|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
22-484 |
0e+00 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 722.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 22 RGLILLLTFLIYACYHMSRKPISIVKSRLHQNCSEQIKPINDthSLNDTMWCSWAPFDKDNYKELLGGVDNAFLIAYAIG 101
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNCSALIPPPNI--VLNNTTWCGWAPFDGKNGTELLGALDSAFLFAYAIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 102 MFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWNIHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWFGKGKRGFIM 181
Cdd:cd17344 79 MFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIM 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 182 GIWNSHTSVGNILGSLIAGIWVNGQWGLSFIVPGIITAVMGVITFLFLIEHPedvdcappqhhgepaenqdnpedpgnsp 261
Cdd:cd17344 159 GIWNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP---------------------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 262 csiresgletvakcskgpceepaaisffgalriPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAKEAGDLSTLFD 341
Cdd:cd17344 211 ---------------------------------PGVIEFSLCLFFAKLVSYTFLYWLPLYISNTAILSAKKAGDLSTLFD 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 342 VGGIIGGIVAGLVSDYTNGRATTCCVMLILAAPMMFLYNYIGQDGIASSIVMLIICGGLVNGPYALITTAVSADLGTHKS 421
Cdd:cd17344 258 VGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMTTNIVLLIVCGLLVNGPYALITTAVSADLGTHKS 337
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38093649 422 LKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPTGWNNVFYMLISADVLACLLLCRLVYKE 484
Cdd:cd17344 338 LKGNARALATVTAIIDGTGSIGAALGPLLAGLISSRGWNNVFYMLIAADVCAGLLLTRLVYKE 400
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
22-481 |
1.72e-101 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 309.20 E-value: 1.72e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 22 RGLILLLTFLIYACYHMSRKPISIVKSRLHQncseqikpindthslndtmwcswapfDKDNYKELLGGVDNAFLIAYAIG 101
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVE--------------------------EIGLSKDDLGIIGSAFLIAYAVG 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 102 MFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGyfwniHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWFGKGKRGFIM 181
Cdd:cd17312 55 KFISGFLSDRSNIRRFMSAGLLLSALANIFMGFS-----TSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVY 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 182 GIWNSHTSVGNILGSLIAGIWVN-GQWGLSFIVPGIITAVMGVITFLFLIEHPedvdcappqhhgepaenqdnpedpgns 260
Cdd:cd17312 130 GIWSTSHNFGGILAPILAASLASyYGWRAAFLVPGIVGLVVAIILFFFLRDSP--------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 261 pcsiresgletvakcskgpceepaaisffgalriPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAKEAGDLSTLF 340
Cdd:cd17312 183 ----------------------------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLY 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 341 DVGGIIGGIVAGLVSDYTnGRATTCCVMLILAAPMMFLYNYIGQD--GIASSIVMLIICGGLVNGPYALITTAVSADLGT 418
Cdd:cd17312 229 EVGGIAGTILAGLLSDKL-FGGRRAPIAVIYMLLMTLSLALFWFFphNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGR 307
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 38093649 419 HkslkgnaKALSTVTAIIDGTGSIGAALGPLLAGLISP-TGWNNVFYMLISADVLACLLLCRLV 481
Cdd:cd17312 308 K-------EAAGTATGFVGLFGYLGASLAGLPLGYIIDhYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
24-477 |
5.02e-91 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 283.44 E-value: 5.02e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 24 LILLLTFLIYACYHMSRKPISIVKSRLhqncSEQIKPINDT---HSLNDTMWCSWAPFDKDNYKELLGGVDNAFLIAYAI 100
Cdd:cd17342 3 VVFILTFFSYALLHATRKTFSNVKPSI----SAEWTPSNSNtsiELHEETWNANPLFPSQDDAALFLGVLDTIFLFSYAI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 101 GMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGL----GYFWNIhelWYFVVIQVCNGLVQTTGWPSVVTCVGNWFGKGK 176
Cdd:cd17342 79 GLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVltewLHFYNK---YLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 177 RGFIMGIWNSHTSVGNILGSLIAGIWVNGQWGLSFIVPGIITAVMGVITFLFLIEHPedvdcappqhhgepaenqdnped 256
Cdd:cd17342 156 RGFVLGLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP----------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 257 pgnspcsiresgletvakcskgpceepaaisffgalriPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAKEAGDL 336
Cdd:cd17342 213 --------------------------------------PGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQL 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 337 STLFDVGGIIGGIVAGLVSDYTNGRATTCCVMLILAAPMMFLYNYIGQDGIASSIVMLiICGGLVNGPYALITTAVSADL 416
Cdd:cd17342 255 SIWYDVGGIIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVYSHSPSDKVLNAFVMT-ITGFFIGGPANLISSAISADL 333
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38093649 417 GTHKSLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPT-GWNNVFYMLISADVLACLLL 477
Cdd:cd17342 334 GRQPQLRGSSEALATVTGIIDGTGSIGAAIGQVLVPLIQNRlGWMWVFYFFIIMTILTIVCI 395
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
87-477 |
8.96e-38 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 143.15 E-value: 8.96e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 87 LGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLgYFWNIHELWYFVVIQVCNGLVQTTGWPSVVT 166
Cdd:cd17345 40 IGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGF-VPSATSSVGLMFILLFLNGWFQGMGWPPSGR 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 167 CVGNWFGKGKRGFIMGIWN-SHTSVGNILGSLI---AGIWVNGQWGLSFIVPGIITAVMGVITFLFLIEHPEDVDCAP-P 241
Cdd:cd17345 119 TMVHWFSKKERGTWTSIWNiSHNVGGGLVGPLAglgLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPiE 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 242 QHHGEPAENQDNPEDPGNspCSIRESGLETVakcskgpceepaaisffgaLRIPGVVEFSLCLLFAKLVSYTFLYWLPLY 321
Cdd:cd17345 199 EYKGDYPEEADGEEEEQE--LSAWEIFVKYV-------------------LKNKLLWYIAIANVFVYLVRYGILDWAPTY 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 322 IANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSD--YTNGRATTCCVMLILAAPMMFLYNYIgqDGIASSIVMLIICGG 399
Cdd:cd17345 258 LSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDklFKGRRAPTGIIFMILVIVALIVYWLA--PNVLVDLIALIALGF 335
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38093649 400 LVNGPYALIttAVSADLGTHKSLKGNAKALSTVTAIIdgtgsIGAALGPLLAGLISP-TGWNNVFYMLISADVLACLLL 477
Cdd:cd17345 336 LIYGPVMLI--GLQALELVPKKAAGTAAGLTGLFGYL-----GGSVLATALIGIIVDhFGWNGGFIVLLASCILAIIFL 407
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-483 |
1.28e-36 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 138.85 E-value: 1.28e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 19 SWFRGLILLLTFLIYACYHMSRKPISIVksrlhqncseqIKPINDTHSLNDTMwcswapfdkdnykelLGGVDNAFLIAY 98
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVA-----------APPLQADLGLSAAQ---------------LGLLASAFFLGY 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 99 AIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLgyfwnIHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWFGKGKRG 178
Cdd:COG2271 59 ALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERG 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 179 FIMGIWNSHTSVGNILGSLIAGIWVNGQ-WGLSFIVPGIITAVMGVITFLFLiehpedvdcappqhhgepaenqdnpedp 257
Cdd:COG2271 134 RALGIFNAGGPLGGALAPPLLGWLLAAFgWRAAFLILGLPGLLLALLRFWLL---------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 258 gnspcsiresgletvakcskgpceepaAISFFGALripgvvefslcllfakLVSYTFLYWLPLYIANVAHFSAKEAGDLS 337
Cdd:COG2271 186 ---------------------------ALAYFLVY----------------FALYGFLTWLPTYLVEVRGLSLAQAGLLL 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 338 TLFDVGGIIGGIVAGLVSDYTN-GRATTCCVMLILAAPMMFLYNYIgqDGIASSIVMLIICGGLVNGPYALITTAVSADL 416
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLSDRLGrRRKLVLAIGLLLAALALLLLALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 38093649 417 GTHkslkgnakALSTVTAIIDGTGSIGAALGPLLAG-LISPTGWNNVFYMLISADVLACLLLCRLVYK 483
Cdd:COG2271 301 PKK--------ARGTASGLVNTFGFLGGALGPLLVGyLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
87-463 |
1.25e-32 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 128.26 E-value: 1.25e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 87 LGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGlgyfWNIHeLWYFVVIQVCNGLVQTTGWPSVVT 166
Cdd:TIGR00881 32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG----FSTS-LWVMAALWALNGIFQGMGWPPCGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 167 CVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGIWVN--GQWGLSFIVPGIITAVMGVITFLFLIEhpedvdcaPPQHH 244
Cdd:TIGR00881 107 TVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAelYSWHWVFIVPGIIAIIVSLICFLLLRD--------SPQSC 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 245 GEPAENQDNPEDPgnspcsiresgleTVAKCSKGPCEEPAAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIAN 324
Cdd:TIGR00881 179 GLPPAEEMPNEEP-------------DGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQ 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 325 VAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSD--YTNGRATTCCVMLILaapmMFLYNYIGQDGIASSIVMLIIC----G 398
Cdd:TIGR00881 246 EKGFSKEKASWAFTLYELGGLVGTLLAGWLSDklFNGRRGPLAVFFMAL----IIVSLLVYWLNPAANPLMDLIClfalG 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38093649 399 GLVNGPYALIttavsadlGTHKSLKGNAKALSTVTAIIDGTGSIGAALGPL-LAGLISPTGWNNVF 463
Cdd:TIGR00881 322 FLVYGPQMLI--------GVIASELAPKKAAGTAAGFVGFFAYLGGILAGLpLGYLADGFGWAGAF 379
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
93-480 |
8.50e-25 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 105.35 E-value: 8.50e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWnihelWYFVVIQVCNGLVQTTGWPSVVTCVGNWF 172
Cdd:cd17319 46 AFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSL-----TSLYVLRFLLGVAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGIWVN-GQWGLSFIVPGIITAVMGVITFLFLiehpedvdcappqhhgepaenq 251
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLlFGWRWAFIIEGLLGLLLAVLWWFYL---------------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 252 dnpedpgnspcsiresgletvakcskgpceepaaisffgalriPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAK 331
Cdd:cd17319 179 -------------------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLK 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 332 EAGDLSTLFDVGGIIGGIVAGLVSDYT-NGRATTCCVMLILAAPMMFLYNYIGQDgIASSIVMLIICGGLVNGPYALITT 410
Cdd:cd17319 216 QVGLLAAIPFLAGAIGMILGGRLSDRLlRGARRLVIIIGLLLAAVGLLLAYLTTS-PVVAVILLSLAGFGIGAASPVFWS 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38093649 411 aVSADLgthkslkGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPT--GWNNVFYMLISADVLACLLLCRL 480
Cdd:cd17319 295 -LPADL-------LPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAtgSYTAAFLFLAAVALLAALLVLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
93-483 |
6.15e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 103.42 E-value: 6.15e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGyfwniHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWF 172
Cdd:COG2223 48 IPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA-----VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWF 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGiWVNGQWGLS--FIVPGIITAVMGVITFLFLIEHPEDVDCAPPQHHGEPAEn 250
Cdd:COG2223 123 PPDRRGLALGLAAGGGNLGAAVAAFLAP-LLIAAFGWRnaFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLE- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 251 qdnpedpgnspcsiresgletvakcskgpceepaaisffgALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSA 330
Cdd:COG2223 201 ----------------------------------------ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 331 KEAGDLSTLFDVGGIIGGIVAGLVSDYTNGRATTCCVMLILAAPMMFLYNYIGQDGIA-SSIVMLIICGGLVNGP-YALI 408
Cdd:COG2223 241 ATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFlVLFLLLGLALGGGNGAvFALV 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38093649 409 TTAVSadlgthkslkgnAKALSTVTAIIDGTGSIGAALGPLLAG-LISPTGWNNVFYMLISADVLACLLLCRLVYK 483
Cdd:COG2223 321 PDIFP------------TKNAGAVYGLVGAAGGLGGFLGPLLFGaLLDATGSYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
93-448 |
2.02e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 98.26 E-value: 2.02e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLgyfwnIHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWF 172
Cdd:pfam07690 40 LFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF-----ASSLWLLLVLRVLQGLGAGALFPAALALIADWF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGIWV-NGQWGLSFIVPGIITAVMGVITFLFLIEHPEDVDcappqhhgepaenq 251
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRP-------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 252 dnpedpgnspcsiresgletvakcSKGPCEEPAAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIaNVAHFSAK 331
Cdd:pfam07690 181 ------------------------KPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 332 EAGDLSTLFDVGGIIGGIVAGLVSDYTNGRATTCCVMLILAAPMMFLYNYIGQDGIASSIVMLIICGGLVNGPYALITTA 411
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315
|
330 340 350
....*....|....*....|....*....|....*..
gi 38093649 412 VSADLGTHKSlkgnakalSTVTAIIDGTGSIGAALGP 448
Cdd:pfam07690 316 VSDLAPKEER--------GTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
93-477 |
8.20e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 94.03 E-value: 8.20e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLgyfwnIHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWF 172
Cdd:cd06174 39 LFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF-----APSFWLLLLGRFLLGLGSGLIDPAVLALIADLF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGIWVnGQWGLSFIVPGIITAVMGVITFLFLIEHPEDvdcaPPQHHGEPAENQD 252
Cdd:cd06174 114 PERERGRALGLLQAFGSVGGILGPLLGGILA-SSLGFGWRAVFLIAAALALLAAILLLLVVPD----PPESARAKNEEAS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 253 NPEDpgnspcsiresgletvakcskgpceepaAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAKE 332
Cdd:cd06174 189 SKSV----------------------------LKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 333 AGDLSTLFDVGGIIGGIVAGLVSDYTNGRATTCCVMLILAAPMMFLYNYigQDGIASSIVMLIICGGLVNGPYALITTAV 412
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLL--APSLLLLLLLLLLLGFGLGGLLPLSFALI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38093649 413 SADLgthkslkgNAKALSTVTAIIDGTGSIGAALGPLLAGLISP--TGWNNVFYMLISADVLACLLL 477
Cdd:cd06174 319 AELF--------PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAatFGLTGAFLVLAVLLLLAAILL 377
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
87-484 |
1.87e-20 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 93.96 E-value: 1.87e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 87 LGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWNIHELWYFVVIQVCNGLVQTTGWPSVVT 166
Cdd:PRK09556 66 LGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYS 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 167 CVGNWFGKGKRGFIMGIWN-SHtsvgNILGSLIAGI-------WVNGQWGLSFIVPGIITAVMGVITFLFLIEHPEDVDC 238
Cdd:PRK09556 146 TITRWTPRRKRGRFLGFWNiSH----NLGGAGAGGValwganyFFDGHVIGMFIFPSIIALIIGFIGLRYGSDSPEELGW 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 239 APPQH-HGEPAENQDnpEDPGNSPCSIRESGLETVAKcskgpceepaaisffgalripGVVEFSLCL--LFAKLVSYTFL 315
Cdd:PRK09556 222 GKAEEiFGEPISEED--KETESTDMTKWQIFVEYVLK---------------------NPVIWLLCFanIFLYIVRIGID 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 316 YWLPLYIANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTNG-RATTCCVMLILAAPMMFLYNYigqdgiASSIVM- 393
Cdd:PRK09556 279 NWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANGrRALVACIALALIIFTLGVYQH------ATSEYMy 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 394 ---LIICGGLVNGPYALI------------TTAVSADLGTHKSLKGNAKALSTVTAIIDGTGSIGAALGPLLaglispTG 458
Cdd:PRK09556 353 lasLFALGFLVFGPQLLIgvaavgfvpkkaIGVANGIKGTFAYLFGDSFAKVGLGMIADPTKNGTPIFGYTL------TG 426
|
410 420
....*....|....*....|....*.
gi 38093649 459 WNNVFYMLISADVLACLLLCRLVYKE 484
Cdd:PRK09556 427 WAGTFAALDIAAIGCICLMAIVAVME 452
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
93-446 |
1.13e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 84.26 E-value: 1.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLgyfwnIHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWF 172
Cdd:COG2814 53 AYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGIWVN-GQWGLSFIVPGIITAVMGVITFLFLiehPEDVDCAPPQHHGepaenq 251
Cdd:COG2814 128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADlFGWRWVFLVNAVLALLALLLLLRLL---PESRPAARARLRG------ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 252 dnpedpgnspcsiresgletvakcskgpceepaaiSFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAK 331
Cdd:COG2814 199 -----------------------------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 332 EAGDLSTLFDVGGIIGGIVAGLVSDYTnGRATTCCVMLILAAPMMFLYNYIGqdGIASSIVMLIICGGLVNGPYALITTA 411
Cdd:COG2814 244 AAGLLLALFGLGGVLGALLAGRLADRF-GRRRLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGLLFPLLQAL 320
|
330 340 350
....*....|....*....|....*....|....*
gi 38093649 412 VSADLGTHkslkgnakALSTVTAIIDGTGSIGAAL 446
Cdd:COG2814 321 VAELAPPE--------ARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
93-480 |
6.91e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 82.24 E-value: 6.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWnihelWYFVVIQVCNGLVQTTGWPSVVTCVGNWF 172
Cdd:cd17325 39 AYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY-----WQLLLARFLQGLASAAVWPAAMALIADIA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGIwVNGQWGLS--FIVPGIITAVMGVITFLFLIEHPEdvdcappqhhgepaen 250
Cdd:cd17325 114 PPEERGRAMGIFSSAIGLGFLIGPLLGGL-LADALGYRapFLVCAALALLALVLALLLLPEPRP---------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 251 qdNPEDPGNSPCSIRESGLEtvakcskgpceepaaISFFGALRIPGVVEFSLCLLFAKLVSYtflywLPLYIANVAHFSA 330
Cdd:cd17325 177 --PPNKRAVSAARLRSGLRL---------------LLRDRRLLALFLAIFVLAFAFGALEPF-----LPLYAAELGGLSP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 331 KEAGDLSTLFDVGGIIGGIVAGLVSDYTnGRATTCCVMLILAAPMMFLYnyigqdGIASSIVMLIICGGLVNGPYALITT 410
Cdd:cd17325 235 AQIGLLFGAQGLASALSQPPAGKLSDRI-GRKPLILIGLLLSAVALLLL------PLATSFWLLLLLLALLGLGLGLVFP 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38093649 411 AVSADLG--THKSLKGnakalsTVTAIIDGTGSIGAALGPLLAGLISPT-GWNNVFYmLISADVLACLLLCRL 480
Cdd:cd17325 308 ATLALLAdiVPPEGRG------TAMGLFNTAFSLGMVLGPLLGGFLYDAfGFATPFL-AAAALLLLAAVLFLL 373
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
87-478 |
8.86e-17 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 82.45 E-value: 8.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 87 LGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYfWNIHELWYFVVIQVCNGLVQTTGWPSVVT 166
Cdd:PRK11273 65 LGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVP-WATSSIAVMFVLLFLCGWFQGMGWPPCGR 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 167 CVGNWFGKGKRGFIMGIWN-SHTSVGNILGSL-IAGIWVNGQWGLSFIVPGIITAVMGVITFLFLIEHPEDVDCAPPQHH 244
Cdd:PRK11273 144 TMVHWWSQKERGGIVSVWNcAHNVGGGLPPLLfLLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEY 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 245 gepaeNQDNPEDpgnspcsiresgletvakCSKGPCEEPAAISFFGALRIPGVVEFSLCL--LFAKLVSYTFLYWLPLYI 322
Cdd:PRK11273 224 -----KNDYPDD------------------YNEKHEQELTAKQIFMQYVLPNKLLWYIAIanVFVYLLRYGILDWSPTYL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 323 ANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSD--YTNGRATTCCVMLIL--AAPMMFLYNYIGQDGIasSIVMLIICG 398
Cdd:PRK11273 281 KEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDkvFRGNRGATGVFFMTLvtIATIVYWLNPAGNPTV--DMACMIVIG 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 399 GLVNGPYALIttavsadlGTH------KSLKGNAKALSTVTAIIDGTGSIGAALGPllagLISPTGWNNVFYMLISADVL 472
Cdd:PRK11273 359 FLIYGPVMLI--------GLHalelapKKAAGTAAGFTGLFGYLGGSVAASAIVGY----TVDFFGWDGGFMVMIGGSIL 426
|
....*.
gi 38093649 473 ACLLLC 478
Cdd:PRK11273 427 AVILLI 432
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
22-477 |
1.78e-15 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 78.15 E-value: 1.78e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 22 RGLILLLTFLIYACYHMSRKPISIVKSRLHQNcseqikpindthslndtmwcswAPFDKDNykelLGGVDNAFLIAYAIG 101
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNE----------------------LGLDKSD----LGLITSSQSLAYAIS 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 102 MFISGVFGERLPLRYYLSAGMLLSGLFTSLFGlgYFwniHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWFGKGKRGFIM 181
Cdd:cd17343 55 KFIGGVLSDQISARWLFSSGLVLSGLTTVAFS--GS---SSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWW 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 182 GIWNSHTSVGNILGSLIAG-IWVNGQWGLSFIVPGIITAVMGVITFLFLIEHPEDVDCAppqHHGEPAENQDNPEDPGNs 260
Cdd:cd17343 130 SVLSTSMNLAGSLGPILATlLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLN---NIEEEESKGKKKKSPRG- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 261 pcsiresgletvakcskgpceepaAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAKEAGDLSTLF 340
Cdd:cd17343 206 ------------------------ESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSL 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 341 DVGGIIGGIVAGLVSDY----TNGRATTCC-------VMLILAAPMMFLYNYIGQDgiASSIVMLIICGGLVNGPYALIT 409
Cdd:cd17343 262 EVGGFVGSIAAGYLSDWavakHGSSSRGNPrmplalvFMAGLTVSLHLFRVHITSD--SSELFILLLGFLIGFSLYGPIA 339
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 38093649 410 T-AVSADLGTHKSLKGNAKALStvtaiidgtgSIGAALGPLLAGL-----ISPTGWNNVFYMLISADVLACLLL 477
Cdd:cd17343 340 IfGVIANESAPSHLCGTSHAIV----------ALAANVGGVLAGLpfsyiAKHYDWRTAFLLLEILCAITVVIL 403
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
94-477 |
2.75e-15 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 77.83 E-value: 2.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 94 FLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGyfwniHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWFG 173
Cdd:PRK11663 67 FYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFS-----SSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYS 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 174 KGKRGFIMGIWNSHTSVGNILGSLIAG-IWVNGQWGLSFIVPGIITAVMGVITFLFLIEHPEDVdcappqhhgepaenqd 252
Cdd:PRK11663 142 RTERGGWWAIWNTAHNVGGALIPLVVGaIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAM---------------- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 253 npedpgnspcsiresGLETVAKCSKGPCE-----EPAAISFFGALRIPGVVEFSLCLLfakLVSYTFLY--------WLP 319
Cdd:PRK11663 206 ---------------GLPSVGEWRHDALElaqqqEGAGLSRKEILTKYVLLNPYIWLL---SFSYVLVYvvraaindWGN 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 320 LYIANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSD--YTNGRATtccVMLILAAP---------MMFLYNYIGQDGIA 388
Cdd:PRK11663 268 LYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDklFNGNRGP---MNLIFAAGillsvgslwLMPFASYVMQAACF 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 389 SSIvmliicGGLVNGPYALITTAvsADLGTHKSLKGNAkalstvTAIIDGTGSIGAAL-GPLLAGLISPTGWNNVFYML- 466
Cdd:PRK11663 345 FTI------GFFVFGPQMLIGMA--AAECSHKEAAGAA------TGFVGLFAYLGAALsGYPLAKVLEIWHWTGFFVVIs 410
|
410
....*....|.
gi 38093649 467 ISADVLACLLL 477
Cdd:PRK11663 411 IAAGISALLLL 421
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
84-233 |
1.12e-14 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 75.52 E-value: 1.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 84 KELLGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGyfwniHELWYFVVIQVCNGLVQTTGWPS 163
Cdd:cd17488 37 KSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFS-----SSLWAFAVLWTLNAFFQGWGWPP 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38093649 164 VVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAG-IWVNGQWGLSFIVPGIITAVMGVITFLFLIEHP 233
Cdd:cd17488 112 CARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGfAALTYGWRAGMYVPGIIAILMGIVLCWRLRDRP 182
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
87-477 |
8.33e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.88 E-value: 8.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 87 LGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWNIHELWYFVvIQVCNGLVQTTGWPSVVT 166
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFL-LGLGLGLLDVAANPYVAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 167 CvgnwfGKGKRGFIMGIWNSHTSVGNILGSLIAGIWVNGQWGLSFIVPGIITAVMGVITFLFLIEHPedvdcaPPQHHGE 246
Cdd:COG0738 124 L-----GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSK------LPEIEEE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 247 PAEnqdnpedpgnspcsiresgletvakcskgpcEEPAAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVA 326
Cdd:COG0738 193 EEE-------------------------------AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 327 HFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTnGRATTCCVMLILAAPMMFLynYIGQDGIASSIVMLIICGGLVNGPYA 406
Cdd:COG0738 242 GLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-GPVRLLRLSALLAAVGLLL--ALLAPGPWLALIGLALVGLGLSLMFP 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38093649 407 LITTAVSADLGTHKslkgnAKALSTVTAIidgtGSIGAALGPLLAGLISP-TGWNNVFYMlisadVLACLLL 477
Cdd:COG0738 319 TIFSLALDGLGKRT-----AAAVSAVLIM----GIVGGAIGPPLIGFLADaFGLRAAFLV-----PLVCYLL 376
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
87-454 |
1.34e-11 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 66.19 E-value: 1.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 87 LGGVDNAFLIAYAIGMFISGVFGERLPLRyylsaGMLLSGLFTSLFGLGYFWNIHELWYFVV----IQVCNGLVQTTGWP 162
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRR-----RTLILGLLLISLALALIFATPSIYLFVVlmflAGLGAGILDTGANT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 163 SVVTcvgnwFGKGKRGFIMGIWNSHTSVGNILGSLIAG--IWVNGQWGLSFIVPGIItAVMGVITFLFLIEHPEDVDCAP 240
Cdd:cd17333 108 FVGA-----LFEESSATRLNVLHGFFGLGALIGPLIATslLTSELSWSWAYLIIGLI-YLLLAILILLTLFPELPSARNP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 241 PQHHGEPAEnqdnpedpgnspcsiresgletvakcskgpceepaaiSFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPL 320
Cdd:cd17333 182 QQSVGAFSA-------------------------------------SASRLLRNPSIILGALALFLYVGAETAFSSWVPS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 321 YIANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTNGRATtccVMLILAAPMMFLYNYIGQDGIASSIVMLIICGGL 400
Cdd:cd17333 225 YLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTL---LVLSGSGALLGLLILLLAPTLVVGLVATALLGLF 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 38093649 401 VNGPYALITTAVSADLGTHKslkgnakalSTVTAIIDGTGSIGAALGPLLAGLI 454
Cdd:cd17333 302 MAALFPTILSLGISNLPYAK---------GKGTSVLLAAGSIGGAIIPFIMGFI 346
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
93-478 |
2.00e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 65.72 E-value: 2.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWnihelWYFVVIQVCNGLVQTTGWPSVVTCVGNWF 172
Cdd:cd17328 42 VFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF-----WQLLLFRALVGIGEASYSPIAPTIIADLF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 173 GKGKRGFIMGIWNSHTSVGNILGsLIAGIWV---NGQWGLSFIVPGIITAVMGVITFLFLIEhpedvdcaPPQHHGEPAE 249
Cdd:cd17328 117 PKEKRTRALGVFYFAIPLGSGLG-YVVGGLVaqaTGGWRWAFRVTGVLGVLLAILLLLFVRE--------PPRGAAEGGV 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 250 NQDNpedpgnspcsiresgletvakcskgpceepAAISFFGAL----RIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANV 325
Cdd:cd17328 188 MAKS------------------------------TATSFLADLkalaKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 326 AHFSAKEAGDLSTLFDVGGIIG----GIVAGLVSDYTN-----GRATTCCVMLILAAPMMFLYNYIGQDGIASSIVMLII 396
Cdd:cd17328 238 FGVGDLSSADVGLIFGAITCIAgvlgVLLGGILADRLRrktprADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 397 CGGLVNGPYALITTAVSAD-LGTHKSLkgnAKALSTVTaiidgTGSIGAALGPLLAGLISPTGWNNVFYMLISADVLACL 475
Cdd:cd17328 318 GEFLLSLNWAPVFAILLYVvIPTRRST---ASAIQILL-----SHLLGDAGSPYLIGLISDLLRQNKDSPLAEAASLQYA 389
|
...
gi 38093649 476 LLC 478
Cdd:cd17328 390 LLL 392
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
93-229 |
1.50e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.98 E-value: 1.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLgyfwnIHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWF 172
Cdd:cd17325 243 AQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL-----ATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 38093649 173 GKGKRGFIMGIWNSHTSVGNILGSLIAG-IWVNGQWGLSFIVPGIITAVMGVITFLFL 229
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGfLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
95-480 |
3.00e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 62.20 E-value: 3.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 95 LIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLgyfwnIHELWYFVVIQVCNGLVQTTG---WPSVVTcvgNW 171
Cdd:COG2807 63 LLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSL-----APSVALLLAGTALIGAGIAVGnvlLPGLIK---RW 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 172 FGKgKRGFIMGIWNSHTSVGNILGSLIAGIWVNGQ-WGLSFIVPGIITAVMGVITFLFLIEHPedvdcappqhhgepaen 250
Cdd:COG2807 135 FPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALgWRGALAVWALLALLALLLWLPLLRRRP----------------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 251 qdnpedpgnspcsiresgletvakcsKGPCEEPAAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANvAHFSA 330
Cdd:COG2807 197 --------------------------AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 331 KEAGDLSTLFDVGGIIGGIVAGLVSDYTNGRATTCCVMLILAAPMMFLYNYIGQDGIASSIVMLIICGGlvnGPYALITT 410
Cdd:COG2807 250 ATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG---GLFPLALT 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38093649 411 AVSADLGTHKSlkgnAKALStvtAIIDGTGSIGAALGPLLAGLISPT--GWNNVFYMLISADVLACLLLCRL 480
Cdd:COG2807 327 LIGLRARTPAE----AAALS---GMAQSVGYLLAALGPLLVGALHDAtgSWTAALLLLAALAVLMLVAGLLA 391
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
86-472 |
8.96e-10 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 60.91 E-value: 8.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 86 LLGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSglftSLFGLGYFWNIHELWYFVVIQvcnGLVQTTGWPSVV 165
Cdd:TIGR00894 77 LQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLS----SVISIVIPWAAGGGIALVVFC---RVIQGLAQGSVS 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 166 TC----VGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGI--WVNGQWGLSFIVPGIITAVMGVITFLFLIEHPEDVDCA 239
Cdd:TIGR00894 150 PAthkiIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWlcESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCI 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 240 ppQHHGEPaenqdnpedpgnspcSIRESGLEtvakcSKGPCEEPAAI-SFFGALRIPGVVEFSLCLLFAKLVSYTFLywl 318
Cdd:TIGR00894 230 --SKFEKK---------------YINSSLQG-----QKGSTRQSLPIkAIPKSLPVWAIWFAIFGHFWLYTILPTYL--- 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 319 PLYIANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDY-----TNGRATTCCVM-----LILAAPMMFLYnYIGQDgIA 388
Cdd:TIGR00894 285 PTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFlksskTLSLTAARKIFngiggLGPGIFAYALP-YLSAA-FY 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 389 SSIVMLIICGGLVNGPYALITTAvsadlgthkSLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPTG----WNNVFY 464
Cdd:TIGR00894 363 LTIIILTLANAVSSGPLAGVLIN---------SLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQDsknvWLIVFL 433
|
....*...
gi 38093649 465 MLISADVL 472
Cdd:TIGR00894 434 IMAFVNIL 441
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
93-477 |
1.02e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 60.28 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGyfwniHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWF 172
Cdd:cd17474 42 AFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS-----DSFALLLAGRALQGIGAAGLGPLALTLIGDLF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGIWVNGQWGLSFIVPGIITAVMGVITFLFLIEHPEDVDCAPPQHHGEPAENQD 252
Cdd:cd17474 117 EGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 253 NPedpgnspcsiresgletvakcskgpceePAAISFFGAlripgvveFSLCLLFaklvsYTFLYWLPLYIANVAHFSAKE 332
Cdd:cd17474 197 GR----------------------------GLLTFLVSA--------FLYFFLY-----FAFLTYLPFLLELLYGISPII 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 333 AGDLSTLFDVGGIIGGIVAGLVSDYTNGRATTCCVMLILAAPMMFLYNYIGQDGIASSIVMLI-ICGGLVNgpyALITTA 411
Cdd:cd17474 236 IGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFgLGLGLNL---PLLTTL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38093649 412 VSAdlGTHKSLKGnakalsTVTAIIDGTGSIGAALGPLLAGLISP-TGWNNVFYMLISADVLACLLL 477
Cdd:cd17474 313 VTE--LAPEEERG------TASSLYNFVRFLGQAVGPLLFGLLLEiFGLSAPFLVGAAIALAAAVLL 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
93-476 |
6.22e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 57.94 E-value: 6.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGyfWNIhelWYFVVIQVCNGLVQTTGWPSVVTCVGNWF 172
Cdd:cd17324 42 AYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA--PSF---ALLLLARALAGLAHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGiWVNGQWG--LSFIVPGIITAVMGVITFLFLiehpedvdcappqhhgepaen 250
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGG-LLGQLLGwrAAFLAIAVLALLAALLLWRLL--------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 251 qdnPEDPGNSPCSIresgletvakcskgpceePAAISFFGALRIPGVVE---FSLCLLFAKLVSYTFlywLPLYIANVAH 327
Cdd:cd17324 175 ---PSLPPKKPGSL------------------GLLSSLLLLLRNPRLRLaylITFLLFGGFFALYTY---LAPFLTDVPG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 328 FSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTNGRATTccVMLILAAPMMFLYNYIGQDGIASSIVMLIICGGLVNGPYAL 407
Cdd:cd17324 231 FSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALL--IALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSAL 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 408 ITTAVSAdlgthkslkgNAKALSTVTAIIDGTGSIGAALGPLLAGL-ISPTGWNNVFYMLISADVLACLL 476
Cdd:cd17324 309 QTRVLRL----------APEARGLASSLYLAAYNLGGALGAALGGLvLDHGGWAGVGWVGAALLLLALLL 368
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
75-234 |
6.65e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 57.63 E-value: 6.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 75 WAPFDKDNY---KELLGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLftSLFGLGYFwniHELWYFVVIQV 151
Cdd:cd17475 18 LAPFLQEDLhlsLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGA--AALLMALV---GSYPVLLVLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 152 CNGLVQTTGWPSVVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLI-AGIWVNGQWGLSFIVPGIITAVMGVITFLFLI 230
Cdd:cd17475 93 LVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALlPPLALHYGWRAAFVVAGLVSILAAVLFWLFYR 172
|
....
gi 38093649 231 EHPE 234
Cdd:cd17475 173 EPPA 176
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
87-452 |
9.84e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 57.37 E-value: 9.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 87 LGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLfgLGYFWNIhelWYFVVIQVCNGLVQTTGWPSVVT 166
Cdd:TIGR00895 54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL--CALATNV---TQLLILRFLAGLGLGGLMPNLNA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 167 CVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGIWV-NGQWGLSFIVPGIITAVMGVITFLFLiehPEDVDCAPPQHhG 245
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIpVFGWRSLFYVGGIAPLLLLLLLMRFL---PESIDFLVSKR-P 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 246 EPAENQDNPEDPgnspcSIRESGLETVAKCSKgpcEEPAAISFFGALRIPGVVEFSL---CLLFAKLVSYTFLY-WLPLY 321
Cdd:TIGR00895 205 ETVRRIVNAIAP-----QMQAEAQSALPEQKS---TQGTKRSVFKALFQGKTARITVllwLLYFMLLVGVYFLTnWLPKL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 322 IANvAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTNGRATTccVMLILAApmMFLYNYIGQDGIASSIVMLIICGGL- 400
Cdd:TIGR00895 277 MVE-LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTA--LLLLLGA--VFAVLVGSTLFSPTLLLLLGAIAGFf 351
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 38093649 401 VNGPYALITTAvsadlgTHKSLKGNAKALSTVTAIidGTGSIGAALGPLLAG 452
Cdd:TIGR00895 352 VNGGQSGLYAL------MALFYPTAIRATGVGWAI--GIGRLGAIIGPILAG 395
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
93-476 |
1.43e-08 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 56.86 E-value: 1.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLfgLGYFWNIHELWYFVViQVCNGLVQTTGWPSVVTCVGNWF 172
Cdd:cd17318 64 SFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLL--TPLAARGGYGALIVL-RILQGLAQGVTFPAMHALWAKWA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 173 GKGKRGFIMGIWNSHTSVGNILGSLIAG-IWVNGQWGLSFIVPGIITAVMGVITFLFliehpedvdcAPPqhhgepaenq 251
Cdd:cd17318 141 PPLERSRLTSIAYSGSQFGTVIAMPLSGfLCESLGWPSIFYIFGGLGLLWCLLWFFL----------VLP---------- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 252 dnpedpgnspcsiresgletvakcskgpceepaaisFFGALripgVVEFSLCLLFaklvsYTFLYWLPLYIANVAHFSAK 331
Cdd:cd17318 201 ------------------------------------VWAIV----VAHFGHNWGF-----YTLLTELPTYMSDVLHFNIK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 332 EAGDLSTLFDVGGIIGGIVAGLVSDY---------TNGRATTCCVMLILAAPMMFLYNYIGQDGIAsSIVMLIICGGLVN 402
Cdd:cd17318 236 SNGFLSSLPYLAMWICSIVGGYLADWlrsrgilstTTVRKLFTSIGFLGPGVFLIALGYLGSNATL-AVVFLTLSVGLSG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38093649 403 GPYALIttavsadLGTHKSLKGNAKalSTVTAIIDGTGSIGAALGPLLAGLI-----SPTGWNNVFYMLISADVLACLL 476
Cdd:cd17318 315 ACYSGF-------LVNHLDLAPNYA--GTLMGITNTAATIAGIISPLIVGAIvkndqTIGQWRIVFFISAAIYILGAIF 384
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
86-228 |
3.15e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 55.20 E-value: 3.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 86 LLGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGyfWNIHELWYFVVIQvcnGLVQTTGWPSVV 165
Cdd:COG0477 50 QLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PSPELLIAARALQ---GIGAGGLMPGAL 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 38093649 166 TCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAG-IWVNGQWGLSFIVPGIITAVMGVITFLF 228
Cdd:COG0477 125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGlLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
93-235 |
6.39e-08 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 54.56 E-value: 6.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLgyfwnIHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWF 172
Cdd:cd17327 49 VFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAA-----VKNFGGLIALRFFLGLFESGVFPGFILYLGMWY 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 173 GKGKRGFIMGIWNSHTSVGNILGSLIA-GIW----VNG--QWGLSFIVPGIITAVMGVITFLFLIEHPED 235
Cdd:cd17327 124 KREEQAKRIAFFYAAAGLGSIFGGLLAyGVFkilgVGGlaGWRWLFIIEGLITIIIGLVIFFWLPDNPSK 193
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
283-478 |
3.18e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.22 E-value: 3.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 283 PAAISFFGALRIPGVVEFSLCLLFAklvSYTFLYWLPLYIANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTnGRA 362
Cdd:cd17316 168 PALLALLLRRRTLLLILLWFFISFG---YYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-GRK 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 363 TTCCVMLILAAPMMFLYNYIGQDGIASSIVMLIICGGLVNGPYALITTAVSADLGThkslkgnaKALSTVTAIIDGTGSI 442
Cdd:cd17316 244 KTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPT--------EVRATGVGLSYNLGRL 315
|
170 180 190
....*....|....*....|....*....|....*.
gi 38093649 443 GAALGPLLAGLISPTGWNNVFYMLISADVLACLLLC 478
Cdd:cd17316 316 GGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
106-478 |
9.79e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 51.02 E-value: 9.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 106 GVFGERLPLRYYLSAGMLLSGLFTSLFGLgyfwnIHELWYFVVIQVCNGLVQTTGWPSVVTCVGNwFGKGKRGFIMGIWN 185
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGF-----APNYWLLLLLVALAGIGSAAFHPEGARLASQ-AAGGRRGLAMSIFS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 186 SHTSVGNILGSLIAGIWVNGQWGLSFIVPGIITAVMGVITFLFLIehpedvdcapPQHHGEPAENQDNPEDPgnspcsir 265
Cdd:cd17478 126 VGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR----------PLKKPEAKKAAAKSSAR-------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 266 esgletvakcskgpceePAAISFFGALRIPGVVEFSLCLLFAKLVSYtflywLPLYIANVaHFSAKEAGDLSTLFDVGGI 345
Cdd:cd17478 188 -----------------STLKGVWRALLLLLIIVFLRSWVLSSLTTF-----LPFYLVQR-GYSLVFAGLLLSLFLFAGA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 346 IGGIVAGLVSDYtNGRATTCCVMLILAAPMMFLYNYIGqdGIAsSIVMLIICGGLVNGPYALITTAVsadlgtHKSLKGN 425
Cdd:cd17478 245 IGTLIGGPLSDR-FGRRRVIIASLLLAAPFLLLFLLTP--GIW-SYILLVLAGFLLFASFPVTVVLA------QELLPGN 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 38093649 426 AkalSTVTAIIDGTG-SIGAALGPLLAGLISPTGWNNVFYMLISADVLACLLLC 478
Cdd:cd17478 315 V---GLASGLMMGLSfGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
93-446 |
1.05e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 50.65 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGyfWNIHELWYFVVIQvcnGLVQTTGWPSVVTCVGNWF 172
Cdd:cd17503 39 SYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA--PNLASLIIFRILQ---GFGGGVLIPLAQTILLRIY 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGIWVNG-QWGLSFIvpgiITAVMGVITFLFliehpedvdcappqhhgepaenq 251
Cdd:cd17503 114 PPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNlSWRWIFY----INLPIGILALLL----------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 252 dnpedpgnspcsiresgletvakcskgpceepAAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAK 331
Cdd:cd17503 167 --------------------------------APLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 332 EAGDLSTLFDVGGIIGGIVAGLVSDYTNGRATTCCVMLILAA---PMMFLYNYIGQDGIASSIVMLIICGGLVNGPyalI 408
Cdd:cd17503 215 ESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALgtlLLAFLTPDTSLWLIILPLFIRGLGMGLVFMP---L 291
|
330 340 350
....*....|....*....|....*....|....*...
gi 38093649 409 TTAVSADLGTHKSlkGNAKALSTVTAIIdgTGSIGAAL 446
Cdd:cd17503 292 NTLALNSLPPEQI--GDATALFNTIRQL--GGSIGTAL 325
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
93-454 |
3.36e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.52 E-value: 3.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMF---ISGVFGERLPLRY-----YLSAGMLLSGLFTSLFGLGYFWN-IHELWYFVVIQVCNGLVQTTGWPS 163
Cdd:COG2211 51 ILLVARLWDAItdpLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSpTGKLIYALVTYLLLGLAYTLVNIP 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 164 VVTCVGNWFGKGK-RGFIMGIWNSHTSVGNILGSLIAGIWVN-------GQWGLSFIVPGIITAVMGVITFLFLIEHPEd 235
Cdd:COG2211 131 YSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAafggdaaLGYRLTALIFAVLGLLAFLLTFFGTKERPV- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 236 vdcappqhhgepaenqdnpedPGNSPCSIRESgletvakcskgpceepaaisFFGALRIPGVVEFSLCLLFAKLVSYTFL 315
Cdd:COG2211 210 ---------------------PEEEKVSLKES--------------------LKALLKNRPFLLLLLAYLLFFLALALVA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 316 YWLPLYIANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTnGRATTCCVMLILAAPMMFLYNYIGQDGIASSIVMLI 395
Cdd:COG2211 249 ALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF-GKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAA 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 38093649 396 ICGgLVNGPYALITTAVSADLGTHKSLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLI 454
Cdd:COG2211 328 LAG-IGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
94-228 |
8.61e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.00 E-value: 8.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 94 FLIAYAIGMFISGV----FGERLPLRYYLSAGMLLSGLFTSLFGLgyfwnIHELWYFVVIQVCNGLVQTTGWPSVVTCVG 169
Cdd:cd06173 249 LLAAFGVGALLGALllgrLSKRRRRGRLLLIGALLLGLALLVLGL-----SPSLWLLLAALFLLGLAGGLFNVPLNTLLQ 323
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38093649 170 NWFGKGKRGFIMGIWNSHTSVGNILGSLIAGiWVNGQWGLS--FIVPGIITAVMGVITFLF 228
Cdd:cd06173 324 LRVPDELRGRVFSVYNALNSGAMPLGALLAG-LLADALGLSavFLLAGALLLLAALLLLLL 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
300-481 |
1.42e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.03 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 300 FSLCLLFAKLVSYTFLYWLPLYIANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTNGRATTCCVMLILAAPMMFLY 379
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 380 nyigqdgIASSIVMLIICG---GLVNGPYALITTAVSADLGTHkslkgnaKALSTVTAIIDGTGSIGAALGPLLAG-LIS 455
Cdd:pfam07690 81 -------FASSLWLLLVLRvlqGLGAGALFPAALALIADWFPP-------EERGRALGLVSAGFGLGAALGPLLGGlLAS 146
|
170 180
....*....|....*....|....*.
gi 38093649 456 PTGWNNVFYMLISADVLACLLLCRLV 481
Cdd:pfam07690 147 LFGWRAAFLILAILSLLAAVLLLLPR 172
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
94-478 |
1.88e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 46.83 E-value: 1.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 94 FLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLftSLFGLGYFWNIHELWYFVviQVCNGLVQTTGWPSVVTCVGNWFg 173
Cdd:cd17353 47 TIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL--GFILSAFAISLPLLFLGY--GVLGGIGAGIGYITPVSTAVKWF- 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 174 KGKRGFIMGIWNSHTSVGNILGSLIAGIWVNGQ-WGLSFIVPGIITAVMGVITfLFLIEHPedvdcaPPQHHGEPAENQD 252
Cdd:cd17353 122 PDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVgVPTTFLILGIIFLIIIVIG-AFLIRDP------PKGWVPPGVDPLA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 253 NPEDPGNSPCSIREsgletvakcskgpceepaaisffgALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAKE 332
Cdd:cd17353 195 NNAENSPRDYTPRE------------------------MLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 333 AGDLSTLFDVGGIIGGIVAGLVSDYTnGRATTCCVMLILAAPMMFLYNYIGQDGIASSIVMLII--CGGlvnGPYALITT 410
Cdd:cd17353 251 AALAVSILSIFNGGGRPFWGWLSDKI-GRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIgfCYG---GGFALFPA 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38093649 411 AVSADLGThkslkgnaKALSTVTAIIDGTGSIGAALGPLLAGLISPT-GWNNVFYMLISADVLACLLLC 478
Cdd:cd17353 327 LTADFFGT--------KNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTgGYNAAFIIAAALSLVALALAL 387
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
93-234 |
2.58e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.40 E-value: 2.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLsagMLLSGLFTSLFGLGYFWNIHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWF 172
Cdd:COG2271 224 LPFLAGIVGSLLGGWLSDRLGRRRKL---VLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38093649 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGIWV-NGQWGLSFIVPGIITAVMGVITFLFLIEHPE 234
Cdd:COG2271 301 PKKARGTASGLVNTFGFLGGALGPLLVGYLLdATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
85-228 |
3.44e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 46.04 E-value: 3.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 85 ELLGGvdNAFLIAYAIG-MFISGV----FGERLPLRYYLSAGMLLSGLFTSLFGLGYFWnIHELWYFVVIQVCNGLVQTT 159
Cdd:cd17335 226 QDLGG--SKTLIGLLWTvGVVSEIpfffFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSF-LENPWLVLPIELLHGLTFAL 302
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38093649 160 GWPSVVTCVGNWFGKGKRGFIMGIWNS-HTSVGNILGSLIAG-IWVNGQWGLSFIVPGIITAVMGVITFLF 228
Cdd:cd17335 303 VWAAAVSYASAAAPPGLRATAQGLLQGlYFGLGGGLGSLIGGyLYEAFGARTTFRFFAIAALAGLLAFFLI 373
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
90-446 |
4.97e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 45.83 E-value: 4.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 90 VDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYfwNIHELWYFVVIQ-VCNGLVQttgwPSVVTCV 168
Cdd:TIGR00711 42 VITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP--NLELMIIFRVIQgFGGGPLI----PLSFSTL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 169 GNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGiWVNG--QWGLSFIVPGIITAVMGVITFLFLiehPEDVdcapPQHHge 246
Cdd:TIGR00711 116 LNIYPPEKRGRAMAIWGLTVLVAPALGPTLGG-WIIEnyHWRWIFLINVPIGIIVVVVAFFIL---PRDK----PAAS-- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 247 paenqDNPEDPGNSPCSIRESGLETVAkcSKGPCEEPAAISFFGALRIPGVVEF-------------------------- 300
Cdd:TIGR00711 186 -----ENFDFLGLLLLSVGLGSLLYGL--SEGPERGWFDSNEILILSITGLVAIiafvvweltddnplvdlrlfkyrnft 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 301 --SLCLLFAKLVSYTFLYWLPLYIANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTNGRA-TTCCVMLILAAPMMF 377
Cdd:TIGR00711 259 igCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKlVTIGLILYAVGFYWR 338
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38093649 378 LYNYIGQDGIASSIVMLIICGGLVNGPYALITTAVSADLGTHKSlkGNAKALSTVTAIIdgTGSIGAAL 446
Cdd:TIGR00711 339 AFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKI--ARGSSLSNFTRQL--GGSIGTAL 403
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
93-230 |
7.97e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 7.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFglgYFWNIHELWYFVVIQVCNGLVQTTGWPSVVTCV---- 168
Cdd:COG2211 272 LYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL---FFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLadvv 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 169 --GNW-FGKGKRGFIMGIWNSHTSVGNILGSLIAGIW----------------VNGQWGLSFIVPGIITAVMGVITFLFL 229
Cdd:COG2211 349 dyDEWkTGRRREGLYFGIFTFAIKLGQALAGALAGLLlalfgyvagaaqspsaLTGIRLLFFLLPAVLLLLAALLLLFYP 428
|
.
gi 38093649 230 I 230
Cdd:COG2211 429 L 429
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
284-454 |
1.03e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.47 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 284 AAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTNGRAT 363
Cdd:cd17321 157 VPIGLVALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLV 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 364 TCCVMLILAAPMMFLYNYIGQDGIASSIVMLIICG---GLVNGPyalITTAVSADLGTHKSlkgnakalSTVTAIIDGTG 440
Cdd:cd17321 237 LVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGlglGLFATP---LTNAALSSVPKEKA--------GAASGILNTAR 305
|
170
....*....|....
gi 38093649 441 SIGAALGPLLAGLI 454
Cdd:cd17321 306 QLGGALGVALLGAL 319
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
89-230 |
2.51e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.35 E-value: 2.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 89 GVDNA--FLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLfGLGYFWNIHELWYFVVIQVCNGLVQTTGWPSVVT 166
Cdd:cd17489 225 GISNAglFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLAL-GLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQA 303
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 38093649 167 CVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGIWVNgqwGLSFIVPGIITAVMGVITFLFLI 230
Cdd:cd17489 304 LAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAE---LFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
94-230 |
2.67e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.18 E-value: 2.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 94 FLIAYAIGMFISGVFGERLPLRYYLsagmLLSGLFTSLFGLGYFWNIHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWFG 173
Cdd:cd06174 248 FGLAGALGSLLLGLLSDRLIGRKPL----LLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP 323
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 38093649 174 KGKRGFIMGIWNSHTSVGNILGSLIAGIWVNGQWGLSFIVpgIITAVMGVITFLFLI 230
Cdd:cd06174 324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF--LVLAVLLLLAAILLL 378
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
88-229 |
4.66e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 42.54 E-value: 4.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 88 GGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWNiheLWYFVVIQVCNGLVQTTGWPSVVTC 167
Cdd:cd17380 37 GLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSS---LPLLILSRILLGLGEGVHFPSMTSL 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38093649 168 VGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGIWVNGQ-WGLSFIVPGIITAVMGVITFLFL 229
Cdd:cd17380 114 FSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYgWPSVFYFFGLLGLLWALVWLIYL 176
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
99-228 |
7.52e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 7.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 99 AIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWNIHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWFGKGKRG 178
Cdd:cd17474 244 SVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERG 323
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 38093649 179 FIMGIWNSHTSVGNILGSLIAGIWVnGQWGLS--FIVPGIITAVMGVITFLF 228
Cdd:cd17474 324 TASSLYNFVRFLGQAVGPLLFGLLL-EIFGLSapFLVGAAIALAAAVLLALL 374
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
102-230 |
8.75e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 41.76 E-value: 8.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 102 MFISGVFGERLPLRYYLSAGMLLSGLFTSLFglgyfWNIHELWYFVVIQVCNGLvqttgWPSVVTCVG----NWFGKGKR 177
Cdd:cd17471 252 MLLAGLLAKRFGKRRLLLAGFLAGVLFYLGL-----ALATSLWQLIALQLLNAI-----FIGITAGLGisyfQDLMPGQP 321
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 38093649 178 GFIMGIWNSHTSVGNILGSLIAGIWVnGQWGLSFIVpgIITAVMGVITFLFLI 230
Cdd:cd17471 322 GLATTLYSNASRIGSLLGGLLAGVIA-QYFGYRAVF--LVCAVLALLALVLLL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
304-481 |
1.14e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.11 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 304 LLFAKLVSYTFLYWLPLYIANVA--------HFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTnGRATTCCVMLILAAPM 375
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPAlpliaadlGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 376 MFLYnyigqdGIASSIVMLIIC---GGLVNGPYALITTAVSADLGTHKSLkgnAKALSTVTAIIdgtgSIGAALGPLLAG 452
Cdd:COG2814 89 SLLC------ALAPSLWLLLAArflQGLGAGALFPAALALIADLVPPERR---GRALGLLGAGL----GLGPALGPLLGG 155
|
170 180 190
....*....|....*....|....*....|
gi 38093649 453 LISPT-GWNNVFYMLISADVLACLLLCRLV 481
Cdd:COG2814 156 LLADLfGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
86-241 |
1.15e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.06 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 86 LLGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWNIHELWYFVVIQVCNGLVQTTGWPSVV 165
Cdd:cd06173 35 LVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQ 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38093649 166 TCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGIWVnGQWGLSFIVPGIITAVMGVITFLFLIEHPEDVDCAPP 241
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV-ALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGES 189
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
93-228 |
1.35e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.99 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWNIHeLWYFVVIQVCNGLVqttgWPSVVTCVGNWF 172
Cdd:COG0738 254 LFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLA-LIGLALVGLGLSLM----FPTIFSLALDGL 328
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 38093649 173 GKgKRGFIMGIWNSHTSVGNILGSLIAGiWVNGQWGL--SFIVPGIITAVMGVITFLF 228
Cdd:COG0738 329 GK-RTAAAVSAVLIMGIVGGAIGPPLIG-FLADAFGLraAFLVPLVCYLLILLLALAL 384
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
99-477 |
1.64e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 40.63 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 99 AIGMFISGVFGERLPLRYYLSAGMLLSGLFtslfGLGYFW--NIHELWYFVVIQ-VCNGLVQTtgwpSVVTCVGNWFGKG 175
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIG----GVAGLFldSLYALLASRALLgIGVAGIMT----LATALIGDYFEGE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 176 KRGFIMGIWNSHTSVGNILGSLIAGIWVNGQWGLSFIVPGIitAVMGVITFLFLIEHPEDVDCAPPQHHGEPAenqdnpe 255
Cdd:cd17473 121 ERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLL--ALPVLILVLLFLPEPARKSKSAASPGAATA------- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 256 dpgnspcsiresgletvakcskgpceepaaisffGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAKEAGD 335
Cdd:cd17473 192 ----------------------------------AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 336 LSTLFDVGGIIGGIVAGLVSDYTNGRATTCCVMLILAAPMMFLynyigqdGIASSIVMLIICGGLVNGPYALITTAVSAD 415
Cdd:cd17473 238 ALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLL-------ALASGLWVVLLGAILAGLGFGLLLPTLNSW 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38093649 416 LGTHKSLKGNAKALSTVTAIIdgtgSIGAALGPLLAGLISPTGWNNVFYMLISADVLACLLL 477
Cdd:cd17473 311 AMSLVPPELRGRAMGIVTSAF----FLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAI 368
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
318-481 |
2.67e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 40.25 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 318 LPLYIANVaHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDyTNGRATTCCVMLILAAPMMFLYnyigqdGIASSIVMLII- 396
Cdd:cd17325 19 LPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSD-RFGRKRLLLLGLLLLAVSTLLF------AFATSYWQLLLa 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 397 --CGGLVNGPYALITTAVSADLGTHKSLkgnAKALSTVTAIIdgtgSIGAALGPLLAGLISPT-GWNNVFYMLISADVLA 473
Cdd:cd17325 91 rfLQGLASAAVWPAAMALIADIAPPEER---GRAMGIFSSAI----GLGFLIGPLLGGLLADAlGYRAPFLVCAALALLA 163
|
....*...
gi 38093649 474 CLLLCRLV 481
Cdd:cd17325 164 LVLALLLL 171
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
174-228 |
3.22e-03 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 39.87 E-value: 3.22e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38093649 174 KGKRGFIMGIWNSHTSVGNILGSLIAGIWVNGQWGLS--------FIVPGIITAVMGVITFLF 228
Cdd:cd17346 334 AKFAGFMMGLWFLASALGNILAGYLAGFYAQPKDPLAsalvytdyFGLIGVIALVAGIILLLL 396
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
100-233 |
5.75e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 39.23 E-value: 5.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 100 IGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWNIHeLWYFVVIQVCNGLVQTTGWPSVVTCVGNWFGKGKRGF 179
Cdd:TIGR00898 138 VGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPN-YTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAI 216
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 38093649 180 IMGIWNSHTSVGNILGSLIAgiWVNGQW-GLSFIV--PGIITAVMgvitFLFLIEHP 233
Cdd:TIGR00898 217 VGTLIQVFFSLGLVLLPLVA--YFIPDWrWLQLAVslPTFLFFLL----SWFVPESP 267
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
93-477 |
6.43e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.79 E-value: 6.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 93 AFLIAYAIGMFISGVFGE---RLPLRYYLSAGMLLSGLFTSLfGLGYFWNIHELWYFVV-IQVCNGLVQTTGWPSVVTCV 168
Cdd:cd17355 39 VISLAFTVGLLAFGLAQPfvgRLLDRFGPRRVMLLGLLLLAA-GLVLLALATSLWQLYLlWGLLGGGGAGTLAAVAFATV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 169 GNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGiWVNGQWG--LSFIVPGIITAVMGVITFLFLIEHPEDVDCAPPQHHGE 246
Cdd:cd17355 118 AAWWFERRRGLALGILTAGGGLGSLVFLPLGA-ALIEAFGwrTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 247 PAenqdnpedpgnspcsiresgletvakcskgpceepAAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANvA 326
Cdd:cd17355 197 AS-----------------------------------PGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-R 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38093649 327 HFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTNGRATTCCVMLILAAPMMFLYNYIGQDGIASSIVMLIicgGLVNGPYA 406
Cdd:cd17355 241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALF---GLGWGATV 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38093649 407 LITTAVSADLGthkslkgNAKALSTVTAIIDGTGSIGAALGPLLAGLI-SPTG-WNNVFYMLISADVLACLLL 477
Cdd:cd17355 318 PLTAALAARYF-------GARSYGTLFGLVFAPHQLGSALGPWLGGLLyDRTGsYTAAWALAVALGLIAALLV 383
|
|
| |
