BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804   6 AAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFD 85
Cdd:cd18419   1 AAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 38257804  86 RDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKREN 143
Cdd:cd18419  81 RDPEVFRCVLNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRKREN 138

Domain of unknown function (DUF3399); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is about 100 amino acids in length. This domain is found associated with pfam02214, pfam00520.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804   468 TTSLIESQHHHLLHCLEKTTglsylvddpllsvrtstikNHEFIDEQMFEQNCMESSMQNYPStRSPSLSSHSGLTTTCC 547
Cdd:pfam11879   1 STSLFESQHHHLLHCLEKTT-------------------NHEFVDEQTYEQNCLEVSLQNRPS-RSPSLSSQDGLTSSCC 60

                          90
                  ....*....|....*.
gi 38257804   548 SRRSKKTTHLPNSNLP 563
Cdd:pfam11879  61 SRRAKRNTRLPNSSVP 76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804   6 AAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFD 85
Cdd:cd18419   1 AAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 38257804  86 RDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKREN 143
Cdd:cd18419  81 RDPEVFRCVLNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRKREN 138

Domain of unknown function (DUF3399); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is about 100 amino acids in length. This domain is found associated with pfam02214, pfam00520.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804   468 TTSLIESQHHHLLHCLEKTTglsylvddpllsvrtstikNHEFIDEQMFEQNCMESSMQNYPStRSPSLSSHSGLTTTCC 547
Cdd:pfam11879   1 STSLFESQHHHLLHCLEKTT-------------------NHEFVDEQTYEQNCLEVSLQNRPS-RSPSLSSQDGLTSSCC 60

                          90
                  ....*....|....*.
gi 38257804   548 SRRSKKTTHLPNSNLP 563
Cdd:pfam11879  61 SRRAKRNTRLPNSSVP 76

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804     42 IVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRyECISAYDDELAFY 121
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPE-ENVEELLELADYL 80

                           90
                   ....*....|....*...
gi 38257804    122 GIlPEIIGDCCYEEYKDR 139
Cdd:smart00225  81 QI-PGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804   6 AAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFD 85
Cdd:cd18419   1 AAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 38257804  86 RDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKREN 143
Cdd:cd18419  81 RDPEVFRCVLNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRKREN 138

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804   7 AWLPFARAAAIGWMPVANCPMPLAPADKNKRQ--DELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFF 84
Cdd:cd18420   1 AWLPFARAAAIGWVPIANNPLPPPPVDQERRRtdDEKLIINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEETKEYFF 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 38257804  85 DRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKREN 143
Cdd:cd18420  81 DRDPDIFRHILNYYRTGKLHYPKHECLTAYDEELAFFGIMPDIIGDCCYEDYRDRKREN 139

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  41 LIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAF 120
Cdd:cd18418   1 LIVLNVSGTRFQTWRNTLERYPDTLLGSSERDFFYHEETQEYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAF 80

                        90       100
                ....*....|....*....|...
gi 38257804 121 YGILPEIIGDCCYEEYKDRKREN 143
Cdd:cd18418  81 FGIIPEIIGDCCYEEYKDRRREN 103

Domain of unknown function (DUF3399); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is about 100 amino acids in length. This domain is found associated with pfam02214, pfam00520.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804   468 TTSLIESQHHHLLHCLEKTTglsylvddpllsvrtstikNHEFIDEQMFEQNCMESSMQNYPStRSPSLSSHSGLTTTCC 547
Cdd:pfam11879   1 STSLFESQHHHLLHCLEKTT-------------------NHEFVDEQTYEQNCLEVSLQNRPS-RSPSLSSQDGLTSSCC 60

                          90
                  ....*....|....*.
gi 38257804   548 SRRSKKTTHLPNSNLP 563
Cdd:pfam11879  61 SRRAKRNTRLPNSSVP 76

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804    42 IVLNVSGRRFQTWRTTLERYPDTLLGSTEKE--FFFNEDTKEYFFDRDPEVFRCVLNFYRT-GKLHYPRYECISAYDDEL 118
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELecDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVCLDEFLEEA 80

                          90
                  ....*....|...
gi 38257804   119 AFYGILPEIIGDC 131
Cdd:pfam02214  81 EFYGLDELALELC 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  42 IVLNVSGRRFQTWRTTLERYPDTLLGS-TEKE---FFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDE 117
Cdd:cd18379   1 IVINVGGVRHETYKSTLRNLPDTRLAWlTETEasaFDYDPVTGEFFFDRHPGVFAQILNYYRTGKLHCPADVCGPLFEEE 80

                        90       100
                ....*....|....*....|....*...
gi 38257804 118 LAFYGILPEIIGDCCYEEYkdRKRENAE 145
Cdd:cd18379  81 LAFWGIDETQIEPCCWMTY--RQHRDAQ 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  39 DELIVLNVSGRRFQTWRTTLERYPDTLLGS-TEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDE 117
Cdd:cd18416   1 ENRVVLNVGGIRHETYKATLKKIPATRLSRlTEALANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPTDVCGPLFEEE 80

                        90
                ....*....|....*....
gi 38257804 118 LAFYGILPEIIGDCCYEEY 136
Cdd:cd18416  81 LEFWGLDANQVEPCCWMTY 99

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804     42 IVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRyECISAYDDELAFY 121
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPE-ENVEELLELADYL 80

                           90
                   ....*....|....*...
gi 38257804    122 GIlPEIIGDCCYEEYKDR 139
Cdd:smart00225  81 QI-PGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNA/Kv1 subfamily of Shaker-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv1, also known as subfamily A, contains eight alpha subunit members, Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.4 (KCNA4), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), and Kv1.8 (KCNA10), which are orthologs of the Shaker gene in Drosophila. They are delayed rectifiers except for Kv1.4 (KCNA4), which is an A-type potassium channel. Delayed rectifiers are slow opening and closing voltage-gated potassium channels. Because of their delayed activation kinetics, they play an important role in controlling action potential duration. A-type channels are fast/rapidly inactivating potassium channels. Kv1/KCNA subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  40 ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFYRT-GKLHYPRYECISAYDDE 117
Cdd:cd18377   1 ERVVINVSGLRFETQLKTLAQFPNTLLGDPNKRMrFFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDIFLEE 80

                ....
gi 38257804 118 LAFY 121
Cdd:cd18377  81 IRFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 7 (KCNA7); KCNA7, also called voltage-gated potassium channel subunit Kv1.7, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA7 plays an important role in the repolarization of cell membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA7 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  40 ELIVLNVSGRRFQTWRTTLERYPDTLLGS-TEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRT-GKLHYPRYECISAYDDE 117
Cdd:cd18408   6 ERVVLNVAGLRFETRARTLGRFPDTLLGDpARRGRFYDDRRREYFFDRHRPSFDAVLYYYQSgGRLRRPAHVPLDVFLEE 85

                        90
                ....*....|..
gi 38257804 118 LAFYGILPEIIG 129
Cdd:cd18408  86 VAFYGLGAAALA 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  42 IVLNVSGRRFQTWRTTLERYPDTLLG-----STEKEFF-----FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECI 111
Cdd:cd18382   1 VIINVGGARYSLPWSTLDRFPLTRLSrlkacRSEDDILrvcddYDVERNEFFFDRSPEAFGVILLFLRAGKLRLLREMCA 80

                        90       100
                ....*....|....*....|....*...
gi 38257804 112 SAYDDELAFYGILPEIIGDCCYEEYKDR 139
Cdd:cd18382  81 LSFQEELAYWGIEEAHLERCCKRRLLRR 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  42 IVLNVSGRRFQTWRTTLERYPDTLLG---STEKEFFF------NEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECIS 112
Cdd:cd18424   1 FTINVGGSRFVLSQQVLSSHPETRLGklaVSVRDSVLelcddaNFVDNEYFFDRSSQAFKYIMNYYKTGHLHVMEELCAI 80

                        90       100
                ....*....|....*....|....*...
gi 38257804 113 AYDDELAFYGILPEIIGDCCYEEYKDRK 140
Cdd:cd18424  81 SFLQEIEYWGIDELSIDSCCRERYYRRK 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  27 MPLAPAD--KNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLG-----STEKEFF-----FNEDTKEYFFDRDPEVFRCV 94
Cdd:cd18412   2 LPPEPVEiiRSKACSRRVKINVGGLNHEVLWRTLDRLPRTRLGklrdcNTHESLLevcddYNLNENEYFFDRHPGAFTSI 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 38257804  95 LNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRK 140
Cdd:cd18412  82 LNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 2 (KCNS2); KCNS2, also called delayed-rectifier K(+) channel alpha subunit 2 or voltage-gated potassium channel subunit Kv9.2, is a modulatory alpha subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  42 IVLNVSGRRFQTWRTTLERYPDTLLG------STEKEFFFNED----TKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECI 111
Cdd:cd18427   2 ISINVGGFKKRLRSHTLLRFPETRLGrllscrSKESILELCDDyddtKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCV 81

                        90       100
                ....*....|....*....|....*
gi 38257804 112 SAYDDELAFYGILPEIIGDCCYEEY 136
Cdd:cd18427  82 FSFSQEIEYWGINEFFIDSCCSYSY 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shaker and similar proteins; Shaker, also termed protein minisleep, represents a family of putative potassium channel proteins in the nervous system of Drosophila. It is a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Shaker plays a role in the regulation of sleep need or efficiency. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaker is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  40 ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFYRT-GKLHYPRYECISAYDDE 117
Cdd:cd18410   1 ERVVINVSGLRFETQLKTLNQFPDTLLGDPQRRNrYYDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDVFSEE 80

                        90       100
                ....*....|....*....|.
gi 38257804 118 LAFYGilpeiIGDCCYEEYKD 138
Cdd:cd18410  81 IKFYE-----LGENAFEKYRE 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A members 2 (KCNA2) and 3 (KCNA3); KCNA2 is also called NGK1, voltage-gated K(+) channel HuKIV, voltage-gated potassium channel HBK5, or voltage-gated potassium channel subunit Kv1.2. KCNA3 is also called HGK5, HLK3, HPCN3, voltage-gated K(+) channel HuKIII, or voltage-gated potassium channel subunit Kv1.3. KCNA2 and KCNA3 mediate transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA2 primarily functions in the brain and the central nervous system, but also in the cardiovascular system. It prevents aberrant action potential firing and regulates neuronal output. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA2 and KCNA3 are alpha subunits that form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  40 ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFYRT-GKLHYPRYECISAYDDE 117
Cdd:cd18403   1 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMrYFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDIFSEE 80

                        90
                ....*....|.
gi 38257804 118 LAFYGILPEII 128
Cdd:cd18403  81 IRFYELGEEAM 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 10 (KCNA10); KCNA10, also called voltage-gated potassium channel subunit Kv1.8, is a cyclic nucleotide-gated, voltage-activated potassium channel that mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA10 is expressed in proximal tubular cells, glomerular and vascular endothelial cells, as well as in vascular smooth muscle cells. It may facilitate proximal tubular sodium absorption by stabilizing cell membrane voltage. The channel activity is up-regulated by cAMP. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA10 is an alpha subunit that forms functional homotetrameric channels through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  42 IVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFYRT-GKLHYPRYECISAYDDELA 119
Cdd:cd18409   3 VIINIAGLRFETQLKTLDQFPDTLLGDPEKRMkYFDSMRNEYFFDRNRPSFDGILYYYQSgGKIRRPANVPLDVFADEII 82

                ..
gi 38257804 120 FY 121
Cdd:cd18409  83 FY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 1 (KCNS1); KCNS1, also called delayed-rectifier K(+) channel alpha subunit 1 or voltage-gated potassium channel subunit Kv9.1, is a modulatory alpha subunit of voltage-gated potassium channel that mediates neuropathic pain following nerve injury. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  42 IVLNVSGRRFQTWRTTLERYPDTLLG-----STEKEFF-----FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECI 111
Cdd:cd18426   1 ININVGGLKRRLSSSTLSKFPDTRLGrllscDSEESILqicddYDVSAKEFYFDRNPGLFPYVLHFYQTGKLHIMEELCV 80

                        90       100
                ....*....|....*....|....*
gi 38257804 112 SAYDDELAFYGILPEIIGDCCYEEY 136
Cdd:cd18426  81 FSFSQEIEYWGINEFFLDSCCSYRY 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  40 ELIVLNVSGRRFQTWRTTLERYPDTLLGS--TEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHyPRYECISAYDDE 117
Cdd:cd18393   2 EVIHLNVGGKRFSTSRQTLTWIPDSFFSSllSGRISTLKDETGAIFIDRDPTVFAPILNFLRTKELD-PRGIHVSLLLHE 80

                ....*...
gi 38257804 118 LAFYGILP 125
Cdd:cd18393  81 AQFYGITP 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  39 DELIVLNVSGRRFQTWRTTLERYPDT----LLG---STEKefffnEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYEcI 111
Cdd:cd18363   1 GDIINLNVGGKRFSTSRQTLTWIPDSfftsLLSgriSSLK-----DETGAIFIDRDPKLFSIILNYLRTKEIDLRNVD-I 74

                        90
                ....*....|..
gi 38257804 112 SAYDDELAFYGI 123
Cdd:cd18363  75 SSLRHEAEFYGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  40 ELIVLNVSGRRFQTWRTTLERYPDTLLGStekefFFN-------EDTKEYFFDRDPEVFRCVLNFYRTGKLHYPryECIS 112
Cdd:cd18365   1 DIVNLNVGGVHYTTTLATLTRFPDSMLGA-----MFSgsmpttrDDQGNYFIDRDGTLFRYILNFLRSSQLSLP--EDFK 73

                        90
                ....*....|....*...
gi 38257804 113 AYD---DELAFYGILPEI 127
Cdd:cd18365  74 EYDlllREADFYQIEPLI 91

Shal-type voltage-gated potassium channels, N-terminal; This family represents the short N-terminal helical domain of Shal-type voltage-gated potassium channels. The domain interacts with Kv channel-interacting proteins to modulate cell surface expression and the function of Kv4 channels. The interaction of the N-terminus of Shal-type protein Kv4.2 and the Kv interacting protein KChiP1 forms a structure which is like the structure between calmodulin and its target peptides when they interact. Interactions of an N terminal alpha helix in Kv4.2 and a C terminal alpha helix in KChIP1 are essential for the modulation of Kv4.2 by KChIPs.

                          10        20
                  ....*....|....*....|....*.
gi 38257804     3 AGVAAWLPFARAAAIGWMPVANCPMP 28
Cdd:pfam11601   1 ASVAAWLPFARAAAIGWVPVARNPLP 26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 38257804  41 LIVLNVSGRRFQTWRTTLERYPDTLLGS--TEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYP 106
Cdd:cd18364   1 LVTLNVGGYLYITQRQTLTKYPDSFLEGmvNGKIQCTVDADGNYFIDRDGLLFRHVLNFLRNGELLLP 68

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  40 ELIVLNVSGRRFQTWRTTLERYPDTLLGS--TEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHyPRYECISAYDDE 117
Cdd:cd18392   2 EIIQLNVGGTRFSTSRQTLMWIPDSFFSSllSGRISSLKDETGAIFIDRDPTAFVPILNFLRTKELD-LRGVNINVLRHE 80

                ....*...
gi 38257804 118 LAFYGILP 125
Cdd:cd18392  81 AEFYGITP 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38257804  42 IVLNVSGRRFQTWRTTLERYPDTLLG---STEKEFFFNEDTKeYFFDRDPEVFRCVLNFYRTGKLHYPrYECISAYDD-- 116
Cdd:cd18376   1 VKLNVGGQKFTTTLDTLTKDPDSMLAamfSGRHSLKKDEDGS-YFIDRDGTHFRHILNYLRDGEVKIP-TEDRSVLKEll 78

                        90
                ....*....|
gi 38257804 117 -ELAFYGILP 125
Cdd:cd18376  79 eEAEYYQLRG 88