intracellular signaling cascades by GPCR. GRKs also modulate cellular response in phosphorylation-independent manner using their ability to interact with multiple signaling proteins involved in many essential cellular pathways. The RGS domain of the GRKs has very little sequence similarity with the canonical RGS domain of the RGS proteins and therefore is often refered to as the RH (RGS Homology) domain. Based on sequence homology the GRK family consists of three major subfamilies: the GRK4 subfamily (GRK4, GRK5 and GRK6), the rhodopsin kinase or visual GRK subfamily (GRK1 and GRK7), and the beta-adrenergic receptor kinases subfamily (GRK2/GRK3). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development.


Pssm-ID: 188679  Cd Length: 114  Bit Score: 41.79  E-value: 1.55e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  73 QDPVGVRYFSDFLrkEFSEEN---ILFWQACEYFNHVPAHDKKElsyRAREIFSKFLCSKA---TTPVNIDSQAQLADDV 146
Cdd:cd08724   4 QQPIGRLLFRQFC--ETRPELvpqIEFLDEIKEYEVAEDEERAK---KAREIYDKYIMKESlahSHEFSKDAVEHVQENL 78

                        90       100       110
                ....*....|....*....|....*....|....
gi 38327599 147 LRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLY 180
Cdd:cd08724  79 EKEVPKDLFQPYIEEIHDYLRGAPFQKFLESDYF 112
RGS-like_1 cd08734
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 1; These ...
 81-176 1.31e-03

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 1; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involved in many crucial cellular processes. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188688  Cd Length: 109  Bit Score: 38.99  E-value: 1.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599  81 FSDFLRKEFSEENILFWQACEYFNHVPahDKKELSYRAREIFSKFLCSKATTPVNIDSQ--------AQLADDVLRAPHP 152
Cdd:cd08734   8 FGFSAESDFSGENLSFLTLVKEYKRLS--NPAEKFTLASKIYKEFISSESPFQINISSAmlrrldndFELLTGAFANVDS 85

                        90       100
                ....*....|....*....|....
gi 38327599 153 DMFKEQQLQIFNLMKFDSYTRFLK 176
Cdd:cd08734  86 GLNTPFNEEISKIEASDLYPAFVK 109
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 568-797 6.42e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 6.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599   568 LPEFLRLPPGSTELTLPTPAAVAKGFSK-RSATGNGRESA--SQPGEQWE--PVQESSDSPSTSPGSASSPPGPPGTTPP 642
Cdd:PHA03307  134 LSEMLRPVGSPGPPPAASPPAAGASPAAvASDAASSRQAAlpLSSPEETAraPSSPPAEPPPSTPPAAASPRPPRRSSPI 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599   643 GQKSPSGPFCTPQSPVSLAQEGTAQIWKRQSQEVEAGGIQTVEDEHVAELTLMG------EGDISSPNSTLLPPPSTPQE 716
Cdd:PHA03307  214 SASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTriweasGWNGPSSRPGPASSSSSPRE 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38327599   717 ---VPGPSRPGSGTHGSRDLPVNRIIDVDLVTGSAPGRDG-GIAGAQAGPGRSQASGGPPTSDLPGLGPVP------GEP 786
Cdd:PHA03307  294 rspSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSeSSRGAAVSPGPSPSRSPSPSRPPPPADPSSprkrprPSR 373

                         250
                  ....*....|.
gi 38327599   787 AKPKTSAHHAT 797
Cdd:PHA03307  374 APSSPAASAGR 384
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 68-142 6.83e-03

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188681  Cd Length: 130  Bit Score: 37.46  E-value: 6.83e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38327599  68 FERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSK----ATTPVNIDSQAQL 142
Cdd:cd08726   1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKyffgPNSPATKEQQNKV 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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